Iranian Journal of

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Background: It has been shown that C1q TNF-related protein 5 (CTRP5) is a novel adipokine and important molecule related to metabolism regulation. This study aims to assess the effectiveness of different training protocols on improving serum levels of CTRP5, fasting blood glucose, insulin, Insulin resistance in patients with T2DM.
Methods: Sixty men with T2DM (mean age [X̅±SD]=51.45±4.26 years) were randomly assigned to combined  exercise group (CEx: n = 15), aerobic  exercise group (AEx: n = 15), resistance  exercise group (REx: n = 15), or the control group (CON: n= 15). Exercise programs consisted of aerobic exercises at either AEx (50% - 75% of HRR) or REx (70% - 85% of 1-RM), of equal volume, 3 times per week, 45 to 60 minutes per session for 12 weeks. Serum levels of CTRP5, fasting blood glucose (FBG), insulin, Insulin resistance (IR) and body mass index (BMI) were measured at baseline and at the end of the study. The data were analyzed using repeated-measures analysis of variance.
Results: After 12 weeks intervention, FBG, insulin, HOMA-IR and BMI levels decreased significantly, whereas the serum CTRP5 levels increased in the CEx, AEx and Rex groups compared to control (P < .05).
Conclusion: It appears that the increased levels of CTRP5 following exercise interventions contribute to the decreased risk of T2DM.

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Background: Family members of C1q/tumor necrosis factor (TNF) related proteins (CTRPs) have been shown to play an important role in metabolism and inflammation. However, there is limited information on the association of high-intensity intermittent exercise (HIIT) with CTRP1 and CTRP3 protein levels in patients with type 2 diabetes. Therefore, this study aims to evaluate the effects of 12 weeks HIIT on CTRP1 and CTRP3 protein levels in women with type 2 diabetes.
Methods: In a quasi-experimental study and pretest and post-test design, 30 women with type 2 diabetes (mean±SD, age: 40.69±4.21 years and body mass index:34.81±2.88 kg/m² ) were randomly into two HIIT group (n=10) and control group (n=15). Exercise group performed a HIIT program three sessions per week, with and intensity of 80-90% MHR, 60 minutes per session for twele weeks. Weight, BMI, Vo2peak, FBG and serum levels of CTRP1 and CTRP3 were measured before and after the study period. The data were analyzed using paired sample t test and analysis of ANCOVA at the level of less than 0.05.
Results: After 12 weeks HIIT, there was significant differences in weight, BMI, Vo2peak, FBG and CTRP3 and CTRP5 serum levels between groups (p >0.05). However, ANCOVA test showed a significant decrease in weight, BMI, FBG and CTRP1 and CTRP3 serum levels and a significant increase in Vo2peak in the HIIT group compared to the control group after intervention (P<0.05).
Conclusion: The findings suggest that 12 weeks of HIIT program were an effective and safe method of improving the CTRP1 and CTRP3 serum levels in obese women with type 2 diabetes. However, more research with more control are needed to determine the effects of this non-pharmacological intervention on anti-inflammatory adipokine.

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Background: TORC1 protein is an important factor in regulating adipose tissue metabolism. Type 2 diabetes can lead to dysfunction and the development of obesity. Therefore, the aim of the present study was to investigate the effect of eight weeks of high-intensity interval training (HIIT) and endurance on blood glucose and TORC1 protein content in subcutaneous adipose tissue of obese with type 2 diabetes rats.
Methods: In this study, 18 head 2 Sprague-Dawley male rats with a mean weight of 270±30 g were selected. After becoming type 1 diabetic through streptozotocin and Nicotine amide solution, they were randomly divided into 3 groups: 1) HIIT training 2) endurance training and 3) control (6 heads per group). Exercise groups exercised 4 days a week for 8 weeks according to HIIT and endurance training programs. SPSS software version 23, one-way ANOVA and Tukey post hoc test were used to analyze the data.
Result: Eight weeks of HIIT and endurance training resulted in a significant decrease in blood glucose level (p<0.0001) and a significant increase in TORC1 protein content (P<0.0001) compared to the control group.
Conclusion: HIIT and endurance training lowered blood glucose levels and increase TORC1 protein content, which this training can be a suitable and non-invasive treatment to control diabetes and also regulate adipose tissue metabolism in type 2 diabetics who are prone to obesity.
 

