Showing 88 results for Diabetes Mellitus
Ghazale Valipur, Zatollah Asemi, Mansooreh Samimi, Zohreh Tabassi, Sima-Sadat Sabihi Sabihi, Parvane Saneei, Ahmad Esmaillzadeh,
Volume 13, Issue 4 (5-2014)
Abstract
Background: There are no available reports indicating the effects of Dietary Approaches to Stop Hypertension (DASH) eating plan on insulin resistance, inflammation and oxidative stress among pregnant women with gestational diabetes mellitus (GDM) We aimed to investigate the effects of DASH diet on insulin resistance, serum hs-CRP and biomarkers of oxidative stress among pregnant women with GDM.
Methods: This randomized controlled clinical trial was performed among 32 pregnant women diagnosed with GDM at 24-28 weeks' gestation. Subjects were randomly assigned to consume either the control (n=16) or DASH diet (n=16) for 4 weeks. The DASH diet was rich in fruits, vegetables, whole grains, and low-fat dairy products and low in saturated fats, total fats, cholesterol, refined grains, and sweets, with a total of 2400 mg/d sodium. The control diet contained 40-55% of its energy as carbohydrates, 10-20% as proteins and 25-30% as total fats. Fasting blood samples were taken at baseline and after 4 weeks of intervention to measure fasting plasma glucose (FPG), serum insulin and hs-CRP, HOMA-IR, plasma total antioxidant capacity (TAC) and total glutathione levels (GSH).
Results: Consumption of DASH diet, compared to the control diet, resulted in decreased FPG (-7.62 vs. 3.68 mg/dL P=0.02), serum insulin levels (-2.62 vs. 4.32 µIU/ml, P=0.03) and HOMA-IR score (-0.8 vs. 1.1 P=0.03). Increased concentrations of plasma TAC (45.2 vs. -159.2 mmol/L P<0.0001) and GSH (108.1 vs. -150.9 µmol/L P<0.0001) were also seen in the DASH group compared with control group. We failed to find a significant difference in mean changes of serum hs-CRP levels between the two diets. Within-group comparisons revealed a significant reduction in plasma TAC and GSH levels in the control diet, while a significant rise in these biomarkers in the DASH diet.
Conclusion: In summary, consumption of DASH diet in pregnant women with GDM had beneficial effects on FPG, serum insulin levels, HOMA-IR score, plasma TAC and total GSH levels. The effects of this dietary pattern on pregnancy outcomes need to be investigated in future studies.
Mohammad Reza Sharif, Saeed Nouri,
Volume 13, Issue 5 (7-2014)
Abstract
Background: Diabetes Mellitus (DM) is one the most common chronic disease, with many complications including renal failure, blindness and non traumatic amputation. Prevention of complications is possible through monitoring and control of blood glucose levels. Considering how easy home blood glucose monitoring is, we decided to evaluate the performance of two available glucometers for detection of blood glucose compared with standard laboratory methods.
Methods: In this study, 369 patients with diabetes who admitted to the Shahid Beheshti hospital laboratory in 2013 selected by simple way. After fasting blood glucose testing at the laboratory by lancet devices for ONCALL and GLUCOCARD Glucometers, capillary blood was taken, and glucose measurements were performed by a special strips. Finally, we compared of capillary blood glucose levels of 369 patients as determined by test strips (Glucometers) with venous blood glucose levels measurements by the enzymatic method (the standard laboratory kit), and the results was evaluated by statistical tests such as the mean ± standard deviation, and Pearson correlation.
Results: The mean blood glucose measurements reported using the Glucocard glucometer, the ONCALL glucometer and the standard laboratory method were 127.0±51.6mg/dl, 117.9±42.1 mg/dL and 118.09±51.9 mg/dL. Results obtained using the ONCALL Glucometer had no differences with the standard method levels)p=0.901(, but obtained results from GLUCOCARD Glucometers had differences with the standard method levels(p≤0.001).
