Showing 25 results for Amini
Azam Teimoury, Zhila Behrouz, Masoud Amini,
Volume 4, Issue 1 (17 2004)
Abstract
Background: Hypertension and dyslipidemia are common in patients with type 2 diabetes mellitus. The high prevalence of cardiovascular disease in diabetic patients is, in part, related to these two risk factors. This study was performed to determine the prevalence of hypertension and dyslipidemia in newly diagnosed patients with type 2 diabetes mellitus in Isfahan.
Methods : In this cross – sectional study during 2001 – 2003, 310 newly diagnosed type 2 diabetic patients, in Isfahan endocrine and metabolism research center, were studied. Height, weight, blood pressure, Plasma lipid and lipoproteins, and HbA1c were determined for all subjects.
Results: Mean age at presentation was 489.83 years, and mean BMI was 28.44.62 Kg/m2. Hypertension was present in 32.9%, hypercholesterolaemia in 61.3%, hypertriglyceridaemia in 61.6%, high LDL in 77.3%, and low HDL in 67.8% of these patietns. The mean systolic and diastolic blood pressure were 119.0816.59 and 70.0214.02mmHg, respectively. The mean for total cholestrol was 216.1043.65, for triglyceride 207.46105.67, for LDL 124.7331.45, and for HDL 43.119.29 mg/dl.
Conclusion: Hypertension and dyslipidemia are common in newly diagnosed type 2 diabetic patients. This fact demonstrates the importance of early interventions for proper diagnosis and treatment of these two risk factors in diabetic patients.
Azamsadat Tabatabaei, Negar Horri, Mahboubeh Farmani, Sasan Haghighi, Badrolmolouk Forghani, Masoud Amini,
Volume 4, Issue 2 (17 2004)
Abstract
Background: Constipation is the most common gastrointestinal complication in diabetic patients. Erythromycin mimics the effects of the gastrointestinal hormone Motilin in gastric contractile activity and insulin secretion. In this study, we compared the effects of Erythromycin and Metoclopramide on glycemic control and constipation in type 2 diabetic patients.
Methods: As a clinical trial, thirty-nine type 2 diabetic patients with constipation were divided into two groups. Patients in group 1 (n=24) were treated with erythromycin (400 mg/day before sleep) and participants in the second group (n=15) received metoclopramide (10mg 3 times / day before each meal) for 3 months. FBS, 2hPP BS, HbA1c and the frequency of defecations during a week were measured and compared before and after the intervention.
Results: In Erythromycin treated group, 2hPP BS decreased from 199.7 ± 47.0 before treatment to 174.0±46.3 after intervention (P=0.01) and a significant improvement in constipational symptoms was observed in both groups.
Conclusion: It seems that Erythromycin not only can improve symptoms of constipation but may have a role in glycemic control in type 2 diabetic patients.
Mahnaz Lankarani, Neda Valizadeh, Ramin Heshmat, Ali Reza Shafaee, Mohammad Reza Amini, Masoumeh Noori, Ashraf Aleyasin, Bagher Larijani,
Volume 4, Issue 2 (17 2004)
Abstract
Background: Polycystic ovary syndrome(PCOS) is the most endocrinopathy in women and the most common causes of anovulatory infertility. Women with this disorder moreover the common manifestations such as,irregular menses, hirsutism and infertility, are susceptible to serious consequences like increase risk of endometrial carcinoma, dyslipidemia, hypertention, glocose intolerance, diabetes, cardiovascular problems and probably breast cancer. This study was conducted to demostrate the demographic, clinical,metabolic and hormonal conditions of the PCOS patients.
Methods: A case-control study was performed on females with PCOS age group 15-40 years referring to endocrine and gynecology clinics. A control healthy woman was selected for each patient. The diagnosis of PCOS was made based upon the prescence of chronic anovolation and hyperandrogenemia .Other causes of hyperandrogenism were excluded by appropriate clinical and laboratory evalution .In all patients with PCOS and control women, appropriate medical history was taken and physical examination was done.Blood pressure ,body weight, height ,BMI,waist/hip ratio,score of hirsotism,acne, and other signs of androgen excess were determined.A venous blood sample were obtained at morning after 12_14hours fasting for measuring FBS, TG, Chol., LDL, HDL and hormonal profile,souch as:PROL,17_OH Progestrone,Te,DHEA-S and TSH.Case of late onset adrenal hyperplasia ,hypotyroidism and pituitary prolactinoma were excluded.The diagnosis of dyslipidemia was made upon the base of NCEP guidelines.Data was analyzed with Mann_Whitney U,T tests and Fisher’s and Chi_Square Tests with SPSS-11.
