Shahnaz Masoumzadeh, Khosro Jalali Dehkordi, Mehdi Kargarfard,
Volume 21, Issue 1 (3-2021)
Abstract
Background: Family members of C1q/tumor necrosis factor (TNF) related proteins (CTRPs) have been shown to play an important role in metabolism and inflammation. However, there is limited information on the association of high-intensity intermittent exercise (HIIT) with CTRP1 and CTRP3 protein levels in patients with type 2 diabetes. Therefore, this study aims to evaluate the effects of 12 weeks HIIT on CTRP1 and CTRP3 protein levels in women with type 2 diabetes.
Methods: In a quasi-experimental study and pretest and post-test design, 30 women with type 2 diabetes (mean±SD, age: 40.69±4.21 years and body mass index:34.81±2.88 kg/m2 ) were randomly into two HIIT group (n=10) and control group (n=15). Exercise group performed a HIIT program three sessions per week, with and intensity of 80-90% MHR, 60 minutes per session for twele weeks. Weight, BMI, Vo2peak, FBG and serum levels of CTRP1 and CTRP3 were measured before and after the study period. The data were analyzed using paired sample t test and analysis of ANCOVA at the level of less than 0.05.
Results: After 12 weeks HIIT, there was significant differences in weight, BMI, Vo2peak, FBG and CTRP3 and CTRP5 serum levels between groups (p >0.05). However, ANCOVA test showed a significant decrease in weight, BMI, FBG and CTRP1 and CTRP3 serum levels and a significant increase in Vo2peak in the HIIT group compared to the control group after intervention (P<0.05).
Conclusion: The findings suggest that 12 weeks of HIIT program were an effective and safe method of improving the CTRP1 and CTRP3 serum levels in obese women with type 2 diabetes. However, more research with more control are needed to determine the effects of this non-pharmacological intervention on anti-inflammatory adipokine.
Mehdi Zarei, Javad Nakhzari Khodakheir,
Volume 23, Issue 4 (11-2023)
Abstract
Background: Physical activity and exercise training are known as an integral part of weight management and control in overweight or obese people. The aim of this study was to compare the effect of high intensity interval training (HIIT) and intense resistance training on asprosin and C1q/tumor necrosis factor related protein1 (CTRP1) serum levels in overweight and obese men.
Methods: In this semi-experimental study, 31 overweight and obese men were randomly divided into three groups: HIIT training (n=10), intense resistance training (n=11) and control (n=10). The subjects of the experimental groups performed HIIT exercises and intense resistance exercises three times a week for nine weeks. Before and after the intervention, blood samples were taken to measure the serum concentration of asprosin and CTRP1 from the subjects. Analysis of covariance test was used to analyze the data and the significance level was considered as p_value less than 0.05.
Results: The concentration of asprosin in the HIIT group (p=0.013) and intense resistance training (p=0.042) decreased significantly compared to the control group. No significant difference in CTRP1 concentration was observed between groups. However, the concentration of CTRP1 in the HIIT group decreased significantly in the post-test compared to the pre-test.
Conclusion: HIIT training and resistance training in overweight and obese men led to a decrease in asprosin levels. Considering the changes in asprosin, CTRP1 and other anthropometric indicators and lipid profiles, HIIT training seems to have a better efficiency in overweight and obese men.
