Showing 31 results for Intensity Interval Training
Bahareh Heidari Sharif Abadi, Farzaneh Taghian,
Volume 17, Issue 6 (10-2018)
Abstract
Background: The purpose of this study was to determine the effect of 10 weeks of Intensity Interval Training and Supplementation green tea on serum level of irisin and insulin resistance in obese women with type 2 diabetes
Methods: In this semi-experimental study,48 women with type II diabetes (aged 49/55±3/04 years with Weight 76/72±5/78 kg, Height 153/33±5/06 Cm, BMI 31/75±1/41 Kg/m2, selected and grouped randomly into four groups the intensity interval training (n=12), combined (green tea extract along with intensity interval training) (n=12) green tea extract (n=12), and the control group(n=12). Training group performed training programs including 3sessions per week at maximum intensity of 75-85% heart rate and the supplement group consumed 3 tablets of green tea (500 mg) daily for 10 weeks high intensity interval training and the supplement group both underwent intervention. Blood samples were collected before and after the intervention in fasting state. The obtained data was analyzed using of variance (ANOVA) and Tukey post hoc test and paired t-test analysis. The significant level was P<0/05.
Results: The results showed that irisin levels and maximum oxygen consumption in all three groups increased significantly after 10 weeks compared to the control group (P≤0.05) Also, the results indicate a significant increase in irezin in the combined group compared with the green tea group. Serum insulin level, glucose, insulin resistance and weight, body mass index decreased significantly in all three groups compared to control group and green tea group and combination group (P≤0.05).No significant difference was found between the groups in the irisin levels)P>0.05).
Conclusion: Regarding the results of this study, it seems that performing periodic exercises along with supplementation of green tea due to increased irisin and glucose reduction can be helpful in improving insulin resistance in patients with type 2 diabetes. Perhaps the desired results can be achieved by increasing the duration of exercise and supplementation with iyrosin and the maximum oxygen intake.
Rahman Soori, Mahdi Angouti, Mohammad Reza Asad, Sadegh Sattarifard, Azam Ramezankhani,
Volume 17, Issue 6 (10-2018)
Abstract
Background: Zinc-Alpha 2-Glycoprotein (ZAG) has recently been implicated in the regulation of adipose tissue metabolism due to its negative association with obesity and insulin resistance. The purpose of this study is to investigate the effect of eight weeks HIIT on level of ZAG in plasma and adipose tissue in type 2 diabetic male rats.
Methods: Twenty one male rats were divided into the three groups of sham control (healthy), control (diabetic), and interval training (diabetic with training). The training group received 8 weeks of training sessions each with 5-12 repetitions of high intensity training for 15-30 seconds at the speed of 27-34 meters per second on a treadmill followed by one minute of active rest. Twenty four hours after the training session blood and body fat samples were taken to measure ZAG levels. The data was analyzed using one-way ANOVA and Tukey’s post hock test at the significance level of 0.05 (P<0.05).
Results: There were significant differences between the sham control and the control with respect to ZAG contents in adipose tissue, which was lower in the diabetic control group (P<0.001). Moreover, significant differences in ZAG contents of adipose tissue were also observed between the sham control and the group receiving the training, with the sham control having higher ZAG contents in adipose tissue (P<0.005). The eight-week HIIT significantly increased the amount of secreted ZAG in adipose tissue compared to the control diabetic group (P=0.003). No significant differences were recorded between the groups in ZAG plasma levels.
Conclusion: The HIIT increased ZAG content in the adipose tissue of the male diabetic rats. This can reduce insulin resistance in type 2 diabetes.
Karim Azali Alamdari, Mousa Khalafi,
Volume 18, Issue 1 (1-2019)
Abstract
Background: Fibroblast growth factor 21 (FGF21) plays an important role in regulation of energy metabolism and insulin resistance; however, the synergistic effects of high intensity interval training (HIIT) on FGF21 and insulin resistance are not elucidated which was focused in this study.