Results: Mean age were similar in both patients and controls.Mean of BMI and diastolic pressure were significantly higher in PCOS women in comparison with controls . Hirsutism and oligomenorrhea were the most frequent clinical features(72.7% and 69.1% respectively). SerumTG level was significantly higher in PCOS women in comparison with controls.There were no significant difference in FBS,Chol,LDL and HDL between patients and controls. The prevalence of high triglyceride ,high cholesterol and high LDL levels were significantly higher in PCOS women in comparison with controls,but there were no significant difference in the prevalence of IFG and low HDL levels. The prevalence of high TG and high Chol level were significantly higher in obese PCOS women in comparison with non obese patients.There was no significant difference in the prevalence of high LDL and low HDL levels between obese and nonobese patients. Serum level of total Testostrone was significantly higher in PCOS women in comparison with controls.There were no significant difference in serum levels of DHEA-S,17-OH Progestrone, Prolactine and TSH between patients and controls.
Conclusion: The prevalence of obesity and dyslipidemia were higher in PCOS women in comparison with healthy women. For obese women with PCOS ,behevioral weight management is the main component of overall treatment strategy and these patients counseling about the importance of life style management ,diet and exercise shoud be emphasized. The patients should screened for dyslipidemia, diabetes and hypertension. In this study there was no significant difference in FBS between two groups and IGT and DM may be better detected by OGTT. In all PCOS women for detecting dyslipidemia a fasting lipid profile is indicated
Seyed Mohammad Mohammadi, Mojgan Kavyani, Ashraf Aminorroaya, Hasan Rezvanian, Ali Kachuei, Masoud Amini,
Volume 4, Issue 4 (17 2005)
Abstract
Background: Hyperhomocysteinemia may increase blood pressure by inducing endothelial cells dysfunction . The aim of this study was determining the relationship between plasma Homocysteine (Hcy) levels and blood pressure in new cases of type 2 diabetes mellitus.
Methods: As a cross sectional study, 46 new cases of type 2 diabetes mellitus referred to Isfahan Endocrine and Metabolism Research Center were selected by convenient sampling. Basal characteristics of patients were recorded. Systolic and diastolic blood pressure was measured two times with 30 minutes interval on two consequent days. After ten hours of overnight fasting, blood samples were taken to measure fasting plasma glucose, HbA1c, triglyceride, Total cholesterol, HDL-C and creatinine. All data were expressed as mean (SD).
Relationship between plasma Homocysteine levels and both systolic and diastolic blood pressure was assessed by Pearson's correlation coefficient. Patients were divided into three groups according to their plasma Homocysteine levels, (Hcy<10mol/L, 10Hcy<15 mol/L and Hcy15mol/L).. Then mean of systolic and diastolic blood pressure between groups were compared by one – way ANOVA and Tuckey-HSD tests.
Results: Mean (SD) of plasma Homocysteine levels was 12.2 (6.8) mol/L and of systolic and diastolic blood pressure was 128.8 (18.1) and 82.3(9) mm/Hg, respectively. There was a significant
correlation between plasma Homocysteine levels, and both systolic (r=0.39, P<0.01) and diastolic (r=0.46, P<0.01) blood pressures. Mean (SD) of systolic and diastolic blood pressure in patients with plasma Homocysteine level of 15mol/L was 152.5 (17.7) and 91.8 (7.3) mm/Hg, respectively, so blood pressure in those group with hyperhomocysteinemia was higher than other two groups (P<0.001). There was no correlation between Homocysteine levels and FPG, HbA1c and lipid profile.
