Showing 4 results for Asprosin
Mahboobeh Rangraz Tabatabaei, Masoud Nikbakht, Rohollah Ranjbar, Farhad Daryanoosh, Mohsen Ghanbarzadeh,
Volume 23, Issue 1 (5-2023)
Abstract
Background: The release of adipokines from adipose tissue depots plays a key role in regulating metabolic homeostasis and several other physiological processes, including diabetes, obesity, and vascular diseases. This study investigated the effect of eight weeks of high intensity interval training (HIIT) on asprosin, lipid profile and insulin resistance in type 2 diabetic male rats.
Methods: 24 male Sprague Dawley rats were randomly divided into four equal groups: control (C), control traning (C+T), diabet (D) and diabet traning (D+T). Diabetes was induced by the combined method of high fat diet and low dose strepotozocin injection. The traning group performed the HIIT program on the treadmill for eight weeks. Data were analyzed using one-way ANOVA and bonferroni post hoc test at a significance level of P<0.05.
Results: The results showed increased plasma asprosin in D group compared to C (P=0.0001) and decreased in C+T group compared to C (P=0.03) and D+T group compared to D (P=0.04). There was no significant difference in HOMA-IR between the C and C+T group (P=0.9) but decreased in D+T compared to D (P=0.0001). HDL increased in D+T group compared to the D (P=0.0001) and decreased TG and LDL (P=0.001). There was no significant difference between TG and LDL in the C group compared to the C+T, but HDL increased in C+T (P=0.01).
Conclusion: Plasma asprosin increases in rats with type 2 diabetes and HIIT can reduce the complications of diabetes by improved lipid profile and reduce asprosin and insulin resistance.
Mehdi Zarei, Javad Nakhzari Khodakheir,
Volume 23, Issue 4 (11-2023)
Abstract
Background: Physical activity and exercise training are known as an integral part of weight management and control in overweight or obese people. The aim of this study was to compare the effect of high intensity interval training (HIIT) and intense resistance training on asprosin and C1q/tumor necrosis factor related protein1 (CTRP1) serum levels in overweight and obese men.
Methods: In this semi-experimental study, 31 overweight and obese men were randomly divided into three groups: HIIT training (n=10), intense resistance training (n=11) and control (n=10). The subjects of the experimental groups performed HIIT exercises and intense resistance exercises three times a week for nine weeks. Before and after the intervention, blood samples were taken to measure the serum concentration of asprosin and CTRP1 from the subjects. Analysis of covariance test was used to analyze the data and the significance level was considered as p_value less than 0.05.
Results: The concentration of asprosin in the HIIT group (p=0.013) and intense resistance training (p=0.042) decreased significantly compared to the control group. No significant difference in CTRP1 concentration was observed between groups. However, the concentration of CTRP1 in the HIIT group decreased significantly in the post-test compared to the pre-test.
Conclusion: HIIT training and resistance training in overweight and obese men led to a decrease in asprosin levels. Considering the changes in asprosin, CTRP1 and other anthropometric indicators and lipid profiles, HIIT training seems to have a better efficiency in overweight and obese men.
Somaye Emamrezaee, Vahid Valipour Dehnou, Aliyavar Azizpour Fard,
Volume 23, Issue 6 (1-2024)
Abstract
Background: BDNF decrease, and HbA1c and Asprosin increase in diabetic people and exercise can reverse these effects, but the effect of vigorous exercise on Asprosin and BDNF in elderly diabetic people have not been investigated. Therefore, the aim of the present study was to investigate the effect of high-intensity functional exercise on Asprosin and BDNF and their relationship with glucose and HbA1c in elderly diabetic men and women.
Methods: In this semi-experimental study, 24 elderly diabetic men and women (age: 67.25 ± 5.84, BM: 70.29 ± 13.01, height: 160.92 ± 10.29) participated. The initial blood sample was taken while fasting. After 90 minutes, the subjects performed the exercise for 50 minutes. The second blood sample was taken 10 minutes after the high-intensity functional exercise. BDNF, Asprosin, HbA1c, and glucose levels were measured by ELISA method. To analyze the data, T-tests, covariance and Pearson's correlation coefficient were used.
Results: Asprosin and BDNF decreased (P< 0.0005) and increased (P< 0.0005), respectively in both groups. There was no significant difference between Asprosin and BDNF in elderly diabetic men and women in pre-test and post-test (P> 0.05). There was a significant negative correlation between BDNF with Asprosin, HbA1c and glucose and a significant positive correlation between Asprosin with HbA1c and glucose (P< 0.05).
Conclusion: Vigorous exercise decrease and increase Asprosin and BDNF in elderly diabetic men and women, respectively. Also, considering the significant negative relationship between BDNF with glucose and HbA1c and the significant positive relationship between Asprosin with glucose and HbA1c, it seems that vigorous exercise by reversing the changes of asprosin and BDNF causes possible improvement in levels of glucose and HbA1c.
Mehrdad Yousefinejad, Mahnaz Omidi, Abdolhossin Taheri Kalani,
Volume 24, Issue 3 (7-2024)
Abstract
Background: Diabetes is a global epidemic and the most common metabolic disorder caused by impaired insulin secretion and glucose metabolism. The aim of this study was to investigate the effect of 8 weeks of aerobic training on serum levels of asprosin and insulin resistance index in diabetic rats.
Methods: The statistical population of this research included 40 10-week-old mice with an initial weight of 250 ± 20 grams, which were randomly divided into four groups (10 mice in each group): diabetic-exercise group (DT), diabetic group - Control (DC), healthy-training group (HT) and healthy-control group (HC) were divided. The program of aerobic exercises was performed for 8 weeks (5 sessions per week) in the form of running on a treadmill. Independent t-test and one-way analysis of variance (ANOVA) with Tukey's post hoc test were used to compare the groups. All data were analyzed at a significance level of 0.05 using SPSS-25 software.
Results: The results of the present study showed that streptozotocin injection induced diabetes in mice (P= 0.001). Induction of diabetes caused a significant increase in the serum levels of asprosin and insulin resistance in mice (P= 0.048 and P= 0.012, respectively). Eight weeks of aerobic training decreased the serum levels of asprosin and decreased insulin resistance in diabetic rats (P= 0.001 and P= 0.036, respectively).
Conclusion: Induced diabetes causes insulin resistance and increase in serum levels of asprosine, which can be improved by performing aerobic exercises.