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Background: FOXO family proteins are important factors in autophagy pathway. Protein kinase-B is an important regulator for this family that can be regulated through exercise training. Therefore, the aim of this study is to investigate the effect of protein kinase-B (PKB) on FOXO autophagy family proteins (FOXO1 and FOXO3a) following high intensity interval training (HIIT) in the left ventricle of the heart of diabetic rats by streptozotocin (STZ) and nicotinamide.
Methods: In this experimental study, 12 two-month-old Sprague-Dawley rats with a mean weight of 270±20 g were selected. After type 2 diabetes induction with STZ and Nicotinamide, rats were randomly assigned to two groups, diabetic training (6 heads) and diabetic control (6 heads). The training group trained for 4 days a week in accordance with the training program for 8 weeks. SPSS software version 23 and independent t-test were used to analyze the data. Significance level is considered p≤0.05.
Results: HIIT training resulted in a significant increase in PKB protein content between training and control groups (P=0.0001). In contrast, a significant decrease in protein content of FOXO1 (P=0.003) and FOXO3a (P=0.006) was observed between the training and control groups.
Conclusion: It seems based on the results HIIT with increasing and regulating PKB leads to a decrease and inactivation of FOXO1 and FOXO3a proteins in the hearts of diabetic subjects. Inhibition of these proteins can prevent excessive cardiac autophagy in diabetic subjects.

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Background: Coronary heart disease is a viral infection that has become a pandemic disease. Given the comprehensive impact that this disease has on the lifestyle of individuals, the economic situation of the country, imported drugs; the present study aims to investigate the self-care status of patients with type 2 diabetes during the Covid epidemic.
Methods: The study population in the present study was people with diabetes in Bushehr. The sampling method in the present study was purposeful and available sampling and the sample size was 13 people (7 men and 6 women). The research information was collected through a semi-structured interview for 40 to 60 minutes using open-ended questions. After the interview process, the answers were interpreted and coded using the content analysis method.
Results: According to the results of the present study, in general, patients with type 2 diabetes during the period of Covid-19 epidemic did not have a favorable self-care status and many problems in the field of self-care behavior (medication, nutrition and exercise and mobility) and in other Fields have experienced.
Conclusion: Diabetics have experienced many problems during the Quaid 19 epidemic, which further reduces their quality of life; therefore, the government, the media, the patient's family, the patient himself, doctors, psychologists and counselors can be used to reduce these problems.

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Background: People with diabetes face psychological challenges. Therefore, it is important to pay attention to cognitive therapies based on mindfulness in this field. The aim of this study was to evaluate the effectiveness of mindfulness-based cognitive therapy on anxiety tolerance and cognitive flexibility in patients with type 2 diabetes.
Methods: The research method was quasi-experimental with pre-test-post-test design with a control group. The statistical population of the present study was all type 2 diabetic patients referred to the Maternal Diabetes Center, Touba Specialized and Sub-Specialized Clinic and Mostafavian Clinic in Sari in 2019-2020. Simple randomization was substituted in experimental (n = 15) and control (n = 15) groups. However, no intervention was performed on the control group during this period. The Simon and Gaher (2005) Emotional Distress Scale and the Doyce and Woodwall (2010) Scale were used to collect data. mean, standard deviation and multivariate analysis of covariance were used to analyze the research data.
Results: The results showed that the effect of Mindfulness-based cognitive therapywas on distress tolerance (F= 28.74, P<0.001) and on Cognitive flexibility (F= 31.57, P<0.001).
Conclusion: Considering the effectiveness of mindfulness-based cognitive therapy on anxiety tolerance and cognitive flexibility, it seems that this treatment can be used to reduce psychological problems in patients with type 2 diabetes.
 

