Showing 118 results for Larijan
Maryam Mortezaee, Abbasali Raz, Shole Mansouri, Zohreh Annabestani, Zahra Mirzaeezadeh, Bagher Larijani, Mehrdad Hashemi, Kobra Omidfar,
Volume 15, Issue 5 (7-2016)
Abstract
Background: Insulin resistance and progressive β-cells failure are the key factors in type 2 diabetes mellitus (T2DM) pathogenesis. Many studies support a primary role of RBP4 in insulin resistance and suggest that genetic variations which alter the expression level of RBP4 might influence the risk of T2DM and its complications. Diabetic foot is one of the main complications of diabetes leading to disability and hospitalization. In addition, it reduces quality of life and imposes great cost to patients. The purpose of this study was to evaluate the correlation between two single nucleotide polymorphisms (rs10882273 and rs10882283) of RBP4 genes with diabetic foot ulcer in order to identify a biomarker for prediction of diabetic foot ulcer.
Methods: This is a case-control study. Two single nucleotide polymorphisms of RBP4 genes were genotyped by hit Tetra ARMS PCR technique. In this study, 100 and 133 diabetic patients with and without foot ulcer were selected as the cases and controls, respectively.
Results: The Chi-square test revealed no significant difference in frequency of TT, CC and TC alleles of rsl0882273 between case and control groups (P=0.414). Also, Comparison of AA, CC and AC alleles of rsl0882283 in both groups did not show significant difference (P=0.85).
Conclusion: According to this study, there is no relationship between two single nucleotide polymorphisms of RBP4 genes (rs10882273 and rs10882283) with diabetic foot ulcer in type2 diabetes patients.
Sharare Hassanzade, Abbasali Raz, Masoumeh Mansouri, Zahra Mirzaeezadeh, Bagher Larijani, Mehrdad Hashemi, Kobra Omidfar,
Volume 16, Issue 1 (1-2017)
Abstract
Background: Type 2 diabetes is a metabolic disorder characterized by high blood sugar levels that can damage nerves. Many organs are affected ،especially the foot that leading to loss of sensation. These factors make favorable conditions for the development of diabetic foot ulcers. Polymorphisms (Thr399Ile) of Toll Like Receptor4 (TLR4) gene due to malfunction of TLR4 protein which plays an important role in immunity. The purpose of this study was to determine the parameters which are affecting the imbalance resulting in chronic inflammation and wound healing. By showing the relationship between single nucleotide polymorphism (Thr399Ile) of TLR4 gene with diabetic foot ulcer we can identify a biomarker for prediction of diabetic foot ulcer.
Methods: This is a case-control study. Single nucleotide polymorphisms of TLR4 gene were genotyped by hit Tetra ARMS PCR technique. In this study, 100 and 120 diabetic patients with and without foot ulcer were selected as the cases and controls, respectively.
Results: The Chi-square test revealed significant difference in frequency of TT, CC and TC alleles of (Thr399Ile) between case and control groups (P=0.021).
Conclusion: According to this study, there is a relationship between single nucleotide polymorphisms (Thr399Ile) of TLR4 gene with diabetic foot ulcer in type 2 diabetes patients
Somaye Fatahi Faradonbeh, Bagher Larijani, Leila Azadbakht,
Volume 16, Issue 3 (3-2017)
Abstract
Background: The higher dietary acid load may affect blood pressure, blood sugar levels, and insulin levels. The purpose of this systematic review study is to examine the relation of dietary acid load with blood pressure and blood glucose.
Methods: We searched in PubMed, Google Scholar, Scopus and Medline up to July 2016, using the keywords "dietary acid load", "serum glucose", "insulin resistance" and "hypertension ". 12 studies (6 cross-sections, 5 cohorts and 1 intervention) were included in this systematic review.
Results: Out of eleven articles related to blood pressure, three studies showed a significant relationship between dietary acid load scale and hypertension. Three studies found only a significant association between dietary acid load and systolic blood pressure, while other studies did not show any significant correlation between dietary acid load and systolic or diastolic blood pressure. Moreover, in relation to blood glucose control, among eight studies, one study demonstrated a significant relationship between increasing dietary acid load and the incidence of diabetes. One study reported a significant relation of dietary acid load with fasting blood glucose and glycosylated hemoglobin concentration. In addition, two studies indicated a significant correlation between increased dietary acid load and insulin resistance, but other studies not revealed a meaningful relationship.
