Showing 3 results for Lipoproteins
Farzad Hadaegh, Hadi Harati, Arash Ghanbarian, Fereidoun Azizi,
Volume 4, Issue 4 (6-2005)
Abstract
Background: To evaluate the role of lipid markers including total cholesterol (TC), LDL-C and HDL-C vs. lipid indices (TC/HDL-C, LDL-C/HDL-C and non-HDL-C) as short term predictors of cardiovascular outcomes in adults over 30 years.
Methods: As a nested case and control study, there were 207 CVD events among participants of Tehran Lipid and Glucose Study (TLGS) documented during 3 years of follow-up. Those cases that were free of CVD at baseline (132 subjects) were matched to 264 controls for age and sex. In all subjects, demographic and clinical data including blood pressure and anthropometric measurements as well as serum lipids, fasting and 2-hour glucose were available from the database of the TLGS. We estimated the relative risk (RR) for each lipid parameter in a multiple stepwise regression model after adjustment for family history of premature CHD, smoking, systolic and diastolic blood pressure, fasting and 2-hour plasma glucose and waist-to-hip ratio.
Results: The RRs associated with an increase of ≈1 SD of independent lipid predictors in the multivariate model were as follow: total cholesterol (RR=1.6 [1.2-2.0], SD= 1.3 mmol/L), LDL-C (RR=1.5 [1.1-2.0], SD= 1 mmol/L), non-HDL-C (RR=1.6 [1.2-2.1], SD= 1.2 mmol/L) and cholesterol/HDL-C (RR= 1.5 [1.1-2.0], SD= 1.8). The comparing of these four independent variables with ROC curve analysis showed that there was no significant difference in their predictive power for cardiovascular outcome. There was no association between HDL-C, triglyceride and LDL-C/HDL-C and CVD outcome in multivariate analysis.
Conclusion: This study showed that TC, LDL-C, non-HDL-C and TC/HDL-C have similar predictive values for short term prediction of CVD outcome. It seems TC may be a reasonable choice for short term prediction of CVD outcome, because of lower cost.
Mohammad Ali Boromand, Negar Maghsoodi, Seyed Hesameddin Abbasi, Shapour Shirani, Saeedeh Forghani, Abbas Ali Karimi, Saeed Davoudi, Nader Fallah,
Volume 5, Issue 3 (5-2006)
Abstract
Background: In many studies, Serum lipoprotein(a) [Lp(a)] levels considered as an independent risk factor for atherosclerosis. The aim of this study was to assess the association between Lp(a) and cervical carotid artery stenosis in one sample the Iranian population.
Methods: As a cross sectional study, between June 2004 and January 2005, at Tehran Heart Center, 1189 candidates for any kind of open heart surgery, were recruited into this study. Carotid Dopplers ultrasonography was performed for all participants. Serum levels of Lp(a), total cholesterol, triglyceride and blood sugar and quantitative CRP were measured in fasting state and their correlations with carotid atherosclerosis were assessed.
Results: Among 1189 participants, 837 (70.5%) were male and 352 (29.4%) were female. Their mean age was 60±9.3 years (range between 35 to 88). There was not significant relation between Lp(a) serum levels and carotid artery stenosis (P=0.46). The relationship between Lp(a) levels and carotid artery stenosis in both ≤55 years and >55 years patients was not significant too (P=0.25). Also gender has no relationship in this regard (P=0.15). Significant relationship was found between Lp(a) level & hypoecho plaques (vulnerable lesions) (P=0.001).
Conclusion: In our study, we found no significant correlation between serum Lp(a) and carotid stenosis. Lp(a) was found to have positive relationship with hypoecho plaques (vulnerable lesions) which predispose patients for CVA. Further investigations suggest for better evaluations.
Ahamad Farajzadeh Sheikh, Saleh Zahdei Asl, Narges Asgarisabzkoohi, Somayeh Berihami,
Volume 6, Issue 1 (8-2006)
Abstract
Background: A high dietary lipid intake is an important mediator of cholesterolemia and cardiovascular disease. Oils such as Sesame oil are not thought to contribute to such complications although information on the subject seems to be spare and contradictory. Since the ground seed of Sesame or “Ardeh” is commonly used in certain parts of this country (Iran), so its effects on the serum lipid profile of the rats have been investigated.
Methods: The study was performed on six groups of male Wistar albino rats (10 in each group) weighing 300-350 gr. Ardeh was prepared by grinding the seeds after they had been roasted at 60ºC. To prepare a high cholesterol diet, 1% cholesterol and 0.5% cholic acid was added. Group 1 consumed the ordinary diet 2 the ordinary diet plus Ardeh (24%), 3 the ordinary diet plus sunflower oil (10%), group 4 the high cholesterol diet, 5 the high cholesterol diet plus Ardeh, and group 6 the high cholestrol diet plus sunflower oil, all for 30 days. Blood samples were obtained and sera were used to determine the lipid profile
Results: The results of the study revealed that addition of Ardeh to the ordinary diet decreased serum cholesterol level significantly (P<0.01) in group 2 (38.2±2.3 mg/dl) as compared to the group 1 (49.9±5.9). Ardeh and sunflower oil had a similar effect on the groups, which consumed the high cholesterol diet. Ardeh also reduced the triglyceride level significantly (P<0.01) in group 2 (65.1±7.6 mg/dl) as compared to group 1 (106.3±15.1). Presence of both Ardeh and sunflower in the diets failed to affect HDL, but VLDL levels in group 2 (13.0±1.5 mg/dl) were significantly (P<0.01) lowered as compared to group 1 (21.2±3).
Conclusion: From the results of this study it appears that Ardeh can have a beneficial effect on lipid profiles and its addition to the diet is recommended.