Methods: This experimental research was conducted by pretest- posttest design with control group. In this study, 24 obese men were assigned into two groups including
HIIT (n=12, age: 39.83 ± 5.63 years, weight: 100.83 ± 5.81 kg and body mass index: 32.73 ± 2.8 kg/m2) and Control (n=12, age: 39.41 ± 5.23 years, weight: 100.08 ± 4.71 kg, and body mass index: 32.34 ± 1.43 kg/m2). The HIIT group experienced eight weeks of intensive exercises (three sessions per week, four bouts in each session at the intensity of 85-90% of maximum heart rate (MHR) with 3-minute active rest intervals (at 60-50% of MHR) between exercise bouts. Blood samples were collected at baseline and also 48 hours following to the last training session. The data were compared using paired and independent samples t tests.
Results: HIIT resulted in a contemporary reduction of plasma glucose and serum insulin and FGF21 and also improved HOMA index (P˂0/05).
Conclusion: High intensity interval training plays an effective role in improvement of insulin resistance and reduction of serum FGF21 in obese subjects, which may be due to an improved FGF21 resistance.
Saleh Afrasyabi, Seyed Mohammad Marandi, Mehdi Kargarfard,
Volume 18, Issue 1 (1-2019)
Abstract
Background: The aim of this study was to investigate the effect of 12 weeks of high intensity training on IL-
6, GLP-1 and lipid profiles in type 2 diabetic patients
Methods: 80 participants (40-50 years old) volunteered to participate in the study and divided into eight groups (four groups of severe periodic exercises and four uncontrolled control groups). Blood samples were collected and analyzed for measuring IL-6, GLP-1, lipid profile and glycemic index before and after weeks 4, 8 and after the training program.
Results: After 12 weeks of training, the effect of time and interaction between time × group on GLP-1 and IL-6 variables was statistically significant. Also, there was a significant difference between groups based on 12 weeks of training in these indices. Lipid profile was significantly improved in type 2 diabetic and glycemic control in obese and non-diabetic groups that had 12 weeks of high intensity interval training.
Conclusion: Overall, high intensity interval training, through changes in various mechanisms, lead to improvement in lipid and glycemic disorders, inflammation and appetite in obese people with type 2 diabetes. Hence, according to the findings of the study, researchers suggest that performing high intensity interval training can lead to significant improvements in obese subjects (with and without type 2 diabetes).
Masoud Jokar, Mohammad Sherafati Moghadam,
Volume 18, Issue 6 (9-2019)
Abstract
Background: Diabetic cardiomyopathy is a complication type 2 diabetes mellitus that can lead to cardiac muscle autophagy through the proteins FOXO3a and Beclin-1. Therefore, the aim of this study is to investigate the effect of 8 weeks High intensity interval training (HIIT) on the content of FOXO3a and Beclin-1 proteins in heart muscle tissue of Sprague-Dawley rats with type 2 diabetic rats.
Methods: In this experimental study, 12 two-month-old Sprague-Dawley rats with a mean weight of 270±20 g were selected. After diabetic induction with STZ and Nicotinamide, rats were randomly assigned to two groups, diabetic training (6 heads) and diabetic control (6 heads). The training group trained for 4 days a week in accordance with the training program (each session 42 minutes, 10-30 m/m) for 8 weeks, while the control group did not have any training program. Also, rats did not receive any insulin treatment during the study period. The independent t-test was used to analyze the data. Significance level is considered p≤0.05.
Results: Eight weeks of HIIT training resulted in a significant decrease in FOXO3a (P=0.008) and Beclin-1 (P=0.002) proteins content in diabetic training group compared to diabetic control group.
Conclusion: It can be said that eight weeks of HIIT training decreased the FOXO3a/Beclin-1 autophagy pathway by decreasing FOXO3a and
Beclin-1 protein content. Therefore, the use of HIIT exercises may be useful for diabetic subjects who are prone to diabetic cardiomyopathy.