Conclusion: There is a significant correlation between plasma Homocysteine levels and both systolic and diastolic blood pressure in newly diagnosed type 2 diabetics. Patients with hyperhomocyteinemia have higher blood pressure.
Hassan Safaei, Masoud Amini, Jila Behroz, Azam Teimori,
Volume 5, Issue 3 (17 2006)
Abstract
Background: Retinopathy is one of the microvascular complications of diabetes which is strongly related to the glycemic control and duration of the disease. According to results of other studies, the prevalence of retinopathy has been reported 5-30% in newly diagnosed patients whit type 2 diabetes (T2DM). The aim of this study was to determine the prevalence of idabeteic retinopathy among newly diagnosed T2DM patients in Isfahan, Iran.
Methods: From july 2001 to March 2004, 710 newly diagnosed patients with T2DM were recruited in this study. Patients with duration of diabetes less than 1 year were considered as newly diagnosed ones. Along with physical examination and laboratory measurment for FBS, HbA1c, lipid profile, urea, Creatinin, and 24 houre urin examniation for albumin, retinoscopy was performed by an experienced ophttalmologist.
Results: In this study, 286 men and 424 women were investigated. The mean age of patients at presentation and the mean duration time of diabetes were 48.8 ±9.8 years (range 31-72years) and 8.6±5.4 months respectively. The prevalence of retinopathy was 9 % (9/8% in males and 8.5% in females). Logistic regression analysis revealed that BMI, diastolic blood pressure and 24 hour urine albumin, were independent risk factors for developing retinopathy.
Conclusion: Nevertheless of relatively moderate prevalence of diabetic retinopathy in our study as compared with other studies, it is necessary to perform retinal examination in newly diagnosed T2DM patients in order to prevent the sight-threatening outcomes of diabetic retinopathy.
Negar Horri, Mahboubeh Farmani, Sasan Haghighi, Goshtasb Sattari, Zahra Pournaghshband, Masoud Amini,
Volume 5, Issue 3 (17 2006)
Abstract
Background : Women with polycystic overy syndrome (PCOS) are sussceptible for developing type 2 diabetes (T2DM) and cardiovascular diseases. In view increased prevalence of T2DM in patients with PCOS and priority of prescription agents capable to decrease insulin resistances for them, It is important to diagnose PCOS in T2DM patients. The aim of this study was to evaluate the prevalence of PCOS in T2DM women.
Methods : Using ‘1990 National Institute of Child Health and Human Development Conference of PCOS’ criteria, 157 premenopausal women with T2DM were assigned into PCOS and non – PCOS groups after they were examined for the evidences of clinical PCOS. A questionnaire on reproductive history was completed and the waist circumference, weight, height and BP were measured for each participant. Biochemical tests were performed in both groups, but hormonal measurements were requested only for PCOS group.
Results : The prevalence of PCOS was high (about 8%) among subjects. Patients with PCOS had significantly lower age at the onset of diabetes, higher BMI and waist circumference. The differences in BP, serum TG, HDL, LDL, cholesterol and HbA1c were non – significant between 2 groups and insulin resistance is more.
Conclusion : PCOS is prevalent in diabetic women and Insulin resistance is more likely in those with both PCOS and T2DM resistant than whom with diabetes alone. Emphasis on reducing insulin resistance may be of benefit to achieve a better diabetes control in these patients.
Hassan Safaei, Masoud Amini,
Volume 5, Issue 4 (17 2006)
Abstract
Background: Microalbuminuria represents the earliest clinical of renal involvement and reflects the progression of diabetic nephropathy and increased risk of mortality in diabetic patients. The incidence of diabetic nephropathy in type 2 diabetes differs widely by race .The aim of this study was to determine the incidence of and risk factors for microalbuminuria in type 2 diabetic patients.
Methods: As a cohort study 505 (22%male, mean age: 57.4±9.5 years and diabetes duration 10.2±4.7 years at initial registration) type 2 diabetic patients with initial normoalbuminuria were followed prospectively for 5 years in isfahan endocrine and metabolism research center. Patients were evaluated for BMI ,HbA1c, blood pressure, lipid profile, serum creatinine and 24 hours urine albumin. Normoalbuminuria were defined as urine albumin excretion less than or equal to 30 mg/24 h and microalbuminuria as 31-299 mg/24 h. Logistic regression model were used to assess the associations.