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Background: The objective of this experimental study was to determine the effect of 6 weeks of high intensity interval training (HIIT) on G6Pase expression in liver tissue, serum insulin and glucose and insulin resistance in obese rats with type 2 diabetic and compared with non-diabetic obese group.
Methods: 28 male Wistar rats aged 10 weeks (220 ± 10 g) were obesed by 6 weeks of high-fat diet (HFD). Then type 2 diabetes induced in 14 rats by intraperitoneal injection of STZ (30 mg/kg). Finally, the studied rats were divided into 4 same groups: 1) control obese, 2) interval obese, 3) control diabetic, 4) interval diabetic. Interval groups participated in an interval exercise program of 5 sessions per week for 6 weeks consists of 10 repetitions of a 40-second run on the treadmill with 2-minute rest (active rest) between repetitions. 48 hours after the lasting session, fasting levels of glucose, serum insulin and G6Pase expression in liver tissue in all 4 groups were measured and compared with 2 way ANOVA.
Results: Compared with diabetic control groups, HIIT in diabetic group resulted in significant decrease fasting glucose (p= 0.001). HIIT also led to an increase in serum insulin (p= 0.006) without change in G6Pase expression (p= 0.102) compared to the diabetic control group.
Conclusion: Improved glucose response to interval training in type 2 diabetic rats may be rooted in increase insulin without changes in hepatic G6Pase expression. Measurement of activity or expression of other liver enzymes is suggested for general conclusion.

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Background: Fat mass and obesity-associated gene (FTO) is directly associated with increased risk of obesity and type 2 diabetes mellitus (T2DM). The purpose of this study was to investigate the effect of 12 weeks of high intensity interval training (HIIT) on FTO expression of subcutaneous fat tissue in T2DM rats.
Methods: In this experimental study, twelve males Wistar rats (220±10 g) with T2DM induced by streptozotocin-nicotinamide injection were randomly divided into exercise (n=6) and control (n=6) groups. The training group performed the HIIT protocol on a treadmill for 12 weeks and 5 days per week. FTO expression in subcutaneous fatty tissue, blood glucose level, insulin and insulin resistance were measured 48 hours after the last training session. Data were analyzed by independent T test at P< 0.05.
Results: Blood glucose level, insulin resistance and FTO expression in fat tissue decreased significantly in training groups compared to control group after the exercise intervention (P˂0.05). Serum insulin increased significantly in training groups compared to control group (P˂0.05).
Conclusion: It seems that HIIT can decrease glucose, insulin resistance and FTO expression of fat tissue of T2DM rats. Improved glycemic control in diabetic rats might be attributed to reduced FTO expression in response to HIIT.

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Background: Irisin is a myokine that is released from FNDC5 membrane protein and has positive effects on carbohydrate metabolism. The aim of this study was to evaluate the effect of 8 weeks of aerobic exercise on irisin levels and insulin resistance in middle-aged women with type 2 diabetes.
Methods In this quasi-experimental study, 24 women with type 2 diabetes were purposefully selected and randomly divided into two groups of aerobic exercise (n = 12) and control (n = 12). The training group performed aerobic exercises for 8 minutes (3 sessions per week) for 50 minutes with an intensity of 45-85% of the maximum heart rate on the treadmill. The control group did not engage in any physical activity during exercise. Blood samples were collected 24 hours before and 48 hours after the last training session and the serum was used to measure the levels of irzin, insulin resistance index (HOMA-IR), fasting glucose and insulin. Correlated t-test and independent t-test were used to examine intra-group changes and differences between groups. Data analysis was performed using SPSS software (version 22) at a significant level (P≥0.05).
Results: Intragroup changes showed that 8 weeks of aerobic exercise increased serum levels of irizin (P = 0.000), significantly decreased insulin resistance index (HOMA-IR) (P = 0.000), fasting glucose and insulin ratio (P = 0.001) ratio He became diabetic in the control group. Also, in comparison between groups, aerobic exercise caused a significant increase in levels of irizin (P = 0.001) and a decrease in insulin resistance index (HOMA-IR), fasting glucose (P = 0.001) and insulin (P = 0.001) compared to the control group. He became diabetic.
Conclusion: Aerobic exercise, through its beneficial effect on increasing irisin levels and decreasing insulin resistance index, is an effective factor in improving glucose metabolism in type 2 diabetic patients.