Conclusion: Diversity glucometer devices used in various parts of the country highlight the need for similar studies. We recommend use the ONCALL Glucometer with standard principles for glucose
monitoring routine.
Abass Bayat Asgari, Sahar Mossanejad, Mina Asgari, Abass Ramazani Farani, Javad Javaheri,
Volume 14, Issue 2 (1-2015)
Abstract
Background: Having high knowledge in patients is not sufficient for disease control and it is necessary to get more skills and capabilities that could be helping in confronting with diabetes associated stresses. This study is aim to assess the relationship between coping styles approaches with adherence to treatment in type 2 diabetic patients. Methods: In a cross sectional design 100 type 2 diabetic patients were selected by convenience route. Folkman and Lazaros as well as adherence to treatment questionnaires were filled by participants. Data was analyzed by SPSS software version 16, spearman correlation test and linear regression model were used for inferential statistics. Results: Problem and excitement oriented subscales were significant correlation. The correlation between problem oriented subscale and adherence was positive and significant (P<0.05) so that regression model showed as this subscale increase the adherence was increasing as well. The correlation between excitement oriented subscale and adherence was negative and significant (P<0.05) so that regression model showed as this subscale increase the adherence was decreasing. Conclusion: The results emphasized that there is significant correlation between copying styles and adherence to treatment in type 2 diabetic patients.
Hosein Rohani, Ahmadali Eslami, Mehdi Raei, Hamid Tavakoli, Mohamad Bidkhori, Arsalan Ghaderi,
Volume 15, Issue 1 (1-2016)
Abstract
Background:Diabetes mellitus is regarded as a major health problem due to its complications that these,nonetheless could be prevented or delayed with changes and modifications in the patients’ behavior and dietby understanding their beliefs..The objective of this study was to explore the utility of the Theory of PlannedBehavior (TPB)and complications of diabetes perceived risk to find modifiable diabetes-related believes inorder to make behavior changes feasible.
Methods: The presentdescriptive-analytical cross sectional study was conducted in Semirom Diabetes Clinicbased on the TPBand complications of diabetes perceived risk, using a self-administered questionnaire. Atotal of 154 diabetic patients without complications of diabetes were participated in the study. Measured variables were patients’ attitude, subjective norm, perceived behavioral control, complications of diabetesperceived risk, intention to eat a healthful diet and nutritional style. Structural equation modeling was used toanalyze data.
Results:The results revealed that the TPBand complications of diabetes perceived risk fitted the data
acceptably well among the Type 2 diabetes and within dietary behavior. Perceived behavioral control,
subjective norm, complications of diabetes perceived risk and intention to eat a healthy diet were related tohealthy diet behavior. No relation was found between attitude and intention to eat a healthy diet.
Conclusion:The TPB and complications of diabetes perceived risk is a useful theory in determining
intentions of diabetic patients’ and their adherence to healthy diets. TPB and complications of diabetes perceived risk forms a framework for promoting dietary practice among Type 2 diabetic patien
Maedeh Moradi, Fahimeh Haghighatdoost, Awat Feizi, Leila Azadbakht,
Volume 15, Issue 3 (2-2016)
Abstract
Background: Several studies have evaluated the effects of coenzyme Q10 on glycemic control, but there are large discrepancies between studies.
Objective: This meta-analysis of randomized controlled trials aimed to summarize the effect of Co-Q10 on diabetes’ biomarkers.
Methods: This systematic review and meta-analysis was conducted on studies published from 1998 until December 2015. We searched Pub med, EMBASE, Science direct, ISI web of science and Google Scholar to find relevant studies. Totally, our search resulted in 16 articles reporting the effects of Co-Q10 on fasting blood glucose, fasting insulin and HbA1c. Mean ± standard deviations (SD) were used for calculating mean differences. 95% confidence interval was considered between intervention and control treatments.
