Showing 7 results for Ability
Farshad Forouzandeh, Alireza Aziz Ahari, Farid Abolhasani, Bagher Larijani,
Volume 4, Issue 4 (6-2005)
Abstract
Background: Foot complications are among the important problems of diabetic patients. Vascular and neurological involvements are two major causes for such complications.
Methods: We studied 142 diabetic outpatients referred to diabetes clinic of Dr.Shariati Hospital from Dec. 2003 to Sep. 2004. We performed different neurological and vascular tests to assess the diabetic foot and data were analyzed by SPSS software.
Results: 54.9% of the cases reached the symptom score of 5 and upper so they had neuropathy regarding the Michigan Neuropathy Disability Score (MNDS). By analyzing the overall symptom and sign scores, 61% had neuropathy. Regarding MNDS, 42.7% of the subjects were neuropathic. Finally 23.9% were unable to sense at least one point from 12 points of monofilament examination. 16.9% of the patients had the complaint of intermittent claudication, in 8.8% at least one of the peripheral pulses was not palpable, whereas 10.6% had some degree of PAD regarding to ABI and toe pressure.
Conclusion: Using a monofilament is the most reliable method for screening of the neuropathy in diabetic patients. On the other hand, relying on symptoms like intermittent claudication and physical examination in order to find peripheral arterial disease in diabetic patients may lead to miss many cases, thus, performing some more precise diagnostic tests, such as ABI and toe pressure are highly recommended and reliable.
Kiarash Aramesh, Mitra Hefazi Targhabeh,
Volume 5, Issue 0 (10-2005)
Abstract
Background: Professionalism is currently a chief concern across the continuum of medical sciences and there is a great deal of efforts to clarify its theoretical components and to measure them. For participation of Iranian medical scientific society in this universal challenge, there is a need to explain and interpret the state of art of this topic in the world.
Methods: We selected the most related articles among the related resources fount through searches of databases, and then asked the related questions of the literature identified
Results: The main core of the professionalism consists of the attitudes and behaviors through them, the patient's interests take priority to the physician's self-interests. Begun in 1990, the professionalism project has reached to its main theoretical results, that is: Physicians' charter on medical professionalism. Regarding the measurement of the professionalism, a reliable and valid measuring method has not been achieved yet.
Conclusion: Achieving to a perfect definition depends on quantifying of its components in the related questionnaires. Regarding the measurement of the professionalism, some great efforts have been done. We propose performing some researches for clarifying the theoretical components and measuring the professionalism in the cultural and professional environment of Iran.
Ali Reza Esteghamati, Mehrshad Abbasi, Abbas Yousefizadeh,
Volume 5, Issue 1 (8-2005)
Abstract
Background: The aim of this study was to compare time action profile of regular human Insulin produced by Exir pharmaceutical Co. and Actrapid® HM produced by Novo Nordisk with euglycemic clamp technique for the first time in Iran.
Methods: Euglycemic glucose clamps were performed with two Insulin brands in a single-center, randomized, double-blind, and crossover study on 6 healthy male volunteers. Glucose disposal kinetics including metabolic clearance rate of glucose (MCRg) and metabolic clearance rate of insulin (MCRi) were determined during a 2-h predetermined intravenous Insulin infusion while blood glucose levels were maintained steady using variable continues intravenous glucose infusions based on method of De Fronzo.
Results: There were no differences in glucose kinetics or time action profile with respect to glucose infusion rates (688.4 vs. 664.6 mg/kg per 120min), MCRg (0.63±0.19 vs. 0.62±0.25 ml/kg), and MCRi(110 % vs110%) between Exir and Novo Nordisk regular human Insulin preparations. Serum insulin levels increased and serum C-peptide levels decreased with both exogenous Insulin infusions which were statistically the same for both preparations.
Conclusion: Time action profile and bioavailability of regular human insulin produced by Exir Pharmaceutical Corporation is comparable with commonly used Novo Nordisk preparation demonstrated by 2 hour euglycemic clamp study.
Bagher Larijani, Seyed Sajad Mohseni Salehi, Shirin Irani, Marjan Akbari Kamrani, Nasim Sheykh Bahaei, Ahmad Sajadi, Seyed Naser Ostad,
Volume 6, Issue 1 (8-2006)
Abstract
Background: Many researches have been conducted on islet cells' transplantation for a definitive treatment of diabetes mellitus type1. As the viability of the islets is the most important factor in predicting the transplantation prognosis, we have designed a study to isolate rat's islets. The aim of the study was to assess the viability of the islets at different stages and suggest the best transplantation time.
Methods: Pancreatic islets were isolated from male rats (250-300gr) by standard surgical procurement followed by intraductal HBSS distension, chopping and digestion with collagenase (type V). After being centrifuged for 3 times, the islets were then hand-picked and incubated in 37oC with RPMI 1640 media for 6 days. Each well contained 35-45 islets. Viability of islets was assessed by 2 independent investigators, giving score 0-2 to the color of islets under florescent microscope after Propidium iodide/Acridine orange staining at 6 times: just after the incubation, 24h, 48h, 3rd day, 5th and 6th day.
