Showing 3 results for Anger
Bijan Farzami, Davood Ahmadvand, Safoora Vardasbi, Jila Majen, Shahnaz Khaghani,
Volume 1, Issue 1 (7-2001)
Abstract
Background: Urtica dioica, or the stinging nettle, is recommended by ancient medical texts for the treatment of high blood sugar.
Methods: We set up a perifusion system, in which an exact number of islets of Langerhans were exposed to an active component of the leaf extract of Urtica dioica, obtained by TLC. The active component was then injected into the peritoneum of both normal and diabetic rats to evaluate response in vivo.
Results: There was a marked increase in insulin secretion in vitro, as determined by ELISA. In vivo, there was an increase in blood insulin content following intraperitoneal injection. The increase in serum insulin observed at 60 minutes was associated with a decrease in blood glucose, checked several times during the observation period. Maximum insulin release over 120 minutes was equal to five times the baseline value. The decrease in blood sugar correlated with both the timing and magnitude of insulin release.
Conclusion: Notwithstanding the magnitude of the changes observed, the results obtained in normal and diabetic rats were similar.
Homeira Zardouz, Saleh Zahedi Asl, Mohammad Kazem Gharib Naseri,
Volume 5, Issue 4 (6-2006)
Abstract
Background: Regarding the adverse effect of stress on glycemic control in type 2 diabetic patients, the present study investigates the function of Glibenclamide on insulin release from β cells of rat pancreatic islets, subsequent to chronic psychological stress exposure.
Methods: In this study 30 male Wistar rats were divided into equal groups of control and experiment (5 groups). Four different restraint stressors with random sequence were used 1h twice daily for 15 and 30 days. 24 hours after the last stress session, static insulin secretion from isolated pancreatic islets of each animal were evaluated in the presence of 5.6, 8.3 and 16.7 mM glucose. Also insulin release in response to 5.6 mM glucose in the presence of 10 μM Glibenclamide was evaluated.
Results: The insulin release from isolated islets of the stress experienced animals was significantly increased only on the 30th day as compared to the control animals. In the experiment group, insulin release from the islets in the presence of 5.6 mM glucose alone was significantly increased on the 15th and 30th days as compared to the first day. However, in the control group there was no significant increase in insulin release at the similar conditions. In contrast to the control group, insulin release in response to 5.6 mM glucose in the presence of 10 μM Glibenclamide revealed no significant difference in the experiment group on the 1st 15th and 30th days as compared to the insulin release in the presence of 5.6 mM glucose alone. Insulin release from the isolated islets exposed to 5.6 mM glucose in the presence of 10 μM Glibenclamide, on different experimental days was not significantly different between the control and experiment groups.
Conclusion: According to the results of this study, it appears that chronic psychological stress decreases the responsiveness of pancreatic β cells to Glibenclamide, subsequently could prevent the augmentation of insulin release induced by the drug. This finding is worthy to consider in metabolic control of diabetic patients whom consume the agent.
Morteza Naghipoor, Mohammad Ali Besharat,
Volume 20, Issue 2 (1-2021)
Abstract
Background: Diabetes is a common, chronic, and debilitating disease that affects millions of people worldwide, causing psychological, social and physical complications. Diagnosis of diabetes, new lifestyle and restrictive diet can pose many psychological problems, including depression for diabetic patients. The purpose of this study was to investigate the role of anger, anger rumination and alexithymia in predicting symptoms of depression.
Method: 218 patients (94 males and 124 females) with type 1 and type 2 diabetes participated in the research and were asked to complete Multidimensional Anger Inventory (MAI), Anger Rumination Scale (ARS), Toronto Alexithymia Scale (TAS-20) and Depression, Anxiety, Stress Scale (DASS).
Results: There was a positive and significant correlation between all the components of anger, anger rumination, and alexithymia with symptoms of depression, though the severity of the correlation in external anger (r=0/14**) and objective thinking (r=0/17**) was less than those of other components. Also, among the dimensions of anger, anger rumination, and alexithymia, anger arousal (p<0/05, B=0/20), angry afterthoughts (p<0/05, B=0/32), revenge thoughts (p<0/05, B=0/25), and difficulty identifying feelings (p<0/05, B=0/32) were able to predict the symptoms of depression in patients with diabetes.
Conclusion: Anger, anger rumination, and alexithymia play a major role in creating the depressive symptoms. Symptoms of depression increase the burden of the disease in patients with diabetes. Therefore, it is important to include these factors in treatment protocols and help patients with diabetes identify, describe, and express negative and positive emotions more efficiently so that they can cope with the complications of the disease better.
