Showing 30 results for Eini
Masoumeh Hosseini, Maryam Hosseini,
Volume 19, Issue 3 (2-2020)
Abstract
Background: The proinflammatory cytokines of tumor necrosis factor alpha TNF-α and anti-inflammatory interleukin-10 have important roles in inducing and preventing systemic inflammation, respectively. The purpose of this study was to the synergistic effect of High-Intensity Interval training and resveratrol consumption on IL-10 and TNF- α in diabetic rats.
Methods: In this experimental study, 32 diabetic rats 225± 10 g based on Cohen's sample size estimation table diabetic with combination of high-fat diet and streptozotocin (STZ) injection, were randomly divided into four groups: control(C), supplement(M), training (T)and training + supplement(TM). The training groups were exposed to high-intensity interval training with an intensity of 90 to 100% VO2max for 8 weeks, 5 sessions per week, each session for 18 minutes. The supplement groups received 10 mg / kg of resveratrol daily for eight weeks, three times a week by gavage. Blood samples were taken 48 hours after the last training session. Data were analyzed using one-way analysis of variance and SPSS software version 24 (ANOVA).
Results: Results showed that IL-10 increased in the experimental groups but was not significant (P=0.109). TNF-α levels decreased in the TM group, whereas it increased in the T and M groups, which was significant compared to the TM group (P=.000). Fasting glucose, insulin and insulin resistance index decreased significantly in experimental groups (P=.000).
Conclusion: Eight weeks of high-intensity interval training plus resveratrol can have a positive effect on inflammation and insulin resistance by increasing IL-10 and decreasing TNF-α.
Esmail Shekari, Seyed Kianoosh Hosseini, Farideh Razi, Ensieh Nasli Esfahani, Mostafa Qorbani, Bagher Larijani,
Volume 19, Issue 4 (4-2020)
Abstract
Background: Diabetes mellitus is one of the most common endocrine diseases. Cardiovascular disease (CVD) is one of the leading causes of death in patients with type 2 diabetes. The aim of this study was to investigate the metabolic profile of plasma amino acids in diabetic patients with cardiovascular disease.
Methods: The present study is a descriptive-analytical cross-sectional study on 140 patients including 35 patients with type 2 diabetes and cardiovascular disease (CVD.DM), 35 patients with type 2 diabetes and non-cardiovascular disease (DM). 35 non-diabetic patients with cardiovascular disease (CVD.nDM) and 35 non-diabetic patients with non-cardiovascular disease (HS) were referred to Diabetes Clinic No. 1 of Tehran University of Medical Sciences.
Results: 76 (54.3%) were male and 64 (45.7%) were female. The highest concentrations of glutamine and isoleucine were observed in DM.CVD, asparagine, serine, arginine, threonine, alanine, tyrosine, valine in DM.nCVD and methionine in CVD.nDM. The lowest concentrations of tyrosine and tryptophan in DM.CVD has been detected , and methionine has been detected in DM.nCVD. The amino acids alanine, glutamine, tyrosine, valine, methionine, leucine, lysine and arginine significantly increased the chances of developing DM.nCVD. For each increase in Z-score per plasma concentration of isoleucine, the chances of developing cardiovascular disease without diabetes were significantly increased.
Conclusion: The amino acids alanine, glutamine, tyrosine, valine, methionine, leucine, lysine and arginine are involved in predicting the risk of DM.nCVD and isoleucine and methionine are involved in predicting the risk of CVD.nDM.
Seyedeh Sogand Hosseini, Mohammedreza Esmaelzadeh Toloee,
Volume 21, Issue 1 (3-2021)
Abstract
Background: TORC1 protein is an important factor in regulating adipose tissue metabolism. Type 2 diabetes can lead to dysfunction and the development of obesity. Therefore, the aim of the present study was to investigate the effect of eight weeks of high-intensity
interval training (HIIT) and endurance on blood
glucose and TORC1 protein content in subcutaneous adipose tissue of obese with type 2 diabetes rats.
