Showing 42 results for Interval Training
Hamed Alizadeh Pahlavani,
Volume 24, Issue 5 (12-2023)
Abstract
Background: Type 2 diabetes is characterized by insulin resistance and hyperglycemia and can lead to heart disease. Therefore, the aim of the present study is to investigate the effect of MIIT on the S6K1 pathway in the myocardium, which is related to the control of cell growth and proliferation.
Methods: In this study, 12 two-month-old male Sprague Dawley rats with an average weight of 280±30 grams participated. To induce diabetes, nicotinamide and streptozotocin solutions were injected with a dose of 110 mg/kg and 60 mg/kg, respectively. The blood sugar of rats was determined between 126-260 mg/dL as an indicator of type 2 diabetes. After the induction of diabetes, the rats were randomly divided into diabetic training group (6 heads) and diabetic control group (6 heads). The diabetic training group trained for 4 weeks and 4 sessions every week. 24 hours after the last training session, the left ventricle of heart was isolated and the amount of protein was measured by western blotting method. Variables were analyzed through independent t-tests. The significance level of study was considered P≤0.05.
Results: The analysis of the data showed that the intracellular content of total, phosphorylated and the ratio of total to phosphorylated S6K1 protein did not show any significant change after 4 weeks of MIIT.
Conclusions: It seems that after 4 weeks of MIIT, S6K1 protein does not change significantly, so it seems that the duration and intensity of training and nutritional conditions to increase S6K1 phosphorylation should be considered in future research.
Phd Saleh Afrasyabi,
Volume 24, Issue 5 (12-2023)
Abstract
Results: After 12 weeks of combined, aerobic, high intensity and resistance training, anti-inflammatory indices (adiponectin and SFRP5) showed a significant increase compared to the baseline (before starting the training program) (P < 0.05). Regarding pro-inflammatory and anti-inflammatory indicators (IL-6, TNF-α, resistin and leptin), a significant decrease was observed in all groups after 12 weeks of training program (P < 0.05). In this study, a significant improvement in weight loss and blood glucose was observed after 12 weeks of exercise program in all 4 exercise groups (P < 0.05). In the second part of the findings (non-training or durability of training effect), it was resistance training that showed a lower percentage decrease (P < 0.05) in anti-inflammatory indices and an increase in pro-inflammatory and inflammatory indices after 12 weeks of non-training, which showed the durability It shows more recovery in obese type 2 diabetic patients (P < 0.05).
Conclusion: The findings of the research showed that high-intensity interval training after 12 weeks can cause a greater effect on inflammatory, pro-inflammatory and anti-inflammatory indicators compared to aerobic, combined and resistance training. But this is the resistance exercise that caused the reduction in inflammatory, pro-inflammatory indicators and increase in anti-inflammatory indicators in obese type 2 diabetic patients to be more permanent.