Results:176 revealed persistently elevated UAE during follow-up, giving an incidence of 82.3/1000 person-years(95%CI:78/3-86/2). Incidence of microalbuminuria were significantly higher in men than wemen(104.4 and 66.2/1000 person-year, P<0.001).The mean values of HbA1c, duration of diabetes, systolic hypertension and serum creatinin during the follow-up period were significantly higher in the microalbuminuric than in the normoalbuminuric patients. Age, BMI, cholesterol and triglyceride were not significantly different in two groups. Logistic regression analysis revealed that duration of diabetes, HbA1c, high blood pressure and retinopathy during follow-up are independent variables that have a statistically significant influence on the development of microalbuminuria.
Conclusion: These result revealed that microalbuminura in this population of type 2 diabetic patients were common and higher than of other studies. These findings suggest that urine excretion of albumin should be monitored routinely in this patients for detection early stages of nephropathy and effective treatment of microalbuminura and associated risk factors are very important.
Soheila Amini Moghadam, Mohammad Reza Mohajeri Tehrani, Zahra Shaban Nejad-Khas, Ramin Heshmat, Ashraf Aleyacine, Bagher Larijani,
Volume 6, Issue 2 (18 2006)
Abstract
Background: Fetal hyperinsulinemia correlated with large birth weight and impaired glucose tolerance test and obesity in second decades of life. In this study we compared the correlation between fetal insulin production (as estimated by amniotic fluid (AF) C-peptide concentration) and AF insulin with macrosomia (as estimated by neonatal birth weight 4000 gr).
Methods: Thirty eight neonates were studied. Ten infants were macrosom and 28 were normal (birth weight < 4000 gr). Amniontic fluid C-peptide and insulin concentration and mother and fetal blood C-peptide and insulin were measured during delivery with radioimmunoassay and mother and fetal glucose were measured at the same time and correlated with neonatal macrosomia within first hour of birth.
Results: There was a significant correlation between infant serum C-peptide level and macrosomia. Amniotic fluid insulin level was higher in the macrosom infants but this correlation was not significant. AF C-peptide was higher in the macrosom group. Also there was a significant correlation between maternal serum C-peptide and macrosomia. Infant and mother serum insulin was higher in the macrosom group.
Conclusion: Our results suggest that fetal insulin (as estimated by AF C- peptide) and mother insulin and C- peptide production, can influence fetal weight and induce fetal macrosomia.
Fereshteh Kalantari, Silva Hovsepian, Sasan Haghighi, Masoud Amini,
Volume 6, Issue 3 (17 2007)
Abstract
Background: The aim of this study was to determine the prevalence of cardiovascular disease (CVD) risk factors among type 1 diabetic patients referring to Isfahan Endocrine & Metabolism Research Center.
Methods: In this cross-sectional study, the prevalence of CVD risk factors including dyslipidemia, smoking and hypertension was determined in type 1 diabetic patients aged 15-30 years. Serum cholesterol <170 mg/dl, LDL<100 mg/dl , HDL>35 mg/dl , TG<150 mg/dl, systolic blood pressure<120 mmHg and diastolic blood pressure<80 mmHg were considered as optimal control levels.
Results: Among 219 studied diabetic patients (mean age=22.5±10.3, female/male=120/99), the mean cholesterol and HDL-C level was higher in women (176±34.9, 46.4±34.1) than men (162.9±32.4 vs. 41.5±10.1) (P<0.05). The prevalence of smoking, hypercholesterolemia, LDL>100 mg/dl, HDL<35 mg/dl, hypertriglyceridemia and hypertension was 6.9% (n=15), 47.4% (n=104), 53.5% (n=117), 22.8% (n=50), 18.3% (n=40) and 7.7% (n=17), respectively. HDL<35 mg/dl was more prevalent among men as compared with women but cholesterol> 170 was more frequently detected in women (P<0.05).
