Showing 29 results for Aria
Zeinab Shayeghian, Parisa Amiri, Maria E. Aguilar-Vafaie, Mohammad Ali Besharat, Mahmoud Parvin, Kobra Roohi Gilani,
Volume 14, Issue 4 (5-2015)
Abstract
Background: One of the important goals in control diabetes to maintain normal levels of glycated hemoglobin, but different social and psychological factors such as social support and alexithymia play role on process of this control. The purpose of present study was to examine the role of alexithymia on the association of social support and glycated hemoglobin in patients with type 2 diabetes. Methods: This was a cross-sectional study. The study sample consisted of 100 (60% females, 40-60 years) type 2 diabetic out-patients visiting the Labbafinejad hospital in 2013. The sample of the present study was a convenience sample. Measures of data collection included demographic and anthropometric questionnaires, Multidimensional Scale of Perceived Social Support, Toronto Alexithymia Scale and test of glycated hemoglobin. The collected data were analyzed, using multiple regression analysis. Results: Pearson's correlation coefficients showed a significant association between better reported perceived social support and lower alexithymia and glycated hemoglobin. Results of hierarchical linear regression analyses indicated that social support explained 23% and alexithymia 31% of glycated hemoglobin variance. As well as, alexithymia moderated association between perceived social support and glycated hemoglobin in patient with type 2 diabetes. Conclusion: Based on the present data, alexithymia has moderate role on the association between perceived social support and glycated hemoglobin in patient with type 2 diabetes. The results of this study highlight effective psychological factors in glycated hemoglobin which can help in the conceptualization, planning and design of treatment policies for control and treatment of type 2 diabetes.
Abdolhossein Shiravi, Maria Sayyad Zomorrodi,
Volume 15, Issue 1 (1-2016)
Abstract
Background: Diabetic foot ulcers are important topic in diabetes care. Diabetes is one of the most common metabolic diseases of endocrinology. Raspberry (Rubus fruticosus) has anti-inflammatory, anti-septic and anti-oxidant effects. The aim of present study is healing effects of raspberry extract on the regeneration process of skin wounds in control and diabetic rats.
Methods: In this study, 48 adult male rats were divided into four groups (n=12 each) including: control group (non-treated and non-diabetic rats), sham (eucerin-treated diabetic rats), experimental1 (non-treated diabetic rats) and experimental 2 (raspberry-treated diabetic rats). Diabetes was induced by 55 mg/kg Streptozotocin (STZ) in three groups of rats. A wound with 3 cm length was created on the skin of back side of animals in all groups. The experimental 1 group was treated by eucerin and experimental 2 groups were treated by raspberry extract two times in a day. Microscopic and macroscopic studies were performed on wound healing process on days of 3, 5, 7, 14 and 21.
Results: The findings showed that sham and experimental 1 group had later healing effect comparing with control group. The speed of wound healing in raspberry extract-treated rats (experimental 2 groups) had significantly increased in comparison with control group and the wound surface area has been significantly decreased in comparison with all other groups (P ≤ 0.05).
Conclusion: It seems that topical application of raspberry extract can accelerate the wound healing in diabetic rats and materials in raspberry extract stimulate the collagen synthesis, faster wound contraction and angiogenesis.
Saeedeh Rahnama Falavarjani, Azizeh Asadzadeh, Fatemeh Heidarian Naini,
Volume 18, Issue 1 (1-2019)
Abstract
Background: Inhibitors of α-glucosidase by interfering with digestion of carbohydrates play a role in controlling diabetes. Thymus vulgaris is an herb belonging to the mint family (lamiaceae). The essence of this plant contain the phenols such as thymol and carvacrol, cymene, linalool, pinene. The aim of this study was to investigate the inhibitory effect of the constituents of the thymus vulgaris extract on the activity of α-glucosidase enzyme by molecular docking.
Methods: In this study, to investigate how the compounds are attached to the active site of the enzyme, mapping of chemical structure of the compounds, energy optimization, docking studies and final analysis were carried out by ChemDraw, HyperChem, AutoDock 4.2, DS Visualizer and Lig Pluto software, respectively.
