Showing 29 results for Aerobic Exercise
Sohila Mardani, Sayed Abbas Binias, Sajjad Ramezani,
Volume 22, Issue 2 (7-2022)
Abstract
Background: Irisin is a myokine that is released from FNDC5 membrane protein and has positive effects on carbohydrate metabolism. The aim of this study was to evaluate the effect of 8 weeks of aerobic exercise on irisin levels and insulin resistance in middle-aged women with type 2 diabetes.
Methods In this quasi-experimental study, 24 women with type 2 diabetes were purposefully selected and randomly divided into two groups of aerobic exercise (n = 12) and control (n = 12). The training group performed aerobic exercises for 8 minutes (3 sessions per week) for 50 minutes with an intensity of 45-85% of the maximum heart rate on the treadmill. The control group did not engage in any physical activity during exercise. Blood samples were collected 24 hours before and 48 hours after the last training session and the serum was used to measure the levels of irzin, insulin resistance index (HOMA-IR), fasting glucose and insulin. Correlated t-test and independent t-test were used to examine intra-group changes and differences between groups. Data analysis was performed using SPSS software (version 22) at a significant level (P≥0.05).
Results: Intragroup changes showed that 8 weeks of aerobic exercise increased serum levels of irizin (P = 0.000), significantly decreased insulin resistance index (HOMA-IR) (P = 0.000), fasting glucose and insulin ratio (P = 0.001) ratio He became diabetic in the control group. Also, in comparison between groups, aerobic exercise caused a significant increase in levels of irizin (P = 0.001) and a decrease in insulin resistance index (HOMA-IR), fasting glucose (P = 0.001) and insulin (P = 0.001) compared to the control group. He became diabetic.
Conclusion: Aerobic exercise, through its beneficial effect on increasing irisin levels and decreasing insulin resistance index, is an effective factor in improving glucose metabolism in type 2 diabetic patients.
Mahin Rasuli, Ebrahim Zarrinkalam,
Volume 22, Issue 4 (11-2022)
Abstract
Background: A high-fat diet causes hyperinsulinemia and increases insulin resistance in the body. On the other hand, the oxidative stress caused by hyperglycemia can lead to the exacerbation of hyperglycemia and increase the complications of diabetes, and cardiovascular diseases are one of the most important complications of diabetes mellitus. Therefore, the aim of this study was to investigate the effect of 4 weeks of aerobic training on catalase enzyme activity in the left ventricle and insulin resistance index in male rats treated with streptozotocin and exposed to a high-fat diet.
Methods: In this experimental study, 19 male wistar rats, with an average age of 8-12 weeks and a weight of 200-250 grams, were divided into 3 groups: diabetic control (CD 8), training diabetes (TD 8) and healthy control (C 3). The exercise program included 4 weeks of aerobic exercise with an average of 60 to 75 Vo2max in an increasing manner. Before and 48 hours after the last training session, blood was taken and left ventricular tissue samples were extracted to check the HOMA-IR index and catalase activity by ELISA method. To compare the study groups, one-way analysis of variance and Scheffe's post hoc test were used in SPSS software (p≥0.05).
Results: The results showed that the induction of diabetes with STZ along with a high-fat diet causes a significant decrease in catalase enzyme (P=0.001) and a significant increase in HOMA-IR index, fasting glucose and Li index (P=0.001) in rats. However, doing 4 weeks of aerobic training caused a significant increase in catalase enzyme activity (P=0.001) and a decrease in HOMA-IR index, glucose and Li index (P=0.001).
Conclusion: Aerobic exercise with moderate intensity can be used as an effective non-pharmacological method in the treatment of diabetic cardiomyopathy by increasing catalase activity and reducing resistance to insulitis in diabetes.
Saeed Naimi, Vahid Valipour Dehnou, Masoud Moeini,
Volume 22, Issue 6 (3-2023)
Abstract
Background: One of the complications of type 2 diabetes is the development of neurocognitive disorders, and DCX and AMPA may be involved in this disorder. Therefore, this study aimed to investigate the effect of aerobic exercise on the DCX and AMPA in the hippocampus of rats with type 2 diabetes.
Methods: 32 eight-week-old male rats were divided into control (C), diabetes (D), diabetes-exercise (DT), and exercise (T) groups. Diabetes was induced by streptozotocin injection. The exercise was carried out for six weeks. Finally, the rats were dissected, and their hippocampus tissue was extracted. Proteins were measured by the ELISA method.
Results: There was nonsignificant difference between the DCX of the C group and the T and DT groups (p>0.05). But there was a significant difference between the DCX of the C and diabetic groups (p =0.05). Also, a significant difference was observed between the diabetic groups and the T group (p<0.05). AMPA in diabetic groups were significantly lower than in C and T groups (p<0.05) While the difference between C and T groups and D and DT groups was not significant (p>0.05). Also, a significant negative correlation was observed between AMPA and DCX with blood glucose.