Methods: In this study, 18 head 2 Sprague-Dawley male rats with a mean weight of 270±30 g were selected. After becoming type 1 diabetic through streptozotocin and Nicotine amide solution, they were randomly divided into 3 groups: 1) HIIT training 2) endurance training and 3) control (6 heads per group). Exercise groups exercised 4 days a week for 8 weeks according to HIIT and endurance training programs. SPSS software version 23, one-way ANOVA and Tukey post hoc test were used to analyze the data.
Result: Eight weeks of HIIT and endurance training resulted in a significant decrease in blood glucose level (p<0.0001) and a significant increase in TORC1 protein content (P<0.0001) compared to the control group.
Conclusion: HIIT and endurance training lowered blood glucose levels and increase TORC1 protein content, which this training can be a suitable and non-invasive treatment to control diabetes and also regulate adipose tissue metabolism in type 2 diabetics who are prone to obesity.
Mohamad Derakhshandeh, Farzaneh Taghian, Khosro Jalali Dehkordi, Ali Hoseini,
Volume 21, Issue 6 (3-2022)
Abstract
Background: Artificial intelligence analysis based on the gene list obtained from the DisGeNET database identified the important genes involved in the heart damage process. Data enrichment highlighted the apoptosis signaling pathway as a vital pathway in cardiovascular risk. Hence, we estimated the binding affinity of chemical and plant bioactive molecules for cytochrome-c protein. Here, we performed to evaluate the effect of eight weeks of resistance training (RT) with Tribulus Terrestris (TT) consumption on the mechanism of apoptosis in the heart tissue of rats exposed to stanozolol.
Methods: Thirty-five male rats were divided into seven groups: (1) Control, (2) Stanozolol (ST), (3) ST + 100 mg / kg TT, (4) ST + 50 mg / kg TT, (5) ST + RT (SRT), (6) S + RT + 100 mg / kg T (SRTT100), and (7) ST + RT + 50 mg / kg T (SRTT50). Differential gene expression was measured by q-RT-PCR. In bioinformatics analysis, the apoptosis signaling pathway was defined as a critical process in heart damage. In addition, adverse effects of Tribulus Terrestris and stanozolol on heart tissue were detected through the apoptotic pathway by molecular docking.
Result: Resistance training along with 100 mg/kg reduced CRP and cytochrome-c Moreover, 100 mg/kg TT as a more favorable effect than 50 mg/kg TT
Conclusion: we showed the beneficial effects of Tribulus Terrestris, the plant’s bioactive compound that can reduce cardiovascular risks by impairing the formation of apoptosome assemblages and inflammation.
Mostafa Boskabadi, Najmeh Mohajeri, Ali Taghipour, Habibollah Esmaily, Syeid Javad Hoseinij, Ehsan Mosa Farkhani,
Volume 22, Issue 6 (3-2023)
Abstract
Background: In Iran, with the advancement of technology and the development of registration statistics, the need to use data mining methods has attracted more attention from researchers. Regression and classification tree is one of the important methods in Big data modeling, which has attracted the attention of many researchers for community control and prediction. The purpose of this study is to determine the influencing variables on the occurrence of complications caused by diabetes.
Methods: This paper is a cross sectional-analytical study. In this research, all diabetic patients covered by Mashhad University of Medical Sciences in 2017 were extracted from the SINA system. The number of diabetics with complications was 5016 and diabetics without complications were 53613. The method of fitting the regression tree model and classification and measurement criteria of the model is the coefficient of determination and the area of the Rock curve and the Lift diagram.
Results: The rock curve for the fitted tree model is 73.8%, which shows the relatively high power of the model. Based on the Lift chart, the decision-making power of diabetes complications increases 3.5 times for the person who comes to visit.
Conclusion: The results of the regression model and tree classification showed that, in descending order, age, risk assessment factor, FBS, HbA1C, total activity time, cholesterol, FBS and HDL, cardiovascular disease, history of stroke, blood pressure, cholesterol Statin prescription, job with hard physical activity, living area, consumed oil, walking, consumption of vegetables and gender are more effective than other factors in the occurrence of diabetes complications.