Results: The present meta-analysis revealed that Co-Q10 decreased fasting blood glucose (-0.20mg/dl, 95%: -0.38,-0.02). However, Co-Q10 supplementation could not effectively reduce HbA1c (0.05%; 95%: -0.22, 0.12) and fasting insulin (0.12pmol/l; 95%: -0.21, 0.44).
Conclusion: Co-Q10supplementation didn’t result in reduction in HbA1c and fasting insulin. However, it had a significant lowering effect on fasting blood glucose. It should be noted that significant changes in fasting blood glucose reported in this study was due to the extended sample size and this is not clinically significant in the present study.
Zahra Jafari, Neda Mehrdad, Farshad Sharifi, Hamid Haghani, Soghra Nikpour,
Volume 15, Issue 4 (5-2016)
Abstract
Background: Prevalence of diabetes increases along with aging. Due to various reasons, rate of falling in the aged suffering from diabetes is higher. Therefore, this study aims at determining factors relating falling of the aged suffering from type 2 diabetes.
Methods: A total of 60 years old or older with type 2 diabetes that referred to selected hospitals of Tehran University of Medical Sciences using continues method. Cases that had experienced falling during last year and controls that had no such experience were assigned to two separate groups. Questionnaire used in this study included demographic data and factors relating falling. Data obtained were analyzed using descriptive statistics, independent t- test, Chi square and logistic regression.
Results: Results showed that postural blood pressure (p=0.02) dizziness (p=0.05), fecal incontinency (p<0.01), auditory disorder (p<0.01), visual disorder (p<0.01), pain in the lower extremity (p= 0.027), taking anti-coagulation medicine (p=0.017) had a significant correlation with falling.
Conclusion: Multivariate logistic regression illustrated that fecal incontinency and auditory disorder happened along with falling in the aged suffering from type 2 diabetes. Therefore, preventing falling must be considered in care plan for such groups of people.
Pouran Varvani Farahani, Davood Hekmat Pou, Mohamad Reza Rezvanfar, Afsaneh Talaei,
Volume 15, Issue 5 (7-2016)
Abstract
Background: Noticing to high prevalence and complications rates of Diabetes Mellitus and its effect on quality of life, and also considering low quality of life, can cause low self-care and increase complications among these patients. The goal of this study is comparing the effect of multimedia education with live successful experiments on quality of life in type 2 diabetic patients.
Methods: This is a semi experimental study. First 160 type 2 diabetic patients were selected First 160 type 2 diabetic patients were selected and then randomly allocated into two tests and one control groups. Research tools were self-statement demographic and WHO-QOL Brief questionnaires which were completed before interventions. For first test group educational classes with multimedia method (group discussion, educational film and slides) were hold in 5 sessions each in 45 minutes. For second test group education was based on narrating of live successful experiments by the patients who controlled their diabetes and answer to questions of the patients. After 3 month WHO-QOL Brief questionnaires which were completed again. All data were analyzed with SPSS version 20 software.
Results: There was no significant difference in means of quality of life among three groups before interventions (p= 0.194). There was significant difference in means of quality of life among three groups after interventions (p= 0.04). There were significant differences between the means of quality of life in first test group (P≤0.001) and second test group (P≤0.001) before and after interventions.
Conclusion: Qualities Of Life in first and second test group were increased more than control one.
Zahra Sadeghian Far, Abdolkarim Sheikhi, Seyed Mohammad Gheibi Hayat,
Volume 16, Issue 6 (10-2017)
Abstract
Background: Usually excess feeding in stored in the body as fat and leads to overweight. One of the causes of catching type 2 diabetes is obesity. Proinflammatory cytokines such as TNF- α and IFNγ can damageTnf- Α And Ifnγ By Peripheral Blood Mononuclear Cells Of Patients With Diabetes Mellitus Type Ii Admitted To Ganjavian Dezful Hospit insulin signaling in insulin-sensitive tissues. In this study, the effect of garlic extract on the expression of TNF-α and IFNγ secreted by the mononuclear cells was measured.
