Showing 10 results for Adiponectin
Atbin Moradi Zirkohi, Mohsen Khoshniat, Farhad Zare, Zhila Maghbooli, Arash Hossein-Nezhad, Alireza Shafaei, Bagher Larijani,
Volume 6, Issue 2 (9-2006)
Abstract
Background: Adiponectin and leptin are hormones which are related to body fat tissues and body weight. In pregnant women, conflicting associations have been reported between the role of serum concentrations of adiponectin and leptin with infant birth weight. The aim of this study was to determine the association between maternal and cord blood adiponectin and leptin concentrations with birth weight.
Methods: As a cross-sectional study 86 pregnant women referred to university hospital clinics were recruited. Maternal and umbilical cord blood samples were obtained in delivery room just after birth. The maternal and umbilical cord serum samples were analyzed for adiponectin and leptin. Their birth weight and height were measured at labor.
Results: The mean of maternal BMI, birth weight, and gestational age was 23.8±4.8 kg/m2, 3.13±0.14 kg, and 38.15±2.6 week, respectively. No correlation between adiponectin and birth weight were found. Birth weight positively correlates with leptin.
Conclusion: leptin concentrations in cord blood may be reflected the alternation of body fat tissue in infant and independently associated with infant birth weight.
Ladan Giahi, Abolghasem Jazayeri, Abbas Rahimi, Mazaher Rahmani, Bagher Larijani,
Volume 6, Issue 2 (9-2006)
Abstract
Background: Plasma concentration of adiponectin was found to play an important role in regulation of glucose metabolism, insulin resistance and conditions commonly associated with obesity. The aim of this study was to assess adiponectin level and its relation with percent of body fat mass and insulin sensitivity in over-weight men.
Method: This study was conducted on two groups of type 2 diabetic (n=20) and non-diabetic (n=20) overweight adult men. Serum level of adiponectin (ELIZA), FBS (GOD-PAP), fasting insulin (immunoreactive assay) and body fat mass (Bio-electric impedance) were measured. Insulin sensitivity was calculated using QUICKI.
Results: Diabetics had significantly higher mean of fat mass% than non-diabetics (26.55± 2.87% vs. 22.93±2.64 p< 0.05), despite fairly similar BMIs (27.7 kg/m2). Adiponectin concentration was lower in diabetics (7.77 ±3.53µg/ml) than non-diabetics (8.13 ± 0.03µg/ml) however, this difference was not statistically significant. The negative correlation between adiponcetin and fat mass didn't reach statistical significance. Adiponectin positively related with insulin sensitivity in non-diabetics (r= +0.5 p= 0.04).
Conclusion: Lower level of adiponcetin in diabetics than their non-diabetic counterparts. As well as the positive association of adiponectin with insulin sensitivity confirm the suggested role of decreased level of adiponectin in conditions such as insulin resistance and diabetes.
Shirin Hasani Ranjbar, Javad Tavakkoly Bazzaz, Parvin Amiri, Mahsa M.amoli, Bagher Larijani,
Volume 6, Issue 3 (5-2007)
Abstract
Background: Single nucleotide polymorphisms of Adiponectin gene have been associated with BMI, insulin sensitivity and type 2 diabetes, reportedly. In present study we performed a genetic association study for Adiponectin gene at position +45*T/G in type 2 diabetes and normal subjects of Tehran population.
Methods: Diabetic patients were selected from diabetes clinic and normal healthy control subjects aged between 25-64 years selected from zone 17 of Tehran. Adiponectin gene polymorphism was analyzed using PCR-RFLP method in normal healthy controls (N=70), obese diabetic patients (N=80) and non-obese diabetic patients (N=72).
Results: Frequency of TT genotype was 62.5% in non-obese diabetic patients and 78% in control group, that was statistically significant (TT vs TG+GG: P=0.02, OR=2.2, CI:0.98-5.00). There was also a significant difference for allele T and G frequencies when we compared between non-obese diabetic patients and controls group. The frequency of allele G was increased in non-obese diabetic (20.1%) patients compared to controls (12%) (P: 0.04 OR: 1.8 CI: 0.9-3.7).
Conclusion: This study showed TG and GG alleles of Adiponectin gene polymorphism at position +45*T/G are risk factors for development of diabetes mellitus while this effect is independent from BMI and obesity.
Ghorban Mohammadzadeh, Nosratollah Zarghami, Amir Bahrami, Baghar Larijani,
Volume 7, Issue 2 (9-2007)
Abstract
Background: Adiponectin is an adipose tissue-derived hormone that low levels of this hormone are associated with obesity, insulin resistance, and type 2 diabetes. The aim of this study was to compare the serum levels of adiponectin in diabetic and non-diabetic obese individuals.
Methods: As a cross-sectional study 35 obese individuals with type 2 diabetes mellitus and 35 non-diabetic obese subjects were enrolled. Two groups were matched for age, gender and body mass index. Fasting lipid profile was measured via the enzymatic methods. The NycoCard HbA1c Kit was used to measure HbA1c.The Serum Adiponectin, insulin and glucose levels were measured via an enzyme immunoassay, using a commercially available kit and glucose oxidase methods, respectively. The HOMA and QUICKI indices were used to determine insulin resistance and insulin sensitivity, respectively.