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Background: Diabetic myopathy is one of the major problems in people with type2 diabetes that knowing its mechanisms can be helpful in controlling and preventing this disease. PAX7 and PGC-1α are two proteins involved in the renewal and metabolism of carbohydrates in skeletal muscle. The aim of this study was to evaluate the effect of 8weeks of resistance training under hypoxia on the content of PAX7 and PGC-1α proteins in the horseshoe muscle of type 2 diabetic rats.
Methods: In this study, 40 male Wistar rats, 10weeks after induction of type2 diabetes, were divided into five groups: healthy control (HC), diabetic control (DC), resistance training (RT), and resistance training in hypoxia (RT-HPX) and hypoxia group (HPX) were divided. Resistance exercises were performed for 8 weeks, 5 sessions per week, in the groups of resistance training and resistance training in hypoxia. The intensity of the exercises started from 30% of the weight of the rats initial and reached 100% of their weight until the end of the training. Resistance training in hypoxia. Hypoxia tent with14.4%oxygen was used to create hypoxia. 48hours after training, tissue samples were taken from horseshoe muscle and evaluated to measure the concentration of PAX7 and PGC-1α proteins.
Results: The results showed that there is a significant difference (P=0.0001) between the research groups in both PAX7 and PGC-1α proteins. Induction of diabetes led to a significant decrease in PAX7, but the hypoxia resistance training group was not significantly different from the healthy control group (P=0.451). PGC1-α protein levels were also significantly decreased in the diabetes induction group compared to the control group (P=0.01), but training in hypoxia increased its levels to more than the healthy control group (P=0.0001).
Conclusion: Hypoxia, resistance training and combination of resistance training in hypoxia increased the amounts of PAX7 and PGC-1α proteins. Therefore, resistance training and temporary and inactive hypoxia exposure can be considered as a suggested solution to improve the indicators related to type2 diabetes in humans.

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Background: MAFbx and MuRF1 proteins are important factors in the ubiquitin pathway and are responsible for muscle atrophy. The purpose of this study was to investigate the effect of long-term high-intensity interval training (HIIT) on the intracellular content of MAFbx and MuRF1 proteins in the left ventricular of the heart of rats with type 2 diabetes.
Methods: In this experimental study, 18 rats 2-month-old male Sprague-Dawley rats with a mean weight of 270±20 g were selected. 12 rats became diabetic by intraperitoneal injection of Streptozotocin and nicotinamide solutions. These rats were randomly divided into 2 groups: diabetic training and diabetic control; A healthy control group was also considered. The training group practiced HIIT 4 days a week for 8 weeks. Data were analyzed using SPSS software version 23 and one-way ANOVA and Tukey post hoc tests.
Results: MAFbx protein content showed a significant decrease after 8 weeks of HIIT (P=0.0001); Tukey post hoc test showed that this change was significant between pairs groups of diabetic training and diabetic control and also between pairs groups of diabetic control and healthy control (P=0.0001). MuRF1 protein content showed a significant decrease (P=0.0001); This was a significant difference between the pairs groups of diabetic training and diabetic control, diabetic training and healthy control groups, as well as diabetic control and healthy control groups (P=0.0001).
Conclusion: HIIT seems to can inhibit the process of atrophy and autophagy of cardiomyocytes by reducing the content of MAFbx and MuRF1 proteins in the hearts of diabetic subjects.

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Background: Type 2 diabetes is a chronic and debilitating disease that affects the life expectancy and self-care behaviors of women with this disease. Therefore, the present study aimed to investigate the effectiveness of existential therapy on life expectancy and self-care behaviors of women with type 2 diabetes.
Methods: The research method was applied and quasi-experimental with pre-test and post-test design with control group. The population included all women with type 2 diabetes in Neyshabur, Iran. Among them, 40 people were selected by available sampling method and randomly assigned to experimental and control groups. Participants completed the Hope Scale (HS), and The Summary of Diabetes Self-Care Activities (SDSCA). Multivariate analysis of covariance was used to analyze the data.
Results: The results of analysis of covariance showed that there was a difference between women in the existential therapy group and the control group in life expectancy (F= 10.11, P= 0.0001) and self-care behaviors (F= 176.5, P= 0.003). Existential therapy has increased the mean score of the participants of the experimental group in the variables of life expectancy and self-care behaviors.
Conclusion: The existential therapy can increase life expectancy and self-care behaviors of women with type 2 diabetes by emphasizing freedom, responsibility, meaning and purpose in life, death and relationship with other. Therefore, existential therapy can be used in along with medical treatments.