Conclusion: Since most studies suggest a significant association between increased dietary acid load and higher blood pressure, therefore it seems which dietary acid load can effect on blood pressure. The results of the investigation of the relationship between dietary acid load with glucose, insulin levels or diabetes have many contradictions. According to limited studies in this field, there is a need to further trial or prospective studies regarding the dietary acid load and the incidence of diabetes, insulin levels, and other blood glucose markers.
Hamideh Moosapour, Farzaneh Saeidi Fard, Bagher Larijani, Akbar Soltani,
Volume 16, Issue 3 (3-2017)
Abstract
Research, as systematic way to discover, interpret, explain, predict, modify, and control events, entails the knowledge-based performance of individuals, organizations and systems. Today, knowledge is a tool for development, entrepreneurship, and improving economic value added rather than be a product of development. Also, Health systems, with their increasing complexity and scope, are causes and especially effects of an increasing rate of production, translation and implementation of health-related knowledge. This knowledge, with complexity, vast range, and variety, is produced by variety of research projects which mainly resulted from different problems addressed and presumed epistemic positions by them.
Authors believe that a comprehensive outlook on the variety of research projects in the health system could help to change the stereotypical view on research in the health system. To the best of our knowledge, this paper is a novel, narrative review gathering and presenting various existing classifications of research projects in the light of an inductive distinction. It aims to help specialists in the different levels of health system to profoundly understand and meticulously apply research results and to help researchers and research bodies to more accurately define, manage, prioritize, and allocate resources for future research projects to solve upcoming problems.
Different aspects used in this paper to classify health research projects are the followings: The purpose of research, the research paradigms, tacit or explicit knowledge, primary or secondary knowledge, relation with known disciplines, functions of the health system, the partnerships of non-academic persons, decision-making level, taxonomy of questions, and levels of evidence.
Ali Jalili, Bagher Larijani, Farideh Razi, Ensieh Nasli, Mostafa Qorbani,
Volume 16, Issue 6 (10-2017)
Abstract
Background: Diabetic nephropathy is a chronic kidney disease and of more common complications of type 2 diabetes mellitus. The current diagnostic markers of diabetic nephropathy, albumin and creatinine, are only able to catch the disease in the stage of renal damage. The aim of this study is evaluation of targeted metabolomics of serum amino acids to identify the association of the changes of serum amino acid profile with diabetes and diabetic nephropathy.
Methods: This cross-sectional study was conducted in 2015-2016 on thirty patients with type 2 diabetes subsequent diabetic nephropathy and thirty type 2 diabetic patients without nephropathy attending diabetes clinic of endocrinology and metabolism institute and thirty non diabetic persons. Blood hemoglobin, HbA1c and BUN and also, serum albumin, uric acid and the albumin/creatinine ratio from a random urine specimen were measured by standard methods and serum amino acids level were identified using high performance liquid chromatography (HPLC). Statistical analysis ANOVA, Kruskal-Wallis, and nominal regression were used for the comparison of the investigated groups.
Results: significant differences were seen in serum levels of 8 essential, branched-chains, aromatic and 8 non-essential amino acids alanine, aspartic acid, serine, glutamine, arginine, glycine, tyrosine and ornithine between three groups. Serum levels of arginine and isoleucine were higher in the diabetic group than non-diabetics. However, Levels of amino acids serine, glutamine, glycine, threonine, tyrosine, tryptophan, methionine, valine, ornithine, and lysine in 2 groups of diabetic nephropathy and diabetes were higher than non-diabetic patients.
For every standard deviation decrease in serum levels of amino acids serine, alanine and isoleucine, in comparison to diabetic patients, the risk of diabetic nephropathy were increased 3.257 (95%CI: 0.10- 0.94, P=0.039), 2.207 (95%CI: 0.18- 0.81, P=0.039) and 2.652 (0.21- 0.96, P=0.012), respectively.
Conclusion: Since this study was conducted in patients in the early stages of the disease, reduced serum levels of the amino acids serine, leucine and alanine may be associated with development and progression of diabetic nephropathy. and in the future with more studies in this field can be used in metabolic control and improvement of the prognosis of patients with diabetic nephropathy.
Sayed Mahmoud Sajjadi-Jazi, Farshad Sharifi, Mehdi Varmaghani, Hamidreza Aghaei Meybodi, Farshad Farzadfar, Vahid Haghpanah, Bagher Larijani,
Volume 19, Issue 3 (2-2020)
Abstract
Background: The aim of this study was to estimate the prevalence of clinical hyperthyroidism at the national and sub-national levels using the claims data.