Maryam Seyed Heaydari, Abbas Aadeghi, Ali Hemati Afif,
Volume 19, Issue 2 (1-2020)
Abstract
Background: Cytokines are immune related factors. Production of pro inflammatory cytokines in diabetic patients is increased, which is exacerbated by vigorous training. This study investigates the response of serum IL-2 and IL-4 to eight-week high Intensity Interval Training (HIIT) with caffeine intake on inflammatory and anti-inflammatory responses in diabetic rats.
Methods: In a clinical-interventional animal study, 50 male rats were randomly assigned to 5 equal groups (control group (C), diabetes group (D), diabetes + caffeine group (D+Ca), diabetes + training group (D+T), diabetes + training + caffeine group (D+Ca+T)) and subjected to 8 weeks of caffeine supplementation (70 mg / kg of caffeine powder was injected five days each week) and 8 weeks of 5 sessions per week with 6 to 12 times, 2-min intervals with intensity of 85-90% of maximal speed. 48 hours after the last training session, immunological factors including IL-2 and IL-4 were measured. Statistical analysis of variables was performed using One-way ANOVA and Tukey tests at the significant level (P<0.05).
Results: The results showed that (D+Ca) group had the lowest IL2 in comparison with (D) group (P= 0.001). IL-4 had the highest in (D+Ca) and (D+Ca+T) groups (P = 0.001). But these differences were not statistically significant between (D+Ca) and (D+Ca+T) groups (P= 0.67).
Conclusion: It seems that caffeine to play a role in improving the status of IL-2 and IL-4 in streptozotocin-induced diabetes, but HIIT exercises are not effective in this regard.
Amir Akbari, Hamid Mohebbi, Elma Tabari,
Volume 19, Issue 2 (1-2020)
Abstract
Background: The aim of this study was to investigate the effects of high fat diet-induced obesity and interval and continuous exercise training on visceral fat SIRT1 and insulin resistance in male rats.
Method: Forty male rats were divided into two groups: high-fat diet (HFD; n=32) and standard diet (C; n=8). After 10 weeks inducing obesity, eight rats from the HFD and C groups were sacrificed, and rest of obese rats were randomly divided into three groups: obesity control (OC), moderate intensity continuous training (MICT) and high intensity interval training (HIIT). The HIIT and MICT protocols were performed for 12 weeks and 5 sessions per week. Visceral fat samples were collected to measure protein levels of SIRT1 by western.
Results: Induction of obesity was associated with a significant decrease in visceral fat SIRT1 and an increase in insulin resistance (P˂0.05). In contrast, both HIIT and MICT significantly increased visceral fat SIRT1 protein levels (P˂0.05), whereas HIIT effects were significantly higher (P˂0.05). Also, both HIIT and MICT protocols improved insulin resistance (P˂0.05).
Conclusion: Exercise training is likely to play an important role in regulation of visceral fat SIRT1 and because of that may be effective in improving insulin resistance. The increase in SIRT1 also appears to be dependent on the intensity of exercise training.
Marzieh Hafezi, Mandana Gholami, Hossein Abednazari ,
Volume 19, Issue 3 (2-2020)
Abstract
of obesity and inactive physical activity, and glucose modulation is of great importance in these individuals. Thyme was studied on type 2 diabetic rats by streptozotocin and high fat diet.
Methods: Male Wistar rats weighing 110±10 g were used in this study. The rats were randomly divided into four groups of Thymus + Exercise, Thymus, Exercise and Control groups. The extract was taken 200 g daily through a gavage syringe. Exercise included: Running on a treadmill at a speed of at least 20 m / min and a maximum of 38 m / min for 60 minutes daily, 5 days a week, for 8 weeks. Serum malondialdehyde (MDA), glutathione peroxidase (GTX), superoxide dismutase (SOD), catalase (CAT) were measured by ELISA method.
Results: Serum MDA and CAT levels were significantly higher in the control group (p = 0.002). The results also showed that there was no significant difference between SOD and GPX levels in different research groups (p = 0.790).
