Showing 45 results for Obesity
Khalid Mohamadzadeh Salamat,
Volume 17, Issue 6 (10-2018)
Abstract
Background: The relationship between adipokines, insulin resistance and type 2 diabetes has been well documented. However, the effect of exercise training modalities on some of the new adipokines and their association with insulin resistance is not clear. The purpose of this study was to compare the effect of endurance and progressive resistance training on serum adiponectin, vaspin and insulin resistance in overweight and obese men.
Methods: 33 overweight men (mean BMI= 27.3 kg/m2) were randomly divided into 3 groups of n=11, including; 1- continues training, 2- progressive resistance training and 3-control. The training protocols was lasted to eight weeks, three days a week in continues and progressive resistance training groups. Before the beginning of the training and 72 hours after the last training session, blood samples were collected for measuring serum adiponectin, vaspin, glucose and insulin.
Results: There was a significant decrease in insulin levels and a significant increase in serum adiponectin and vaspin in both groups of continuous and progressive resistance training (P<0.05). After the training, there was a significant difference between the groups in the concentration of adiponectin (P= 0.001) and vaspin (P= 0.021). However, there was no significant difference between continuous and progressive resistance training groups in any of the variables.
Conclusion: It seems that progressive resistance training like the endurance training, improves anti-inflammatory indices and insulin resistance of overweight and obese men.
Karim Azali Alamdari, Mousa Khalafi,
Volume 18, Issue 1 (1-2019)
Abstract
Background: Fibroblast growth factor 21 (FGF21) plays an important role in regulation of energy metabolism and insulin resistance; however, the synergistic effects of high intensity interval training (HIIT) on FGF21 and insulin resistance are not elucidated which was focused in this study.
Methods: This experimental research was conducted by pretest- posttest design with control group. In this study, 24 obese men were assigned into two groups including
HIIT (n=12, age: 39.83 ± 5.63 years, weight: 100.83 ± 5.81 kg and body mass index: 32.73 ± 2.8 kg/m2) and Control (n=12, age: 39.41 ± 5.23 years, weight: 100.08 ± 4.71 kg, and body mass index: 32.34 ± 1.43 kg/m2). The HIIT group experienced eight weeks of intensive exercises (three sessions per week, four bouts in each session at the intensity of 85-90% of maximum heart rate (MHR) with 3-minute active rest intervals (at 60-50% of MHR) between exercise bouts. Blood samples were collected at baseline and also 48 hours following to the last training session. The data were compared using paired and independent samples t tests.
Results: HIIT resulted in a contemporary reduction of plasma glucose and serum insulin and FGF21 and also improved HOMA index (P˂0/05).
Conclusion: High intensity interval training plays an effective role in improvement of insulin resistance and reduction of serum FGF21 in obese subjects, which may be due to an improved FGF21 resistance.
Saleh Afrasyabi, Seyed Mohammad Marandi, Mehdi Kargarfard,
Volume 18, Issue 1 (1-2019)
Abstract
Background: The aim of this study was to investigate the effect of 12 weeks of high intensity training on IL-
6, GLP-1 and lipid profiles in type 2 diabetic patients
Methods: 80 participants (40-50 years old) volunteered to participate in the study and divided into eight groups (four groups of severe periodic exercises and four uncontrolled control groups). Blood samples were collected and analyzed for measuring IL-6, GLP-1, lipid profile and glycemic index before and after weeks 4, 8 and after the training program.
Results: After 12 weeks of training, the effect of time and interaction between time × group on GLP-1 and IL-6 variables was statistically significant. Also, there was a significant difference between groups based on 12 weeks of training in these indices. Lipid profile was significantly improved in type 2 diabetic and glycemic control in obese and non-diabetic groups that had 12 weeks of high intensity interval training.
Conclusion: Overall, high intensity interval training, through changes in various mechanisms, lead to improvement in lipid and glycemic disorders, inflammation and appetite in obese people with type 2 diabetes. Hence, according to the findings of the study, researchers suggest that performing high intensity interval training can lead to significant improvements in obese subjects (with and without type 2 diabetes).