Methods: National anti-thyroid medications (methimazole and propylthiouracil) sales data in 2014 were extracted from pharmaceutical sales data that were reported by Iran's Food and Drug Administration (FDA). By using prescriptions data of Social Security Insurance Organization (SSIO) and Medical Services Insurance Organization (MSIO) in 2014, age-sex-province proportions of drug consumptions and Defined Daily Dose (DDD) of anti-thyroid medications were calculated. Moreover, by systematic review and meta-analysis of published literatures in hyperthyroidism in Iran, the prescription rate of anti-thyroid medications was calculated. Finally by using the whole data, the prevalence of clinical hyperthyroidism was estimated in each age and sex groups in national and provincial levels.
Results: : The prevalence (95% confidence interval) of clinical hyperthyroidism in Iran in 2014 is 0.32% (0.21-0.51%); 0.44% (0.29-0.68%) in females and 0.2% (0.12-0.33%) in males. Among provinces the least prevalence rate of clinical hyperthyroidism is 0.24% (0.16-0.38%) which belongs to Sistan and Baluchistan, and the highest prevalence rate is 0.38% (0.24-0.6%) which belongs to Gilan.
Conclusion: The prevalence rate that reported by this study is compatible with other surveys which performed in the world and Iran. As a result using claims data is a good source to predict prevalence of chronic diseases that have specific drugs.
Esmail Shekari, Seyed Kianoosh Hosseini, Farideh Razi, Ensieh Nasli Esfahani, Mostafa Qorbani, Bagher Larijani,
Volume 19, Issue 4 (4-2020)
Abstract
Background: Diabetes mellitus is one of the most common endocrine diseases. Cardiovascular disease (CVD) is one of the leading causes of death in patients with type 2 diabetes. The aim of this study was to investigate the metabolic profile of plasma amino acids in diabetic patients with cardiovascular disease.
Methods: The present study is a descriptive-analytical cross-sectional study on 140 patients including 35 patients with type 2 diabetes and cardiovascular disease (CVD.DM), 35 patients with type 2 diabetes and non-cardiovascular disease (DM). 35 non-diabetic patients with cardiovascular disease (CVD.nDM) and 35 non-diabetic patients with non-cardiovascular disease (HS) were referred to Diabetes Clinic No. 1 of Tehran University of Medical Sciences.
Results: 76 (54.3%) were male and 64 (45.7%) were female. The highest concentrations of glutamine and isoleucine were observed in DM.CVD, asparagine, serine, arginine, threonine, alanine, tyrosine, valine in DM.nCVD and methionine in CVD.nDM. The lowest concentrations of tyrosine and tryptophan in DM.CVD has been detected , and methionine has been detected in DM.nCVD. The amino acids alanine, glutamine, tyrosine, valine, methionine, leucine, lysine and arginine significantly increased the chances of developing DM.nCVD. For each increase in Z-score per plasma concentration of isoleucine, the chances of developing cardiovascular disease without diabetes were significantly increased.
Conclusion: The amino acids alanine, glutamine, tyrosine, valine, methionine, leucine, lysine and arginine are involved in predicting the risk of DM.nCVD and isoleucine and methionine are involved in predicting the risk of CVD.nDM.
Kamyar Khoshnevisan, Sayed Mahmoud Sajjadi-Jazi, Farnoush Faridbod, Bagher Larijani, Mohammad Reza Khorramizadeh,
Volume 19, Issue 5 (6-2020)
Abstract
Background: A novel nanocomposite-modified electrode based on reduced graphene oxide (rGO) decorated with crown-ether and gold nanoparticles (GNPs) on the surface of a glassy carbon electrode (GCE) was fabricated to investigate 5-HT determination.
Methods: The morphology of nanocomposite was characterized by scaning electron microscopy (SEM). Diabetic zebrafish was obtained by overfeeding via glucose. 5-HT was successfully determined in the presence of dopamine (DA), ascorbic acid (AA), urea, glucose, and L-tryptophan (L-Trp) by using electrochemical methods.
Results: The nanocomposite exhibited satisfactory electrochemical catalytic activity for 5-HT determination using square-wave voltammetry (SWV). The electrochemical behavior of 5-HT at the nanocomposite/GCE displayed reasonable oxidation current and potential. The limit of detection (LOD) of 5-HT obtained from the real samples, containing the control and diabetic group by using the proposed system and HPLC method, was calculated to be about 0.3 and 0.1 µg/L, respectively. The prposed system also demonstrated high selectivity, reasonable sensitivity, and good stability and reproducibility for 5-HT sensing. The nanocomposite was applied for the determination of the biomarker 5-HT in the diabetic and control groups of zebrafish and displayed excellent recoveries about 93 and low relative error about 3% while compared with standard method.
