Showing 8 results for Diabetes Type 2
Mahnaz Lankarani, Fatemeh Bandarian, Ozra Tabatabaei, Mohammad Pajouhi, Bagher Larijani,
Volume 4, Issue 1 (7-2004)
Abstract
Background: Gliclazide is a second generation sulfonylurea which its efficacy and safety in the treatment of diabetes has been established. Diamicron MR (30 mg) is a new formulation of gliclazide with modified release which offer once daily dosage administration. This study was designed to assess the effect of combination therapy with diamicron and metformin in the treatment of type 2 diabetes.
Methods: 16 patients with type 2 diabetes (2 males, 14 females) more than 35 years old who despite treatment with glibenclamide and metformin had poor diabetes control participated in this clinical trial.HbA1c, lipid profile, liver and renal function tests at the end of study were compared with before.
Results: No significant changes was found in FBS, BS2hpp, lipid profile and renal and liver function tests at the end of study. Patients' weight was stable during the study.
Conclusion: Regardless of well efficacy of diamicron in the treatment of new diabetics cases, it is not recommended for patients with poor diabetes control despite of combination therapy with metformin and glibenclamide.
Hossein Salari, Bijan Farzami, Parvin Pasalar, Bagher Larijani,
Volume 5, Issue 1 (8-2005)
Abstract
Background: The determination of insulin receptors on RBC membrane is a suitable tool for the study of these receptors in diabetes and its related complications. The common methods for the study is the biopsy of fat or muscular tissues, cell culture or a preparation of certain amount of monocytes which is associated with some difficulties. Present study utilizes RBC's for this purpose.
Methods: Certain amount of RBCs were exposed to a known amount of labeled Insulin and varying concentration of unlabelled Insulin. The competitive effect of Insulin replacement was determined by the measurement of residual receptor radioactivity. This study was carried out in three groups of healthy, poor controlled and good controlled diabetics.
Results: There were significant differences between the normal and poor controlled diabetics (P=0.017). In addition differences in receptor binding was obtained between good controlled diabetics and normal which were not significant (P=0.09). All changes were inversely proportional to the HbA1C of specimen. Using Scat chard plots the number of receptors in each group, normal, poor controlled and good controlled were determined to be 1820 (± 72.8), 1026 (±40.4) and 1230 (± 49.2) respectively.
Conclusion: Considering the above results, it could be seen that the evaluation of the number of receptors in RBC could be a suitable tool for studying the state of insulin receptor in both physiological and pathological conditions.
Javad Heidari, Bagher Larijani,
Volume 6, Issue 4 (6-2007)
Abstract
It is estimated that there are 1.1-1.5 billion Muslims worldwide, and prevalence of diabetes is approximately 4.6%. Many patients with diabetes insist on fasting during Ramadan, thereby creates a medical challenge for themselves and their physicians. These patients are susceptible to diabetic complications such as hypoglycemia and hyperglycemia. It is therefore important that medical professionals be aware of potential risks that may be associated with fasting during Ramadan. Patients who insist on Ramadan fasting be assessed before Ramadan and receive appropriate education and instructions related to physical activity, meal planning, glucose monitoring, and dosage and timing of medications. In this article, management of diabetes in Ramadan is discussed.
Maryam Aalaa, Maryam Peimani, Hamid Reza Aghaei Meybodi,
Volume 13, Issue 3 (3-2014)
Abstract
Background: Today, the internet has been emerged as a potentially effective medium for information
exchange and in recent years, the use of web-based training programs has been steadily considered in
the prevention and management of chronic diseases such as diabetes. This technology provides an
opportunity to make health care more accessible for a large number of people and reduce costs. This
review provides a descriptive discussion of web-based behavioural interventions for the management
of type 2 diabetes mellitus.
Methods: Systematic literature searches were performed using Medline, Embase, Psycinfo, Web of
Science and Cochrane library to retrieve articles written in english and published between 2000 and
2012 which fulfilled all inclusion criteria. The search keywords were “diabetes” AND “intervention”
AND (“internet OR web”). Only randomised controlled trials and quasi experimental studies were
included in this review.
Results: A total of 15 studies were reviewed. Goal-setting, personalised coaching, interactive
feedback and online peer support groups were some of the successful approaches which were applied
in e-interventions to manage type 2 diabetes mellitus. Strong theoretical background, use of other
technologies and longer duration of intervention were proven to be successful strategies as well.
Conclusion: The web-based interventions have demonstrated some level of favourable outcomes,
provided they are further enhanced with proper e-research strategies.
Maryam Peimani, Camelia Rambod, Robabeh Ghodsi, Ensieh Nasli Esfahani,
Volume 15, Issue 4 (5-2016)
Abstract
Background: The objective of the current study is to assess the effectiveness of Mobile Short Message Service (SMS) intervention on education of basic self-care skills in patients with type 2 diabetes. Moreover, we aimed to determine whether delivering individually-tailored educational messages can be more effective than general educational messages.
Methods: A total of 150 patients with diabetes type 2 were randomized into three groups: tailored SMS group, non-tailored SMS group, and the control group. Biochemical parameters including HbA1c, FBS, lipid profile were evaluated for the three groups at baseline and after 12 weeks. Moreover, self-care Inventory (SCI), Diabetes Management Self-Efficacy Scale (DMSES) and Diabetes Self -Care Barriers assessment scale for Older Adults (DSCB-OA) were completed. In the tailored SMS group, each person received 75% of their messages based on the top two barriers to adherence that they had experienced and reported in their scale. In the non-tailored SMS group, random messages were sent to every patient.