Mahmoud Asle Mohammadi Zadeh, Mehdi Kargarfard, Parvaneh Nazarali,
Volume 18, Issue 3 (3-2019)
Abstract
Background: Interleukin-6(IL-6) and Tumor Necroes Factor-alpha (TNF-α) are secreted by adipose tissue and are potential regulators of low grade inflammation and metabolic disorders in Obesity Type 2 Diabetes (OT2D). hence, present study examined the effects of interval training with different diet on low grade inflammation and some of metabolic indexes in OT2D.
Methods: forty-five OT2D men were randomly assigned into a High intensity interval training(HIIT) plus normal diet group (ND+H), low carbohydrate diet plus HIIT group(LC+H) or HIIT plus low fat diet group(LF+H) that involved adherence to a 1200-1500 kcal/day(ND+H: 28% fat, 54% carb and 18% protein; LC+H: 42% fat, 40% carb and 18% protein; LF+H: 20% fat, 62% carb and 18% protein) while participating in a supervised HIIT (3 d/week for 12 weeks). Anthropometrics, physiologic features and fasting blood samples were obtained at 0, 8(8 weeks diet only), 16, 20(12 weeks HIIT plus diet) and 24(4 weeks diet only) weeks.
Results: Maximum Oxygen Consumption (VO2max) after 24 weeks of intervention, the LC + H group (P = 0.001, F = 2.195) and LF + H group (P = 0.014, F = 3.548) showed a significant decrease Compared to the pre-test, this decrease was not observed in the ND + H group. The decrease in IL-6 index with other variables (except for maximum oxygen consumption) showed a significant relationship, but the VO2max index had a significant reverse relationship [for LC + H group (p = 0.001, r = -0.54); For LF + H group (p = 0.019, r = -0.41 =), they showed IL-6. In line with changes in IL6, there was a significant difference in TNF-α index in all stages of the study. After 24 weeks of intervention, the LC + H group (P = 0.001, F = 5.541) and LF + H group (p = 0.001, F = 9.654) had a significant reduction compared to the pre-test , But this decrease was not observed in the ND + H group. Significant increase in VO2peak with significant decreases in insulin, HOMA-IR and HbA1c was observed in all groups. Also, there was a significant decrease in IL-6 and TNF-α in LC + H and LF + H groups. Changes in IL-6 and TNF-α showed an inverse association with peak oxygen consumption. Pearson's analysis revealed meaningful relationships between changes in lipid profiles with peak oxygen consumption. VO2peak significant increases in all groups with significant decreases in insulin, HOMA-IR and HbA1c in all groups. Also, IL-6 and TNFα significant decreases in LC+H and LF+H groups. Changes in IL-6 and TNFα significantly Inverse correlated with VO2peak. Pearson analysis revealed significant correlations between changes in lipid profile to VO2peak.
Conclusion: Results support contentions that diet and exercise affects low grade inflammatory and fitness, lipid and glycemic profiles that changes in IL-6 and TNF-α be correlated with some of these changes.
Niloofar Salavati, Farzaneh Taghian, Khosro Jalali,
Volume 19, Issue 1 (1-2020)
Abstract
Background: The purpose of this study was to compare the effect of eight weeks of resistance training with and without the use of aqueous extracts of barberry and saffron on serum levels of RBP4, glucose, insulin and insulin resistance in obese mice.
Methods: In this study, 80 mice with a mean weight of 41± 2 g were exposed to high fat diet for 10 weeks. Then, they were randomly assigned to 8 resistance training groups (10 n), resistance and saffron (10 n), saffron (10= n ), Resistance and barberry (n =10), barberry (n =10), saffron and barberry (10n =), resistance training with extract of saffron and barberry (10n =) and control group (n = 10). The resistance training program included raising the mice from the ladder with weight (three sets and 5 repetitions each) three times a week for 8 weeks. The consumption of saffron and barberry extracts was done at 0.08 for total weight of mice for 8 weeks. After 14 hours of fasting, the initial blood sample was taken at 5 ml of the left ventricle of the rats and RBP4, glucose, insulin and insulin resistance levels were measured. One-way analysis of variance was used to compare the data between groups. All calculations were considered at P≤0.05
Results: The results showed that there was a significant difference in the levels of RBP4 (P = 0.002), glucose (P = 0.03), insulin (P = 0.02), and insulin resistance (P= 0.004) There are different research groups.