Conclusions: It seems that the 5-HT level can be used for earlier diagnosis of diabetes.
Aboozar Ramezani, Leila Shahmoradi, Fereydoon Azadeh, Fatemeh Sheikhshoaei, Rasha Atlasi, Nazli Namazi, Bagher Larijani,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Background: A key aspect of Scientific collaboration increases scientific productivity. This study aimed to draw up a scientific collaboration network of the Endocrinology and Metabolism Research Institute (EMRI) at Tehran University of Medical Sciences.
Methods: A Descriptive Cross-Sectional Study was conducted by the Scientometrics method. Data collection from the Scopus and Web of Science Core collection databases between 2002 until 30 October 2020. MS-Excel, HistCite, VOSviewer, and ScientoPy were used for descriptive statistics and data analysis.
Results: A total of 4190 records with the affiliation of the EMRI are indexed in two international databases. All of the records received a sum of 89480 citations. The EMRI Researchers were published in 1118 journals. The annual growth rate of publication and citation of the scientific output of the EMRI was 20.3% and 22.7%, respectively. A total of 17662 authors from 186 countries participated in the publication. The co-authorship pattern shows. The next section of the Study was classified and visualized based on authorship (institutes and country of affiliation), keywords (co-occurrence and trend).
Conclusion: Overall, these results indicate that the pattern of collaborations in the authorships' articles increases the flow of knowledge among the institute's researchers as a result of international collaborations, interaction with leading countries, and interdisciplinary collaborations. To develop a full picture of co-authorship, additional studies will need a comprehensive picture of network cooperation to analyze the situation with other social network analysis indicators.
Akram Tayanloo-Beik, Hamidreza Aghayan, Sepideh Alavi-Moghadam, Mostafa Rezaei-Tavirani, Shayesteh Kokabi Hamidpour, Babak Arjmand, Bagher Larijani,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Background: In many years, finding modern and appropriate treatments for diseases, especially chronic diseases (such as chronic metabolic diseases) have been one of the most important issues. On the other hand, limitations related to organ transplantation have made a serious need for advanced therapeutic strategies. In this respect, researchers have recognized the benefits of stem cells as a suitable tool. Accordingly, the application of stem cells for the treatment of various diseases has been considered in many countries around the world especially Iran.
Methods: A review of the history of stem cell studies in Iran and the world was conducted and the Cell Therapy and Reconstructive Medicine Research Center was introduced as one of the leading centers in this field and a review was conducted on the activities of this center.
Results: The history of studies related to cell-based therapy in Iran back to 1990. Subsequently, the Cell Therapy and Reconstructive Medicine Research Center, by providing services based on GMP principles, has provided clinical services in accordance with international standards and has conducted various researches in this field.
Conclusion: The purpose of the current review is to examine the strategies and challenges around the research and treatment opportunities using stem cells in mentioned center.
Mandana Hasanzad, Negar Sarhangi, Shekoufeh Nikfar, Bagher Larijani,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Background: Precision medicine is a new approach in the field of medical sciences that utilizes the genetic characteristics of each patient along with clinical information to guide decisions related to diagnosis and early treatment of diseases. The Personalized Medicine Research Center, as the only center approved by the Ministry of Health, is working on precision medicine context and producing the related knowledge.
Methods: In this systematic review, studies that are conducted at the personalized medicine research center with a precision medicine theme based on specific eligibility criteria and a designed search strategy in three databases PubMed, Scopus, and Web of Science (Wos) from December 2016 to December 2019 were retrieved.
Results: Finally, 18 studies focusing on different approaches of precision medicine in prediction, prevention through “omics” including genomics, transcriptomics, and proteomics were selected for further evaluation.
Finally, 18 studies focusing on precision medicine in non-communicable diseases (diabetes) and cancer (prostate and thyroid) were selected for further studies.
Conclusion: Since one of the important goals of precision medicine is prediction and prevention, the identified genetic changes can be used for early diagnosis in high-risk individuals. Actually, the initiative studies are needed to meet the goal of precision medicine.