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Background: Myogenin (MyoG) and Myostatin (Mstn) play role in muscle growth and wasting, respectively. The present study aimed to investigate the combined effect of High-intensity Interval Training (HIIT) and Metformin drug (Metf) on gene expression of MyoG and Mstn in skeletal muscle of type 2 diabetic mice.
Methods: 25 mice (C57BL/6) were assigned to two groups, including 1) Control © (n=5), and 2) HFD (n=20). The mice of the HFD group were fed a high-fat diet for 16 weeks. After 16 weeks, the mice with over 200 mg/dl were selected as diabetic mice. Then, the diabetic mice were divided into four groups including 1) Control Diabetic (CD) (n=5), 2) Diabet with Metf (DM) (n=5), 3) Diabet with HIIT (DH) (n=5) 4) Diabet with Metf and HIIT (DMH) (n=5). The mice of experimental groups underwent the interventions for eight weeks. The Real-Time–PCR methods were used to measure the mRNA expression of MyoG and Mstn in the Rectus-Femoris muscle.
Results: HIIT (but no Metf) upregulated the gene expression of MyoG (p=0.05). Metformin did not affect Mstn expression (p=0.45), However, HIIT downregulated the expression of Mstn (p=0.001). Metformin did not affect decreasingly or incrementally the downregulating effect of HIIT on Mstn expression (p=0.95).
Conclusion: Metf may not positively or negatively affect the expression changes of MyoG and Mstn induced by HIIT in skeletal muscle of mice with type 2 diabetes.

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Background: mTOR and CREB proteins are two important factors in cellular pathways and regulating fat tissue metabolism. Therefore, the aim of this research is the effect of endurance training on the amount of mTOR and CREB proteins in the adipose tissue of type 2 diabetic rats.
Methods: In this experimental study, 18 rats 2-month-old male Sprague-Dawley rats with a mean weight of 270±20g were selected. 12 rats became type 2 diabetic by intraperitoneal injection of Streptozotocin solutions. These rats were randomly divided into 2 groups: diabetic training and diabetic control (6 heads per group); A healthy control group (6 heads) was also considered. The training group practiced endurance training 4 days a week for 6 weeks. Data were analyzed using SPSS software version 23 and one-way ANOVA and Tukey post hoc tests.
Results: mTOR protein content showed a significant change after 6 weeks of endurance training (P=0.0001); Tukey's post hoc test showed that this change was significant between the pairs of diabetic training groups to healthy controls (P=0.004) and diabetic control groups to healthy controls (P=0.0001). CREB protein content showed a significant change (P=0.0001); this change was significant between the pairs of diabetic training to diabetic control groups (P=0.02), diabetic training to healthy control (P=0.0001), and diabetic control to healthy control groups (P=0.0001).
Conclusion: mTOR and CREB proteins decreased after Endurance Training, which can be effective in regulating adipose tissue metabolism; however, more training conditions should be considered.