Follow-up test results showed that RBP4 levels decreased in the resistance training group compared to the barberry and control groups. In saffron group, resistance to barberry and control group decreased. The saffron group also decreased compared to the saffron and barberry training groups.
Conclusion: The findings of this study emphasize the effect of resistance training, the use of saffron extract and barberry extract on reducing the metabolic effects of obesity by reducing RBP4 and reducing glucose, insulin and insulin resistance.
Yazdan Ahmadi, Parisa Shabanzadeh,
Volume 19, Issue 6 (8-2020)
Abstract
Background: Over the past half-century, the prevalence of obesity and related metabolic disorders such as fat disorders, cardiovascular disease, myocardial infarction and stroke have increased dramatically. Various types of organisms, including bacteria, fungi, protozoan, and viruses, have evolved to live in the human gut, called microbiota. Scientists have found that thin people have a balanced microbiota in their gut that causes them to lose weight, so they use a method called fecal grafting and fecal capsules to treat obesity. The aim of this study is to introduce fecal graft and its capsule in the treatment of drug-resistant obesity.
Methods: This article is a systematic review of the study which English and Persian articles are obtained from regular search of Internet resources using logical AND, OR function between keywords in Pub Med, Google scholar databases using English keywords, FMT, obesity, poop capsule, weight loss has been done from 2010-2020. The total search for fecal transplant related resources was 474 articles. Then, by applying the time filter, this number was reduced to 237 articles. In the final stage, by eliminating duplicate articles and examining the relationship of articles with the subject under study, 23 articles were selected as relevant and final sources.
Results: In the treatment of obesity with FMT, the donor's stool is transferred to the recipient after screening and necessary tests using various methods such as enema or colonoscopy, and then the recipient gradually loses weight by receiving a balanced microbiota of the donor. Instead of a stool transplant, which is a relatively invasive procedure, stool capsules consisting of the donor's dried stool can be used.
Conclusions: Stool transplantation and fecal capsule are an effective method in weight loss of obese people (BMI> 30) with due consideration. Due to the novelty of the treatment method, further studies in this field, especially clinical studies of this method in the treatment of obese people in the country are also recommended.
Mahmoud Asle Mohamadi Zadeh, Saleh Afrasyabi, Zynab Asle Mohamadi,
Volume 20, Issue 2 (1-2021)
Abstract
Background: Inflammation is one of the main causes of obesity and type 2 diabetes due to obesity and can increase metabolic disorders. Because exercise and diet are effective in reducing inflammation, Hence, Present Study Examined the Effects Of 24 Weeks Interventions On IL-6 Index Changes in Obesity Type 2 Diabetic Men: Influenced by HIIT And Diet Regimes
Methods: In this study, 70 men (Obese Type 2 Diabetic Patients) were randomly assigned into 7 groups (4 groups in different diet plus HIIT intervention and 3 groups only in different diet) that involved adherence to a 1,200 kcal/day for 1 week until 1,900 kcal/d diet for 24 weeks while participating in a supervised HIIT (12 week) followed with 4 weeks primarily diet regimes. Diet regimes consist of standard diet (50% CHO, 32% fat), low carbohydrate diet (25% CHO, 57% fat; 70% of 57% fat was unsaturated fat), low fat diet (67% CHO, 15% fat) and high fat (25% CHO, 57% fat; 50% of 57% fat was saturates fat), while protein was 18% for all groups. Anthropometrics and physiologies parameters, Body composition and fasting blood samples were obtained at 0, 4, 8, 14, 20 and 24 weeks. Data were analyzed by repeated measures analysis, one-way ANOVA test. Data are presented as mean±SD changes from baseline.
Results: results indicated that between differences times wasn’t show significant different (F (5,315) =3.66; P=0.002; η2=0.055). also results demonstrated that within groups changes interactions don’t show significant different (F (5,315) =1.61; P=0.025; η2=0.133). This results also revelated that maximum increase and decrease of IL-6 was in high fat diet (28.09±19.80) and low CHO+HIIT (-28.89±25.13) after 24 weeks interventions. maximum increase and decrease of IL-6 was in high fat diet (26.74±25.33) and low fat +HIIT (-32.11±29.17) After 12 weeks HIIT + diet interventions.
