Showing 3 results for Microalbuminuria
Manouchehr Nakhjavani, Farid Azmoudeh-Ardalan, Arman Mazouji,
Volume 1, Issue 2 (7-2002)
Abstract
Introduction: The urinary excretion of minimal quantities of albumin (microalbuminuria) is predictive of renal failure and cardiovascular mortality. The detection and prompt treatment of microalbuminuria is crucial to the prevention and progress of renal failure in patients with diabetes. The aim of this study is to evaluate the relative frequency of microalbuminuria in different age groups of men and women attending the diabetes clinic at Imam Khomeini University Hospital.
Methods: 123 patients each provided a 12-hour urine sample, collected in standard fashion. Urinary albumin was measured by immunoturbidometry. The frequency of microalbuminuria (urinary albumin excretion between 30mg and 300mg in a 24-hour sample) was assessed in different age groups in men and women, according to duration of diabetes, glomerular filtration rate (GFR), glycosylated haemoglobin levels (A1C), body mass index (BMI), and both systolic and diastolic blood pressure.
Results: Overall, 20.3% of patients had microalbuminuria, 61.1% normoalbuminuria, and 10.6% macroalbuminuria. Patients with microalbuminuria were significantly older (mean age = 58.5 years) than patients with normal albumin excretion (50.3 years). The male-to-female ratio was highest in patients with microalbuminuria and lowest in those with normoalbuminuria. There was no significant difference in GFR, A1C, and blood pressure between patients with normo-, micro-, or microalbuminuria. There was a significant difference in duration of diabetes between normoalbuminuric (9.3 years) and microalbuminuric patients (11.5 years). There was a significant, inverse correlation between BMI and urinary albumin excretion.
Conclusions: Renal function in patients with type 2 diabetes deteriorates with increasing age and duration of diabetes. Renal impairment is more common in men than women.
Mohammad Afkhami Ardakani, Mojgan Modarresi, Elham Amirchaghmaghi,
Volume 3, Issue 1 (5-2004)
Abstract
Diabetes is one of the most common metabolic diseases. The prevalence of diabetes, which is around 4.5 - 6% in Iran, reaches as high as 14.2% in population of age 30 years and over in Yazd. Microalbuminuria is diagnosable before development of nephropathy and could be detected at an early stage when effective therapy can still be carried out. In this stage near normalization of blood glucose, strict blood pressure control and administration of ACE inhibitors can prevent nephropathic complications.
This study was aimed to determine the correlation among microalbuminuria, age, duration of diabetes, body mass Index, serum triglyceride, serum cholesterol and blood pressure in type 2 diabetic inhabitants of Yazd diabetes research center.
Methods: This cross-sectional study was carried out during November 2002-July 2003 to investigate the correlation between microalbuminuria and assumed risk factors. Two hundred and eighty eight type 2 diabetic patients (141 males and 147 females) were selected through consecutive sampling. Results: Overall prevalence of microalbuminuria was 14.2%. Chi-square analysis revealed the association between microalbuminuria and high diastolic blood pressure (P-value=0.003) and duration of diabetes (P-value = 0.001). No statistically significant correlation was found between microalbuminuria and body mass index, serum triglyceride, serum cholesterol and systolic blood pressure.
Conclusion: Determination of urine albumin/creatinin ratio is an easy method for screening microalbuminuria which is recommended for all diabetics especially those with hypertension and a long term history of diabetes.
Fatemeh Mohammadzadeh, Kobra Omidfar, Ramin Heshmat, Mazaher Rahmani, Bagher Larijani,
Volume 6, Issue 3 (5-2007)
Abstract
Background: Microalbominuria (MA) is early presentation of renal damage which acts as an independent factor of cardiovascular events in these patients. There are various methods for sampling and also different laboratory tests to measuring albominuria. The aim of this study was to compare of different urine collection methods for measuring albominuria using immunoturbidometry assay which has acceptable accuracy and sensitivity after HPLC (High Performance Lipid Chromathography).
Methods: Forty seven diabetic patients were selected for a cross-sectional study in 2006. For all patients 24-h urine sample were collected, also an overnight urine sample (8 hour long) and spot urine sample (morning time) was provided in the next day. The level of albumin in all samples were measured via immunoturbidometry assay. Then the results of agreement coefficient were accounted and comprised with each others.
Results: In this study 47 patients were selected which 46 of them were type 2 and one of them type 1 diabetic. Our results revealed significant correlation between all methods. In addition agreement coefficient (kappa) was accounted for all methods, time 24-h urine in comparison with 8 hours overnight urine, timed 24-h urine in comparison with spot urine and overnight urine samples in comparison with spot urine which were 0.876, 0.936 and 0.807 respectively.
Conclusion: Regarding significant agreement for screening of microalbominuria between different collecting methods, we suggest 8-h overnight or spot urine sampling carry out instead of 24-h urine collection.