Results: After12 weeks, although HgA1c levels did not significantly change, significant decline was observed in FBS and mean BMI in both intervention groups. Mean SCI-R scores significantly increased and mean DSCB and DMSES scores significantly decreased in both tailored and non-tailored SMS groups. In the control group, mean SCI-R scores decreased and mean DSCB and DMSES scores significantly increased (P< 0.001).
Conclusion: Sending short text messages as a method of education in conjunction with conventional diabetes treatment can improve glycemic control and positively influence other aspects of diabetes self-care. According to our findings, sending SMS regularly in particular times appears to be as effective as sending individually tailored messages.
Seyd Sayed Mazloomi, Mitra Mody, Hakimeh Malakimoghadam, Elahe Tavasoli, Zahra Vahdani Nia, Bi Bi Fatemeh Baghernezhad Hesary,
Volume 17, Issue 2 (3-2018)
Abstract
Background: Diabetes types 2 are non- communicable disease. During the past three decades, the number of people who have type 2 diabetes become more than doubled. In this disease more than 95 percent of process curing done by patients. Self – care behaviors are important way of controlling disease. Various studies have shown that many factors affect in self-care behaviors. This study aimed to determine the predictors of self- care in type 2 diabetic patients of Yazd and Brijand.
Methods: this study is analytical, descriptive and crosses – sectional. Data collected by using of questionnaire that was designed in 4 parts:
Knowledge questionnaire, self- care questionnaire, self – efficacy questionnaire and social support questionnaire. Data analysis by description and regression test.
Result: Mean score of Knowledge, self- efficacy, self – care and perceived social support don’t have significant different between two citys. Social support with a total direct and indirect have the most effect.
Conclusion: The aim of the training program in type 2 diabetic are promoting in self – care behaviors there for we can achieve this goal by increase perceived social support, self- efficacy and Knowledge.
Gholamreza Jafari Nadoushan, Hossein Hadinedoushan, Nasim Namiranian, Saeed Rezaei,
Volume 18, Issue 5 (7-2019)
Abstract
Background: Diabetes mellitus, which is associated with elevated blood glucose, lipids and liver enzymes, may results in alterations in the production of inflammatory cytokines, including chitinase-3-like protein 1 (YKL-40) and high-sensitivity C-reactive protein (hs-CRP), which induce and promote complications of diabetes such as atherosclerosis.The aim of this study was to evaluate the serum level of chitinase-3 like 1 protein (YKL-40) and high-sensitive C-reactive protein (hs-CRP) in type 2 diabetes with coronary artery disease compared to diabetic and healthy control.
Methods: This cross-sectional study was performed on 87 subjects in four groups, including: 23 samples as healthy control (Group 1), 22 patients with type 2 diabetes (Group 2), 20 patients with coronary artery disease (Group 3) and 22 patients with type 2 diabetes and coronary artery disease (Group 4). Serum Fasting blood sugar (FBS), Cholesterol, Triglyceride, Low density lipoprotein (LDL-C), High density lipoprotein (HDL-C), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), YKL-40 and hs-CRP were determined.
Results: The mean serum levels of FBS (Group 1 with 2 and 4, Group 2 and 3, P = 0.001), Cholesterol (Group 1 and 3, P = 0.03), Triglyceride (Group 2 and 3,p=0.027), HDL-C (Group 1 with 3 and 4, P = 0.02, P = 0.01 respectively), ALT (Group 1 and 4, P = 0.03, Group 2 and 4, P = 0.02) and AST (Group 2 and 4, P = 0.009) were significantly different..The mean serum levels of YKL-40 were significantly difference in the group 1(4.81±1.27 ng/ml) and group 2 (15.52±4.61 ng/ml) (P=0.01), group 3 (19.2±2.75 ng/ml, P=0.017) and group 4 (16.1±4.17 ng/ml, P=0.04). Also, The mean serum levels of hs-CRP in the group 3 (4.49± 1.53 μg/ml) and group 4 (1.28 ± 0.43 μg/ml) was significantly difference (P= 0.028).
Conclusion: Serum levels of YKL-40 are increased in people with type 2 diabetes and coronary artery disease. It is recommended to determine the serum level of this marker in these patients.
Bahram Jamali Gharakhanlou, Akram Ameghani, Ali Zarghami Khameneh,
Volume 21, Issue 3 (9-2021)
Abstract
Background: Imbalanced production of adipokines as leptin and adiponectin in diabetic patients may lead to the development of metabolic complications. Therefore, the aim of this study was to determine the effects of 2-month of caffeine ingestion along with aerobic training on changes in serum leptin and adiponectin levels and leptin/adiponectin ratio (LAR) in type 2 diabetic men.
Methods: Thirty-two diabetic men participated in
a quasi-experimental designs in the four groups for two-months period of a aerobic training (treadmill walking 3 times/week, 1.5 hour/session, 65-85% HRR) with and without caffeine ingestion (3 mg.kg
-1.day). Serum changes in leptin and adiponectin were measured during two phases (baseline and 24-hours after completing of the training program). Data were analyzed by one-way ANOVA and bonferroni's post-hoc test at level P≤0.05.
Results: Administration of two-months caffeine (CA) alone and combination with aerobic training (AT) were significantly could reduced and increased in leptin and adiponectin level, respectively (P=0.001). Thus, the combined group (AT+CA) effect were far more appropriate intervention in changing the studied indices (P=0.001). Also, the LAR method was notable reduced in all study groups, although these effects were more significantly in the combined group (AT+CA) (P=0.001).
Conclusion: It seems administration of caffeine supplementation and aerobic training for two-months have a positive effects on the improved relative of leptin and adiponectin levels as well as their ratio in diabetics, although the combination of these two variables has been shown to have far more dual effects.
