Habib Moazami Goodarzi, Bagher Larijani, Abbasali Keshtkar, Patricia Khashayar,
Volume 13, Issue 2 (1-2014)
Abstract
Background: Discordance (the presence of different categories of T scores in two skeletal sites of a
single patient) can affect the physician’s decision to start medication or not. The present study was
therefore conducted to assess the prevalence of T-score discordance between spine and femoral neck
as well as its risk factors in a group of postmenopausal Iranian women.
Methods: The present analytical cross sectional research was conducted based on the results of
IROSTEOPs study on 8146 postmenopausal women referred to the bone mineral density (BMD)
center of Shariati Hospital affiliated to Tehran University of Medical Sciences between 2000 and
2011. Based on their BMD results, the patients were categorized into three groups: Concordance and
Minor and Major discordance. The factors affecting the risk of developing discordance was then
studied through uni/and multivariate logistic regression.
Results: Discordance between spine and femoral neck was reported in 3741 (45.9%) of the
participants. Multivariate logistic regression revealed that older age, higher number of pregnancies and
higher body mass index (BMI) are the main risk factors for T-score discordance at the studied sites.
The use of hormonal replacement therapy (HRT) on the other hand played a protective role.
Conclusion: It could be concluded that performing BMD at two different sites is necessary for the
Iranian population, particularly postmenopausal women.
Mohsen Taimouri, Khosro Jalali Dehkordi, Mehdi Kargarfard, Farzaneh Taghian,
Volume 25, Issue 2 (7-2025)
Abstract
Background: The current study aimed to ascertain the impact of pulsed magnetic therapy, multicomponent exercise, and a combination of both modalities on bone markers type 2 diabetic patients with osteoporotic.
Methods: In a randomized controlled clinical trial study, 56 older patients with type 2 diabetic osteoporosis (age: 68.18±3.67 yr; weight: 78.13±7.65 kg, body mass index: 28.40±1.76 kg/m2) were randomly assigned to either the multicomponent exercise + Full-body pulsed electromagnetic field (MCEx+PEMF, n= 18) multicomponent exercise + placebo full-body PEMF (MCEx+PPEMF, n=17) and a full-body PEMF alone (PEMF, n= 21). PEMF was applied for the whole body using a full-body mat three times per week, 60 minutes for 12 weeks, with a multicomponent exercise protocol that includes flexibility, aerobic exercise, strengthening, weight-bearing, and balance exercises followed by whole-body vibration (WBV) training. The body composition, bone mineral density (BMD), bone metabolism markers (phosphorus, calcium, sclerostin, osteocalcin, Bone-specific alkaline phosphatase (BALP)) before and after the intervention. The data were analyzed using the dependent t test and the two-way repeated measures ANOVA at the level of less than 0.05.
Results: After 12 weeks of intervention, there is a significant difference in the serum levels of bone mineral density and bone metabolism markers (phosphorus, calcium, sclerostin, BALP) between the groups (P< 0.05). However, the bonferoni post-test showed an increase in serum levels of BMD, phosphorus, sclerostin, BALP with a significant decrease in calcium in the MCEx+PEMF group in compared to alone PEMF group.
Conclusion: The findings showed that the PEMF rehabilitation method combined with multicomponent exercise is more effective and safer than exercise or PEMF only for improving BMD and bone metabolism markers in the type 2 diabetic population with osteoporosis. Therefore, exercise rehabilitation clinics should be encouraged to consider exercise rehabilitation as a treatment method for type 2 diabetic patients with osteoporosis. More studies with long-term follow-up should be considered to confirm these findings.
