Showing 24 results for Ng
Mehdi Changizi, Rozita Fathi, Rostam Ali Zadeh, Seyed Mohsen Avandi, Ali Khaleghian,
Volume 24, Issue 6 (2-2025)
Abstract
Background: Obesity is known to have metabolic complications including insulin resistance (IR) and metabolic disorder. The aim of this study was to compare the effect of two traditional 12-week circular resistance training methods on the levels of branched and aromatic amino acids and insulin resistance of overweight and obese men.
Methods: The current research method is of the clinical trial type, with Thirty-three overweight and obese men with mean and standard deviation of age, weight and body mass index were 17.7±0.13 years, 92±2.45 kg and 30.70±32 1.32 kg / m2, respectively. They were selected and randomly divided into three groups: circular resistance training (n= 11), traditional resistance training (n= 11) and control (n= 11). The training program consisted of two traditional resistance training protocols and 12-week wave circuits that were exactly the same volume; Which was run three times a week. Blood sampling was performed 48 hours before and after the training protocol and after 8 hours of fasting. HPLC was used to measure serum levels of amino acids.
Results: The results of analysis of variance in the groups showed that circuit training more than 2 times compared to traditional training reduces total BCAAs (35.9 vs. 15.5%) and AAAs in serum (19.5 vs. 9%) and equally the level of insulin resistance. (23 and 26.7 percent, respectively) reduced the door in overweight and obese young men.
Conclusion: The results of this study showed that the level of changes in circular resistance training was higher than traditional. Circular resistance training may be able to prevent obesity-related metabolic disorders.
Negar Sarhangi, Mandana Hasanzad, Fatemeh Rouhollah, Shekoufeh Nikfar, Farshad Sharifi, Negar Niknam,
Volume 25, Issue 2 (7-2025)
Abstract
Background: Pharmacogenomics (PGx), as a growing field of personalized medicine, aims to optimize the efficacy and safety of medications by studying the association between germline genetic variations and drug responses. The present cross-sectional study aims to evaluate the allele frequency of the NUDT15 genetic variant in the Iranian population to provide insights into personalized treatment decisions in the Iranian population.
Methods: A representative sample set of 1142 unrelated healthy Iranian individuals aged 18 and older genotyped using the Infinium Global Screening Array-24 BeadChip.
Results: We identified a pharmacogenetic variant with minor allele frequency (MAF) ≥1% among the present studied population which may explain the substantial variability in drug response phenotypes among different populations
Conclusion: The results of our study revealed significant genetic variation among Iranian populations that could significantly influence clinical decision-making. This study shows the frequency pattern of the effective variant of NUDT15 in determining the phenotype in Iranian population.
Fatemeh Rostai, Samaneh Fallah Karimi, Zahra Khalilzadeh Farsangi, Fatiheh Kerman Saravi,
Volume 25, Issue 6 (1-2026)
Abstract
Background: Diabetes is a chronic condition that can significantly impairs quality of life and requires long-term care due to its complications. Effective self-care education plays a key role in blood glucose control and in the prevention of diabetes-related complications. Telenursing is considered a promising approach to enhance self-care education in patients with type 2 diabetes.
Methods: This study was a systematic review conducted using a three-stage search strategy. Using Persian and English keywords including "telenursing," "self-care," and "diabetes," as well as their MeSH equivalents, relevant literature was searched in Persian databases (Magiran, SID) and international databases (PubMed, Scopus, Google Scholar) within the time frame of 2000 to 2023. After applying inclusion criteria, 17 out of 1,092 retrieved articles were selected for final review and analysis.
Results: A total of 1,092 articles were initially retrieved. After removing duplicates and applying the inclusion criteria, 17 relevant articles were included in the review. These studies evaluated the use of telenursing—either via telephone or in combination with other technologies—for effectively improving self-care behaviors in diabetic patients.
Conclusion: The findings indicated that telephone calls can serve as a potential method of remote nursing care for educating patients on diabetes self-management. Nurses can utilize telenursing as an effective and efficient educational tool to enhance blood glucose control in diabetic patients. This approach not only improves the quality of healthcare services but also empowers patients to manage their disease more consciously and prevent its complications.
Parisa Karimzadeh, Mahdis Khazaeli Najafabadi, Sina A Sharghi, Farzaneh Karimi Birgani, Effat Asadollahpour, Somayeh Parichehreh-Dizaji, Mahnaz Pejman Sani, Sayed Mahmoud Sajjadi-Jazi, Mahmood Naderi, Hilda Samimi, Shirzad Nasiri, Seyed Mohammad Tavangar, Bagher Larijani, Vahid Haghpanah,
Volume 25, Issue 6 (1-2026)
Abstract
Background: Biobanks are biological repositories that collect, process, store, and distribute human biological samples. Among them, tumor banks play a central role in biomedical research. The overall goal of a tumor bank is to collect cancerous and normal samples under standardized conditions for basic, clinical, or applied research.
Methods: Tumor samples from patients with endocrine neoplasms were collected from excess tissue samples not required for diagnostic purposes after surgery in the surgical department of Dr. Shariati Hospital, Tehran, Iran. In addition, relevant biological samples such as serum, plasma and DNA were collected in parallel. Prior to sampling, informed consent was obtained from the patients and a questionnaire was completed. After rapid freezing with isopentane, tissue samples were stored in a liquid nitrogen tank, while other biological materials, such as serum, were stored in a -80°C freezer.
Results: Tissue, plasma, serum, and DNA samples collected from patients with endocrine neoplasms were stored in separate barcoded storage boxes in the biobank and were made available to researchers.
Conclusion: The use of bioproducts in domestic research and international networks has strengthened research collaborations through supporting the collection and distribution of tissues, especially cancer tissues. This trend plays an important role in facilitating basic and applied research in various fields of cancer, including molecular biology, immunology, genetics and pharmacology, and will pave the way for scientific advances and therapeutic innovations.
