Iranian Journal of

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Background: Coronary heart disease is the leading cause of death in many nations. .Hyperlipidemia with elevated serum total cholesterol, LDL cholesterol and triglyceride are known as cardiovascular risk factors. HDL cholesterol is considered to be a protective factor. Any effort for management of dyslipidemia directly reduces cardiovascular mortality and morbidity and cause increasing public health .The ignorance of the extent and impact of hyperlipidemia prompted us to determine the prevalence of hyperlipidemia in Rafsanjan urban population over than 20 years old.
Methods: In this study 247 men and 244 women were evaluated for serum total cholesterol , LDL cholesterol , HDLcholesterol and triglyceride levels.Blood samples were obtained at morning, after 14 hours fasting and for data analysis SPSS-11 soft ware was used. Results: Mean age of subjects was 38.35±13.14 years.High cholesterol level was present in 20.6%, LDL levels were high in 10.8% , 5.7% had elevated level of triglyceride and 8.4% of participants had low HDL cholesterol. Total cholesterol , LDL cholesterol and triglyceride levels were significantly increased by age and HDL levels were also decreased by age.
Conclusion:According to our finding about 29% of studied population had at least one lipid abnormality and this important finding showed very high prevalence of dyslipidemia and requires specific attention and planning.

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Background: Atherosclrosis is a process that initiated with hypercholestrolemia and fatty streak formation. Previous studies showed oxidative modification of LDL render immunogenic and autoantibodies to epitopes of oxidized LDL. Oxidized LDL (OX-LDL), has antigenic properties. Antibodies against oxidized LDL have been proposed to be independent predictors of atherosclerosis development. The main aims of the current study were to compare antibody titers to different types of oxidized LDL (Cu+2-LDL, Malondialdehyde-LDL) and Native-LDL between angiographically documented coronary patients, non-documented patients and healthy subjects. Correlation between autoantibodies against oxidized LDL and increased risks of cardiovascular diseases has been shown. Methods: As a case-control study, we evaluated angiographically documented coronary patients, non-documented patients and healthy subjects to measure anti-OX-LDL autoantibody levels. Enzyme-linked immunosorbent assay was used to measure anti-OX-LDL autoantibodies. ANOVA test used for statistical analysis. Results: Titers of anti-Malondialdehydo-LDL autoantibodies were 3.55±0.415, 0.361±0.20, 0.093±0.078 respectively in each group (P<0.005). There was not statistically meaningful difference, between native-LDL and Cu+2-LDL antibodies. Conclusion: It seems the titre of autoantibodies against OX-LDL considered as a predictor of progression of atherosclerosis. Our data provide further support for a role of oxidatively modified LDL in atherogenesis.

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Background: Dyslipidemia accounts as a major risk factor for cardiovascular diseases. The aim of this survey was to determine the prevalence of dyslipidemia among relatives of patients with premature coronary artery disease (PCAD).
Methods: As a cross-sectional study 232 first degree relatives of patients with PCAD were recruited. A questionnaire was filled out by all of the participants all of them undergone physical examination and blood sampling. Lipid profile was categorized according to the NCEP: ATPIII criteria.
Results: Total Cholesterol>200 in 29.7%, LDL>160 in 10.3%, HDL<40 in 12.9%, TG>200 in 32.8%, ApoB100>130 in 14.2%, Apo A1<90 in 1.7% and LP(a)>30 in 47% of participants were seen. Serum levels of TG were significantly higher in men than women levels of HDL and ApoA1 were lower in men than women. The Prevalence of dyslipidemia among relatives was 59.6%.
Conclusion: In view of high prevalence of Dyslipidemia among relatives of PACD patients, active interventions in order to primary prevention of cardiovascular diseases via exact screening is recommended.

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Background: Atherosclerosis manifests earlier and more extensive in severity among diabetic patients. It seems Homocystein is one of the accelerating factors in development of atherosclerosis and serum levels Homocystein increase in patients with coronary artery involvement. The aim of this investigation was to compare Homocystein levels between diabetic and non-diabetic patients with coronary artery disease (CAD).
Methods: As a case-control study via non-randomized sampling method we collected 33 diabetic CAD patient and 34 CAD patient with normal GTT test. All participants were matched in age, sex, family history of atherosclerosis, blood pressure, smoking, the level of triglyceride, total cholesterol, LDL-C and Body Mass Index (BMI). Fasting serum Homocystein was measured via ELISA technique and other selected variables also were assessed via conventional laboratory methods. The quantitative variables between two groups analyzed by student t-test, while the qualitative variables examined by X2. We used Pearson –spearman test for correlation analysis between two groups.
Results: 33 diabetic and non-diabetic CAD/MI cases were participated. Among diabetic and non-diabetic subjects, mean age were 59.5±10.5 and 62.5±9.5 respectively. The mean duration of diabetes was 5.4 ± 4.1years. Comparison of the mean Homocystein levels between two groups revealed a significant differences,16.2 ± 4.8 mmol/L in diabetics vs. 10.6 ± 4.8 mmol/L in non-diabetics (P<0.5). Correlation between Homocystein levels and blood glucose, uric acid, triglyceride were r≤0.69, r=0.46 and r=0.51, respectively.
Conclusion: Fasting serum Homocystein in diabetic CAD subjects were higher than non-diabetic CAD cases .Our findings may suggest that the increased level of Homocystein is correlated to high prevalence and severity of atherosclerosis among diabetic individuals.