Methods: After taking peripheral blood from patient with type 2 diabetes, mononuclear cells were extracted by Ficoll Method. Cells were a culture with two different concentration of garlic extract (10% and 30%) for 48 and 24 hours. Then for measuring TNF-α and IFNγ release level, ELISA method was used.
Results: Garlic extract can reduce the amount of TNF-α secretion from cells mononuclear, although the timing and concentration of the extract had no effect on the results. Moreover, garlic extract had no effect on the secretion of IFNγ.
Conclusion: Using garlic extract can be adopted therapeutic strategies aimed at adipose tissue inflammation and insulin resistance that is useful for the prevention and treatment of type 2 diabetes.
Ali Jalili, Bagher Larijani, Farideh Razi, Ensieh Nasli, Mostafa Qorbani,
Volume 16, Issue 6 (10-2017)
Abstract
Background: Diabetic nephropathy is a chronic kidney disease and of more common complications of type 2 diabetes mellitus. The current diagnostic markers of diabetic nephropathy, albumin and creatinine, are only able to catch the disease in the stage of renal damage. The aim of this study is evaluation of targeted metabolomics of serum amino acids to identify the association of the changes of serum amino acid profile with diabetes and diabetic nephropathy.
Methods: This cross-sectional study was conducted in 2015-2016 on thirty patients with type 2 diabetes subsequent diabetic nephropathy and thirty type 2 diabetic patients without nephropathy attending diabetes clinic of endocrinology and metabolism institute and thirty non diabetic persons. Blood hemoglobin, HbA1c and BUN and also, serum albumin, uric acid and the albumin/creatinine ratio from a random urine specimen were measured by standard methods and serum amino acids level were identified using high performance liquid chromatography (HPLC). Statistical analysis ANOVA, Kruskal-Wallis, and nominal regression were used for the comparison of the investigated groups.
Results: significant differences were seen in serum levels of 8 essential, branched-chains, aromatic and 8 non-essential amino acids alanine, aspartic acid, serine, glutamine, arginine, glycine, tyrosine and ornithine between three groups. Serum levels of arginine and isoleucine were higher in the diabetic group than non-diabetics. However, Levels of amino acids serine, glutamine, glycine, threonine, tyrosine, tryptophan, methionine, valine, ornithine, and lysine in 2 groups of diabetic nephropathy and diabetes were higher than non-diabetic patients.
For every standard deviation decrease in serum levels of amino acids serine, alanine and isoleucine, in comparison to diabetic patients, the risk of diabetic nephropathy were increased 3.257 (95%CI: 0.10- 0.94, P=0.039), 2.207 (95%CI: 0.18- 0.81, P=0.039) and 2.652 (0.21- 0.96, P=0.012), respectively.
Conclusion: Since this study was conducted in patients in the early stages of the disease, reduced serum levels of the amino acids serine, leucine and alanine may be associated with development and progression of diabetic nephropathy. and in the future with more studies in this field can be used in metabolic control and improvement of the prognosis of patients with diabetic nephropathy.
Sepideh Rahimi Moshkeleh, Ebrahim Masoudnia, Vahid Nik Seresht,
Volume 17, Issue 2 (3-2018)
Abstract
Background: One of the risk factors that have been little attention to it in the etiology of type 2 diabetes is lifestyle. The aim of this study was to determine the relationship between components of lifestyle and incidence of type 2 diabetes among people aged 30 to 60 years in Rasht.
Methods: This study was conducted with a case-control design. Data were collected from 150 patients with type 2 diabetes symptoms that had been admitted to Golsar and Heshmat hospitals and Rasht Diabetes Association (Cases) and 150 subjects without type 2 diabetes symptoms (controls) aged 30 to 60 years in Rasht. Measuring tools included checklist of socio-demographic and clinical characteristics and short-form Health-Promoting Lifestyle Profile. Data were analyzed using t-test and chi-square statistics and the software SPSS version 22.
