Iranian Journal of

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Background: Nesfatin-1 is an adipokine that released by adipose tissue and participated in the regulation of insulin activity and glucose metabolism. The aim of this research is the investigation the effect of 10 week resistance exercise training on serum levels of nesfatin-1 and insulin resistance index in women with type 2 diabetes. Methods: Eighteen women with type 2 diabetes recruited this study by using of the Purposive Sampling method and were randomly divided into two experimental (n= 10) and control (n= 8) groups. The experimental group participated in resistance exercise training (the exercises training started with 30-50% intensity of one maximum repetition in the first training session and increased to 70-80% intensity of one maximum repetition in the final session) in three times per week for 10 weeks. Also, the control group not participated in exercise program. Blood samples were taken pre-and post-exercise test in the 12 h fasting conditions for evaluation of nesfatin-1, insulin and glucose levels. The resulting data was analyzed by SPSS 21 and used of Kolmogorov-Smirnov, t-independent and dependent t-tests at a significance level of &alpha<0.05. Results: Intra-group changes in the experimental group showed that a significant increase in nesfatin-1 levels and a significant reduction in blood glucose and insulin resistance levels after 10 weeks resistance training (P<0.05). However, there was no significant change in insulin levels (P>0.05). In the comparison between groups, the changes of nesfatin-1 and glucose levels were significantly in pre- and post-exercise test in the experimental group compared with the control group (P<0.05). Conclusion: According to the results of this research, resistance exercise training could be recommended as adjunctive therapy method for women with type 2 diabetes.

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Background: Nesfetin-1 is known as the peptide which interfere in appetite and glucose hemostasis. The aim of the present study is to investigate the effects of two kinds of acute exercise to nesfatin-1 gene expression of diabetic rats.
Methods: In this study, has utilized the diabetic vistar staggy rats with STZ (12 week-age, 220-240 gr-weight). Animals were divided into four group: high DIABETIC MALE RATSintensity interval exercise (HIIE-0), control (C-0), (witch immediately has murdered after the exercise) and high intensity interval exercise (HIIE-2), and control (C-2), (which has murdered 2 hours after the exercise). HIIE group activated on the treadmill with 25 and 14 meter/minute in the 12 interval-one-minute period.
 Results: After removing hypothalamus and extraction of RNA, has down RT.PCR. The Independent T test analyzed and level of significance has been considering at 0/01 The exercise activity caused the significant increase of gene expression in the HIIE-0 group (P=0/001). But there was not significant increase in the HIIE-2 group (P=0/234).
 Conclusion: The results of this study displayed that one session of high intensity interval activity caused an increase immediately after the exercise in the hypothalamic nesfatin-1 gene expression of vistar staggy rats.
 

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Background: Nesfatin-1 is an adipokine that released by adipose tissue and participated in the regulation of insulin activity and glucose metabolism. The aim of this research is the investigation the effect of aerobic training and walnut consumption on nesfatin-1 and insulin resistance index of women Type 2 diabetes.

Methods: 40 women aged 40 to 50  years old with type 2 diabetes after homogenization based on Bruce test were selected through targeted sampling and they were randomly assigned to four groups of training, walnut, training + walnut and control (each group was 10). The 8-week aerobic training was three sessions per week for 16 minutes with 65% of maximal heart rate in the first week, while in the eighth week it reached 30 minutes with 80% of maximal heart rate. The walnut groups each day replaced 25 to 27 grams of walnuts as part of a diet rich in PUFA fatty acids, replacing one third of total dietary fat. 24 hours before the first session and 48 hours after the last session of the protocol, all subjects received blood samples. The inter-subject inter-analysis variance analysis was used. The significance level was considered as P <0.05.

Results: In the training groups, weight, body mass index, glucose, insulin and insulin resistance decreased significantly and the maximum oxygen consumption and nesfatin -1 increased significantly(P<0.05). 

Conclusion: Aerobic training with this intensity and amount can be recommended as auxiliary treatment for type 2 diabetic women. Walnut consumption with this value did not affect the level of blood glucose, insulin resistance index and nesfatin-1 in type 2 diabetic women. It is recommended that high-dose walnuts be used for effective operation.