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Background: Type 2 diabetes is the most common endocrine disease that can cause tissue damage and apoptosis. The purpose of the present study was to study the changes in the expression of related liver apoptosis genes after High Intensity Training (HIT) and royal jelly in type 2 diabetic rats.
Methods: The statistical sample of the study was 36 male rats that became diabetic after 20 weeks of high-fat diet and injection of 25 ml/kg of STZ. Fasting glucose between 150 and 400 mg/dl was considered as the criteria for type 2 diabetes. Diabetic rats were placed in 4 groups: control, HIIT, Jelly, and HIIT-Jelly. The HIITprotocol was performed 8 weeks, 5 sessions / week with intense 2-minute intervals with 2-8 intervals and 80-90% vo2max and one-minute rest intervals with 50-56% vo2max and Royal Jelly gavage at 100 mg/kg for 5 days / week. Data analysis was done using one-way and two-factor analysis of variance and post hoc test.
Results: The results showed that compared to the control group, HIIT led to a significant decrease in glucose and insulin resistance index. Also, HIIT and royal jelly consumption led to a decrease in Bax gene expression and an increase in Bcl2 gen expression and a decrease in the Bax/Bcl2 ratio in liver cells compared to the control group (P<0.05).
Conclusion: HIIT with royal jelly in diabetic rats led to the reduction and improvement of glycemic index and insulin resistance and appropriate changes in the expression of liver apoptotic genes.

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Background: The release of adipokines from adipose tissue depots plays a key role in regulating metabolic homeostasis and several other physiological processes, including diabetes, obesity, and vascular diseases. This study investigated the effect of eight weeks of high intensity interval training (HIIT) on asprosin, lipid profile and insulin resistance in type 2 diabetic male rats.
Methods: 24 male Sprague Dawley rats were randomly divided into four equal groups: control (C), control traning (C+T), diabet (D) and diabet traning (D+T). Diabetes was induced by the combined method of high fat diet and low dose strepotozocin injection. The traning group performed the HIIT program on the treadmill for eight weeks. Data were analyzed using one-way ANOVA and bonferroni post hoc test at a significance level of P<0.05.
Results: The results showed increased plasma asprosin in D group compared to C (P=0.0001) and decreased in C+T group compared to C (P=0.03) and D+T group compared to D (P=0.04). There was no significant difference in HOMA-IR between the C and C+T group (P=0.9) but decreased in D+T compared to D (P=0.0001). HDL increased in D+T group compared to the D (P=0.0001) and decreased TG and LDL (P=0.001). There was no significant difference between TG and LDL in the C group compared to the C+T, but HDL increased in C+T (P=0.01).
Conclusion: Plasma asprosin increases in rats with type 2 diabetes and HIIT can reduce the complications of diabetes by improved lipid profile and reduce asprosin and insulin resistance.

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Background: Type 2 diabetes is the most common metabolic disease, a chronic and progressive disorder that causes permanent complications and increased cardiovascular, cerebrovascular, peripheral vascular disease, nephropathy, retinopathy, neuropathy, diabetic foot, amputation and death in patients.The aim of the present study was to examine the predictor role of negative repeating thoughts, emotion regulation strategies and self-care in remedial acceptance and adherence of patients with type 2 diabetes.
Methods: The method of the present study was descriptive, correlation type, and the population was from all the patients with type 2 diabetes who were members of Diabetes Association in Chahar-Mahal-o Bakhtiyari. Among this group, using the convenience sampling method, and on the basis of Morganʼs table, 300 patients with type 2 diabetes were recruitment. Using MackEuy and othersʼ negative repeating thoughts questionnaire (2014), Mans & Malouf emotion regulation­ strategies questionnaire (2009), Toobert & Glasgow self-care questionnaire (2000) & Modanloo acceptance and treatment follow-up questionnaire (2014), the experiment group was investigated. The data were analyzed by SPSS software.
Results: Our findings have shown that negative repeating thoughts, emotion regulation strategies and self-care predict the remedial acceptance and adherence of patients with type 2 diabetes significantly.
Conclusion: With pay attention to identify of the predictor role of negative repeating thoughts, emotion regulation strategies and self-care in remedial acceptance and adherence of patients with type 2 diabetes, and high prevalence of this disease too, it seems that psychological intermediations, with pay attention to role of mentioned variables to decrease of psychological problems and increase of adherence in them, pay attention to role of negative repeating thoughts too, compatible and incompatible strategies of emotion regulation and adhere to self-care could be taken as prevention of deterioration type 2 diabetes and better controlling.