Conclusion: Diabetes reduces the AMPA and DCX but exercise nonsignificantly reduces the effect of diabetes on those. According to the appropriate duration of exercise, there is a possibility that due to the significant negative correlation between these proteins and glucose, the intensity of exercise can significantly reduce the negative effect of diabetes on those.
Alireza Zandinezhad, Hossein Abednatanzi, Farshad Ghazalian, Alireza Barari,
Volume 23, Issue 3 (9-2023)
Abstract
Background: The aim of the present study was to study the changes in the expression of Cox-1 and Cox-2 genes in liver tissue and tumor volume after aerobic exercise and consumption of pineapple extract in mice with skin cancer.
Methods: This fundamental-laboratory study was conducted on 32 male C57BL/6 mice in four groups including control, aerobic exercise, pineapple extract and aerobic-pineapple exercise. After tumor induction, the animals underwent aerobic training program for six weeks and pineapple extract was gavage at 300mg/kg. The weight and tumor volume of mice were measured. After obtaining blood and tissue samples, expression of Cox-1 and Cox-2 genes in liver tissue was done by RT-PCR method. Then the data were analyzed using one-way analysis of variance, two-factor analysis of variance and post hoc test, and the significance level of p≤0.05 was considered.
Results: Compared to the control group, aerobic exercise and pineapple-exercise showed a significant decrease in tumor volume and a decrease in the expression of Cox-1 (0.59±0.97) and Cox-2 (0.5±0.4) gene expression in the aerobic-Pineapple compared to the control group (1±0) (p≤0.05). Cox1 gene expression increased significantly in the Aerobic exercise group, but a significant decrease was observed in the pineapple-Aerobic group. Also, Cox2 gene expression in the liver tissue in the exercise group Aerobic and interactive Aerobic-pineapple group had a significant decrease compared to the control, but in the pineapple group compared to the control, the difference in the expression of this gene was not significant.
Conclusion: The results of the present study showed that the expression of Cox 1 gene was significantly increased in the aerobic training group and significantly decreased in the pineapple-training group. Cox-2 gene expression in the liver tissue in the aerobic training group and the pineapple-training interactive group had a significant decrease compared to the control, because the Cox-2 enzyme is related to inflammation and pain, angiogenesis, cancer and Alzheimer's disease. Therefore, it can be concluded that its inhibition or reduction can be considered as a promising and effective strategy for the treatment and prevention of cancer.
Fatemeh Sabaghian, Fatemeh Kazeminasab, Amir Ghanbarpour,
Volume 23, Issue 4 (11-2023)
Abstract
Background: The purpose of this study was to investigate the impact of aerobic exercise on the function of local renin-angiotensin system and insulin resistance in the Gastrocnemius muscle of type 2 diabetic mice.
Methods: The number of 18 male C57BL/6 mice were divided into two groups: 1. Mice fed with a standard diet for 12 weeks (control group), 2. Mice fed with a high-fat diet for 12 weeks with streptozotocin injection (diabetes group). Diabetic mice were randomly divided into two groups: 1. Diabetes-Sedentary group, 2. Diabetes-exercise group. The mice of the training group exercised on the treadmill for eight weeks and five days/week with an average speed of 19 m/min and for 45 minutes. 24 hours after the last training session, the mice were sacrificed. The Gastrocnemius muscle tissue was extracted and stored in -80°C freezer to measure the expression level of angiotensin 2, Mass receptor, At1 receptor and glucose transporter 4 (Glut 4).
Results: The results showed that the expression of Mass and Glut4 receptor in diabetes-exercise mice was significantly higher than diabetes-sedentary group. Also, the expression of angiotensin 2, HOMA-IR, and fasting glucose in the muscle of diabetes-exercise mice were significantly lower vs. diabetes-sedentary mice. Also, the expression of At1 receptor in the diabetes-exercise group was insignificantly lower than in the diabetes-sedentary group.
Conclusion: The findings of the present study show the important role of exercise in improving the local renin-angiotensin system in skeletal muscle. Eight weeks of aerobic training can reduce muscular insulin resistance and improve type 2 diabetes by decreasing the expression of angiotensin 2, At1 receptor and increasing the Mass receptor.
Monireh Khalili, Habib Asgharpour, Asra Askari, Jahanbakhsh Asadi,
Volume 23, Issue 6 (1-2024)
Abstract
Background: The health and proper functioning of the endoplasmic reticulum in the liver can lead to an increase in the quality of the metabolism of liver cells. Exercise can lead to liver health by regulating liver enzymes and factors related to apoptosis pathway. Therefore, the aim of the current research is to compare the performance of the endoplasmic reticulum chaperone protein of the liver of healthy model rats with the intervention of different training sessions and starvation.
Methods: In this experimental research, 30 Wistar male rats with a weight range of 330 ± 25 grams were selected and divided into six groups: 1) control, 2) starvation, 3) 3 days of training per week, 4) 5 days of training per week, 5) starvation + 3 training days per week, 6) starvation + 5 training days per week. Training consisted of one hour of continuous running on a treadmill for 4 weeks, and starvation was performed for 14 hours when the rats were awake. Data analysis was performed using one-way analysis of variance and post hoc LSD statistical tests in SPSS version 23 software. A significance level of P≤ 0.05 was considered.
