Showing 3 results for Diabetes.
Hassan Safaei, Masood Amini,
Volume 3, Issue 1 (5-2004)
Abstract
Patients with type 2 diabetes have a higher risk of coronary heart disease and a worse prognosis compared with patients without diabetes. In this study, the prevalence of cardiovascular risk factors have been investigated in type 2 diabetic patients.
Methods: A Cross Sectional study with a target population of known type 2 diabetic subjects was conducted in 2002 in Isfahan. From registered patients, 1150 were selected and evaluated for age. sex.duration of diabetes, BMI, hypertension, lipid profile, proteinuria, fasting blood glucose. HbAlc and smoking using convenience sampling methods.
Results: Mean fasting blood glucose and HbAl were 165.16 x 53.4 mg/dl and 9.2+ 3.5 percent respectively. The number of women with 3 cardiovascular risk factors was significantly greater than men (50.7% VS 33.5% PO.001). 19.5% of men and 50.2% of wjomen had high serum cholesterol level (>230 mg/dl). The prevalence of obesity (BMI >30Kg/m2) was 13.6% for men and 30.8% for women. 56.6% were hypertensive and 29.3% had proteinuria (P<0.001).
Conclusion: Cardiovascular risk factors are present in a considerable proportion of studied type 2 diabetic patients. Control of risk factors and life style modifications should be tightly considered in order to decrease the prevalence ofTHD in the up -coming years of their life.
Farzad Najafipour, Masoumeh Zareizadeh,
Volume 4, Issue 1 (7-2004)
Abstract
Background: Type 2 diabetes is a hereditary disease but the inheritance and responsible genes have not been clearly clarified yet.
According to the most studies, diabetes is one of the most common causes of mortality and morbidity in populations. Diabetes occurs in 30% of first degree family members of diabetic patients, But most people are not aware of their disease.
Methods: We studied first degree relatives of type 2 diabetes and screened them for diabetes, IFG and IGT.174 families(1556 people) of Tabriz residents were studied, among them 1232 persons grater than 30 years were alive and FBS and OGTT were done in this group .
Results: According to this study, 1232 persons were alive and 324 persons had died and DM was found in 343 (27.9%) and 82 (25.3%) of them respectively. We found 179 (14.5%) persons with IFG and 89 (7.2%) with IGT.The percent of diabetes in offspring and siblings were 32.9% and 22.1% respectively. The majority of patients had 41 – 50 years old. Risk of diabetes among offspring who had diabetes in both parents was more than the ones who had diabetic father or mother. In this study, women with diabetes were more than men (32.4% vs. 22.2% respectively). The prevalence of Diabetes type 2 in first-degree relatives was more frequent between sister and brother (41.95%), followed by that between father and son (10.9%).
Conclusion: Prevalence of diabetes in most populations is 8 – 10 %. If diabetes occurs in someone, risk of development of diabetes will increase to 30% in their family members. Therefore, screening must be done in all family members of diabetic patients to recognize the problem and to prevent from diabetes complication.
Mohammad Dastyar, Fatemeh Nikseresht,
Volume 25, Issue 1 (4-2025)
Abstract
Background: The aim of this study was to determine effect of resistance training on the expression of PI3K, AKT1 and mTORc1 in the heart tissue of type 2 diabetes rats and their physiological cardiac hypertrophy.
Methods: 21 male wistar rats (220±20 g) were obese by 6 weeks high fat diet (HFD). After inducing obesity, T2D induced by intraperitoneal injection of streptozotocin (30 mg/kg) in 14 rats. Finally, the rat were randomly assigned to 1) non-diabetes, 2) control T2D, 3) resistance diabetes groups. Rats in the resistance group were completed a resistance
training program, 5 sessions weekly for 6 weeks. PI3K, AKT1 and mTORc1 expression and the weight ratio of left ventricular to heart, left ventricular to body and heart to body were compared by ANOVA between groups.
Results: In response to induction of diabetes, the expression of PI3K, AKT1 and mTORc1 in heart tissue decreased significantly compared to the non-diabetic group (p < 0.05). Resistance training resulted in significant increase in the expression of PI3K, AKT1 and mTORc1 and the weight ratio of left ventricular to heart, heart to body and left ventricular to body compared to control diabetes rats (p < 0.05).
Conclusion: Resistance training is associated with physiological cardiac hypertrophy in diabetic rats, and this improvement can be attributed to the PI3K/AKT1/mTORc1 signaling pathway.