Conclusion: Results support contentions that different diet regimes and exercise were selectively affects Pro Inflammatory markers and that changes in low CHO and low fat plus HIIT and low CHO meals plus with HIIE may be benefit for obese type 2 diabetic patients
Ammar Rashet, Ahmad Abdi,
Volume 21, Issue 2 (7-2021)
Abstract
Background: Evidence has suggested that high-fat diet (HFD) promote hyperinsulinemia and pancreatic islet dysfunction with insulin resistance in adipose tissue. The aim of the present study was to examine the effect of aerobic exercise and capsaicin on the gene expression of pancreaticPdx1 and GLUT2 in Rats HFD.
Methods: this experimental study, 40 male Wistar rats were fed a normal diet (ND, n = 8) or high-fat diet (HFD) (n = 32) for 8 weeks. After 8 weeks, all rats were divided into 5 groups: normal diet (ND), high-fat diet (HFD), high-fat diet-training (HFDT), high-fat diet-capsaicin (HFDCap), high-fat diet-training-capsaicin (HFDTCap). Training groups have performed a moderate intensity aerobic running program (60-50% VO2max, at 15-25 m/min, 30-60 min/day, and 5 days/week) on a motor-driven treadmill for eight weeks. Capsaicin (4 mg/kg/day) were administered orally, by gavage, once a day. Data were analyzed using ANOVA at p<0.05.
Results: the results showed significant increase in expression of Pdx1 and GLUT2 in HFDT (p = 0.002 and p = 0.003, respectively), HFDCap (p = 0.022 and p = 0.026, respectively) and HFDTCap (p = 0.000 and p = 0.000, respectively) groups.
Conclusion: also, a significant increase in the expression of Pdx1 and GLUT2 was observed in the HFDTCap compared to the HFDCap (respectively P=0.037, and p=0.044).
The results showed that HFD impaired pancreatic beta cell function and that aerobic exercise alone and with capsaicin could significantly increase islet cell function by increasing Pdx1 and GLUT2 expression.
Zahra Hajhashemy, Elham Moslemi, Parvane Saneei,
Volume 21, Issue 2 (7-2021)
Abstract
Background: Although the relation of serum vitamin D levels with abdominal obesity has been investigated by previous observational studies, the results are inconsistent. In the current study, a dose-response meta-analysis was conducted on epidemiologic studies that evaluated this association in adults.
Methods: We performed a systematic search of all published articles, up to May 2020, in five electronic databases. A total of 41 observational studies that reported odds ratios (ORs) or relative risks (RRs) with 95% confidence intervals (CIs) for abdominal obesity in relation to serum vitamin D levels in adults were found.
Results: Meta-analysis on 36 cross-sectional studies (combining 44 effect sizes) with 257699 participants, illustrated that the highest serum vitamin D level in comparison with the lowest serum vitamin D level was significantly related to 23% decreased odds of central obesity (OR=0.77; 95%CI:0.71-0.83). This inverse association was also significant in almost all subgroups based on different covariates. Based on dose-response analysis, each 25 nmol/l increase in serum vitamin D levels, was related to 8% reduced risk of central obesity (OR=0.92;95%CI:0.85,0.99). After limiting the analysis to 23 effect sizes from 17 studies with representative population (242135 participants), the same results were obtained (OR=0.79; 95%CI: 0.71-0.87). Based on dose-response analysis on studies with representative populations, each 25 nmol/l increase in blood vitamin D levels was linked to 10% decreased central adiposity risk(OR=0.90; 95%CI: 0.82, 0.99).
Conclusion: In this meta-analysis of epidemiologic studies, we demonstrated an inverse significant relation between serum vitamin D levels and risk of central obesity in adults, in a dose-response manner. The same findings were obtained in representative populations.