Conclusion: Intermittent exercise (HIIT) and thyme extract can improve oxidative and antioxidant balance in diabetic rats.
Afshar Jafari, Ali Zarghami Khameneh, Saeid Nikookheslat, Pooran Karimi,
Volume 19, Issue 4 (4-2020)
Abstract
Background: Autophagy is a new therapeutic strategy aimed at reducing the diabetic abnormalities. While excessive or insufficient autophagic activity during diabetes leads to altered cellular homeostasis. So, aim of the present study was conducted to determine the effect of eight-week high-intensity interval training (HIIT) along with caffeine injection on the levels of some myocardial autophagy-related proteins in diabetic rats.
Methods: In experimental design, fifty male white wistar rats with an age range of 3-2 months (average weight 250±25 g) were randomly divided into 5 groups of homogeneous 10 rats in each group: Healthy control (C: intraperitoneal injection of saline), Diabetic control (D: high-fat diet combined with a single intraperitoneal injection of streptozotocin, Diabetic with training (D+T: running with intensity at the 85-90% of maximum speed in 5 to 12 bout of 2 min-1; 5 days/week for 8 weeks), Diabetic with caffeine supplementation(D+CA: intraperitoneal injection of pure caffeine at 70 mg.kg-1 5 days/week for 8 weeks), Diabetic with training and with caffeine supplementation (D+T+CA). For evaluate changes in the expression profile of some of the genes associated with autophagy signaling pathway (LC3-II, ULK-1, Beclin1) in the myocardium (left ventricular), based on Western blot analysis will be used. Also, the one-way analysis of variance (ANOVA) and Tukey post hoc test were be used to analyze the data.
Results: The expression of all autophagic proteins in diabetic with trained and non-trained groups was higher than in healthy
group (P≤0.05). On the one hand, the expression of autophagy-related proteins in the trained group with caffeine supplementation was significantly higher than that of the training group without caffeine intake (P=0.001).
Conclusion: The findings of this study suggest that caffeine injection exacerbated the expression of autophagic proteins induced by diabetes; On the other hand, high-intensity interval training can as a preventive strategy, modulate diabetes-induced myocardial autophagy.
Sepideh Salehi, Niku Khosravi, Maryam Delfan,
Volume 19, Issue 5 (6-2020)
Abstract
Background: The prevalence of type 2 diabetes is rapidly increasing in the world. As a result of this disease, long-term insulin resistance develops, as a result of which pancreatic beta cells are destroyed and disappear, as a result insulin is not released. Recently, a protein called lipasin, which is responsible for signaling the liver to beta cells, has been discovered, and previous reports have shown that lipasin/betatrophin increases pancreatic β cell proliferation. Therefore, the aim of this study was to investigate the effect of eight weeks of high intensity interval training (HIIT) and endurance training on lipasin gene expression in rats with type 2 diabetes.
Methods: The study was performed on 25 Wistar rats with a mean weight of 160±10 g and age of 8 weeks. After induction of diabetes, the rats were randomly divided into three groups of 6: control and endurance and HIIT. And exercise was performed for eight weeks (5 sessions per week). QRT-PCR technique was used to evaluate changes in hepatic lipasin gene expression.
Results: The present study showed that after eight weeks of endurance training and HIIT, the expression of lipasin gene in the liver of rats in the training group increased significantly compared to the control group (P = 0.037); Also, a significant negative correlation was observed between lipasin gene expression and insulin resistance index in the exercise group compared to the control group (r = -0.605, P = 0.037).
Conclusion: It seems that performing eight weeks of endurance training and HIIT, by increasing the expression of lipasin gene can increase beta cells in diabetic patients and may be an effective non-pharmacological intervention to reduce the symptoms of this disease.