Result: There was a significant difference between people with type 2 diabetes symptoms (cases) and healthy individuals (controls) regarding to age, body mass index (BMI), education level (P< 0.01), marital status (P< 0.05), family history of diabetes, history of smoking, hypertension hypertension, heart disease and job status (P< 0.01). Also, there was a significant difference between the two groups in terms of the components of spiritual growth and self-actualization, stress management, physical activity (P< 0.01), and health responsibility (P< 0.05).
Conclusion: Insufficiency of the lifestyle components, especially spiritual growth and self-actualization, stress management, health responsibility and physical activity are major risk factors for Type 2 Diabetes. Therefore, cognitive and behavioral interventions to modify and improve health-related lifestyles seems necessary.
Maryam Hor, Asghar Aghaei, Ahmad Abedi, Mohsen Golparvar,
Volume 17, Issue 5 (7-2018)
Abstract
Background: Diabetes is a chronic disease with consequences affecting many aspects and dimensions of life. Patients experience relates to many aspects of their lives because the disease involves their whole life.
The present study aims at defining the role of life style in patient's life. Reviewing their lived-experience can provide basic solutions to reform the life style of patients with diabetes.
Method: in this phenomenology qualitative research, sampling was done among patients referred to Isfahan Diabetes Charity Center in a purposeful manner with the most possible variety. A number of 33 women with diabetes in the age range of 35 to 69 years with an experience of at least one year of living with diabetes and without a history of acute mental disease were chosen. Gradual sampling was conducted from January 2017 to March 2017. Patients took part in 45 to 50 minute semi-structured interviews. The interviews were recorded and then the Colaizzi method format was analyzed.
Results: analysis process of data gathered from these patients' lived-experiences, resulted in extracting four themes including physical health, psychologic health, spiritual health and social health.
Conclusion: In order to reform the life style of patient's' with diabetes, a general comprehensive attitude in way of living is needed. Understanding the lived-experience and analyzing the life style experiences results in the field of health among patients with diabetes can assist the health care staff in providing better services and prevent returns to the inappropriate life style in the future.
Mohammad Azimi Alamouti , Niloufar Shayan, Maryam Momeni, Masoumeh Nouri, Azam Koohkan, Ensiyeh Hajizadeh-Saffar, Fatemeh Soltanolizadeh, Maliheh Mahmoudi, Mahin Jamshidi Makiani, Marzieh Ebrahimi,
Volume 18, Issue 3 (3-2019)
Abstract
Background: For nearly 100 years, amniotic membranes have been used to treat various types of skin wounds. Amniotic extract is one of the derivatives of amniotic membrane that contains all the properties of amniotic membrane. The aim of this study was to evaluate the safety of the amniotic membrane extract in the treatment of diabetic ulcers.
Methods: This study was an Open labeled clinical trial without control group. A total of 10 patients with Wagner Grade 2 diabetic foot ulcers were selected in both sexes. The extract was used every 48 hours in the first week and every 72 hours from the second week until the end of the wound treatment. Patients were followed up weekly until wound healing.
Results: In this study 80% of patients were men and 20% were women with mean age (56.7 ± 8.7) years. The ulcer duration was 8.9 ± 2.12 weeks. The mean area of ulcers at the time of entry into the wound group ≥ 500 mm2, 977.5 ± 201.9 and in the wound group ≤500 mm2 was 145.6 ± 36.4. At 4 weeks post treatment, the wound healing rate in the wound group was ≤500mm2 ,98.9 ± 2.40 % and in the wound group ≥mm2 500 was 92.1 ± 7.23%. in sixth week of treatment, ulcers were complete closure in both groups.
Conclusion: The results of this study suggest that the use of amniotic extract can be effective in the healing of diabetes foot ulcer without any side effects.
