Showing 5 results for Curcumin
Mahsa Mohammad Amoli, Rohollah Mousavizadeh, Parvin Amiri, Bagher Larijani,
Volume 6, Issue 2 (9-2006)
Abstract
Background: Pancreatic islet transplantation has been reported as an appropriate method for treatment of type I diabetes patients, however there are strong indications that cytokine and chemokines secreted from transplanted islets play an important role in islet graft rejection in different stage post-transplantation. The NF-kB signaling pathway is activated in response to the stress resulted from isolation and purification process of pancreatic islets. Secretion and release of inflammatory mediators, including MCP-1, result from activation of this pathway which plays important part in activation of inflammatory processes accelerating graft rejection.
Methods: This study was performed to examine the effect of curcumin on secretion of inflammatory mediators and function of pancreatic islets.
Results: We observed that curcumin significantly decreased MCP-1 release from mouse islets compared to the control group and had no effect on function of pancreatic islets.
Conclusion: Investigating the stimulatory signals leading to production and secretion of inflammatory mediators from pancreatic islets and discovering their underlying mechanisms will be useful in finding new therapeutic interventions for blocking inflammatory pathways and improvement in outcome of islet cell transplantation.
Elahe Dianati, Sahar Molzemi, Mohsen Aminian,
Volume 15, Issue 5 (7-2016)
Abstract
Background: In the event of damage to the skin, the epidermis of which goes to the disintegration of the body, is a wound that is common in diabetics. The purpose of this study was to evaluate microscopic effects of Aqueous extract of curcumin on wound healing in diabetic male rats.
Methods: In this study 48 male Wistar rats were divided into 4 groups (control, sham, experimental, empirical two) were tested. The extra pawn injured area of 3 cm to the left of the spine created. Wound healing was examined microscopic.
Results: The streptozocin diabetic wound healing compared to the control group later showed and wound healing in experimental groups treated with Aqueous extract of curcumin was faster than the control group.
Conclusion: The results showed that the Aqueous extract of curcumin skin accelerates wound healing in normal and diabetic samples.
Akbar Hajizadeh Moghaddam, Marzieh Ahmadalizadeh, Reza Seyrafi, Mahbobeh Aghagolzadeh, Sedigheh Khanjani,
Volume 17, Issue 6 (10-2018)
Abstract
Background: Diabetes mellitus is a worldwide prevalence of metabolic diseases and its important complications are gastrointestinal disturbances. A wide range of studies have been conducted on the physicochemical traits and pharmacological effects of curcumin on different diseases like diabetes and cancer. However, the poor oral bioavailability and instability of curcumin had greatly limited its further applications. The purpose of this study was to evaluate the effects of Nanocurcumin on the oxidative stress and tissue changes of small intestine in diabetic mice.
Methods: In this experimental study, animals were divided to five groups: Control, sham, diabetic (Intraperitoneal injection of 120 mg/kg of Streptozotocin) and diabetic groups treated with Nanocurcumin (7.5 and 15 mg/kg body weight) for 21days. At the end of experiment, catalase (CAT) activity and Malondialdehyde (MDA) level were measured in intestinal tissue. For histological assessment, villi length and crypt depth in small intestine were investigated.
Results: The oral administration of Nanocurcumin significantly increased intestinal CAT activity (P<0.05) and decreased MDA level (P<0.001). Also, the Villi length in diabetic groups treated with Nanocurcumin showed a significant increase compared to diabetic group (P<0.05).
Conclusion: The findings of this study showed that Nanocurcumin has a protective effect on diabetes-induced digestive disorders due to its antioxidant properties.
Maryam Delfan, Malihe Rabiee, Raheleh Amadeh Juybari,
Volume 20, Issue 3 (2-2021)
Abstract
Background: Imbalance of apoptotic factors plays important role in pathogenesis of diabetes. Considering the role of curcumin supplementation and high-intensity interval training (HIIT) on these factors, the aim of this study was to investigate effects of four weeks of HIIT with curcumin supplementation on Bax and Bcl-2 gene expression in the soleus muscle of diabetic rats.
Methods: Present study was experimental research. 30 male Wistar rats were divided into one normal control (NC), and four diabetic groups: control (DC), supplement (SDC), high-intensity interval training (DHIIT) and high-intensity interval training supplement (SDHIIT). The training protocol was performed five days a week for four weeks, which included five to seven two-minute intervals at 80 to 90% of maximum power until exhaustion and one-minute recovery at 30% of maximum power until exhaustion. At the same time, Curcumin gavage at a dose of 100 mg/kg was performed daily. Bax and BCL-2 gene expression levels were measured by the qReal-TimePCR method and data were analyzed by two-way analysis of variance at a significant level of p≥0.05.
Results: Bcl-2 gene expression was significantly increased in DHIIT and SDHIIT groups compared to DC (P= 0.000). Also, a significant decrease in Bax gene expression was observed in DHIIT and SDHIIT groups compared to DC (P=0.000). There was a significant difference between DHIIT and SDHIIT in Bcl-2 (P=0.000) and Bax (P=0.013) gene expression.
Conclusion: It seems that HIIT in combination with curcumin supplementation, is more effective in improving the balance between apoptosis factors than any of these interventions alone.
Sedigheh Babaee, Maghsoud Peere, Mohammad Ali Azarbayjani, Maryam Delfan,
Volume 23, Issue 1 (5-2023)
Abstract
Impaired insulin function with exogenous changes is a major cause of heart failure. The purpose of this study was to investigate the effect of four weeks of high intensity interval training with curcumin supplement on the expression of IRS-1 and IRE-1α gene in the Left ventricle of type 2 diabetic rats.
Methods: In the present experimental study, 30 male mice with diabetes were divided into five groups of 6; high intensity interval training (HIIT), High intensity interval Training+Curcumin(S+HIIT), Diabetic control+curcumin(S+DC), Diabetic Control (DC), Normal control (NC). The High intensity interval training protocol was performed five days a week for four weeks. Curcumin gavage at a dose of 100 mg/kg was performed daily. The expression of IRS-1 and IRE-1α were measured by the qReal-TimePCR method, and data were analyzed by one-way ANOVA at the alpha level of 0.05.
Results: IRS-1 gene expression in the S+HIIT group compared to the DC (P=0.003) and S+DC (P=0.001) groups and in the HIIT group compared to the DC (P=0.002), and S groups +DC had a significant decrease (P=0.019). IRE-1α gene was significantly decreased in S+HIIT group compared to DC (P=0.003), S+DC (P=0.001) and HIIT (P=0.008) groups.
Conclusion: It seems that HIIT with curcumin supplement can reduce the process of myocardial apoptosis in diabetic patients by improving metabolic conditions and genetic factors.