Results: All of the studied compounds were able to occupy the active site of the enzyme, among all of them, the best results of docking was related to the combination of Caryophlla-4- (12), 8 (13) -dien-5-β-ol. In fact, this compound has the most negative energy level of connection, the highest affinity for binding to the active site of the enzyme and the interaction site is similar to that of the co-crystal molecule.
Conclusion: considering the high efficacy of plant extract compounds in the bioinformatics study, and for complementary studies, the effect of the extract of this plant can be analyzed in order to control the increase of glucose in vitro and in vivo conditions.
Fatemeh Bandarian, Nazli Namazi, Mohammad Pajouhi, Mohammadreza Amini, Neda Mehrdad, Bagher Larijani,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Endocrinology and Metabolism Research Institute (EMRI) was established in 1993. EMRI has progressed step by step from the beginning and has reached maturity in the last 25 years. EMRI has expanded, advanced in human resources and infrastructures (laboratories and new technologies) and gained first rank in endocrine research in various fields. It has also worked with regional and international organizations such as the World Health Organization (WHO), the International Osteoporosis Foundation (IOF), and the American Clinical Endocrine Society (AACE). This article provides an overview of EMRI activities over a quarter of a century.
Shahnaz Esmaeili, Fatemeh Bandarian, Farideh Razi, Hossein Adibi, Ali Jalili, Babak Arjmand, Camelia Rambod, Ensieh Nasli-Esfahani, Bagher Larijani,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Background: Endocrinology and Metabolism Research Institute (EMRI) is one of the largest research institutes in Iran, which has been established to develop research strategies and manage endocrine and metabolic diseases such as diabetes. The purpose of this report is to review and summarize research activities related to diabetes over a quarter of a century at EMRI.
Methods: A comprehensive search of PubMed, Scopus and EMBASE was conducted to find diabetes-related studies in EMRI. After extracting the data, the articles were classified according to the type of article, the level of evidence, the types of diabetes and their subject.
Results: After eliminating duplicates and screening, finally 228 articles were classified. Most diabetes research conducted at the Diabetes Research Center (DRC) was on type 2 diabetes (37%). By article type, most of the articles were original. In addition, clinical studies provided the most evidence in the obtained documents. By topic, most of the articles were related to the basic sciences and factors related to diabetes, followed by studies on the management and prevention of diabetes.
Conclusion: Most of the research conducted in the Diabetes Research Center in the past quarter of a century is of original studies in the field of basic sciences in the field of type 2 diabetes and most of the evidence produced is related to observational studies.
Farnaz Onsori, Mina Akbari Rad, Maryam Emadzadeh, Ali Moradi, Mohammad-Javad Mojahedi, Alireza Shariati, Mohammad-Ali Yaghoubi,
Volume 23, Issue 3 (9-2023)
Abstract
Background: Diabetic nephropathy is the main cause of end-stage kidney disease in diabetic patients. Several inflammatory markers related with diabetic nephropathy have been investigated so far. It is necessary to identify easily available and cost-effective indices. We aimed to determine the relationship between the neutrophil to lymphocyte ratio and mean platelet volume with diabetic nephropathy.
Methods: This cross-sectional study was performed from 2021 to 2022 in diabetes clinic of Ghaem hospital, Mashhad. Patients with type II diabetes were categorized into two groups: without and with nephropathy (urinary albumin excretion greater than 30 mg/24h or GFR less than 60). Patients’ data, including demographic data, past medical and drug history and lab data were gathered and analyzed.
Results: In total, 100 diabetic patients including 50 with (mean age=64.04±7.40 years) and 50 without nephropathy (mean age=56.06±6.36 years), were studied. Patients with nephropathy were older, had a longer history of diabetes and a higher blood pressure (P < 0.05). However, the distribution of gender, weight, height, and BMI was not significantly different the two groups (P>0.05). The absolute neutrophil count was not significantly different between the two groups (P>0.05), while the mean platelet volume, neutrophil% and neutrophil/lymphocyte ratio were significantly higher in patients with nephropathy (P<0.05).
