Seyed Mehrdad Sulati, Arash Ghanbarian, Maziayar Rahmani, Narghes Sarbazi, Sima Alah Verdian, Fereidoun Azizi,
Volume 2, Issue 2 (6-2003)
Abstract
Background: Risk factors of cardiovascular disorders have been the subject of several studies. Recently, simultaneous high waist circumference (WC) and high serum triglyceride (Tg) has been proposed as a simple screening measure to predict non-traditional risk factors. This study has looked at the risk factors of cardiovascular disorders present in subjects with this phenotype.
Methods: Non diabetic females of age 18-65 years who had been enrolled in the Tehran Lipid and Glucose Study (TLGS) were recruited.
Based on fasting Tg and WC, subjects fell into four categories: TgHWH ( Tg>160 mg/dl, WC>80 cm), TgHWL (Tg>160 mg/dl,WC<80 cm), TgLWH(Tg<160 mg/dl,WC>80 cm) and TgLWL (Tg<160 mg/dl,WC<80 cm).
Cardiovascular risk factors including lipid profiles and anthropometric variables were compared between the categories. The prevalence of hypertension, LDL-C>130 mg/dl, total cholesterol>220 mg/dl and HDL- C<45 mg/dl were also determined in each category.
Results: 5630 subjects were studied. TgLWL and TgHWH constituted to 27.5 % and 31.9 % of subjects, respectively. Mean age of subjects dropping in TgLWL, TgLWH, TgHWL and TgHWH groups was 28±10, 39±12, 36+12 and 46±11, respectively and TgHWH subjects were significantly older than other groups (p<.001).
Systolic and diastolic blood pressures, body mass index and WC were significantly higher in TgHWH. Significantly higher levels of total cholesterol, triglycerides and LDL-C and significantly lower level of HDL-C were found in the TgHWH group. The prevalence of subjects with four or more risk factors was 61.4% in TgHWH versus 1% in TgLWL group.
Conclusion: Parallel high waist circumference and high serum triglycerides (TgHWH) can find use as a simple screening measure to predict other risk factors of cardiovascular disorders.
Shahram Safa, Alireza Esteghamati, Mohsen Nasiri Tousi, Hosein Foroutan, Hadi Ghofrani, Akram Sarbyaei, Mehrshad Abbasi,
Volume 5, Issue 2 (9-2005)
Abstract
Background: The liver plays a main role in the production and metabolism of lipoproteins, and then impaired lipid metabolism is often seen in patients with liver cirrhosis and chronic hepatitis (CH). As a result, plasma lipid levels could be as useful indicators of liver function and patient's prognosis especially in liver cirrhosis.
Methods: We measured the lipoprotein levels in 77 consecutive patients with liver cirrhosis and CH. 47 men (61%) and 30 women (39%) with mean age 43years (SD=16.4) and mean BMI 26(SD=4.2) have been recruited as patients group. Child score and MELD scale was determined in patients group. The control group was age and sex matched with patients group.
Results: In case group, the levels of HDL LDL, TG, and total cholesterol were significantly lower than control group (p <0.0001). In patients with cirrhosis, the levels of LDL, HDL and total cholesterol were progressively lower when comparing patients in Child class A with patients in class C (p<0.0001).This difference was more significant in LDL and total cholesterol and between upper Child scores ,similarly decreasing in LDL, HDL ,and total cholesterol level was observed when MELD score increased (P<0.0001).
Conclusion: There is a correlation between plasma lipid levels and liver function, so it may be mentioned as an accessible and reliable indicator of liver function in cirrhotic and CH patients.