Results: Data analysis showed a significant change in the levels of liver enzymes alanine aminotransferase (ALT) and aspartate transaminase (AST) (P≤ 0.05). This change in CHOP gene expression was also significant (P≤ 0.05).
Conclusion: Aerobic training for 3 and 5 days with starvation can lead to liver health by reducing liver enzymes (AST and ALT) and cell death-related factor (CHOP) through the apoptosis pathway.
Mehrdad Yousefinejad, Mahnaz Omidi, Abdolhossin Taheri Kalani,
Volume 24, Issue 3 (7-2024)
Abstract
Background: Diabetes is a global epidemic and the most common metabolic disorder caused by impaired insulin secretion and glucose metabolism. The aim of this study was to investigate the effect of 8 weeks of aerobic training on serum levels of asprosin and insulin resistance index in diabetic rats.
Methods: The statistical population of this research included 40 10-week-old mice with an initial weight of 250 ± 20 grams, which were randomly divided into four groups (10 mice in each group): diabetic-exercise group (DT), diabetic group - Control (DC), healthy-training group (HT) and healthy-control group (HC) were divided. The program of aerobic exercises was performed for 8 weeks (5 sessions per week) in the form of running on a treadmill. Independent t-test and one-way analysis of variance (ANOVA) with Tukey's post hoc test were used to compare the groups. All data were analyzed at a significance level of 0.05 using SPSS-25 software.
Results: The results of the present study showed that streptozotocin injection induced diabetes in mice (P= 0.001). Induction of diabetes caused a significant increase in the serum levels of asprosin and insulin resistance in mice (P= 0.048 and P= 0.012, respectively). Eight weeks of aerobic training decreased the serum levels of asprosin and decreased insulin resistance in diabetic rats (P= 0.001 and P= 0.036, respectively).
Conclusion: Induced diabetes causes insulin resistance and increase in serum levels of asprosine, which can be improved by performing aerobic exercises.
Mr 3- rozita Hassanizadeh, Mr 2- khosro Jalali Dehkordi, Ms Farzaneh Taghian,
Volume 24, Issue 5 (12-2023)
Abstract
Background: the purpose of this research is Comparison of the effect of aerobic exercise and gymnema sylvestre supplement on some markers related to cardiomyopathy in type 2 diabetic mice.
Methods: The statistical population consisted of 40 male C57BL/6 mice that became diabetic after 20 weeks of feeding with a high-fat diet. Then they were randomly divided into 5 groups of eight, diabetes and aerobic exercise, diabetes and gymnema sylvester supplement, diabetes and aerobic exercise with gymnema sylvester supplement, diabetes control and healthy control. The aerobic exercise program consisted of exercises at a speed of 10 m/min for six weeks and five training sessions per week on a treadmill. Daily consumption of gymnema sylvester at the rate of 0.1 g/kg orally alone and also with training intervention was done for six weeks.
Results: The findings showed that aerobic exercise and gymnema sylvestre supplement caused a significant decrease in the levels of glucose, insulin, insulin resistance and the expression of CASPASE-1 and NLRP3 genes in the heart tissue, the largest decrease in the dependent variables related to the aerobic exercise group with Gymnema Sylvester supplement.
Conclusion: Aerobic exercise and Gymnema sylvester supplement improves blood variables by reducing glucose, insulin and insulin resistance, as well as improving markers related to cardiomyopathy by reducing the expression of caspase-1 and NLRP3 genes in the heart tissue in type 2 diabetic mice.
. Zahra Goli, Dr Farzaneh Taghian, Dr Khosro Jalali,
Volume 24, Issue 5 (12-2023)
Abstract
Introduction:The purpose of the research was to compare the effect of two types of raeobic exercise with and without incline on the modulation of oxidative stress and kidney function in CKD mice.Methods:The number of 24 two-month-old C57bl6 female mice weighing 25±26.1 grams were randomly divided into four groups:healthy control,CKD-affected mice,CKD and aerobic exercise without incline and CKD and aerobic exercise with incline were divided. In order to induce CKD,they received adenine powder of 0.2% mg/kg for 4 weeks.The training groups performed eight weeks of treadmill training(5 sessions perweek)one group performed with a 20-degree incline and the other group performed with a zero-degree incline.After the last training session, sampling of blood was done to measure blood urea nitrogen and urea and glutathione concentration by ELISA method.The expression of SIRT1,NRF1 and TNF-α genes was measured by qPCR-Real Time technique. For statistical analysis,one way ANOVA test and Tukey's post hoc test and significance level P≤0.05 were used.Findings:The results showed that induction of CKD caused a significant increase in blood urea nitrogen and a significant decrease in glutathione concentration compared to the healthy control group (P<0.05).On the other hand, in the exercise group, there is a significant increase in glutathione concentration and a significant decrease in blood urea nitrogen (P<0.05).The expression level of SIRT1 and NRF1 in the slope training group increased significantly and the expression level of TNF-α decreased significantly (P<0.05).