Mahnaz Omidi, Parya Vismoradi,
Volume 21, Issue 6 (3-2022)
Abstract
Background: Adipulin is a hormone secretd by fat cells that acts as a metabolic regulator with anti-inflammatory properties and is reduced through obesity, diabetes and inflammation. Therefore, the aim of this study was to compare the effect of high and moderate intensity aerobic exercise on serum adipolin levels and some indicators of metabolic syndrome in obese women.
Methods: In this quasi-experimental study, 36 people were randomly divided into three groups of 12 people (2 experimental groups and one control group). Aerobic exercise group with an intensity of 85-95% of maximum heart rate performed intermittent walking and running on the treadmill for 33 minutes per session and exercise group with an intensity of 50-70% of maximum heart rate walked continuously for 41 minutes. (Training duration for 2 groups was 8 weeks and 3 sessions per week, The control group was not active during this period). One-way analysis of variance statistical and Bonferroni post hoc tests were used at the significant level (P> 0.05).
Results: High intensity aerobic exercise significantly increased serum adipolin levels (P= 0.001) and decreased total cholesterol (P= 0.020), triglyceride (P= 0.021) and insulin resistance (P= 0.001). The results also showed no significant differences in the levels of high-density lipoprotein (P= 0.615), low-density lipoprotein (P= 0.604), and blood pressure (P= 0.269) in the three groups. Medium-intensity aerobic exercise had no effect on serum adipoline levels (P= 0.192), only glucose, (P= 0.025), triglycerides (P= 0.010), systolic blood pressure (P= 0.028) and insulin (P= 0.043) decreased and the levels of cholesterol, low-density lipoprotein and high-density lipoprotein did not change significantly.
Conclusion: In the end, it can be said that it seems that individuals can use high-intensity aerobic exercise to increase the amount of adipolin as an indicator of improving insulin sensitivity and also improving the indicators of metabolic syndrome.
Bahman Hasanvand, Ahmad Mohammadi Moghaddam, Rohollah Geravand,
Volume 22, Issue 1 (4-2022)
Abstract
Background: The aging process is usually accompanied by a decrease in the function of the body's systems and physiological capacity, along with an increase in susceptibility to diseases, especially metabolic syndrome. This study looked at the effect of eight weeks of resistance training on levels of Irisin, IL-15, CRP, and Cholesterol in elderly men with metabolic syndrome.
Methods: The statistical population was elderly men in Khorramabad, of whom 18 were selected and randomly divided into two experimental groups and control (65/2±2/2, 65/4±2/1). The exercise program included leg presses, chest presses, row movements, bending the knees, head, back of the arm, opening of the knees and front of the arm. The above program started with 30% of a maximum repetition and reached 50% of a maximum repetition at the end of the eighth week. Blood samples were taken 48 hours before and after the training sessions. Correlated t-test and independent t-test were used to examine the research data. The level of significance was also considered (P<0.05).
Results: Eight weeks’ resistance exercise significant increase in Irisin (P=0.01) and interleukin-15 (P=0.007), as well as a significantly decreased levels of CRP (P=0.007) and total cholesterol(P=0.02) in elderly men with metabolic syndrome.
Conclusion: Finding non-pharmacological solutions to improve metabolic indicators is very important. Based on the results of research, doing resistance exercises is recommended as a low-cost and non-pharmacological solution for the treatment of metabolic syndrome in elderly men.
Mahdieh Ghasemi, Ahmad Abdi, Asieh Abbassi Daloii,
Volume 22, Issue 5 (12-2022)
Abstract
Background: Inflammation plays a critical role in the promotion of hepatocyte damage and liver fibrosis. In recent years the protective role of exercise and royal jelly (RJ), has been suggested for metabolic and inflammatory disorders. In this study, we aimed to evaluate the effects of aerobic training (AT) and RJ on pro-inflammatory markers in a rat's model of a high-fat diet (HFD).
Methods: In this experimental study, 45 male rats were randomly divided into five groups (Each group: n=9): Normal Diet (ND), High-Fat Diet (HFD), High-Fat Diet +Training (HFDT), High-Fat Diet + Royal Jelly (HFDRJ), and High-Fat Diet +Training + Royal Jelly (HFDTRJ). The supplement groups received 100 mg of royal jelly (kg/body weight) diluted in distilled water orally during the intervention period. The aerobic exercise program included treadmill running with an intensity of 50-60% oxygen consumption (VO2max), 5 days/week for 8 weeks.
