Shahnaz Masoumzadeh, Khosro Jalali Dehkordi, Mehdi Kargarfard,
Volume 21, Issue 1 (3-2021)
Abstract
Background: Family members of C1q/tumor necrosis factor (TNF) related proteins (CTRPs) have been shown to play an important role in metabolism and inflammation. However, there is limited information on the association of high-intensity intermittent exercise (HIIT) with CTRP1 and CTRP3 protein levels in patients with type 2 diabetes. Therefore, this study aims to evaluate the effects of 12 weeks HIIT on CTRP1 and CTRP3 protein levels in women with type 2 diabetes.
Methods: In a quasi-experimental study and pretest and post-test design, 30 women with type 2 diabetes (mean±SD, age: 40.69±4.21 years and body mass index:34.81±2.88 kg/m2 ) were randomly into two HIIT group (n=10) and control group (n=15). Exercise group performed a HIIT program three sessions per week, with and intensity of 80-90% MHR, 60 minutes per session for twele weeks. Weight, BMI, Vo2peak, FBG and serum levels of CTRP1 and CTRP3 were measured before and after the study period. The data were analyzed using paired sample t test and analysis of ANCOVA at the level of less than 0.05.
Results: After 12 weeks HIIT, there was significant differences in weight, BMI, Vo2peak, FBG and CTRP3 and CTRP5 serum levels between groups (p >0.05). However, ANCOVA test showed a significant decrease in weight, BMI, FBG and CTRP1 and CTRP3 serum levels and a significant increase in Vo2peak in the HIIT group compared to the control group after intervention (P<0.05).
Conclusion: The findings suggest that 12 weeks of HIIT program were an effective and safe method of improving the CTRP1 and CTRP3 serum levels in obese women with type 2 diabetes. However, more research with more control are needed to determine the effects of this non-pharmacological intervention on anti-inflammatory adipokine.
Mousa Khalafi, Marzieh Faramarzi, Kayvan Sharifmoradi,
Volume 23, Issue 2 (5-2023)
Abstract
Background: CTRP3 is known to be an adipose tissue-derived anti-inflammatory hormone that leads to improved insulin resistance. However, the effects of exercise training on this adipokine are poorly understood. Therefore, the aim of the present meta-analysis was to investigate the effect of exercise training on circulating CTRP3 levels in adults with metabolic disorders.
Methods: A comprehensive search was conducted in PubMed and Web of Science databases through October 2022 using the keywords "exercise training" and "CTRP3". The inclusion criteria for the current research included human studies with metabolic disorders, exercise training intervention, and circulating CTRP3 values. Standardized mean difference (SMD) and 95% confidence interval were calculated using random method.
Results: A total of 9 studies including 12 intervention arms and 365 participants with metabolic disorders were included in the meta-analysis. The results of data analysis showed that exercise training led to a significant increase in CTRP3 [0.57, (CI: 1.10 to 0.03) P=0.03]. Also, the results of the I2 test showed that there is a high and significant heterogeneity (I2 =84.59, P=0.001) and the results of the Egger test showed a significant publication bias (P=0.001).
Conclusion: Exercise training with a moderate effect size leads to a significant increase in circulating CTRP3 levels in individual with metabolic and cardiovascular diseases, which may be a mediator of the beneficial effects of exercise training.