Results: The mean of insulin resistance index (HOMA-IR), HbA1c, diastolic blood pressure, triglyceride and fasting glucose in diabetes were significantly higher than non-diabetics (P<0.05). The serum Adiponectin levels was significantly lower in diabetes than non-diabetics (15.74±6.70 vs. 21.52 ± 9.35) and was significantly higher in women than men (19.38 ± 7.33 vs. 12.68 ± 4.28) among diabetic and (24.63 ± 10.52 vs. 17.83 ± 6.21) among non-diabetics groups.
Conclusion: type 2 diabetes mellitus is associated with low serum adiponectin concentrations and probably adiponectin involved in the pathophysiology linking obesity to type 2 diabetes.
Alireza Safarzade, Khadije Esmailpour, Elahe Talebi-Garakani, Rozita Fathi,
Volume 13, Issue 3 (3-2014)
Abstract
Background: Adiponectin and omentin-1 are adipokines with insulin-sensitizing properties. The aim
of this study was to investigate the effect of resistance training on serum levels of adiponectin and
omentin-1 in Streptozotocin-induced diabetic rats.
Methods: Twenty four male Wister rats (12-14 weeks’ old) were randomly divided into three groups:
non-diabetic control, diabetic control, and diabetic training. The rats in diabetic training group were
subjected to a resistance training program (3 days/wk, for 4 wk) consisted of climbing a ladder
carrying a load suspended from the tail. Following four weeks resistance training serum glucose,
insulin, lipid profile, adiponectin, and omentin-1 concentrations were measured.
Results: Serum levels of omentin-1 and adiponectin were significantly lower in diabetic control group
compare with non-diabetic control group (P<0.001). After 4 weeks of resistance training serum
adiponectin levels was significantly higher in diabetic trained group compared with diabetic control
group (P= 0.028), but we did not find any significant difference in omentin-1 levels between two
diabetic groups. Morever, we did not find any significant difference in serum lipid profile among all
groups. Four weeks resistance training did not change serum glucose and insulin concentrations in
diabetic rats.
Conclusion: This study indicated that resistance training could increase serum adiponectin levels in
diabetic rats without significant changes in lipid profile, glucose, insulin, and omentin-1
concentrations. It seems low intensity and short term duration of resistance training had important
roles in failure of significant changes of omentin-1, glucose, and insulin concentrations.
Shahin Riyahi Malayeri, Azam Azadniya, Mohammad Javad Rasaee,
Volume 18, Issue 1 (1-2019)
Abstract
Background: Adiponectin and resin; Adipocytokine relateted with insulin resistance. The purpose of this study was to the Effect of eight-week high intensity interval training and resveratrol intake on Serum Adiponectin and resistin in type 2 diabetic rats.
Methods: During this experiment 32 diabetic rats with High-Dieting Diet Sprague Dowley race with an average weight of 250 ±10 grams and an average age of 10 weeks, were randomly divided into four groups, including the “control group”, the “supplement group”, the “training group” and the “training and supplement group”. For up to 8 weeks, the “practice” groups participated in 5 training sessions weekly; session was 18 minutes under the influence of High-Intensity Interval training with an intensity of 90 to %100 VO2max. moreover, the supplement groups were given 10 milligram daily doses of resveratrol intake solution per kilogram of body weight Gavage was given for 8 weeks and three times a week. The outcome data was analyzed using one-way analysis of variance and significance level of (P≤0.05).
Results: The results showed that eight weeks of exercise and resveratrol consumption increased on serum adiponectin, but did not have a statistically significant effect (P = 0.62). However, serum resistin decreased and significantly affected the training group (P = 0.001). Also, the mean values of fasting glucose, insulin and insulin resistance index decreased significantly in experimental groups (P = 0.001).
Conclusion: It seems high intensity interval training with resveratrol intake can lead to glucose control in type II diabetes by changing its insulin resistance factors.
Bahram Jamali Gharakhanlou, Akram Ameghani, Ali Zarghami Khameneh,
Volume 21, Issue 3 (9-2021)
Abstract
Background: Imbalanced production of adipokines as leptin and adiponectin in diabetic patients may lead to the development of metabolic complications. Therefore, the aim of this study was to determine the effects of 2-month of caffeine ingestion along with aerobic training on changes in serum leptin and adiponectin levels and leptin/adiponectin ratio (LAR) in type 2 diabetic men.
Methods: Thirty-two diabetic men participated in
a quasi-experimental designs in the four groups for two-months period of a aerobic training (treadmill walking 3 times/week, 1.5 hour/session, 65-85% HRR) with and without caffeine ingestion (3 mg.kg
-1.day). Serum changes in leptin and adiponectin were measured during two phases (baseline and 24-hours after completing of the training program). Data were analyzed by one-way ANOVA and bonferroni's post-hoc test at level P≤0.05.
