Showing 6 results for Hyperglycemia
Hossein Hossein Zadeh, Farid Ilami,
Volume 1, Issue 1 (7-2001)
Abstract
Objective: To evaluate the effect of hyperglycemia on the antinociceptive activity of baclofen, a GABAB agonist, in mice.
Methods: We examined the antinociceptive effect of baclofen (2.5–7.5mg/kg injected intraperitoneally) in alloxan-induced mice using the hot-plate and tail-flick tests, both thermal tests.
Results: Baclofen produced a dose-dependent inhibition of hot-plate response in both normoglycemic and diabetic mice. The antinociceptive activity of baclofen was slightly reduced in diabetic mice. In comparison, the antinociceptive activity of morphine (10mg/kg), used as control, was significantly reduced in diabetic mice.
Conclusion: Our results show that hyperglycemia reduces the antinociceptive action of baclofen less than it does that of morphine.
Masoomeh Kourosh Arami, Abdolrahman Sarihi, Jila Behzadi, Seyed Mansour Malakouti, Iraj Amiri, Rafat Zare Ekbatani,
Volume 4, Issue 3 (5-2005)
Abstract
Background: The role of nucleus tractus solitarius in cardiovascular system regulation is controversial. On the other hand, study on the problem of hypertension in diabetic animals is the subject of many research programs. The aim of the present study was to determine wheather inactivation of nucleus can affect blood pressure in diabetic rats.
Methods: To this end , stereptosotocin-induced diabetic rats were anesthetized with Urethane and a cannula was inserted above nucleus. Blood pressure and heart rate were monitored using an intraarterial cannula. The cannulas were filled with L-glutamate (78 pmol/60 nL, to functionally identify the NTS see below), L-NAME(1nmol, to inhibit the nitric oxidergic neurons) and sodium nitroprusside (100mmol,as a NO-donor) .
Results: The results indicated that inactivation of nucleus in diabetic rats, had no effect on systolic and mean arterial pressure but enhanced diastolic blood pressure (P<0.05). There was no significant difference in heart rate between control and test groups.
Conclusion: Glucose affect on increasing blood pressure in rats with induced diabetes, in part, is caused by nitric oxidergic neurons resided in neucleus tractus solitarius.
Reza Rajabian, Mohammad Khajedeluee, Afsoon Fazlinejad, Javad Rezazadeh,
Volume 4, Issue 4 (6-2005)
Abstract
Background: Myocardial infarction is the most important cause of mortality all over the world. Complications may increase with some risk factors including stress hyperglycemia. The aim of this study was to evaluate the correlation and importance of hyperglycemia in acute intrahospital complications after AMI.
Methods: Prevalence of stress hyperglycemia among 160 patients with acute myocardial infarction (Q wave MI) was determined. These patients were divided into normoglycemic and stress hyperglycemic groups. These were compared according to complications such as heart failure, cardiogenic shock and mortality.
Results: 61% were normoglycemic and 7.5% had stress hyperglycemia. 25% had history of diabetes and 4.4% were not aware of diabetes. Among 18 patients with stress hyperglycemia, 6 patient (50%) and among 101 normoglycemic patients 18 (17.8%) were affiliated with cardiac failure that the difference were significant (P=0.02 and χ 2= 6.25). There were no cases of cardiogenic shock in both groups. Three patients died during first hours of admission (2.97%). They hadn't have history of diabetes. We could not assign them to normoglycemic or stress hyperglycemic groups since blood sampling had not been done yet.
Conclusion: Stress hyperglycemia can increase complications of AMI, significantly stress hyperglycemia caused increased incidence of heart failure in this study.
Farhad Hosseinpanah, Mehdi Rambod, Fereidoun Azizi,
Volume 6, Issue 3 (5-2007)
Abstract
Background: To determine the prevalence and characteristics of subjects with isolated post challenge hyperglycemia (IPH) defined as fasting plasma glucose (FPG) <126 mg/dl and 2-hour plasma glucose (2h-PG) ≥200 mg/dl.