Morteza Khalili, Abbas Sadeghi, Mohammad Javad Javad Maleki,
Volume 19, Issue 5 (6-2020)
Abstract
Background: The relationship between low PGC-1α expression and several metabolic diseases such as diabetes and obesity has been identified. This study investigates the effect of eight-week high intensity interval training (HIIT) and caffeine intake on mitochondrial biogenesis in soleus muscle in diabetic rats induced Streptozotocin.
Methods: In a clinical-interventional animal study, 50 male rats were randomly assigned to 5 equal groups (control group(C), diabetes group(D), diabetes + caffeine group(D+Caf), diabetes + training group(D+T), diabetes + training + caffeine group(D+CAF+T)) and subjected to 8 weeks of caffeine supplementation (70 mg / kg of caffeine powder was injected five days each week) and 8 weeks of 5 sessions per week with 6 to 12 times, 2-min intervals with intensity of 85-90% of maximal speed. Blood was collected directly from the left ventricle to measure blood glucose levels. The soleus muscle of the left leg was extracted and PGC-1α measured by Western Blot method. Independent t-tests, two-way analysis of variance, and Eta squared (p <0.05) were used to analyze the data.
Results: The results showed that induction of diabetes significantly increased blood glucose (P <0.01) and significantly decreased mRNAPGC-1α (P = 0.002). Also, both high-intensity interval training (p = 0.001) and caffeine supplementation (p = 0.03) significantly increased mRNAPGC-1α.
Conclusion: Based on the results of this study, it is possible to suggest the use of HIIT and caffeine consumption as an effective intervention in increasing mitochondrial biogenesis in diabetics. However, a clear statement in this regard requires further research in this area.
Farzaneh Karimi, Farhad Daryanoosh, Mohsen Salesi, Javad Nemati,
Volume 19, Issue 6 (8-2020)
Abstract
Background: Obesity and type 2 diabetes can impair the function of cells, including CREB and CRTC2 proteins, which are important for regulating adipose tissue metabolism. Therefore, the purpose of the present study was to investigate the effect of eight weeks of high intensity interval training (HIIT) on CREB and CRTC2 proteins levels in subcutaneous adipose tissue of obese rats with type 2 diabetes.
Methods: In this experimental study, 12 head two-month-old Sprague-Dawley rats with a mean weight of 300±20 g were selected. After diabetic induction with Streptozotocin and Nicotinamide, rats were randomly assigned to two groups, diabetic training (6 heads) and diabetic control (6 heads). The training groups performed the training program 4 days a week for 8 weeks, including 5
interval 4-minute with an intensity of 85 to 95% of the maximum speed, and 3-minute active rest periods with an intensity of 50 to 60% of the maximum speed; SPSS software version 23 and independent t-test were used to analyze the data.
Result: After eight weeks of HIIT training, no significant change in CREB protein level was observed in the
training group compared to the control (P<0.22); However, a significant increase in CRTC2 protein level was observed in the training group compared to the control (P<0.005);
Conclusion: HIIT training did not result in a change in CREB protein level. But, it was able to increase the CRTC2 protein level, which could lead to the regulation of adipose tissue metabolism in diabetic subjects.
Maryam Delfan, Malihe Rabiee, Raheleh Amadeh Juybari,
Volume 20, Issue 3 (2-2021)
Abstract
Background: Imbalance of apoptotic factors plays important role in pathogenesis of diabetes. Considering the role of curcumin supplementation and high-intensity interval training (HIIT) on these factors, the aim of this study was to investigate effects of four weeks of HIIT with curcumin supplementation on Bax and Bcl-2 gene expression in the soleus muscle of diabetic rats.
Methods: Present study was experimental research. 30 male Wistar rats were divided into one normal control (NC), and four diabetic groups: control (DC), supplement (SDC), high-intensity interval training (DHIIT) and high-intensity interval training supplement (SDHIIT). The training protocol was performed five days a week for four weeks, which included five to seven two-minute intervals at 80 to 90% of maximum power until exhaustion and one-minute recovery at 30% of maximum power until exhaustion. At the same time, Curcumin gavage at a dose of 100 mg/kg was performed daily. Bax and BCL-2 gene expression levels were measured by the qReal-TimePCR method and data were analyzed by two-way analysis of variance at a significant level of p≥0.05.
