Showing 23 results for Mahdi
Mahdi Faramoushi, , ,
Volume 24, Issue 5 (12-2023)
Abstract
Introduction: Type 2 diabetes is a chronic metabolic disease and a complex disorder with several micro and macro vascular complications in different parts of the body, which is associated with cardiac fibrosis. On the other hand, endurance training seems to prevent the development of cardiac fibrosis in diabetes by reducing fasting glucose levels and increasing antioxidant indices. Methods: 24 male Wistar rats were randomly divided into three groups: healthy control (NC, n=8), diabetes control (DC, n=8) and exercise diabetes (DT, n=8) after familiarization with the laboratory environment. Diabetes was induced to diabetic animals through streptozotocin injection. Training groups, performed 8 weeks of intermittent endurance training on a treadmill. Hematoxylin-eosin and Masson trichrome staining were used to check the level of fibrosis and cell disorder. Serum malondialdehyde (MDA) was measured by thiobarbituric acid spectrophotometry. Also, total serum antioxidants were measured by FRAP method.
Results: Compared to the diabetic control group, rats in the training group showed a decrease in fibrosis, fasting glucose, and also a decrease in triglyceride and total cholesterol (P<0.05).
Conclusion: Based on the results, it seems that Endurance training in diabetic Rats prevents the development of cardiac fibrosis caused by diabetes by reducing fasting blood sugar, lipid profile and increasing total antioxidants. However, more studies are needed.
Dr Alireza Moumivand, Dr Bahareh Tavakoli-Far, Dr Gelareh Vahabzadeh, Dr Saeideh Momtaz, Dr Maliheh Farid, Dr Hosein Hosein Rafiemanesh, Dr Mahdi Goudarzvand,
Volume 24, Issue 5 (12-2023)
Abstract
Introduction: Diabetes is one of the most common disorders of the endocrine glands, the main characteristic of which is an increase in the concentration of glucose in the serum of patients. Herbal medicines are widely accepted by people due to less side effects. The purpose of this study is to investigate the protective effect of the silybum marianum, melissa officinalis, vaccinium arctostaphylos, trigonella foenum, urtica dioica and citrullus colocynthis extracts mixtures in the PC12 cell model in a high glucose environment.
Methods and Methods: After 24, 48, and 72 hours of adding different concentrations of plant extracts (silybum marianum, melissa officinalis, vaccinium arctostaphylos, trigonella foenum, urtica dioica and citrullus colocynthis) in the normal culture medium of PC12 cells and the medium with high glucose (25 mg/ml, 13/5), cell viability was measured by MTT method.
Results: The results showed that the viability of PC12 cells did not change in 24, 48 and 72 hours after treatment with a mixture of plant extracts. The survival rate of cells in the high dose glucose group was significantly reduced compared to the control group, and the mixture of plant extracts in high doses significantly reduced cell death in these conditions.
Conclusion: Based on the available findings, glucose with a concentration of 25, 13.5 mg/ml caused the death of PC12 cells and the mixture of plant extracts was able to reduce the cell death caused by high glucose in all three times 24, 48 and 72 hours after exposure with nerve cells.
Fateme Moshirenia, Moradali Zareipour, Mahdieh Joukar, Faezeh Afkhami Aghda,
Volume 24, Issue 5 (12-2023)
Abstract
Introduction: gestational diabetes is one of the most common diseases during pregnancy, and health literacy of pregnant mothers plays an important role in the prevention and management of the disease. The study aimed to examine and compare the health literacy of pregnant women with gestational and non-diabetic diabetes visiting health centers in the city of Yazd in 1402.
Methods: This descriptive-analytical study was conducted on 206 diabetic and non-diabetic pregnant women, the cluster health center sampling method and pregnant mothers were randomized sampling method. The data was collected using a health literacy questionnaire and analyzed using kayscore tests, Independent t-Tests and variance analysis.
Results: the mean health literacy score of non-diabetic pregnant mothers (74/26±13/75) was significantly higher compared to diabetic mothers (47/27±21/06) (p< 0/05). And 67% of diabetic women had insufficient health literacy. The study also found a strong link between health literacy and maternal diabetes. And diabetic mothers showed an inverse relationship between health literacy and the number of pregnancies and offspring, a trend not observed in non-diabetic mothers.
Conclusion: higher health literacy can help promote diabetes prevention behaviors during pregnancy. Pregnant mothers with higher health literacy levels are likely to make the best decisions about their health and that of their fetus. Which is an indication of the importance of proper health awareness and education for pregnant women.