Conclusion: According to our findings, patients with diabetic nephropathy had higher mean platelet volume, neutrophil%, and neutrophil/lymphocyte ratios compared to diabetic patients without nephropathy.
Saeid Shamlou Kazemi, Ali Heidarianpour,
Volume 23, Issue 3 (9-2023)
Abstract
Background: During menopause, women are more exposed to the risk factors of many diseases, including metabolic syndrome, and sirtuin-1 may be involved in this disorder. The aim of this study was to investigate the effect of circular resistance training and moderate intensity continuous training on metabolic indices and Sirtuin1 serum level in women with metabolic syndrome.
Methods: This study was conducted as a clinical trial in women with metabolic syndrome in two intervention groups (15 people in resistance training group and 15 people in continuous training group) and a control group (15 people). The intervention group underwent an exercise program for eight weeks and three sessions per week, and the control group had their own routine program. After the last training session, serum levels of Sirtein1 and lipid factors were measured. To analyze the data, t-test and covariance were used at a significant level (P≤0.05).
Results: The results of the t-test showed that there was a significant difference in the intra-group changes of the studied variables (SIRT1, HDL, LDL, TG, FBS, Total Cholesterol) in both exercise groups (P≥0.05), but in No significant difference was observed in the control group (P<0.05). The results of the covariance test showed that there is a significant difference between the three groups in the indices (SIRT1, HDL, LDL, TG, FBS, Total Cholesterol) after the test (P<0.05).
Conclusion: Eight weeks of circular resistance training program and continuous training with moderate intensity has a positive effect on metabolic indices and serum level of Sirtuin1 in people with metabolic syndrome.
Mahin Bndarian, Fatemeh Bandarian,
Volume 23, Issue 5 (12-2023)
Abstract
Sodium-glucose transporter-2 (SGLT-2) inhibitors are a relatively new class of anti-diabetic drugs with potent effect in glycemic control and weight loss, as well as beneficial effects in the prevention and control of cardiac and renal complications in non-pregnant patients with type 2 diabetes. However, there is no enough clear and strong evidence about the beneficial or adverse effect of SGLT-2 inhibitors usage during pregnancy for management of gestational diabetes (GDM) in human. This short letter discusses challenges in application of SGLT-2 inhibitors in management of GDM.
Paria Maghouli, Roghayyeh Afroundeh, Mohammad Ebrahim Bahram, Amaneh Pourrahim Ghoroughchi,
Volume 24, Issue 2 (6-2024)
Abstract
Background: The aim of this study was to investigate the effect of eight weeks of circuit resistance training and saffron supplement on visfatin serum levels and insulin resistance in overweight men.
Methods: In this semi-experimental study, 40 obese and overweight students were randomly divided into 4 groups: exercise, exercise+supplement, supplement and control (10 people in each group). The exercise groups performed circular resistance exercises for eight weeks and three sessions each week for 90 minutes in the evening. The supplement and exercise+supplement groups used saffron tablets with a dose of 30 mg per day as a supplement. Blood samples were collected in two phases of the pre-test and 48 hours after the last training session. The data were analyzed using covariance and paired t test at a significant level of P≤0.05.
Results: Correlated t results showed a significant decrease in visfatin and insulin resistance in the post-test of the training, training+supplement and supplement groups compared to the pre-test (P<0.05). The results of the analysis of covariance showed that visfatin increased and the insulin resistance index decreased significantly in the exercise, exercise+supplement and supplement groups compared to the control group (P<0.05).
Conclusion: It seems that eight weeks of circuit resistance training and the addition of saffron help on visfatin serum levels and insulin resistance can lead to the reduction of these two variables in overweight men. The saffron plant can play a protective role due to the presence of flavonoids and by stimulating the secretion of Visfatin.