Mahkameh Abdollahi, Masoumeh Hosseini, Shahin Riyahi Malayeri,
Volume 22, Issue 6 (3-2023)
Abstract
Background: NRF1 and TFAM are proteins that affect mitochondrial biogenesis and play an important role in diabetes. The aim of the present study was to investigate the effect of high intensity training (HIT) training and beetroot consumption on NRF1 and TFAM in visceral adipose tissue of aged type 2 diabetic rats.
Method: In this experimental study, 40 male rats (weight range 270-300 grams and age 12-14 weeks) diabetic with streptozotocin were randomly divided into 5 groups (healthy control, diabetic control, supplement, exercise, exercise + complement) were divided. The training groups were subjected to intense interval training with an intensity of 50 to 90% of the maximum speed for 4 weeks and 4 sessions each week and 44 minutes each session. The groups receiving the supplement received 10 mg of beetroot per kilogram of body weight daily for 4 weeks and 4 times a week orally. The data are statistically significant using two-way ANONA test and (P < 0.05) was evaluated.
Results: The results of the study showed that the induction of diabetes led to a significant decrease in the protein levels of NRF1 and TFAM, so that in the exercise group, beetroot had a significant effect on the changes of NRF1 in the visceral fat tissue of elderly rats with diabetes. (P=0.001), but the interaction of HIT training and beetroot supplement in NRF1 changes is not significant (P=0.56) and also the factor of exercise and beetroot supplement, as well as the interaction of HIT training and beetroot also has a significant effect on TFAM changes in visceral adipose tissue of elderly rats with diabetes. (P=0.001).
Conclusion: Based on the findings of the present research, it seems that high interval training with beetroot consumption can lead to an increase in NRF1 and TFAM gene expression and thus help to improve and control diabetes in the elderly.
Saeed Naimi, Vahid Valipour Dehnou, Masoud Moeini,
Volume 22, Issue 6 (3-2023)
Abstract
Background: One of the complications of type 2 diabetes is the development of neurocognitive disorders, and DCX and AMPA may be involved in this disorder. Therefore, this study aimed to investigate the effect of aerobic exercise on the DCX and AMPA in the hippocampus of rats with type 2 diabetes.
Methods: 32 eight-week-old male rats were divided into control (C), diabetes (D), diabetes-exercise (DT), and exercise (T) groups. Diabetes was induced by streptozotocin injection. The exercise was carried out for six weeks. Finally, the rats were dissected, and their hippocampus tissue was extracted. Proteins were measured by the ELISA method.
Results: There was nonsignificant difference between the DCX of the C group and the T and DT groups (p>0.05). But there was a significant difference between the DCX of the C and diabetic groups (p =0.05). Also, a significant difference was observed between the diabetic groups and the T group (p<0.05). AMPA in diabetic groups were significantly lower than in C and T groups (p<0.05) While the difference between C and T groups and D and DT groups was not significant (p>0.05). Also, a significant negative correlation was observed between AMPA and DCX with blood glucose.
Conclusion: Diabetes reduces the AMPA and DCX but exercise nonsignificantly reduces the effect of diabetes on those. According to the appropriate duration of exercise, there is a possibility that due to the significant negative correlation between these proteins and glucose, the intensity of exercise can significantly reduce the negative effect of diabetes on those.
Mehdi Mirzaei-Alavijeh, Seyyed Nasrollah Hosseini, Marzieh Niksirt, Amir Hossein Hashemian, Farzad Jalilian,
Volume 23, Issue 1 (5-2023)
Abstract
Background: Control of Type 2 Diabetes Mellitus (T2DM) is influenced by lifestyle. The aim of this research was to determine the predictors of treatment adherence behaviors among T2DM based on Social Cognitive Theory (SCT).
