Zeinab Mohebbi, Keivan Kakabraee, Khodamorad Momeni,
Volume 25, Issue 4 (9-2025)
Abstract
Background: This study aimed to investigate the relationship between stigma associated with type 2 diabetes and subjective well-being measures (life satisfaction and positive/negative affect) mediated by emotional stress and illness perception in people with type 2 diabetes.
Methods: The present research was descriptive based on correlation models. The statistical population included patients with type 2 diabetes who referred to the diabetes clinic of Ayatollah Taleghani hospital in Kermanshah, 207 adults were selected using the convenient sampling method and data were collected using questionnaires Type 2 Diabetes Stigma Assessment Scale (DSAS-2) (Browne et al., 2016), life satisfaction (Diener, 1985), Positive/Negative Affect Schedule (Watson et al., 1988), Illness Perception (Broadbent et al., 2006) then analyzed with SPSS and Amos software.
Results: The results showed that there was a significant relationship between stigma, life satisfaction, and positive/negative affect (P < 0.01). Stigma was also able to predict life satisfaction indirectly and negatively through emotional distress, and negative affect indirectly and positively through emotional distress and illness perception.
Conclusion: The results indicate the need for interventions to reduce the stigma associated with type 2 diabetes and improve the mental well-being of people with this disease.
Afshin Khaman Hatami, Kamal Azizbeigi, Zaher Etemad, Parvin Farzanegi,
Volume 25, Issue 5 (12-2025)
Abstract
Background: Aging is associated with Sarcopenia as well as oxidative stress (OS) caused by Ferroptosis. The aim of the present study was to investigate the effect of aerobic exercise training (AT) on OS caused by ferroptosis in sarcopenia model mice.
Methods: Twenty-one C57BL/6 mice (16-24 wks. age) sarcopenia model with an average weight (25-35 g), and 21 healthy mice (6-7 weeks age) were randomly assigned to the following (1) healthy-young control (HYC; n= 7), (2) aerobic training-young (ATY; n= 7), (3) healthy-old control (HOC; n= 7), (4) old control-sarcopenia model (OCS; n= 7), (5) aerobic training-healthy-old (ATHO; n= 7), (6) healthy-old sarcopenia model (HOS= 7). The intervention group underwent AT for eight weeks, five sessions per week at an intensity of 60-80% of aerobic capacity (VO2max). The expression of the glutathione peroxidase (GPX-4) and superoxide dismutase (SOD) genes was measured using Real Time PCR. The Malondialdehyde (MDA) and Fe²⁺concentration in the gastrocnemius muscle was also measured.
Results: It was observed that the enzymes gene expression of SOD and GPX-4 in the (OSC) was significantly decreased compared to the (HOC) (P= 0.001, P= 0.002, respectively), and the MDA and Fe²⁺ was significantly increased (P= 0.001; P= 0.002, respectively). Also, the of SOD and GPX-4 gene expression of enzymes in the ATY, ATHO was significantly increased compared to the HYC, and HOS (P= 0.001; P= 0.002, respectively), and the concentration of MDA and Fe²⁺ was significantly decreased (P= 0.001; P= 0.002, respectively).
Conclusion: Finally, it can be said that aerobic training reduces oxidative stress caused by ferroptosis in Sarcopenia by increasing the enzymes GPX and SOD gene expression and reducing the concentration of MDA and Fe²⁺.