Conclusion: Considering the rather high prevalence of CVD risk factors in type 1 diabetic patients in Isfahan, and in view of modifiability of these risk factors, educating patients on appropriate glycemic control and increasing physical activity is necessary as well as close monitoring of these risk factors.
Hasan Safaei, Masoud Amini,
Volume 6, Issue 3 (17 2007)
Abstract
Background: Type 2 diabetic patients have higher risk for death from coronary heart diseases than non-diabetic patients. Studies have revealed showed intensive treatment of hyperglycemia only have a small effect on CVD risk. Other risk factors such as Lipid abnormality play a leading role in the increased CVD risk associated with diabetes. The aim of this study was to assess the quality of lipid control and treatment in type 2 diabetic patient with dyslipidemia.
Methods: We studied Data from 602 type 2 diabetic patients who had at least four regular clinic visits every year for medical care in outpatient clinics of Isfahan Endocrinology and Metabolism Research Center, 1999-2003. Patients for Classified in three groups according to lipid levels as low, moderate and high risk. ADA )American Diabetes Association) standard criteria were used for appropriate lipid control.
Results: The mean age, duration of diabetes, HbA1c and BMI were 52.2±9.5 years, 6.8±4.6 years, 9.2±1.7% and 29.4±4.2 Kg/m2 respectively at initial registration. Eighty four percent of patient had LDL cholesterol above 100 mg/dl and 71% had triglyceride level >150 mg/dl, of these patients 47.8% and 41.6% had high risk levels and only 12.4% taking statins and 21.5% taking fibrate for treatment at end of study. Among hyperlipidemic patients levels of LDL-C decreased from 170.8±35.6 mg/dl to119±30.20 (p < .001), triglyceride decreased from 273.8±126 to225.2±97 mg/dl (P<0.004) and HDL-C increased from 43.3±10.6 to 48.4±14.1mg/dl ((P<0.6). Percentage change of lipid level was -35.8%, -17.7% and +7.3% respectively. At the end of fallow-up 50.4% of patients treated with statins and 14.7% with fibrate. Finally, overall control of cholesterol and triglyceride in patients with dyslipidemia was 30% and 37% respectively.
Conclusion: Our findings showed that many of type 2 diabetic patients with dyslipidemia have inadequate control of lipid and lipoprotein. The prevalence of cardiovascular events due to hyperlipidemia in type 2 diabetic patients is high. This fact demonstrates the importance of early interventions for control and treatment these risk factors for prevention of cardiovascular complication in this patients.
Aliakbar Nejati Safa, Begher Larijani, Behnam Shariati, Homayon Amini, Adeleh Rezagholizadeh,
Volume 7, Issue 2 (17 2007)
Abstract
Background: The prevalence of depression in diabetic patients is 2-3 times more than general population. The quality of life (QOL) and glycemic control are two important outcome measures of diabetes management. The aim of this research is to study the relationship between depression, glycemic control and QOL in a sample of Iranian diabetic patients.
Methods: One hundred diabetic patients who were referred to diabetes clinic of Dr. Shariati Hospital were included in the study consecutively. The depression subscale of Hospital Anxiety and Depression Scale (HADS-D) were used to determine depression. The World Health Organization Quality of life brief version questionnaire (WHOQOL-BREF) was used to measure QOL. The status of glycemic control was evaluated through measuring HbA1c. Other measured variables included: demographic variables, smoking, diabetes type, body mass index, duration and complications of diabetes and previous history of depression. The linear regression method was implemented to analyze the data.
Results: Depression was observed in 28% of the patients. Glycemic control had a reverse significant correlation with diabetes complications. No significant relationship was found between HbA1c and scores of HADS-D. WHOQOL-BREF subscales scores had no significant relationship with glycemic control. There was a significant relation between scores of HADS-D and WHOQOL-BREF subscales.
Conclusion: Improving quality of life (QOL) is one of the main outcomes in the management of diabetes. According to the result of this study, depression had a prominent relationship with QOL. Thus, careful management of depression may be necessary to improve QOL of diabetic patients.