Results: HFD increased hepatic NF-κB (p=0.006), TNF-α (p=0.0001) and IL-1β (p=0.0001). AT, RJ as well as the combination of AT with RJ decreased NF-κB, TNF-α and IL-1β (p≤0.05). Decrease in NF-κB, TNF-α and IL-1β were significant in HFDTRJ group compared to HFDT and HFDRJ groups (p≤0.05).
Conclusion: The combination of AT and RJ may decrease inflammatory markers and improve HFD-induced hepatic steatosis by reducing the expression of NF-κB, TNF-α, and IL-1β.
Mohammad Javad Pourvaghar, Saeid Reza Noorimofrad, Mousa Khalafi,
Volume 23, Issue 6 (1-2024)
Abstract
Background: Adiponectin is one of the most well-known adipokines with anti-inflammatory effects that plays an important role in regulating the whole-body metabolism. The aim of this study was to investigate the effect of high-intensity interval training (HIIT) versus moderate intensity continuous training (MICT) on the circulating levels of adiponectin in individuals with and without metabolic disorders.
Methods: A systematic search was conducted in the databases of PubMed, Web of Science, Academic Jihad Center and Magiran using the keywords "HIIT" and "adiponectin" to identify Persian and English languages published articles until October 2022. Effect size (SMD) and 95% confidence interval were calculated using CMA2 software. I2 test for calculation of the heterogeneity and visual interpretation of funnel plot test and Egger test for assessment of the publication bias were used.
Results: Data analysis of 28 interventions (24 studies) showed that HIIT resulted in a significant increase in adiponectin [0.40 CI: 0.12 to 0.68), P=0.004]. Also, the data analysis of eight interventions showed that HIIT led to a non-significant increase in adiponectin compared to the MICT [0.41 CI: -0.04 to 0.86), P=0.07].
Conclusions: The findings of the present study showed that HIIT is a suitable and efficient training method to increase adiponectin, especially in people with metabolic disorders.
Hanieh-Sadat Ejtahed, Shirin Hasani-Ranjbar, Hanieh Malmir, Azin Pakmehr, Rezvan Razmande, Yasaman Khorshidi, Golaleh Asghari, Ahmadreza Soroush, Afshin Ostovar, Bagher Larijani,
Volume 23, Issue 6 (1-2024)
Abstract
Background: Considering the increasing and alarming trend of overweight and obesity as well as its related complications, in this study, a comprehensive clinical guide for the medical care of patients with obesity was written based on the clinical recommendations of the American Endocrinology Association and the American College of Endocrinology, and it has been adjusted as much as possible based on the conditions in Iran.
Methods: A complete search was performed in the available databases without any restrictions with a specific strategy. Using the opinions of experts in this field, the best clinical guidelines were selected and obesity clinical guidelines were written for Iranian adults. Recommendations were given based on a detailed review of available clinical evidence and considering objective factors.
Results: A total of 1788 references were used and in response to 9 clinical questions, 123 recommendations, including 160 special statements, were provided to determine a comprehensive medical care program for obesity. In this article, we discuss the prevention, screening, diagnosis, benefits and goals of obesity treatment. Questions 6 to 9 regarding obesity treatment steps and its individualization will be published in the next part of the article.
Conclusion: The detailed evidence-based questions and recommendations outlined in this study identify clinical considerations that facilitate decision-making in obese patients from screening and diagnosis to goals of treatment.
Hanieh-Sadat Ejtahed, Shirin Hasani-Ranjbar, Hanieh Malmir, Rezvan Razmandeh, Azin Pakmehr, Yasaman Khorshidi, Golaleh Asghari, Amir Mohammad Mortazavian, Mohammad Reza Mohajer-Tehrani, Afshin Ostovar, Bagher Larijani,
Volume 24, Issue 1 (3-2024)
Abstract
Background: The prevalence of overweight, obesity and related complications is increasing rapidly in the world. Also, treating this disease in the presence or absence of co-morbidities has become a challenge. In this article, based on the clinical recommendations of the American Endocrinology Association and the American College of Endocrinology, a comprehensive clinical guide has been written for the stages of treating obese patients and its individualization, and it has been tried to be adjusted as much as possible based on the conditions in Iran.
