Iranian Journal of

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Background: Artichoke with the scientific name of Cynara scolymuse is a plant from compositae family. In this research, the effect of hydro alcoholic artichoke extract on serum glucose, lipids and lipoproteins and prevention of type 1 diabetes mellitus was investigated.
Methods: Twenty mature male Rats with mean weight of 200-250 gr in four groups were arranged. Rats in the control group, received physiological serum. The Second group (diabetic) received 120 mg/kgbw Alloxan monohydrate. The Third group (diabetic + Glibenclamide) received 0.5 mg/kgbw Glibenclamide in addition of the similar treatment with second group. The Fourth group (Alloxan monohydrate + Cynara scolymus), received 120 mg/kgbw Alloxan monohydrate with 300 mg/kgbw of Cynara scolymus simultaneously. Prescribing materials in all groups was done as interaperitoneal injection(IP). Fourty eight hours after last IP, blood sample was taken from each animal via cardiac puncture to measure blood factors.
Results: The results indicated significant reduction in glucose, cholesterol, triglyceride, VLDL and LDL levels in the treated group with extract and Alloxan monohydrate simultaneously as to compared diabetic group. Also, the result indicated significant increase in HDL level. Hydroalcoholic Artichoke extract could not reduce blood glucose level as compared with Glibenclamide, but had similar effects on other factors in comparison with Glibenclomide.
Conclusion: Artichoke contains antioxidants compounds, that plays a protective role on beta cells against Alloxan. The results of this research indicate that hydro alcoholic extract of Cynara scolymus could effectively prevent type 1 diabetes mellitus.

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Background: plants have been used in treatment of diabetes mellitus (DM) all over the world for centuries. Studies have indicated that, numerous classes of chemical compounds found in plants are potential effective in the treatment of diabetes. Lemon balm (Melissa officinal is) is a member of Lamiaceae family. In this study, were studied the effect of Melissa officinal is hydroalcoholic extracts in the prevention of diabetes and its effect on serum lipids and lipoproteins in rats.

Methods: Inthisstudy25male rats, weighing200-250grams were semi-randomly divided into5groups of 5 each. Group1(control),group2(diabetic),and groups3, 4and5, respectively extract with doses20, 100and500 mg/Kg/BW, for a period of two weeks every day through were gavaged and then diabetes was induced by way of intra peritoneal injection of alloxan at a dose120mg/kg WB .Blood from rats was performed in order to measure the serum concentrations of glucose, cholesterol, triglycerides, HDL and LDL.

Results: The results indicated a significant decrease (P<./.5) in levels of blood sugar, cholesterol, triglycerides and LDL in rats treated with the extract of Melissa officinal is. In addition, significant increase (P<./.5) in HDL level were observed in treating rats in comparison to the diabetic group.

Conclusion: The results of this study indicated that the Melissa officinal llis extract may be used effectively in preventing, controlling and attenuating the complications of DM. This effect can be due to the presence of flavono ides and their antioxidant features in these plant.