Sina Azadnajafabad, Sahar Saeedi Moghaddam, Esmaeil Mohammadi, Negar Rezaei, Nazila Rezaei, Shohreh Naderimagham, Rosa Haghshenas, Erfan Ghasemi, Yosef Farzi, Elham Abdolhamidi, Sahar Mohammadi Fateh, Hossein Zokaei, Ameneh Kazemi, Ozra Tabatabaei-Malazy, Farshad Farzadfar, Bagher Larijani,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Non-Communicable Diseases (NCDs) are the major cause of premature death and disability due to diseased globally, imposing a heavy burden on the health systems. Four main categories of NCDs are cardiovascular diseases, neoplasms, diabetes, and chronic respiratory diseases. Iran, the second greatest country in the Middle East Region, has been through an important transition period of communicable diseases toward NCDs in the last decades. One of the effective approaches to control NCDs is implementation of population-based studies and interventions, trying to reduce risk factors and incidence of NCDs through investigations in the populations. Endocrinology and Metabolism Research Institute (EMRI) and Non-Communicable Diseases Research Center (NCDRC) are the pioneers trying to study and control various NCDs during the last decades in Iran. In this review, we are going to inspect some of the major completed and ongoing projects of this research institute to highlight valuable efforts to reduce burden of NCDs in Iran, and make a successful example for national and regional public health policy makers and authorities.
Fatemeh Bandarian, Nazli Namazi, Mohammad Pajouhi, Mohammadreza Amini, Neda Mehrdad, Bagher Larijani,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Endocrinology and Metabolism Research Institute (EMRI) was established in 1993. EMRI has progressed step by step from the beginning and has reached maturity in the last 25 years. EMRI has expanded, advanced in human resources and infrastructures (laboratories and new technologies) and gained first rank in endocrine research in various fields. It has also worked with regional and international organizations such as the World Health Organization (WHO), the International Osteoporosis Foundation (IOF), and the American Clinical Endocrine Society (AACE). This article provides an overview of EMRI activities over a quarter of a century.
Shahnaz Esmaeili, Fatemeh Bandarian, Farideh Razi, Hossein Adibi, Ali Jalili, Babak Arjmand, Camelia Rambod, Ensieh Nasli-Esfahani, Bagher Larijani,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Background: Endocrinology and Metabolism Research Institute (EMRI) is one of the largest research institutes in Iran, which has been established to develop research strategies and manage endocrine and metabolic diseases such as diabetes. The purpose of this report is to review and summarize research activities related to diabetes over a quarter of a century at EMRI.
Methods: A comprehensive search of PubMed, Scopus and EMBASE was conducted to find diabetes-related studies in EMRI. After extracting the data, the articles were classified according to the type of article, the level of evidence, the types of diabetes and their subject.
Results: After eliminating duplicates and screening, finally 228 articles were classified. Most diabetes research conducted at the Diabetes Research Center (DRC) was on type 2 diabetes (37%). By article type, most of the articles were original. In addition, clinical studies provided the most evidence in the obtained documents. By topic, most of the articles were related to the basic sciences and factors related to diabetes, followed by studies on the management and prevention of diabetes.
Conclusion: Most of the research conducted in the Diabetes Research Center in the past quarter of a century is of original studies in the field of basic sciences in the field of type 2 diabetes and most of the evidence produced is related to observational studies.
Azadeh Aletaha, Maryam Aalaa, Akbar Soltani, Bagher Larijani,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Background: The purpose of this study is to identify patterns of information sharing in the field of evidence-based medicine to determine the main areas of evidence dissemination, including co-authorship patterns and citation networks, and to provide a scientific horizon for improving evidence-based medical research in Iran. Accordingly, evidence-based medicine related research at the Endocrinology and Metabolism Research Institute of Tehran University of Medical Sciences is suggested.
Methods: This study is a bibliographic study using scientometric methods. In this regard, the network of co-authorship and analysis of scientific articles indexed with the subject of evidence-based medicine in the Scopus database from 2004 to 2019 were analyzed.
Results: The status of scientific production of evidence-based medicine of Endocrinology and Metabolism research Institute has been increasing in recent years. The Journal of Diabetes and Metabolic Disorders contains a great collection of information about evidence-based medicine in this field and its contents have been widely cited in many Iranian journals. In lexical analysis, the most widespread evidence was osteoporosis.
Conclusion: The results indicated that evidence-based medical research topics are widely focused on other medical fields such as osteoporosis and obesity and have shifted from evidence-based clinical practice to evidence-based clinical management.