Results: The viability of the islet cells was gradually increased after the incubation as we had the most viability rate after the second day, while it decreased after this period and reached the least rate on the 5th and 6th day.
Conclusion: The islets' viability increased following the cell culture after the isolation procedure, as they have the best condition for transplantation after 48 hours. As the islets’ viability is the most critical point in transplantation, further studies evaluating the effects of different interventions on viability is needed.
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Volume 14, Issue 1 (1-2015)
Abstract
Background: Obesity is one of the most important risk factors for cardiovascular disease and genetic and environmental factors play important role in this risk factor. The aim of present study was to estimate the heritability of anthropometric variables in Tehran Lipid and Glucose Study (TLGS) families.
Methods: In this cross-sectional study, 529 two generation families were selected from among phase III TLGS. At least two members of the families were overweight or obese. Anthropometric variables, resting energy expenditure (REE) and body size index (BS) were determined. The heritability (h2) of variables was estimated using SOLAR software.
Results: In this study, 2460 individuals (493 fathers, 573 mothers, 720 sans, 674 daughters) participated, and the mean age of parents and offspring were 45.7±10.2 and 18.4±9.7 years respectively. In Tehran families, the sex and age adjusted heritability for anthropometric variables varied from 0.21(0.037) (hip) to 0.51(0.035) (BS) as expected, body size as a skeletal trait had the highest heritability. By considering the BS as a confounder, the REE heritability increased from 0.26 to 0.47. Therefore body size may have important role in determining the heritability of this variable.
Conclusion: genetic factors have decisive role in obesity phenotype of Tehran families.
Nasimeh Sadat Razavi, Fereshteh Majlessi, Bahram Mohebbi, Azar Tol, Kamal Azam,
Volume 16, Issue 3 (3-2017)
Abstract
Background: Patient’s adherence to treatment regimen can predict treatment plan and decrease intensity and symptoms of sickness. This study aimed at determining the effect of educational intervention based on AIM (Ability, Information, Motivation) model on improving adherence of patients with type 2 diabetes.
Methods: This semi experimental interventional study was performed on 180 patients with type 2 diabetes as intervention and control groups. The patients selected using simple random sampling. Study instrument was a questionnaire including demographics (14 items) and AIM model questionnaire (10 items about information, 9items about motivation, 6 items for ability). After baseline, educational intervention was performed in intervention group and post test conducted after six months for both groups. Collected data was analyzed with SPSS software version 23using Mann–Whitney U, Wilcoxon and chi-squared tests. The significant level was considered less than 0.05.
Results: There was no significant difference in demographics and AIM model constructs between two groups (p>0.05). After educational intervention, intervention group revealed a significant difference with control group in terms of information (P<0.001), motivation (P<0.001), ability (P<0.001) and level of HbA1C (P<0.001).
Conclusion: study results revealed AIM model based educational intervention has an important role on treatment adherence among type2 diabetic patients. With increasing patient information and belief regarding disease patient’s motivation will be improved.
Reza Masoodi, Soleiman Kheiri, Fateme Ali Akbari, Ahmad Ali Eslami, Leili Rabiei,
Volume 19, Issue 6 (8-2020)
Abstract
Background: Assessing the health literacy of diabetic patients requires the availability of a tool specific to this group. The Diabetes Health Literacy Assessment Questionnaire (LAD) is one of the tools used to measure the health literacy of diabetic patients. The present study was conducted with the aim of translating and validating the Persian version of the LAD questionnaire.
Methods: The present study aimed to determine the validity and reliability of the Persian version of the Health Literacy Assessment Questionnaire for diabetic patients on 300 patients with diabetes in 1398, by sampling. Stages of study: First: Translation and preparation of the Persian version of the health literacy questionnaire in order to design and select items and their qualitative evaluation by the second group: Quantitative evaluation of narrative features using the opinions of the third group of experts: Formal narrative evaluation (comprehensibility) and The reliability of the questionnaire was assessed by a small group of the target population in a fourth experimental study: analysis of items, validity assessment and reliability of the final questionnaire.
Results: In the analysis of organizational structure items, the effects of roof and floor were not observed. The highest averages were for items 8 and 12 and the lowest averages were for items 6. According to the Skewness Index, no deviation was observed in the items. Based on the results, the instrument had acceptable internal stability. Detective factor analysis identified two factors for the Diabetes Health Literacy Questionnaire: one was individual understanding and the second was social support.
Conclusion: The results of exploratory factor analysis, Diabetes Health Literacy Questionnaire (LAD) have good validity and reliability and can be used to measure the health literacy of diabetic patients.