Results: Bcl-2 gene expression was significantly increased in DHIIT and SDHIIT groups compared to DC (P= 0.000). Also, a significant decrease in Bax gene expression was observed in DHIIT and SDHIIT groups compared to DC (P=0.000). There was a significant difference between DHIIT and SDHIIT in Bcl-2 (P=0.000) and Bax (P=0.013) gene expression.
Conclusion: It seems that HIIT in combination with curcumin supplementation, is more effective in improving the balance between apoptosis factors than any of these interventions alone.
Seyedeh Sogand Hosseini, Mohammedreza Esmaelzadeh Toloee,
Volume 21, Issue 1 (3-2021)
Abstract
Background: TORC1 protein is an important factor in regulating adipose tissue metabolism. Type 2 diabetes can lead to dysfunction and the development of obesity. Therefore, the aim of the present study was to investigate the effect of eight weeks of high-intensity
interval training (HIIT) and endurance on blood
glucose and TORC1 protein content in subcutaneous adipose tissue of obese with type 2 diabetes rats.
Methods: In this study, 18 head 2 Sprague-Dawley male rats with a mean weight of 270±30 g were selected. After becoming type 1 diabetic through streptozotocin and Nicotine amide solution, they were randomly divided into 3 groups: 1) HIIT training 2) endurance training and 3) control (6 heads per group). Exercise groups exercised 4 days a week for 8 weeks according to HIIT and endurance training programs. SPSS software version 23, one-way ANOVA and Tukey post hoc test were used to analyze the data.
Result: Eight weeks of HIIT and endurance training resulted in a significant decrease in blood glucose level (p<0.0001) and a significant increase in TORC1 protein content (P<0.0001) compared to the control group.
Conclusion: HIIT and endurance training lowered blood glucose levels and increase TORC1 protein content, which this training can be a suitable and non-invasive treatment to control diabetes and also regulate adipose tissue metabolism in type 2 diabetics who are prone to obesity.
Neda Aghaei Bahmanbeglou, Reza Salboukhi, Mohammad Sherafati Moghadam,
Volume 21, Issue 2 (7-2021)
Abstract
Background: FOXO family proteins are important factors in autophagy
pathway. Protein kinase-B is an important regulator for this family that can be regulated through exercise training. Therefore, the aim of this study is to investigate the effect of protein
kinase-B (PKB) on FOXO autophagy family proteins (FOXO1 and FOXO3a) following
high intensity interval training (HIIT) in the left ventricle of the heart of diabetic rats by streptozotocin (STZ) and nicotinamide.
Methods: In this experimental study, 12 two-month-old Sprague-Dawley rats with a mean weight of 270±20 g were selected. After type 2 diabetes induction with STZ and Nicotinamide, rats were randomly assigned to two groups, diabetic training (6 heads) and diabetic control (6 heads). The training group trained for 4 days a week in accordance with the training program for 8 weeks. SPSS software version 23 and independent t-test were used to analyze the data. Significance level is considered p≤0.05.
Results: HIIT training resulted in a significant increase in PKB protein content between training and control groups (P=0.0001). In contrast, a significant decrease in protein content of FOXO1 (P=0.003) and FOXO3a (P=0.006) was observed between the training and control groups.
Conclusion: It seems based on the results
HIIT with increasing and regulating PKB leads to a decrease and inactivation of FOXO1 and FOXO3a proteins in the hearts of diabetic subjects. Inhibition of these proteins can prevent excessive cardiac autophagy in diabetic subjects.
