Showing 2 results for Cardiomyopathy
Sedigheh Babaee, Maghsoud Peere, Mohammad Ali Azarbayjani, Maryam Delfan,
Volume 23, Issue 1 (5-2023)
Abstract
Impaired insulin function with exogenous changes is a major cause of heart failure. The purpose of this study was to investigate the effect of four weeks of high intensity interval training with curcumin supplement on the expression of IRS-1 and IRE-1α gene in the Left ventricle of type 2 diabetic rats.
Methods: In the present experimental study, 30 male mice with diabetes were divided into five groups of 6; high intensity interval training (HIIT), High intensity interval Training+Curcumin(S+HIIT), Diabetic control+curcumin(S+DC), Diabetic Control (DC), Normal control (NC). The High intensity interval training protocol was performed five days a week for four weeks. Curcumin gavage at a dose of 100 mg/kg was performed daily. The expression of IRS-1 and IRE-1α were measured by the qReal-TimePCR method, and data were analyzed by one-way ANOVA at the alpha level of 0.05.
Results: IRS-1 gene expression in the S+HIIT group compared to the DC (P=0.003) and S+DC (P=0.001) groups and in the HIIT group compared to the DC (P=0.002), and S groups +DC had a significant decrease (P=0.019). IRE-1α gene was significantly decreased in S+HIIT group compared to DC (P=0.003), S+DC (P=0.001) and HIIT (P=0.008) groups.
Conclusion: It seems that HIIT with curcumin supplement can reduce the process of myocardial apoptosis in diabetic patients by improving metabolic conditions and genetic factors.
Mr 3- rozita Hassanizadeh, Mr 2- khosro Jalali Dehkordi, Ms Farzaneh Taghian,
Volume 24, Issue 5 (12-2023)
Abstract
Background: the purpose of this research is Comparison of the effect of aerobic exercise and gymnema sylvestre supplement on some markers related to cardiomyopathy in type 2 diabetic mice.
Methods: The statistical population consisted of 40 male C57BL/6 mice that became diabetic after 20 weeks of feeding with a high-fat diet. Then they were randomly divided into 5 groups of eight, diabetes and aerobic exercise, diabetes and gymnema sylvester supplement, diabetes and aerobic exercise with gymnema sylvester supplement, diabetes control and healthy control. The aerobic exercise program consisted of exercises at a speed of 10 m/min for six weeks and five training sessions per week on a treadmill. Daily consumption of gymnema sylvester at the rate of 0.1 g/kg orally alone and also with training intervention was done for six weeks.
Results: The findings showed that aerobic exercise and gymnema sylvestre supplement caused a significant decrease in the levels of glucose, insulin, insulin resistance and the expression of CASPASE-1 and NLRP3 genes in the heart tissue, the largest decrease in the dependent variables related to the aerobic exercise group with Gymnema Sylvester supplement.
Conclusion: Aerobic exercise and Gymnema sylvester supplement improves blood variables by reducing glucose, insulin and insulin resistance, as well as improving markers related to cardiomyopathy by reducing the expression of caspase-1 and NLRP3 genes in the heart tissue in type 2 diabetic mice.
