Iranian Journal of

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Background: Cardiomyopathy is a side effect caused by diabetes. Prolonged hyperglycemia gives rise to an increase in the expression of the receiver gene RAGE subsequently triggering pathogenesis cardiac signaling pathways in the heart of rats with type II diabetes. The present paper aims to examine how a 12 week Resistance training on gene expressions RAGE, ICAM, VCAM in the heart of diabetic rats with STZ.
Methods: 16 male Wistar rats with weight mean ranging from 200 ± 20 g were randomly assigned to two groups of Resistance diabetes (n = 8) and control diabetes (n = 8) and were kept under lab circumstances. A 12 week Resistance training was administered with the experimental group and 48 hours after the end of the last training session the rats were made unconscious and examined. Their hearts were, afterwards, cut out and the extent of gene expressions RAGE, ICAM, VCAM in the left ventricular heart was measured using Real time-PCR method.
Results: The results indicated there was a significant difference between left ventricular heart of the Resistance diabetes and that of control diabetes in terms of gene expression RAGE, yet no significant difference was detected between the two groups in terms of gene expressions ICAM, VCAM.
Conclusion: According to the results, in seems that Resistance trainings effectively reduce gene expressions RAGE and reduction pattern but non-significant in the Gene ICAM, VCAM in left ventricular heart of diabetic rats and therefore can be considered an effective way in reducing pathogenesis cardiac signaling pathways in the heart of rats with type II diabetes.

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Background: Inflammation plays an important role in the incidence and development of metabolic disorders and exercises along with dietary restrictions for weight loss. It has beneficial effects on reducing inflammatory markers, especially in type 2 diabetes. The purpose of this study was to evaluate the effect of combined exercise (resistance-aerobic) with and without diet restriction on weight loss on some inflammatory markers (CRP, TNF-α and ICAM-1) in elderly men with type 2 diabetes.
Methods: 42 elderly men with type 2 diabetes (age: 67.6 ± 2.2, weight: 85.2 ± 7.4, BMI: 28.2 ± 0.2) after homogenization based on serum levels Glucose and mass index were randomly assigned to one of 3 groups: Combined exercise (15), combined exercise with weight loss diet (14), and weight loss diet alone (n = 13). The combined exercise program included aerobic training with 50-70 percent of reserved heartrate and resistance training included chest press, cable pull-down, machine leg extention and machine lying leg curl on 3 sessions per week for 12 weeks.

Results: After 12 weeks of intervention, there was a significant decrease in serum inflammatory markers levels (CRP, ICAM-1 and TNF-α) in the post-test compared to the pre-test in all three groups (P<0.001). However, bonferroni post-hoc analysis showed that combined exercise with diet compared to combined exercise and dietary restriction alone had more effects on reducing CRP, ICAM-1 and TNF-α (P<0.001). In addition, reduction of ICAM-1 (P<0.001) and TNF-α (P<0.001) after combined exercise compared to dietary restriction and CRP reduction after dietary restriction than combined exercise was significantly higher (P<0.001).

Conclusion: It suggested that in elderly type 2 diabetic patients, caloric restriction-induced weight loss with combine exercise is more appropriate for modulating of endothelial biomarkers and Inflammation dysfunctional levels than resisted exercise training or aerobic training alone.