Akbar Ghodratnama, Maryam Shabani, Mohammad Sherafati Moghadam,
Volume 21, Issue 5 (1-2022)
Abstract
Background: Diabetes is an important factor in heart defects that can lead to atrophy of heart cells. Exercise can prevent the complications of diabetes by regulating cellular factors. Therefore, the aim of the present study was to evaluate the effect of endurance and
high-intensity interval training on the content MSTN and Follistatin proteins in the left ventricular tissue of the heart of type 1 and 2 diabetic rats
Methods: In this study, 36 head 2-month-old male Sprague-Dawley male rats with a mean weight of 280±30 g were selected.
After induction of type 1 (18 head) and 2 (18 head) diabetics through streptozotocin and nicotinamide solution, each type of diabetes was randomly divided into 3 groups: endurance training, HIIT and control (6 heads per group); The training groups performed endurance (50 to 70% of maximum speed) and HIIT (intensity 85 to 95% of maximum speed) training program 4 days a week for 4 weeks; Data analysis was performed by one-way ANOVA and Tukey post hoc tests in SPSS software.
Results: Endurance training and HIIT in diabetic training groups led to a significant decrease in MSTN protein content (P=0.0001) and an increase in Follistatin protein content (P=0.0001).
Conclusion: It seems that four weeks of endurance
training and HIIT can prevent excessive myocardial atrophy by decreasing the MSTN content and increasing
Follistatin. Therefore, exercise training with the intensity, duration and type can be a good defense and treatment mechanisms for diabetics to prevent or reduce heart complications.
Abdol Nasser Seidi, Neda Aghaei Bahmanbeglou, Habib Asgharpour, Mozhgan Ahmadi,
Volume 22, Issue 3 (9-2022)
Abstract
Background: MAFbx and MuRF1 proteins are important factors in the ubiquitin pathway and are responsible for muscle atrophy. The purpose of this study was to investigate the effect of long-term high-intensity interval training (HIIT) on the intracellular content of MAFbx and MuRF1 proteins in the left ventricular of the heart of rats with type 2 diabetes.
Methods: In this experimental study, 18 rats 2-month-old male Sprague-Dawley rats with a mean weight of 270±20 g were selected. 12 rats became diabetic by intraperitoneal injection of Streptozotocin and nicotinamide solutions. These rats were randomly divided into 2 groups: diabetic training and diabetic control; A healthy control group was also considered. The training group practiced HIIT 4 days a week for 8 weeks. Data were analyzed using SPSS software version 23 and one-way ANOVA and Tukey post hoc tests.
Results: MAFbx protein content showed a significant decrease after 8 weeks of HIIT (P=0.0001); Tukey post hoc test showed that this change was significant between pairs groups of diabetic training and diabetic control and also between pairs groups of diabetic control and healthy control (P=0.0001). MuRF1 protein content showed a significant decrease (P=0.0001); This was a significant difference between the pairs groups of diabetic training and diabetic control, diabetic training and healthy control groups, as well as diabetic control and healthy control groups (P=0.0001).
Conclusion: HIIT seems to can inhibit the process of atrophy and autophagy of cardiomyocytes by reducing the content of MAFbx and MuRF1 proteins in the hearts of diabetic subjects.
Mahboobeh Rangraz Tabatabaei, Masoud Nikbakht, Rohollah Ranjbar, Farhad Daryanoosh, Mohsen Ghanbarzadeh,
Volume 23, Issue 1 (5-2023)
Abstract
Background: The release of adipokines from adipose tissue depots plays a key role in regulating metabolic homeostasis and several other physiological processes, including diabetes, obesity, and vascular diseases. This study investigated the effect of eight weeks of high intensity interval training (HIIT) on asprosin, lipid profile and insulin resistance in type 2 diabetic male rats.
Methods: 24 male Sprague Dawley rats were randomly divided into four equal groups: control (C), control traning (C+T), diabet (D) and diabet traning (D+T). Diabetes was induced by the combined method of high fat diet and low dose strepotozocin injection. The traning group performed the HIIT program on the treadmill for eight weeks. Data were analyzed using one-way ANOVA and bonferroni post hoc test at a significance level of P<0.05.