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Background: Control of Type 2 Diabetes Mellitus (T2DM) is influenced by lifestyle. The aim of this research was to determine the predictors of treatment adherence behaviors among T2DM based on Social Cognitive Theory (SCT).
Methods: This descriptive-analytical research was done among 500 T2DM patients in Tehran during 2021. Simple random sampling was performed among patients based their medical records in the Diabetes Control Clinic of Tehran's District Five. The data collection tools were written questionnaire based on the SCT determinants. Data were analyzed using descriptive statistics (frequency, percentage, mean, standard deviation) and analytical statistics (Pearson's correlation and linear regression) in SPSS software version 16. Results: The mean score of treatment adherence behaviors was 56.34 [SD: 10.41], ranged from 16 to 80. The outcome expectations, perceived self-efficacy, and social support accounted for 43% of the variation in the outcome measure of the treatment adherence behaviors. Self-efficacy was the strongest predictor (Beta = 0.430 and P<0.001). Increasing age (ß= -0.126 and P= 0.004), insulin treatment (ß= -0.250 and P<0.001) and smoking (ß= -0.146 and P= 0.001) conversely and having health insurance (ß= 0.181 and P<0.001) were positively predictive of treatment adherence behaviors.
Conclusion: The development, implementation and evaluation of educational interventions based on SCT with emphasis on promoting perceived self-efficacy can lead to useful findings in promoting treatment adherence behaviors among T2DM patients.

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Background: Expression of FoxO transcription factors whould increase during certain forms of atrophy. In a dephosphorylated state, FoxOs participate in ubiquitin-mediated proteasomal degradation through the transcriptional activation of E3-ubiquitin ligases such as MAFbx/atrogin-1. Therefore, the study aimed to determine the effect of combination of continuous exercise and resveratrol supplementation on foxo-1 and Atrogin-1 gene expression in the left ventricular tissue of male Wistar rats.
Methods: In this study, 25 male Wistar rats with 180-250 g weight were randomly classified into 5 groups, including healthy control (n=5), diabetic control (n=5), diabetic resveratrol (n=5), diabetic-continuous exercise (n=5), and resveratrol+ continuous exercise+ diabetes (n=5). After inducing diabetes by intraperitoneal injection of streptozotocin, animals in expremental groups were carried out an 8-week exercise program on a treadmill with 60-75% Vo2max. One-way ANOVA and Tukey test with statistical level (P<0.05) was used to compare the differences between groups.
Results: The results showed that gene expression of Atrodin-1 were significantly markedly in the ARDM group compared to the DM group (P= 0.02) but the gene expression of foxo-1 only was significantly changed (P= 0.001) in ARDM group to compared with the other groups (P>0.05).
Conclusion: It seems that the Foxo1 gene expression fluctuations along with the significant decrease in the expression of the atherogen-1 gene can be improving the diabetic heart as a non-pharmacological method.

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Background: During recent decades, physical activity has become a key auxiliary tool in controlling many diseases, including diabetes. The aim of this study was to investigate the effect of 8 weeks of resistance training on the plasma levels of preptin and endothelin 1 in men with type 2 diabetes.
Methods: The current research is semi-experimental. The statistical sample of this study consisted of 38 men with type 2 diabetes, who were randomly divided into two groups of 19 experimental and control. Subjects in the experimental group performed 8 weeks of resistance training three sessions a week with moderate intensity. 24 hours before and after 8 weeks of training, plasma levels of preptin, endothelin 1, and indicators related to type 2 diabetes were measured by the ELISA method. Correlated t-tests and independent t-tests were used to examine intra-group changes. SPSS software was used to analyze the data (P≥ 0.05).
Results: Correlated t results showed that plasma levels of preptin and insulin resistance index (P= 0.001) as well as plasma endothelin 1 (P= 0.001) decreased significantly in the post-test compared to the pre-test of the experimental group. has been found Also, the independent t-test results showed that the plasma levels of preptin, insulin resistance index (P= 0.001) and endothelin 1 (P= 0.002) were significantly lower in the post-test of the experimental group compared to the control.
Conclusion: According to the obtained results, it seems that doing resistance exercises improves glucose sensitivity by reducing preptin and reducing the possibility of blood pressure by reducing endothelin 1 in preople with type 2 diabetes.