Iranian Journal of

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Background: The purpose of this study is to the comparison of the effect of 12 weeks of sprint training and concurrent aerobic and strength training on high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and insulin resistance in women with diabetes mellitus (T2DM)

Methods: 52 overweight female type 2 diabetic patients (age; 45-60 years old and fasting blood glucose ≥ 126 mg/dl (7.0 mmol/l)) were assessed for eligibility. Participants were assigned to intense interval training group (N=17), concurrent resistance- endurance training group (N=17) and control group (N=18). The combined strength-endurance group did 12 weeks, three sessions per week endurance training with 60 % of maximal heart rate and two session resistance training with 70 % 1-RM. Intense interval training group did three session/week of 4-10 repetition of all out 30s Wingate on ergometer were included 10 weeks of concurrent resistance- endurance training and intense interval training.

Results: The results showed that following sprint training, there were significant changes in hs-CRP (p<0.001), but it wasn’t significant following concurrent training (p=0.062). According to results, TNF-α change were not significant in intense sprint (p=0.11) and concurrent training (p=0.23). Differences were not significant for the fasting blood glucose in the intense interval training groups (p=0.000). Serum insulin levels showed significant increases in the SIT (p<0.000) and concurrent training (p=0.000) significantly. The data showed significant differences in insulin resistance index (HOMA-IR) in intense interval training (p=0.000) and concurrent resistance- endurance training (p=0.008). ANCOVA test showed no significant difference in fasting blood glucose concentrations (P=0.171).

Conclusion: Intense sprint training compare to concurrent strength-endurance training can have better inflammatory status for patients with type 2diabete.

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Background: Considering the negative effects of inactivity and increasing fat mass in inactive people, the aim of this study was to investigate the effect of six weeks of aerobic exercise along with the consumption of fenugreek seeds supplementation on C-reactive protein and some blood parameters in inactive women.
Methods: 40 subjects were randomly assigned to 4 groups: exercise and fenugreek (n=10), exercise and placebo (n=10), fenugreek (n=10), placebo (n=10). Two exercise groups participated in the aerobic exercise program for 6 weeks, 3 sessions per week, and each session lasted from 20 to 30 minutes. Subjects consumed 500 mg of fenugreek seeds or placebo (starch) daily after breakfast. The blood samples of the subjects were collected from the vein of the right hand of the subjects in a sitting position. In order to analyze the data, Shapiro-Wilk test, correlated t-test, and Benferroni's post hoc analysis of covariance test were used for natural data at the significance level of p<0.05.
Result: The results showed that aerobic exercise combined with fenugreek seeds supplementation had a decreasing effect (p=0.001) on the response of C-reactive protein (CRP) in inactive women, and an increasing effect on the amount of platelets in inactive women (p=0.003). It had an increasing effect on the amount of red blood cells in inactive women (p=0.003) and a decreasing effect on the amount of white blood cells (p=0.03).
Conclusion: Aerobic training with fenugreek seeds leads to a decrease in C-reactive protein and a decrease in white blood cells and an increase in platelets and red blood cells. These changes reduce the inflammatory condition and increase the immune system and better oxygen supply to the tissues and optimal metabolism of inactive women.
 

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Background: Blood fat is a global problem and one of the major threats to society's health. Hyperlipidemia is considered a multigenic disease, most of the genes related to it remain unknown. rs1205 is one of the polymorphisms of the C-Reactive Protein (CRP) gene that causes the change of the nucleotide C to T and is one of the risk factors for increasing low-density lipoprotein (LDL) level. This study aimed to investigate the prevalence of rs1205 polymorphism in CRP gene and its relationship with LDL level in Iranian population.
Methods: The total number of samples was 137, including 79 controls and 58 patients (LDL above 130 mg/dL). Then the samples were analyzed using the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) method for the presence or absence of rs1205 polymorphism in the CRP gene. The PCR product was transferred on agarose gel. After observing the bands and checking their correctness, different alleles were examined.
Results: 56.2% of the samples had a body mass index (BMI) lower than 25 and 43.8% had a BMI higher than 25. The frequency percentage of genotypes showed that CT genotype is equal to 47.4%, CC genotype is equal to 36.5% and TT genotype is equal to 16.1%. 57.7% of the samples had LDL below 130 and 42.3% had LDL above 130.
Conclusion: A significant relationship wasn't observed between the rs1205 polymorphism and the serum LDL level of the studied population. Also, the difference in age and gender of the samples had no effect on this relationship. It is possible that the lack of difference in ethnicity is one of the possible reasons for the non-significance of the results of this study.