Results: The results showed increased plasma asprosin in D group compared to C (P=0.0001) and decreased in C+T group compared to C (P=0.03) and D+T group compared to D (P=0.04). There was no significant difference in HOMA-IR between the C and C+T group (P=0.9) but decreased in D+T compared to D (P=0.0001). HDL increased in D+T group compared to the D (P=0.0001) and decreased TG and LDL (P=0.001). There was no significant difference between TG and LDL in the C group compared to the C+T, but HDL increased in C+T (P=0.01).
Conclusion: Plasma asprosin increases in rats with type 2 diabetes and HIIT can reduce the complications of diabetes by improved lipid profile and reduce asprosin and insulin resistance.
Sedigheh Babaee, Maghsoud Peere, Mohammad Ali Azarbayjani, Maryam Delfan,
Volume 23, Issue 1 (5-2023)
Abstract
Impaired insulin function with exogenous changes is a major cause of heart failure. The purpose of this study was to investigate the effect of four weeks of high intensity interval training with curcumin supplement on the expression of IRS-1 and IRE-1α gene in the Left ventricle of type 2 diabetic rats.
Methods: In the present experimental study, 30 male mice with diabetes were divided into five groups of 6; high intensity interval training (HIIT), High intensity interval Training+Curcumin(S+HIIT), Diabetic control+curcumin(S+DC), Diabetic Control (DC), Normal control (NC). The High intensity interval training protocol was performed five days a week for four weeks. Curcumin gavage at a dose of 100 mg/kg was performed daily. The expression of IRS-1 and IRE-1α were measured by the qReal-TimePCR method, and data were analyzed by one-way ANOVA at the alpha level of 0.05.
Results: IRS-1 gene expression in the S+HIIT group compared to the DC (P=0.003) and S+DC (P=0.001) groups and in the HIIT group compared to the DC (P=0.002), and S groups +DC had a significant decrease (P=0.019). IRE-1α gene was significantly decreased in S+HIIT group compared to DC (P=0.003), S+DC (P=0.001) and HIIT (P=0.008) groups.
Conclusion: It seems that HIIT with curcumin supplement can reduce the process of myocardial apoptosis in diabetic patients by improving metabolic conditions and genetic factors.
Moazameh Malekpour, Rasoul Rezai, Mohsen Salesi, Farhad Daryanoosh, Javad Nemati,
Volume 23, Issue 2 (5-2023)
Abstract
Background: Diabetes leads to numerous side effects in the cardiovascular system and also to improper functioning of the body's antioxidant system. The aim of this study is to investigate the effect of six weeks of high-intensity interval training with coenzyme Q10 supplementation on the values of Nrf2 and NQO1 in heart muscle of elderly diabetic rats.
Methods: In this experimental study, 48 elderly male rats (18 months old) were randomly divided into four groups of intense aerobic exercise with coenzyme Q10 supplementation, intense aerobic exercise group, coenzyme Q10 supplement intake group, and control group. Induction of diabetes was done by injecting a single dose of streptozotocin in the amount of 60 mg/kg intraperitoneally. The program of high intensity interval training was done for six weeks. Coenzyme Q10 supplement group received orally at a dose of 200 mg/kg. Western blot method was used to measure Nrf2 and NQO1 values. The data were analyzed by one-way analysis of variance and Tukey's post hoc test at a significance level of P <0.05.
Results: The results showed taking coenzyme Q10 supplement (P= 0.014), intense intermittent exercise (P= 0.001) and intense intermittent exercise with coenzyme Q10 supplement (P= 0.001) significantly increased Nrf2 values in the hearts of diabetic elderly rats. Also, the use of coenzyme Q10 supplement (P=0.0366), intense intermittent exercise (P= 0.014) and intense intermittent exercise along with coenzyme Q10 supplement use (P= 0.002) significantly increased the amount of NQO1 in the hearts of diabetic aged male rats.
Conclusion: Intermittent intense training along with supplement consumption improves heart function in elderly diabetic patients through increasing endogenous antioxidant enzymes.
