Hossein Madani, Sadegh Valian Boroujeni, Noushin Naghsh,
Volume 4, Issue 2 (8-2004)
Abstract
Background: Alloxan is on of the xenobiotic agents which is classified as diabetogenic materials. Magnesium is an important cofactor regulating the activity of carbohydrate enzymes and lipid synthesis. In this study the contrasting effects of Alloxan and magnesium on plasma free fatty acids (FFA) in rats was investigated.
Methods: Male mature rats were used as test models for the diabetes induction. 28 rats received Alloxan (120mg/kg) intraperitoneally and plasma glucose level measurement after 72 hours demonstrated diabetes induction.
Results: The results were compared to the control groups, and confirmed the presence of diabetes in rats. Analysis of plasma FFA showed a significant increase (751.25 mM), compared to the control group (286.68 mM). In contrast, Measurement of red blood cell (RBC) Magnesium showed a significant decrease from 7.18 mg/dL in control group to 4.89 mg/dL in diabetic rats.
Conclusion: The results of this study showed that in diabetic condition, there was an inverse relationship between plasma FFA and RBC Magnesium. Therefore, these data suggest that analysis of the effects of Magnesium upon induction of diabetic condition could provide important information for management of diabetes.
Fatemeh Janbozorgi, Farshad Ghazalian, Khosrow Ebrahim, Hosein Abed Natanzi , Mandana Gholami,
Volume 22, Issue 4 (11-2022)
Abstract
Introduction: The purpose of this research was to explain the protective effect of quercetin on cardiac fatigue caused by exercise in skyrunning runners.
Methods: 26 professional sky running athletes voluntarily and purposefully participated in this race. Random people were placed in 2 groups: quercetin (13 people) and placebo (13 people). The race was held in the central Alborz mountains, the total distance traveled was 21 km and 200 meters, the altitude of the starting point was 1650 meters above sea level, the maximum altitude was 3150 meters above sea level. Before and immediately and 1 hour after the end of the race, blood was taken from the subjects. In order to check the changes of the studied variables, the independent T-test was used at the significance level of alpha 0.05.
Results: The amount of cardiac troponin T decreased significantly immediately and 1 hour after the end of the race in the quercetin group compared to the placebo group (P < 0.05). No significant difference was observed between the two groups of quercetin and placebo in the pre-test, immediately after the test and 1 hour after the test (P>0.05).
Conclusion: It seems that the increase of free fatty acids after the competition and long-term sports play an important role in reducing cardiac inotropic during the same period. Skyrunning competitions cause an increase in heart damage indices in professional athletes, despite this, quercetin supplementation reduces the increase in cardiac troponin T and can have a protective effect on the athlete's heart