Methods: This descriptive-analytical research was done among 500 T2DM patients in Tehran during 2021. Simple random sampling was performed among patients based their medical records in the Diabetes Control Clinic of Tehran's District Five. The data collection tools were written questionnaire based on the SCT determinants. Data were analyzed using descriptive statistics (frequency, percentage, mean, standard deviation) and analytical statistics (Pearson's correlation and linear regression) in SPSS software version 16. Results: The mean score of treatment adherence behaviors was 56.34 [SD: 10.41], ranged from 16 to 80. The outcome expectations, perceived self-efficacy, and social support accounted for 43% of the variation in the outcome measure of the treatment adherence behaviors. Self-efficacy was the strongest predictor (Beta = 0.430 and P<0.001). Increasing age (ß= -0.126 and P= 0.004), insulin treatment (ß= -0.250 and P<0.001) and smoking (ß= -0.146 and P= 0.001) conversely and having health insurance (ß= 0.181 and P<0.001) were positively predictive of treatment adherence behaviors.
Conclusion: The development, implementation and evaluation of educational interventions based on SCT with emphasis on promoting perceived self-efficacy can lead to useful findings in promoting treatment adherence behaviors among T2DM patients.
Seyedeh Neda Mousavi, Sara Gharacheh, Mir Saeed Seyed Dorraji, Elham Hosseini, Fariba Koohdani,
Volume 23, Issue 1 (5-2023)
Abstract
Background: Animal studies have shown maternal low/ high-calorie diet during pregnancy can alter metabolism of offspring through change in Sirtuin 1 (SIRT1) expression, as a metabolic sensor. However, there is no study on the effects of isocalorie diet. Herein, effects of two isocalorie diets with different amounts of fat were assessed on SIRT1 gene and protein level in the liver of male and female offspring.
Methods: The control group received AIN93G diet. In this diet, 16% and 64% of total calorie were prepared from fat and carbohydrate, respectively. The intervention group received high fat AIN93G diet contained 48% and 32% of calorie from fat and carbohydrate, respectively. In both diets, fat was prepared from soy oil. Diets were isocaloric and 20% of total calorie was provided from protein. Mothers categorized to one of these diets and offspring received the control diet after weaning (3 weeks after the birth).
Results: SIRT1 gene and protein levels were lower in male and female offspring born from mothers received high-fat diet than the controls (p<0.001).
Conclusion: Change in maternal dietary fat, without increase in calorie, effects on gene and protein levels of SIRT-1 in the liver of next generation.
Atefeh Ketabdar, Seyed Reza Attarzadeh Hosseini, Mehrdad Fathei, Mohamad Mosaferi,
Volume 23, Issue 5 (12-2023)
Abstract
Background: Fatty liver disease and its relationship with cardiovascular diseases is one of the concerns of today's society, therefore the present study was conducted to investigate the effect of eight weeks of endurance training and growth hormone injections on Cardiac mitochondrial PGC1α content and some oxidative stress indices in mice with hepatic damage.
Methods: In this experimental study, 21 male mice were, randomly, divided into three groups (n=7): control (C), Exercise (E), Exercise + Growth Hormone (EGH) group. The Medium intensity endurance training program was performed for eight weeks and 5 sessions with an intensity of 50% VO2max of per week. The somatropin injection protocols were 1 mg/ kilogram/body weight, respectively. Statistical analysis of the data was performed using the software SPSS, using One-Way ANOVA and post hoc Tukey tests.
Results: PGC1a levels increased in both groups compared to the control group. SOD and MDA levels increased and decreased in both groups compared to the control group, respectively. The reduction of HOMA levels was significant only in E group compared to the control group. Also, the difference between E and E-GH group was significant. ALT/AST ratio decreased in both groups compared to the control group. The reduction of LDL/HDL ratio was significant only in group E compared to the control group.
Conclusion: Endurance training has produced a more effective response in improving NAFLD markers than GH peptides. Growth hormone injection can have negative consequences on some indicators of this abnormality.