Elahe Dianati, Sahar Molzemi, Mohsen Aminian,
Volume 15, Issue 5 (7-2016)
Abstract
Background: In the event of damage to the skin, the epidermis of which goes to the disintegration of the body, is a wound that is common in diabetics. The purpose of this study was to evaluate microscopic effects of Aqueous extract of curcumin on wound healing in diabetic male rats.
Methods: In this study 48 male Wistar rats were divided into 4 groups (control, sham, experimental, empirical two) were tested. The extra pawn injured area of 3 cm to the left of the spine created. Wound healing was examined microscopic.
Results: The streptozocin diabetic wound healing compared to the control group later showed and wound healing in experimental groups treated with Aqueous extract of curcumin was faster than the control group.
Conclusion: The results showed that the Aqueous extract of curcumin skin accelerates wound healing in normal and diabetic samples.
Mehdi Zarei, Mohamadreza Hamedinia, Amirhossein Haghighi, Raha Noorafshar, Sara Amini,
Volume 16, Issue 1 (1-2017)
Abstract
Background: The purpose of this study was to compare effects of three combined aerobic-resistance exercise training protocols with different intensities on metabolic control and Visfatin levels in men with type 2 diabetes.
Methods: 43 male patients with type 2 diabetes were randomly divided into 4 groups (three combined aerobic-resistance exercise training groups 1, 2, 3 and control). Training groups performed combined aerobic-resistance exercises for 12weeks, 3 times a week with given intensities )group 1:resistance 50-60% one repetition maximum- aerobic 70-80%maximum heart rate, group 2:resistance 60-70% one repetition maximum- aerobic 60-70% maximum heart rate and group 3:resistance 70-80% one repetition maximum- aerobic 50-60% maximum heart rate). Blood sampling to determine the levels of Visfatin, insulin, HbA1c, fasting glucose before and after 12weeks, were conducted.
Results: Visfatin levels and HbA1c in all training groups and fasting glucose in 2 combined training groups significantly decreased compared with control group (P<0.05). Vo2max was significantly increased in all training groups (P<0.05). No significant difference were observed between groups in body weight, Body mass index, fat mass, insulin levels and resistance insulin.
Conclusion: 12 weeks of combined aerobic-resistance exercise training protocols with were executed intensities through decreasing Visfatin and HbA1c levels and improving aerobic capacity could be helpful in patient with type 2diabetes. In addition to the above benefits, combined exercise training protocols of with intensity of 60-70% maximum heart rate–intensity 60-70% repetition maximum due to reducing fasting blood glucose could give greater benefits to patients.
Mahbobeh Hadizadeh, Sahar Molzemi, Mitra Bagheri, Mohsen Aminiyan,
Volume 16, Issue 2 (1-2017)
Abstract
Background: In the event of damage to the skin, the epidermis of which goes to the disintegration of the body, is a wound that is common in diabetics. The purpose of this study was to evaluate Effect of alcohol extract of Nigella Sativa on wound healing in diabetic male rats
Methods: In this study 48 male Wistar rats were divided into 4 groups (control, sham, experimental, empirical two) were tested. The extra pawn injured area of 3 cm to the left of the spine created. Wound healing was examined macroscopically.
Results: The streptozocin diabetic wound healing compared to the control group later showed and wound healing in experimental groups treated with alcohol extract of Nigella Sativa was faster than the control group.
Conclusion: The results showed that the alcohol extract of Nigella Sativa skin accelerate wound healing in normal and diabetic samples.
Maryam Aalaa, Mohammad Reza Mohajeri-Tehrani, Ghobad Ramezani, Mohammad Reza Amini, Maryam Aboeerad, Mahnaz Sanjari,
Volume 19, Issue 1 (1-2020)
Abstract
Background: Peripheral neuropathy is one of the most common problems in diabetic patients. The increased risk of Diabetic Foot Ulceration (DFU) and amputation would be a complication of diabetic neuropathy. The aim of this study was to compare the DFU healing in different severity classification of neuropathy.
Methods: This is a retrospective study that was conducted over a two-year period from April 2016 to March 2018 according to the information of patients records with Diabetes Mellitus (DM) referred to clinic of diabetes and metabolic disorders of Endocrinology and Metabolism Research Institute of Tehran University of Medical Sciences. Wound healing criteria including area, depth and healing duration were studied. Accordingly, changes in the area and depth of wounds were evaluated and reported during the first, third and sixth months after baseline. Data were analyzed using descriptive and inferential statistics using SPSS software version 16.