Zahra Moradi, Mehrnaz Sadat Ravari, Effat Farrokhi, Morteza Hashemzadeh Chaleshtori,
Volume 19, Issue 1 (1-2020)
Abstract
Background: Type II diabetes is a chronic inflammatory condition that is associated with a combination of genetic and environmental factors. Tumor necrosis factor alpha or TNF-α as an adipocyte cytokine, which affects the signaling pathway of insulin, can contribute to insulin resistance in type 2 diabetes patients. Considering the importance of epigenetic changes in multifactorial diseases, this study aimed to investigate TNF-α promoter methylation in patients with type 2 diabetes.
Methods: This study was performed on 61 patients with type 2 diabetes and 31 non-diabetic patients. The Groups were matched in terms of demographic characteristics. The lipid profiles were measured by standard kits. TNF-α promoter methylation levels were measured by bisulphite treatment method, Nested PCR and sequencing.
Results: There was no association between TNF-α promoter methylation gene promoter and type 2 diabetes in the studied groups. Also, there was no association between TNF-α promoter methylation in diabetic and non-diabetic groups between males and females.
Conclusion: The epigenetic changes in cytokines that contribute to insulin resistance in type 2 diabetic patients seem to be ineffective in peripheral blood samples, and other tissues may need to be investigated in this regard.
Shahnaz Esmaeili, Fatemeh Bandarian, Farideh Razi, Hossein Adibi, Ali Jalili, Babak Arjmand, Camelia Rambod, Ensieh Nasli-Esfahani, Bagher Larijani,
Volume 20, Issue 1 (1-2021)
Abstract
Background: Endocrinology and Metabolism Research Institute (EMRI) is one of the largest research institutes in Iran, which has been established to develop research strategies and manage endocrine and metabolic diseases such as diabetes. The purpose of this report is to review and summarize research activities related to diabetes over a quarter of a century at EMRI.
Methods: A comprehensive search of PubMed, Scopus and EMBASE was conducted to find diabetes-related studies in EMRI. After extracting the data, the articles were classified according to the type of article, the level of evidence, the types of diabetes and their subject.
Results: After eliminating duplicates and screening, finally 228 articles were classified. Most diabetes research conducted at the Diabetes Research Center (DRC) was on type 2 diabetes (37%). By article type, most of the articles were original. In addition, clinical studies provided the most evidence in the obtained documents. By topic, most of the articles were related to the basic sciences and factors related to diabetes, followed by studies on the management and prevention of diabetes.
Conclusion: Most of the research conducted in the Diabetes Research Center in the past quarter of a century is of original studies in the field of basic sciences in the field of type 2 diabetes and most of the evidence produced is related to observational studies.
Reza Sadeghi, Saeid Keshavarz, Mahdi Kargarfard, Jamshid Banaei,
Volume 20, Issue 3 (2-2021)
Abstract
Background: It has been shown that C1q TNF-related protein 5 (CTRP5) is a novel adipokine and important molecule related to metabolism regulation. This study aims to assess the effectiveness of different training protocols on improving serum levels of CTRP5, fasting blood glucose, insulin, Insulin resistance in patients with T2DM.
Methods: Sixty men with T2DM (mean age [X̅±SD]=51.45±4.26 years) were randomly assigned to combined exercise group (CEx: n = 15), aerobic exercise group (AEx: n = 15), resistance exercise group (REx: n = 15), or the control group (CON: n= 15). Exercise programs consisted of aerobic exercises at either AEx (50% - 75% of HRR) or REx (70% - 85% of 1-RM), of equal volume, 3 times per week, 45 to 60 minutes per session for 12 weeks. Serum levels of CTRP5, fasting blood glucose (FBG), insulin, Insulin resistance (IR) and body mass index (BMI) were measured at baseline and at the end of the study. The data were analyzed using repeated-measures analysis of variance.
Results: After 12 weeks intervention, FBG, insulin, HOMA-IR and BMI levels decreased significantly, whereas the serum CTRP5 levels increased in the CEx, AEx and Rex groups compared to control (P < .05).
