Iranian Journal of

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Background: Adiponectin and omentin-1 are adipokines with insulin-sensitizing properties. The aim of this study was to investigate the effect of resistance training on serum levels of adiponectin and omentin-1 in Streptozotocin-induced diabetic rats. Methods: Twenty four male Wister rats (12-14 weeks’ old) were randomly divided into three groups: non-diabetic control, diabetic control, and diabetic training. The rats in diabetic training group were subjected to a resistance training program (3 days/wk, for 4 wk) consisted of climbing a ladder carrying a load suspended from the tail. Following four weeks resistance training serum glucose, insulin, lipid profile, adiponectin, and omentin-1 concentrations were measured. Results: Serum levels of omentin-1 and adiponectin were significantly lower in diabetic control group compare with non-diabetic control group (P<0.001). After 4 weeks of resistance training serum adiponectin levels was significantly higher in diabetic trained group compared with diabetic control group (P= 0.028), but we did not find any significant difference in omentin-1 levels between two diabetic groups. Morever, we did not find any significant difference in serum lipid profile among all groups. Four weeks resistance training did not change serum glucose and insulin concentrations in diabetic rats. Conclusion: This study indicated that resistance training could increase serum adiponectin levels in diabetic rats without significant changes in lipid profile, glucose, insulin, and omentin-1 concentrations. It seems low intensity and short term duration of resistance training had important roles in failure of significant changes of omentin-1, glucose, and insulin concentrations.

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Background: obesity is the major health problems affecting communities worldwide and the prevalence is rapidly rising. Obesity as a lifestyle-related factor increases the risk of many diseases. Omentin is a new adipocytokine that is abundantly expressed in visceral fat tissue and its expression levels reversely correlated with obesity. The purpose of this study was to investigate the association between Val109Asp genetic polymorphism of Omentin gene and obesity risk in women. Methods: This case - control study was done on 260 women, including 186 women with BMI<30 as a control group and 74 women with BMI&ge30 with obesity. Omentin genotypes were determined by the use of polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP). The data were analyzed using the computer software SPSS for windows version17. Results: Genotype frequencies of the Asp/Asp, Asp/Val and Val/Val in the control group were 65.6%, 31.7%, 2.7% and obese patients were 51.4%, 39.2%, 9.5%, respectively. Comparison of genotype frequencies in the two groups showed that women with Val/Val genotype in compare to Asp/Asp had greater risk for complications of obesity (OR: 4.5, 95%CI: 1.3-14.9, P: 0.01). Conclusion: There is significant association between Val109Asp polymorphism in omentin gene and obesity in Iranian women.

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Background: Omentin-1 is recognized as new Adipokine that mostly is excreted from visceral fatty tissue. Circulating levels of Omentin-1 are inversely associated with obesity. The aim of the present study on two training methods of endurance and resistance on Omentin-1 levels of plasma and factors related to obesity and overweight in obese girls, respectively.

Methods: Thirty four obese and overweight girls (BMI>25) were chosen purposefully then they were categorized at random to three endurance group (n=12), resistance group (n=12) and control (n=10). A total of 8 weeks of endurance and resistance training and endurance training was 4 times a week with 65 to 80 percent of HRmax and intensity resistance training was 65-80% of 1RM. Phlebotomizing was done at various stages with similar conditions and plasma Omentin-1 levels by ELISA method was measured. Data were analyzed by Kolmogorov-Smirnov and related t tests for studying the changes within the ANOVA and LSD post Hoc test for comparison between groups at the significance level of p<0.05.

Results: The results showed a significant increase Omentin-1 in both the experimental group (p _endurance =0.001, p _resistance =0.004) and reduce factors associated with obesity such as weight (p _endurance =0.003, p _resistance =0.005), fat mass body (p _endurance =0.001, p _resistance =0.001), BMI (p _endurance =0.002, p _resistance =0.004) and WHR (p _endurance =0.011, p _resistance =0.013) in both experimental groups after 8 weeks of training (p<0.05).

Conclusion: It can be stated that both endurance and resistance practices after 8 weeks of training, to improve factors related to obesity, maximal oxygen uptake and increased plasma levels Omentin-1 was.

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Background: Omentin-1 is known as adipokines that are secreted by visceral fat tissue. Omentin-1 levels are inversely associated with obesity. The aim of this research was investigation of the effect of Rhythmic aerobic exercise on serum concentration of Omentin-1 and same Anthropometric markers in obese women.

Methods: Thirty two obese women voluntarily selected with mean age 37± 8 years old and body mass index of  32.34±3.54 kg/m² and randomly were divided into two groups of experimental (n=17) and control group (n=15). Subjects in the experimental group performed the exercise training with intensity 80-70% of maximum heart rate for 45-60 minutes per session, three times a week for 10 weeks. The control group did not participate in any exercise program. Omentin-1 serum levels, weight, body mass index and waist-to-hip ratio was calculated before and after exercise. Collected data were analyzed by using of Shapiro-Wilk, Leven, dependent t test and analysis of covariance (ANCOVA) with software SPSS version 21 in significant level of α<0.05 or α<0.001.

Results: 8 week aerobic exercise in the experimental group was associated with a significant increase in the omentin-1 levels (P=0.0001) and significant reduction of weights and body mass index (p= 0.0001) (P<0.05). Whereas there was no significant change in WHR levels (P>0.05). Reviews for between group indicated a significant increase in the amount of omentin-1 (P=0.009) and a significant reduction in weight values (P=0.0001) and BMI (P=0.001) in the experimental group compared with the control group (P<0.01).

Conclusion: It seems that rhythmic aerobic exercise is an important role in improving cardiovascular health and obesity-related disorders in obese women by increasing omentin-1 and reducing obesity-related factors.