Results: The results of the study of patients with neuropathic ulcer showed that males and age group of 56 to 65 years had the highest frequencies. In addition, most of these patients suffered from type 2 DM (79%). The rate of wound healing, which was measured by area and depth of wound in three time periods, differed in different severity classification of neuropathy; at mild level of neuropathy the area and depth of wound decreased faster but in severe neuropathy, duration of wound healing in both mentioned criteria has increased. Regarding to the increase in the duration of DM, the healing time increased too. However the rate of wound healing decreased with increased age (p-value = 0.001).
Conclusion: Evidence suggests that early identification of neuropathy can reduce the incidence of DFU and amputation. Due to the slow healing of the size and depth of the wound in diabetic patients with severe neuropathy, it is necessary to prevent DFU by conducting preventive care and educational interventions.
Mahnaz Sanjari, Maryam Aalaa, Mohammadreza Amini, Neda Mehrdad, Mohammadreza Mohajeri,
Volume 19, Issue 3 (2-2020)
Abstract
Background: Diabetic foot is one of the main complications of diabetes, which is caused by a significant proportion of patients with diabetes and which imposes costs on the family and the health system around the world. This review aims to summarize the latest findings in the field of diabetic foot based on clinical guidelines.
Methods: In this review study, in order to achieve the best clinical guide in the field of diabetic foot by determining the search strategy and inclusion criteria, all related clinical guides were searched in the databases and websites of clinical guidelines. Clinical guidelines related to diabetic foot care were searched and retrieved from January 2000 to early 2019 and screened separately by two researchers to select the selected clinical guideline.
Results: Based on the study criteria, the clinical guide of the International Diabetic Foot Working Group was selected as the most complete guide in the field of diabetic foot. This summary is based on the International Working Group on the Diabetic Foot (IWGDF) Guidance 2015, consist of five documents including prevention of foot ulcers in at‐risk patients, footwear and offloading principles, diagnosis, prognosis and management of peripheral artery disease, foot infections in patients with diabetes and enhance healing of chronic ulcers of the foot in diabetes.
Conclusion: This Summary Guidance for Daily Practice is intended to overview of the main aspects of the prevention and treatment of foot problems in patients with diabetes. This summary guidance is adviced at healthcare providers and specialists in foot care throughout the world.
Fatemeh Bandarian, Nazli Namazi, Mohammad Pajouhi, Mohammadreza Amini, Neda Mehrdad, Bagher Larijani,
Volume 20, Issue 1 (25th Anniversary of the Foundation, Special Issue 2021)
Abstract
Endocrinology and Metabolism Research Institute (EMRI) was established in 1993. EMRI has progressed step by step from the beginning and has reached maturity in the last 25 years. EMRI has expanded, advanced in human resources and infrastructures (laboratories and new technologies) and gained first rank in endocrine research in various fields. It has also worked with regional and international organizations such as the World Health Organization (WHO), the International Osteoporosis Foundation (IOF), and the American Clinical Endocrine Society (AACE). This article provides an overview of EMRI activities over a quarter of a century.
Fatemeh Dekamini, Mohammad Ehsanifar,
Volume 21, Issue 4 (10-2021)
Abstract
Background: Diabetes is one of the major health problems in Iran and about 4.6 million adults suffer from this disease. Poor diagnosis of this disease has caused half of this number to be unaware of their disease. In recent years, along with the use of computers in data analysis and storage, the volume and complexity of data has increased dramatically.
Methods: In health organizations, data play an essential role in the value of the organization. Therefore, data mining has become one of the most widely used processes in the field of health and disease diagnosis. In this study, the information of 768 laboratory clients in Tehran was kept confidential and the opinions of experts were used to identify the variables affecting the incidence of diabetes.
Results: The findings indicate the study of 5 algorithms on the presented data, which by implementing 5 data mining algorithms J48, Bayes, Beginning, Cohen and simple clustering to classify the data, the efficiency of these algorithms in terms of speed and accuracy in calculations was evaluated.