Results: Administration of two-months caffeine (CA) alone and combination with aerobic training (AT) were significantly could reduced and increased in leptin and adiponectin level, respectively (P=0.001). Thus, the combined group (AT+CA) effect were far more appropriate intervention in changing the studied indices (P=0.001). Also, the LAR method was notable reduced in all study groups, although these effects were more significantly in the combined group (AT+CA) (P=0.001).
Conclusion: It seems administration of caffeine supplementation and aerobic training for two-months have a positive effects on the improved relative of leptin and adiponectin levels as well as their ratio in diabetics, although the combination of these two variables has been shown to have far more dual effects.
Mohammad Javad Pourvaghar, Saeid Reza Noorimofrad, Mousa Khalafi,
Volume 23, Issue 6 (1-2024)
Abstract
Background: Adiponectin is one of the most well-known adipokines with anti-inflammatory effects that plays an important role in regulating the whole-body metabolism. The aim of this study was to investigate the effect of high-intensity interval training (HIIT) versus moderate intensity continuous training (MICT) on the circulating levels of adiponectin in individuals with and without metabolic disorders.
Methods: A systematic search was conducted in the databases of PubMed, Web of Science, Academic Jihad Center and Magiran using the keywords "HIIT" and "adiponectin" to identify Persian and English languages published articles until October 2022. Effect size (SMD) and 95% confidence interval were calculated using CMA2 software. I2 test for calculation of the heterogeneity and visual interpretation of funnel plot test and Egger test for assessment of the publication bias were used.
Results: Data analysis of 28 interventions (24 studies) showed that HIIT resulted in a significant increase in adiponectin [0.40 CI: 0.12 to 0.68), P=0.004]. Also, the data analysis of eight interventions showed that HIIT led to a non-significant increase in adiponectin compared to the MICT [0.41 CI: -0.04 to 0.86), P=0.07].
Conclusions: The findings of the present study showed that HIIT is a suitable and efficient training method to increase adiponectin, especially in people with metabolic disorders.
Fatemeh Kazeminasab, Nafiseh Hasanpour,
Volume 24, Issue 1 (3-2024)
Abstract
Background: Leptin and adiponectin are adipokines produced by fat cells and play an important role in obesity. The purpose of this study was to compare the effect of low-calorie diet (LCD) and exercise (Exe) on leptin and adiponectin in middle-aged and elderly adults with overweight and obesity.
Methods: A systematic search was conducted in PubMed, Web of Science, SID, Magiran, and Google scholar databases for English and Persian articles published until August 2023. The effect size and 95% confidence interval (CI) were calculated using the random effect model.
Results: The results of 25 studies with 2063 middle-aged and elderly people with overweight and obesity showed that the combination of exercise and diet compared to exercise alone causes a significant decrease in serum leptin [SMD=-0.4, P=0.001], and a significant increase in serum adiponectin [SMD=0.17, P=0.02] in middle-aged and elderly adults with overweight and obesity. Also, findings showed that the diet compared to exercise alone causes a decrease in serum leptin [SMD=-0.16, P=0.1], and a significant increase in serum adiponectin [SMD=0.05, P=0.7] in middle-aged and elderly adults with overweight and obesity. Also, diet compared to exercise alone does not cause a significant change in serum leptin [SMD=-0.11, P=0.2], and serum adiponectin [SMD=0.02, P=0.8] in middle-aged and elderly adults with overweight and obesity. Conclusion: It is suggested that middle-aged and elderly people to achieve hypoleptinemia and hyperadiponectinemia, use a combination Include exercise training and low-calorie diet in your lifestyle.
Sajjad Ramezani, Marefat Siahkouhian,
Volume 24, Issue 2 (6-2024)
Abstract
Background: This review aims to investigate and analyze recent studies related to the effects of various exercise training on adipokines secreted from adipose tissue in patients with type 2 diabetes.
Methods: Search in Persian and Latin databases PubMed, ScienceDirect, Google Scholar, Magiran, and SID with the keywords aerobic exercise, resistance training, High-intensity interval training, diabetes, Adipokine, Leptin, Adiponectin, and Resistin, resistance training, intense interval training, aerobic exercise, combined exercise, adipokine, leptin, adiponectin and resistin were performed to retrieve articles published in the period from 2010 to 2023.
Results: The results obtained from the study showed that aerobic exercise with moderate intensity (60 to 80%) reduces the leptin levels of diabetic patients, however, the effect of combined exercises (aerobic and resistance) is much greater than other types of exercises. In addition, aerobic exercises with moderate intensity (50 to 70%) lead to an increase in adiponectin levels in diabetic patients, however, high-intensity interval training (HIIT) had a greater effect in increasing adiponectin levels than other exercises. Also, studies showed that all three types of activities, aerobic exercise (50-70% intensity), intense intermittent exercise, and resistance exercise (30-70% 1RM) have the same effects in reducing the resistance levels of diabetic patients.
Conclusion: Aerobic exercises with medium and high intensity and especially combined exercises (aerobic and resistance) while improving adipokines, decreasing leptin and resistin levels, and also increasing adiponectin in diabetic patients.