Methods: We evaluated data and results of Oral Glucose Tolerance Test (OGTT) from 9745 participants in Tehran Lipid and Glucose Study (5589 women and 4156 men) aged>20years, without previously diagnosed diabetes mellitus (DM). A logistic regression model for having IPH was developed among subjects with FPG<126mg/dl to predict.
Results: The prevalence of IPH was 3.1% (n=302). 26.5% (n=80) of subjects with IPH had FPG<100mg/dl. The odds ratios for IPH were statistically significant for FPG≥100mg/dl (OR=9.5 95% CI: 7.1-12.5), age≥40 years (OR=2.6 95% CI: 1.8 - 3.7), triglycerides≥200 mg/dl (OR=2.1 95% CI: 1.6-2.7), hypertension (OR=2.0, 95% CI: 1.5-2.6) and abnormal waist circumference (females≥80, males≥90cm) (OR=1.9, 95%CI: 1.3-2.8).
Conclusion: This analysis showed that in Tehran urban subjects with FPG<126 mg/dl, variables such as FPG≥100 mg/dl, older age, hypertriglyceridemia, hypertension and abnormal waist circumference were significantly associated with higher likelihood of IPH OGTT would hence be recommended in subjects with above mentioned characteristics.
Javad Heidari, Bagher Larijani,
Volume 6, Issue 4 (6-2007)
Abstract
It is estimated that there are 1.1-1.5 billion Muslims worldwide, and prevalence of diabetes is approximately 4.6%. Many patients with diabetes insist on fasting during Ramadan, thereby creates a medical challenge for themselves and their physicians. These patients are susceptible to diabetic complications such as hypoglycemia and hyperglycemia. It is therefore important that medical professionals be aware of potential risks that may be associated with fasting during Ramadan. Patients who insist on Ramadan fasting be assessed before Ramadan and receive appropriate education and instructions related to physical activity, meal planning, glucose monitoring, and dosage and timing of medications. In this article, management of diabetes in Ramadan is discussed.
Fatemeh Nohtani, Morteza Behnam Rasouli, Sajad Sahab Negah, Masumeh Kheirabadi,
Volume 24, Issue 2 (6-2024)
Abstract
Background: Under hyperglycemic conditions, inflammatory processes with damage to the peripheral nerves are involved in the occurrence of neuropathy. This study aimed to compare the anti-inflammatory effects of metformin (synthetic drug) with gallic acid (natural compound) in hyperglycemic conditions.
Methods: Hyperglycemia was induced in male rats by the intraperitoneal injection of Streptozotocin (STZ) at a dose of 60 mg/Kg. For this research, rats were divided into four groups. Two groups were healthy control and hyperglycemic control rats that did not receive any drugs. The other two groups were hyperglycemic rats, which respectively received Metformin at a dose of 300 mg/kg/day and gallic acid at a dose of 40 mg/kg/day. At the end of the 8-week period, the rats in all groups were anesthetized and a sample of their sciatic nerve was taken to measure the expression level of genes related to pro-inflammatory cytokines IL-6, IL-1β and TNF-α. Data analysis was done by SPSS software and comparison between average data was done by one-way ANOVA and Tukey's post hoc test.
Results: Induction of hyperglycemic conditions in rats increased the expression of genes related to pro-inflammatory cytokines IL-6 (p=0/000), IL-1β (p=0/008) and TNF-α (p=0/005). However, administration of metformin and gallic acid to hyperglycemic rats for 8 weeks reduced the expression of IL-6, IL-1β and TNF-α genes (p˂0.05).
Conclusion: Gallic acid, like metformin, with its anti-inflammatory properties, can be effective in improving complications caused by hyperglycemic conditions, especially neuroinflammation, and it is hoped that it will be clinically useful for diabetic patients in the future.