Conclusion: The data set for classification is the database of a laboratory, which includes 768 samples with 9 characteristics. Finally, J48 algorithm is recommended for data mining of diabetes due to high speed, acceptable accuracy and lack of sensitivity to raw data.
Reza Amini, Abbas Sarmi, Mohammad Reza Afarinesh ,
Volume 24, Issue 5 (12-2024)
Abstract
Background: Alzheimer's disease is the most common type of dementia, which is associated with progressive loss of memory and reaction to the environment. The aim of this study was to investigate the effect of 12 weeks of resistance training with sumac intake on the serum levels of SIR3, SIR4 and AMPK in Alzheimer's male rats.
Methods: In this experimental study, male Wistar rats with an age of 8-10 weeks and an average weight of 230±30 grams were randomly divided into five groups: control, Alzheimer's disease, Alzheimer's disease with sumac supplementation, Alzheimer's disease with resistance training, and Alzheimer's disease with resistance training. Received sumac supplements were divided. To induce Alzheimer's disease, 8 mg/kg of trimethyl tin chloride along with 200 microliters of normal saline were injected intraperitoneally to mice. Resistance training was performed for 12 weeks and 5 days a week on a special rat ladder. 48 hours after the last training session, a blood sample was taken. Serum levels of SIR3, SIR4 and AMPK were evaluated by ELISA method. To check the changes between the control group and other groups using the independent T-test and to check the difference between the other groups using the one-way analysis of variance test and if significant, using the Tukey post hoc test, by SPSS version 29 software at a significance level of P< 0.05 used.
Results: The results of this research showed that 12 weeks of resistance training increases the levels of SIR3 (P< 0.036), SIR4 (P< 0.029) and AMPK (P< 0.447) compared to the Alzheimer group. In addition, adding sumac to the resistance training program had a significant effect on the levels of SIR3 (P< 0.078), SIR4 (P< 0.024) and AMPK (P< 0.002).
Conclusion: Our results suggest that resistance training is associated with the improvement of sirtuin 3, sirtuin 4 and adenosine monophosphate kinase levels in Alzheimer's rats and receiving sumac antioxidant compound leads to doubling of these responses.
Shahin Riyahi Malayeri, Mohammad Ali Azarbayjani, Nastaran Amini, Azadeh Abdolahzadeh,
Volume 25, Issue 4 (9-2025)
Abstract
Background: Insulin resistance plays a fundamental role in disorders such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. Regular physical activity and the use of medicinal plants are important strategies for its reduction and management. Ginger has attracted research attention due to its phytochemical compounds that influence insulin signaling pathways. Despite numerous studies, a bibliometric analysis examining the effects of exercise and ginger supplementation on insulin resistance has not yet been conducted. Therefore, the present study aimed to analyze the trends in Iranian research in this field.
Methods: In a bibliometric review, the keywords “training,” “ginger supplementation,” and “insulin resistance” were searched in the Magiran database. According to the entry criteria, 13 eligible articles were selected and data extracted from them, including writing pattern, collaboration, prolific authors and institutions, selected journals and study trends, and common keywords were extracted from the database of recipients and analyzed using VOSviewer software.
Results: The results indicated that 36 authors had an average of 3.23 ± 0.89 cooperation in writing articles. Fifty-four percent of the articles were published by public university faculty and 46% by independent universities. The most frequent keywords included "ginger", "insulin resistance", "obesity", "diabetes mellitus", "irisin" and "lipid peroxidation".
Conclusion: The results of this bibliometric study showed that exercise with ginger supplement reduced insulin resistance. In particular, 84% of the articles showed the positive effect of combined exercises (resistance and aerobic exercises) along with ginger supplements on the reduction of insulin resistance. Compared to other types of exercise, these exercises have had the greatest effect on improving the glycemic profile and body composition. In addition, high intensity interval training (HIIT) has also shown positive effects on reducing insulin resistance, but is not as effective as combined training. Also, due to the relationship between insulin resistance and various diseases, it is felt to conduct more studies on diverse statistical populations and people suffering from various diseases.
