Showing 3 results for Glycosylated Hemoglobin
Massoud Amini, Mehrdad Hosseinpour, Gashtasb Sattari, Sasan Haghighi,
Volume 1, Issue 1 (7-2001)
Abstract
Background: Oral glucose tolerance testing (OGTT) is the gold standard for the diagnosis of diabetes mellitus and impaired glucose tolerance (IGT), but is time-consuming and difficult to perform. We investigated the value of glycosylated hemoglobin (HbA1C) in screening for diabetes mellitus and IGT.
Methods: In a cross-sectional study, we measured the HBA1C levels of 497 people referred for OGTT. We calculated the sensitivity and specificity of HbA1C at 1, 2, 3 and 4 SD above the normal mean. We plotted receiver operating characteristic (ROC) curves after assigning our subjects to the diabetic, IGT, ‘diabetic+IGT’, or normal group, based on WHO criteria for OGTT.
Results: HbA1C levels (mean ± SD) in the four groups were 9.2±1.5, 8.4±1.3, 7.9±0.8 and 6.8±0.7 percent in the diabetic, diabetic+IGT, IGT and normal groups, respectively. All differences were statistically significant (p<0.0001). ROC curve analysis showed that HbA1C levels above 7.5% (mean + 1SD) gave the best combination of sensitivity and specificity for the detection of diabetes (97.53% and 73.8%), IGT (66.37 and 69.44%), and diabetes+IGT (80.22% and 86.66%).
Conclusions: An HbA1C level of >7.5% is an optimal cutoff point for diabetes screening programs.
Melika Beihaghi, Hamideh Ghodrati Azadi, Zhila Taherzadeh, Hamid Reza Bahrami,
Volume 16, Issue 3 (3-2017)
Abstract
Background: In recent years, dietary supplements play an important role in maintaining a healthy diet in most chronic diseases such as diabetes. Spirulina platensis as a food supplement has been raised and regulator effects on cholesterol and antioxidant and immune regulating effects of this supplement are also considered. It contains vitamin B, beta-carotene, vitamin E, high value proteins, minerals, gamma linolenic acid and antioxidants.
Methods: In this study 50 patients with type II diabetes were randomly selected and after taking patient's history they were divided into two equal groups including control. 8 grams of spirulina that was prepared in tablet (each 1 gram) form was administered daily to patient group for three months. Fasting blood sugar levels monthly and hemoglobin A1C levels at the beginning and end of the projects were measured in both groups and their results were compared with each other.
Results: Fasting plasma glucose in patient group after 3 months of treatment with spirulina powder gave a significant reduction from the 158.1± 44.2 mg/dl at the beginning of study to 127.8 ± 36.7 mg/dl but was not significant in the control group. Glycosylated hemoglobin in the both groups decreased but this decrease was not statistically significant.
Conclusion: Spirulina platensis as a supplement can be administered in type II diabetic patients that used oral anti-diabetic drugs. It is effective in reducing fasting blood glucose in the short term but its effect on hemoglobin A1C need to prescribe longer.
Mahtab Aligholipour, Hossein Feizollahzadeh, Mozaffar Ghaffari, Faranak Jabbarzadeh,
Volume 18, Issue 2 (2-2019)
Abstract
Background: Patients with diabetes need to be educated efficiently and effectively in order to increase their quality of life. According to modern technological developments, multimedia message-based education is considered as one of the effective educational strategies. The purpose of this study was to investigate the effect of multimedia-based education in the Telegram application and in-person method on fasting blood glucose and glycosylated hemoglobin levels in patients with insulin-dependent diabetes.
Methods: In this clinical trial study, a sample of 66 patients with insulin-dependent diabetes who referred to the emergency department and the clinic of Sina hospital in Tabriz, were randomly assigned in double blocks into two groups: in-person education and multimedia-based education. Data gathering tools included a demographic form, glycosylated hemoglobin and fasting blood glucose were measured before and three months after the educational intervention. Data were analyzed with independent and paired samples t-tests.
Results: The results indicated that there were no significant differences in the mean values of glycosylated hemoglobin and fasting blood glucose between two groups before and after education(P >0.05). In within-group comparison, there was a statistically significant difference in the multimedia message group on the reduction of mean values of glycosylated hemoglobin (p= 0.02) but these values differences were not significant in in-person group (p= 0.33).
Conclusion: Multimedia-based education in the Telegram application compared to in-person education improves self-care and reduces the mean values of glycosylated hemoglobin in diabetic patients. This educational context can be used to facilitate the self-care education process to patients.