Hanieh-Sadat Ejtahed, Shirin Hasani-Ranjbar, Hanieh Malmir, Azin Pakmehr, Rezvan Razmande, Yasaman Khorshidi, Golaleh Asghari, Ahmadreza Soroush, Afshin Ostovar, Bagher Larijani,
Volume 23, Issue 6 (1-2024)
Abstract
Background: Considering the increasing and alarming trend of overweight and obesity as well as its related complications, in this study, a comprehensive clinical guide for the medical care of patients with obesity was written based on the clinical recommendations of the American Endocrinology Association and the American College of Endocrinology, and it has been adjusted as much as possible based on the conditions in Iran.
Methods: A complete search was performed in the available databases without any restrictions with a specific strategy. Using the opinions of experts in this field, the best clinical guidelines were selected and obesity clinical guidelines were written for Iranian adults. Recommendations were given based on a detailed review of available clinical evidence and considering objective factors.
Results: A total of 1788 references were used and in response to 9 clinical questions, 123 recommendations, including 160 special statements, were provided to determine a comprehensive medical care program for obesity. In this article, we discuss the prevention, screening, diagnosis, benefits and goals of obesity treatment. Questions 6 to 9 regarding obesity treatment steps and its individualization will be published in the next part of the article.
Conclusion: The detailed evidence-based questions and recommendations outlined in this study identify clinical considerations that facilitate decision-making in obese patients from screening and diagnosis to goals of treatment.
Hanieh-Sadat Ejtahed, Shirin Hasani-Ranjbar, Hanieh Malmir, Rezvan Razmandeh, Azin Pakmehr, Yasaman Khorshidi, Golaleh Asghari, Amir Mohammad Mortazavian, Mohammad Reza Mohajer-Tehrani, Afshin Ostovar, Bagher Larijani,
Volume 24, Issue 1 (3-2024)
Abstract
Background: The prevalence of overweight, obesity and related complications is increasing rapidly in the world. Also, treating this disease in the presence or absence of co-morbidities has become a challenge. In this article, based on the clinical recommendations of the American Endocrinology Association and the American College of Endocrinology, a comprehensive clinical guide has been written for the stages of treating obese patients and its individualization, and it has been tried to be adjusted as much as possible based on the conditions in Iran.
Methods: with a specific search strategy, a complete search was performed in PubMed, Scopus, ISI Web of Science, EMBASE and Google Scholar Cochrane databases. Then, the best clinical guidelines suitable for the Iranian society were selected and using the opinions of specialists and clinical experts, a clinical guideline was prepared for the treatment of obesity in Iranian adults.
Results: In this article, in continuation of the previous article, we answered the questions number 4 to 6 regarding the stages of obesity treatment and its individualization in adults of Iranian society, and presented a total of 60 recommendations in this regard.
Conclusion: In this part of the clinical guide for obesity in Iranian adults, we tried to have a special view on the treatment of these patients and by providing evidence-based recommendations and statements, the treatment process was personalized as much as possible for patients with special conditions so that decision-making in this regard is facilitated for the relevant colleagues in this field.
Dr. Alireza Bagheri, Dr. Hamidreza Aghaei Meybodi, Dr. Mohammadreza Mohajeri, Dr. Akbar Soltani, Dr. Ramin Heshmat, Dr. Bagher Larijani,
Volume 24, Issue 5 (12-2023)
Abstract
Background: Vitamin D (vitD3) deficiency is common in Iran. Although there are several studies on therapeutic doses of vitD3, the optimal dose is to be evolved. we compared the effects of high dose supplemental vitD3 versus its recommended dose on the serum level of 25(OH)D.
Methods: This clinical trial study is performed at Endocrine & Metabolism Research Institute in Shariati Hospital within 2008-2009. The subjects were osteopenic women older than 50 years who had been referred to Bone Densitometry laboratory. They were received either (group P) 50000u vitD3 weekly for 3 months then monthly for another 9 months, or (group M) 800u vitD3 daily for one year. 1000 mg calcium carbonate was given to both groups. Serum 25(OH)D, Calcium, Phosphorus, PTH was checked at base, 3rd, 6th and 12th month. 24h Urine for calcium was collected before and at the end of trial.
Results: Serum 25(OH)D level was significantly higher in group P at 3rd month (p<0.05), but it gradually declined and there was not statistically difference to group M. PTH decreased in both groups. Urine calcium to creatinine ratio did not rise in both groups.
Conclusion: vitD3 supplement at doses of 50000u weekly for 3 months then monthly for another 9 months as compare to 800u vitD3 daily for one year increases serum 25(OH)D at higher level without causing hypercalcemia and hypercalciuria, but it seems that more frequent doses in monthly period would be required to maintain the optimal 25(OH)D level.
