Iranian Journal of

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Background: Patients with type 2 diabetes mellitus are more prone to depression. Prevalence of depression in the Iranian results of studies is different. Therefore, the present study aims to study the prevalence of depression in Iranian patients with type II diabetes mellitus.

Methods: This study is a systematic review based on PRISMA guideline for systematic reviews and meta-analyses study. Literature searches of, Scopus, MEDLINE, PubMed, Science Direct, Cochrane, EMBASE, Web of Science, Springer, Online Library Wiley, Google Scholar search engine and Iranians database for publications in Persian and English were conducted up to December 2015. Searches were performed by two researchers independently using standard keywords. Reviewers extracted data and assessed methodological quality in duplicate.  Meta-analysis was performed using STATA, version 11.1 to combine data through Random Effects Model.

Results: Sixteen studies and 3,284 subjects with a mean age of 48.6 years were included in the analysis.  The prevalence of depression in Iranian patients with type II diabetes was estimated 54.8% (95% CI: 43.5- 66.1). This range for males and females were calculated 32.2 %( 95% CI: 16.3-48.1) and 60% (95% CI: 46.4-73.7), respectively. The highest prevalence of depression was in the center of Iran (60%) and the lowest rate was in the west of Iran (38%).

Conclusion: Regarding to high prevalence of depression in patients with type II diabetes, Implementation of screening program for psychiatric disorders, especially depression as well as conducted psychiatric consultation routinely for diagnosis and treatment of depression in these patients it seems necessary.

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Background: Assessing the health literacy of diabetic patients requires the availability of a tool specific to this group. The Diabetes Health Literacy Assessment Questionnaire (LAD) is one of the tools used to measure the health literacy of diabetic patients. The present study was conducted with the aim of translating and validating the Persian version of the LAD questionnaire.
Methods: The present study aimed to determine the validity and reliability of the Persian version of the Health Literacy Assessment Questionnaire for diabetic patients on 300 patients with diabetes in 1398, by sampling. Stages of study: First: Translation and preparation of the Persian version of the health literacy questionnaire in order to design and select items and their qualitative evaluation by the second group: Quantitative evaluation of narrative features using the opinions of the third group of experts: Formal narrative evaluation (comprehensibility) and The reliability of the questionnaire was assessed by a small group of the target population in a fourth experimental study: analysis of items, validity assessment and reliability of the final questionnaire.
Results: In the analysis of organizational structure items, the effects of roof and floor were not observed. The highest averages were for items 8 and 12 and the lowest averages were for items 6. According to the Skewness Index, no deviation was observed in the items. Based on the results, the instrument had acceptable internal stability. Detective factor analysis identified two factors for the Diabetes Health Literacy Questionnaire: one was individual understanding and the second was social support.
Conclusion: The results of exploratory factor analysis, Diabetes Health Literacy Questionnaire (LAD) have good validity and reliability and can be used to measure the health literacy of diabetic patients.

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Background: Imbalance of apoptotic factors plays important role in pathogenesis of diabetes. Considering the role of curcumin supplementation and high-intensity interval training (HIIT) on these factors, the aim of this study was to investigate effects of four weeks of HIIT with curcumin supplementation on Bax and Bcl-2 gene expression in the soleus muscle of diabetic rats.
Methods: Present study was experimental research. 30 male Wistar rats were divided into one normal control (NC), and four diabetic groups: control (DC), supplement (SDC), high-intensity interval training (DHIIT) and high-intensity interval training supplement (SDHIIT). The training protocol was performed five days a week for four weeks, which included five to seven two-minute intervals at 80 to 90% of maximum power until exhaustion and one-minute recovery at 30% of maximum power until exhaustion. At the same time, Curcumin gavage at a dose of 100 mg/kg was performed daily. Bax and BCL-2 gene expression levels were measured by the qReal-TimePCR method and data were analyzed by two-way analysis of variance at a significant level of p≥0.05.
Results: Bcl-2 gene expression was significantly increased in DHIIT and SDHIIT groups compared to DC (P= 0.000). Also, a significant decrease in Bax gene expression was observed in DHIIT and SDHIIT groups compared to DC (P=0.000). There was a significant difference between DHIIT and SDHIIT in Bcl-2 (P=0.000) and Bax (P=0.013) gene expression.
Conclusion: It seems that HIIT in combination with curcumin supplementation, is more effective in improving the balance between apoptosis factors than any of these interventions alone.