Search published articles


Showing 2 results for Osteopenia
OSTEOPOROSIS PREVALENCE AND T-SCORE DISCORDANCE BETWEEN FEMUR AND LUMBAR SPINE IN IRAN AND SOME RELATED FACTORS: IMOS STUDY
Marziyeh Hadavi, Bagher Larijani, Mostafa Qorbani, Babak Eshrati,
Volume 14, Issue 5 (7-2015)
Abstract

Background: Osteoporosis is the most prevalent metabolic bone disease which is characterized by low bone mass and increased risk of fracture. The present study was conducted to assess the prevalence of osteoporosis and T-score discordance between femur and lumbar spine as well as their risk factors in a group of healthy postmenopausal women and men older than 50 years old based on Iranian Multicenter Osteoporosis Study data in phase 3 compared to phase 1.

Methods: This research is a cross-sectional study. 295 men and 397 women in IMOS 3 from Arak and Sanandag, and 868 men and 685 women  from Tehran, Mashad, Tabriz, Shiraz and Bushehr were recruited based on randomized cluster sampling

Results:  osteoporosis and osteopenia prevalence in men were 32% and 50% respectively, which were more in IMOS 3 compared to IMOS 1 (28% and 49.3%) but no statistical significance was noticed p=0.258. In postmenopausal women there were no difference in osteoporosis and osteopenia prevalence between IMOS 3 and IMOS1. There were no difference in discordance prevalence in IMOS 3 compared to IMOS 1. Logistic regression analysis revealed body mass index and physical activity had protective role against osteoporosis and osteopenia.

Conclusion: It seems osteoporosis in men has greater rate compared to women. Lifestyle changes especially physical activity and nutrition can play a significant role in the prevention of osteoporosis. And based on T-score discordance between femur and lumbar spinebperforming BMD at two different sites is necessary for the Iranian population.


Effect of high dose versus the recommended dose of vitamin D supplement on the serum level of 25(OH) vitamin D in the osteopenic women older than 50 years
Dr. Alireza Bagheri, Dr. Hamidreza Aghaei Meybodi, Dr. Mohammadreza Mohajeri, Dr. Akbar Soltani, Dr. Ramin Heshmat, Dr. Bagher Larijani,
Volume 24, Issue 5 (12-2023)
Abstract
Background: Vitamin D (vitD3) deficiency is common in Iran. Although there are several studies on therapeutic doses of vitD3, the optimal dose is to be evolved. we compared the effects of high dose supplemental vitD3 versus its recommended dose on the serum level of 25(OH)D.
Methods: This clinical trial study is performed at Endocrine & Metabolism Research Institute in Shariati Hospital within 2008-2009. The subjects were osteopenic women older than 50 years who had been referred to Bone Densitometry laboratory. They were received either (group P) 50000u vitD3 weekly for 3 months then monthly for another 9 months, or (group M) 800u vitD3 daily for one year. 1000 mg calcium carbonate was given to both groups. Serum 25(OH)D, Calcium, Phosphorus, PTH was checked at base, 3rd, 6th and 12th month. 24h Urine for calcium was collected before and at the end of trial.
Results: Serum 25(OH)D level was significantly higher in group P at 3rd month (p<0.05), but it gradually declined and there was not statistically difference to group M. PTH decreased in both groups. Urine calcium to creatinine ratio did not rise in both groups.
Conclusion: vitD3 supplement at doses of 50000u weekly for 3 months then monthly for another 9 months as compare to 800u vitD3 daily for one year increases serum 25(OH)D at higher level without causing hypercalcemia and hypercalciuria, but it seems that more frequent doses in monthly period would be required to maintain the optimal 25(OH)D level.
Page 1 from 1     

© 2024 , Tehran University of Medical Sciences, CC BY-NC 4.0

Designed & Developed by: Yektaweb