Conclusion: It appears that the increased levels of CTRP5 following exercise interventions contribute to the decreased risk of T2DM.
Marayam Arabloei Sani, Parichehreh Yaghmaei, Zahra Hajebrahimi, Nasim Hayati Roodbari,
Volume 22, Issue 3 (9-2022)
Abstract
Diabetes is a serious public health problem in low- and middle-income countries. There is a strong association between hyperglycemia, oxidative stress and the development of diabetes. Therefore, screening and early diagnosis of this disease in people at high risk can be effective in preventing these complications. The main route of insulin signaling is to control lipid and glucose metabolism, and its imbalance leads to type 2 diabetes. P-Cymene is an aromatic monoterpene with a wide range of therapeutic properties including antioxidant activity. The aim of this study was to evaluate the effect of p-Cymene at a dose of 50 mg / kg in preventing the symptoms of diabetes and serum factors.
Materials and Methods: 30 male Wistar rats weighing approximately 250 g were randomly selected and divided into five groups: control, diabetic control (sham), metformin-treated diabetic (met), and non-diabetic treated. P-Cymene and diabetics treated with P-Cymene were divided. One week after streptozotocin injection, treatment with P-Cymene at a dose of 50 mg / kg was performed by sunflower oil solvent for 28 days by gavage. At the end of the experiment, blood samples were taken from the hearts of rats and the parameters of glucose, insulin, and superoxide dismutase (SOD) were measured.
Results: The results showed that diabetes increased water and food intake as well as glucose levels and decreased insulin (P <0.001) and superoxide dismutase activity in rats and administration of P-Cymene extract improved the symptoms of diabetes and oxidative stress in Became diabetic rat.
Mehdi Mirzaei-Alavijeh, Seyyed Nasrollah Hosseini, Marzieh Niksirt, Amir Hossein Hashemian, Farzad Jalilian,
Volume 23, Issue 1 (5-2023)
Abstract
Background: Control of Type 2 Diabetes Mellitus (T2DM) is influenced by lifestyle. The aim of this research was to determine the predictors of treatment adherence behaviors among T2DM based on Social Cognitive Theory (SCT).
Methods: This descriptive-analytical research was done among 500 T2DM patients in Tehran during 2021. Simple random sampling was performed among patients based their medical records in the Diabetes Control Clinic of Tehran's District Five. The data collection tools were written questionnaire based on the SCT determinants. Data were analyzed using descriptive statistics (frequency, percentage, mean, standard deviation) and analytical statistics (Pearson's correlation and linear regression) in SPSS software version 16. Results: The mean score of treatment adherence behaviors was 56.34 [SD: 10.41], ranged from 16 to 80. The outcome expectations, perceived self-efficacy, and social support accounted for 43% of the variation in the outcome measure of the treatment adherence behaviors. Self-efficacy was the strongest predictor (Beta = 0.430 and P<0.001). Increasing age (ß= -0.126 and P= 0.004), insulin treatment (ß= -0.250 and P<0.001) and smoking (ß= -0.146 and P= 0.001) conversely and having health insurance (ß= 0.181 and P<0.001) were positively predictive of treatment adherence behaviors.
Conclusion: The development, implementation and evaluation of educational interventions based on SCT with emphasis on promoting perceived self-efficacy can lead to useful findings in promoting treatment adherence behaviors among T2DM patients.
Marziyeh Alijani, Mansour Siavash, Parvaneh Abazari,
Volume 23, Issue 5 (12-2023)
Abstract
Background: The health assistant and treatment assistant in the Ministry of Health and Medicine are in charge of educating people with diabetes and empowering them to achieve self-management of diabetes. The present study was conducted with the aim of determining the status of education and support for diabetes self-management in comprehensive health service centers and diabetes clinics in Isfahan province.