Methods: with a specific search strategy, a complete search was performed in PubMed, Scopus, ISI Web of Science, EMBASE and Google Scholar Cochrane databases. Then, the best clinical guidelines suitable for the Iranian society were selected and using the opinions of specialists and clinical experts, a clinical guideline was prepared for the treatment of obesity in Iranian adults.
Results: In this article, in continuation of the previous article, we answered the questions number 4 to 6 regarding the stages of obesity treatment and its individualization in adults of Iranian society, and presented a total of 60 recommendations in this regard.
Conclusion: In this part of the clinical guide for obesity in Iranian adults, we tried to have a special view on the treatment of these patients and by providing evidence-based recommendations and statements, the treatment process was personalized as much as possible for patients with special conditions so that decision-making in this regard is facilitated for the relevant colleagues in this field.
Hamid Reza Zolfi, Amir Shakib, Mehdi Zarei, Nagisa Farhangi,
Volume 24, Issue 4 (10-2024)
Abstract
Background: The effects of regular exercise on miRNA profile and oxidative stress indices are less known. The aim of this study was to investigate the changes in expression of miR-17 and oxidative stress indices in overweight and obese women following high-intensity functional training.
Methods: In this semi-experimental study, 22 overweight and obese women were randomly divided into two groups of high-intensity functional training (n= 10) and control (n= 12). The subjects of the training group performed high-intensity functional exercises 3 times a week for 8 weeks and intensity of rating of perceived exertion≥7. Before and after 8 weeks, blood samples were taken to measure expression of miR-17 gene, malondialdehyde (MDA), superoxide dismutase, glutathione peroxidase (GPx) and total antioxidant capacity (TAC). Analysis of covariance test was used to analyze the data.
Results: After eight weeks of high-intensity functional training, expression of miR-17 in the experimental group significantly decreased compared to the control group (P= 0.001). After eight weeks of high-intensity functional training, TAC (P= 0.0001), GPX (P= 0.007) and SOD (P= 0.001) increased significantly in the experimental group compared to the control group. No significant change was observed in MDA (P= 0.778).
Conclusion: The results of the present study showed that eight weeks of high-intensity functional training may lead to the reduction of miR-17 expression and the improvement of oxidative stress indices and antioxidant enzymes, which may be effective in improving metabolic indices and obesity complications.
Omid Zafarmand, Fatemeh Kazeminasab,
Volume 24, Issue 5 (12-2023)
Abstract
Background: Physical activity and green tea is one of the recommended ways to control obesity and its complications such as cardiovascular diseases, diabetes and liver inflammation. The aim of this study was the combined effect of exercise training and green tea on lipid profile in adults with overweight and obesity.
Methods: A systematic search of English and Persian articles published in PubMed, Web of Science, Scopus, SID, Civilica, and Magiran databases was conducted until June 2024.
Results: A total of 14 studies with 390 adults with overweight and obesity, of which 198 subjects were in the combined exercise and green tea group with an average age of 34 years old and BMI with an average of 30 kg.m2, of which 192 subjects in the control group with an average age of 34 years old and BMI with an average of 31 kg.m2 entered the present meta-analysis. The results showed that the combination of exercise training and green tea caused a significant decrease in TC [WMD=-22.923 mg/dl, P=0.001], TG [WMD=-9.946 mg/dl, P=0.001], LDL [WMD=-11.675 mg/dl, P=0.001] and insignificant increase HDL [WMD=8.888 mg/dl, P=0.017] in adults with overweight and obesity, compared to the control group.
Conclusion: The results of this meta-analysis showed that the combination of exercise training and green tea in overweight and obese adults decreases TC, TG, LDL and increases HDL. Therefore, exercise and green tea can be suggested to them as a non-medicinal and practical solution to improve lipid profile and reduce cardiovascular diseases, diabetes and liver inflammation.