Methods: The diabetes education units of 20 comprehensive health service centers and 11 diabetes clinics in Isfahan province formed the sample size. The data collection tool was a checklist with 107 items, which was completed by observing and reviewing 170 paper/electronic files of patients with diabetes.
Results: In more than two-thirds of the files of diabetes centers/clinics, initial assessment were neither performed nor recorded. Educational needs assessment was recorded in 5% of the files and educational planning was not recorded in nearly 100% of them. In more than a third of the files (36.5%), diet education was recorded once when the case was filed. In 3.4% of files, educational effectiveness evaluation was recorded and in three quarters of files (75.78%), continuous support for self-management was not recorded.
Conclusion: There is a significant gap between the status of education and support for diabetes self-management and the process and outcome standards of DSMES in the educational units covered by the provincial health and treatment department. This gap seriously and negatively affects the results of this approach.
Mehrdad Yousefinejad, Mahnaz Omidi, Abdolhossin Taheri Kalani,
Volume 24, Issue 3 (7-2024)
Abstract
Background: Diabetes is a global epidemic and the most common metabolic disorder caused by impaired insulin secretion and glucose metabolism. The aim of this study was to investigate the effect of 8 weeks of aerobic training on serum levels of asprosin and insulin resistance index in diabetic rats.
Methods: The statistical population of this research included 40 10-week-old mice with an initial weight of 250 ± 20 grams, which were randomly divided into four groups (10 mice in each group): diabetic-exercise group (DT), diabetic group - Control (DC), healthy-training group (HT) and healthy-control group (HC) were divided. The program of aerobic exercises was performed for 8 weeks (5 sessions per week) in the form of running on a treadmill. Independent t-test and one-way analysis of variance (ANOVA) with Tukey's post hoc test were used to compare the groups. All data were analyzed at a significance level of 0.05 using SPSS-25 software.
Results: The results of the present study showed that streptozotocin injection induced diabetes in mice (P= 0.001). Induction of diabetes caused a significant increase in the serum levels of asprosin and insulin resistance in mice (P= 0.048 and P= 0.012, respectively). Eight weeks of aerobic training decreased the serum levels of asprosin and decreased insulin resistance in diabetic rats (P= 0.001 and P= 0.036, respectively).
Conclusion: Induced diabetes causes insulin resistance and increase in serum levels of asprosine, which can be improved by performing aerobic exercises.
Dr Maryam Nazari, Dr Vazgen Minasian,
Volume 24, Issue 5 (12-2023)
Abstract
Background: Clinical studies have demonstrated that diabetes, as a metabolic disorder, can significantly impact the quality of life of individuals affected by the condition. Physical activity has been identified as a potentially effective therapeutic intervention for managing diabetes in these individuals. This study examined the correlation between serum levels of GLP-1 and the hormones thyroxine, TSH, insulin, glucose, HbA1c, VO2peak, as well as various anthropometric indicators after eight weeks of calisthenics exercises.
Methods: This semi-experimental study involved 14 sedentary children with type 1 diabetes, averaging 12.42±1.28 years, selected through non-random sampling. The participants performed calisthenics exercises for eight weeks (three sessions per week). Physiological assessments and blood samples were collected 48 hours before and after the training period. The relationship was analyzed using Pearson's correlation test, and intra-group changes were assessed using paired t-tests.
Results: The findings demonstrated a positive and significant correlation between GLP-1 and insulin both before (r=0.703, p=0.005) and after the exercise intervention (r=0.668, p=0.009). Additionally, an inverse and significant correlation was observed between GLP-1 and waist circumference (WC) levels before (r=0.633, p=0.019) and after exercise (r=0.575, p=0.043), as well as between GLP-1 and body fat percentage after exercise (r=0.676, p=0.007). In terms of intra-group changes, the results indicated a significant increase in GLP-1, insulin, and VO2peak, along with a significant decrease in WC.
Conclusion: The findings of this study show that engaging in calisthenics exercises can be effective in reducing the negative effects of type 1 diabetes and increasing the health of diabetic children.