Phd Saleh Afrasyabi,
Volume 24, Issue 5 (12-2023)
Abstract
Results: After 12 weeks of combined, aerobic, high intensity and resistance training, anti-inflammatory indices (adiponectin and SFRP5) showed a significant increase compared to the baseline (before starting the training program) (P < 0.05). Regarding pro-inflammatory and anti-inflammatory indicators (IL-6, TNF-α, resistin and leptin), a significant decrease was observed in all groups after 12 weeks of training program (P < 0.05). In this study, a significant improvement in weight loss and blood glucose was observed after 12 weeks of exercise program in all 4 exercise groups (P < 0.05). In the second part of the findings (non-training or durability of training effect), it was resistance training that showed a lower percentage decrease (P < 0.05) in anti-inflammatory indices and an increase in pro-inflammatory and inflammatory indices after 12 weeks of non-training, which showed the durability It shows more recovery in obese type 2 diabetic patients (P < 0.05).
Conclusion: The findings of the research showed that high-intensity interval training after 12 weeks can cause a greater effect on inflammatory, pro-inflammatory and anti-inflammatory indicators compared to aerobic, combined and resistance training. But this is the resistance exercise that caused the reduction in inflammatory, pro-inflammatory indicators and increase in anti-inflammatory indicators in obese type 2 diabetic patients to be more permanent.
Alireza Bagheri, Dr Mehdy Morady, Dr Mohammad Malekipooya, Dr Bahram Abedi,
Volume 24, Issue 5 (12-2023)
Abstract
Background: Obesity is a disease whose incidence and burden on societies around the world is increasing. Sexual performance in these patients is an important aspect that is often ignored. Therefore, the aim of the present study was to investigate the effect of a period of exercise along with electrical stimulation on the gene expression of some sex markers in testicular tissue of fasted obese rats.
Methods: In this experimental study, with a control group of 40 male rats after induction of obesity and weight gain, randomly divided into 5 groups: control, fasting-obese, fasting-endurance exercise, fasting-electrical stimulation and Fasting-endurance training-electrical stimulation were divided. Intervention groups for a period of 4 weeks under endurance sports activity (with a speed of 10 to 20 m/min and duration of 20 to 40 minutes), electrical stimulation (foot shock device for 0.5 mA and 20 minutes) and fasting were placed. After exercise and anesthesia, brain tissue was done and after molecular processes, gene expression was measured using Real time-PCR machine.
Results: The results showed that training led to a significant increase in the expression of 5-alpha reductase and aromatase genes in samples compared to the fasted obese group (P=0.0001). Also, electrical stimulation and its combination with endurance training showed a significant increase in the 5-alpha reductase gene (P=0.0001).
Conclusion: It seems that endurance training and combined electrical stimulation of both during fasting by increasing the expression of 5-alpha reductase and aromatase genes in obese samples are effective in their sexual health and lead to its improvement.
Ms. Khadigeh Zameni Jafarkolaei, Dr. Mohammadreza Esmaelzadeh Toloee,
Volume 24, Issue 5 (12-2023)
Abstract
Abstract
Background: This study aimed to compare the effects of high-intensity interval games and high intensity interval training on body composition indicators, aerobic capacity and lipid profiles of obese and overweight girls aged 10 to 12 years.
Methods: In this semi-experimental research, 30 girls (average height 149.26 ± 5.32 m, weight 67.41 ± 7.65 kg, and body mass index 30.14 ± 2.3 kg/m2) with overweight and obesity participated and were randomly divided into the groups of high intensity interval training (10), high intensity interval game (10) and the control (10). Training programs for eight weeks(3d/w), (90-85% of maximum heart rate) and 3-minute recovery (65-75% of maximum heart rate) with 4 times Repetition was done, which was done in the form of running in high intensity interval training and in the form of playing in high intensity interval game. Blood samples were taken to measure the serum levels of lipid profiles (48 hours before and after the intervention period).
Results: The two training groups compared to the control group, increased aerobic capacity and HDL and body fat percentage, TG, TC and LDL (P < 0.010) showed a significant decrease and between the two training groups in TG, LDL and HDL (P<0.01) was a significant difference, with a greater increase in HDL and a greater decrease in TG and LDL was accompanied in the high intensity game group.
Conclusion: High intensity interval games can be suggested as a more suitable solution to improve the lipid profile of obese and overweight girls.
