Showing 6 results for Osteoporosis
Arash Hossein-Nezhad, Bagher Larijani, Mohammad Pajouhi, Hossein Adibi, Jilla Maghbouli,
Volume 3, Issue 1 (5-2004)
Abstract
There are controversies on the effects of diabetes and lifestyle of affected patients on their bone mineral densities (BMDs). This study has investigated the effects of lifestyle of type 2 diabetics on BMD at the lumbar spine and proximal femur in pre and postmenopausal women.
Methods: In a historical cohort study, 20 pre-menopausal type 2 diabetics and 57 non-diabetics and 126 type 2 Diabetics and 315 non-diabetics postmenopausal women, were recruited. BMD measurements were also made to the spine and proximal femur (Neck, Wards, and Shaft) by dual energy X-ray absorptiometry (DXA) technique. Exclusion criteria were endocrine, rheumatologic or chronic diseases. Type 2 diabetic cases and non-diabetics were matched for age and body mass index (BMI) in both pre menopausal or postmenopausal groups.
Results: A total of 146 type 2 Diabetic patients without any other endocrine disorder and 372 non-diabetic women, aged 40-81 years were enrolled. No significant differences were found between diabetics and healthy controls in terms of BMD values of spine and femur regions in the premenopausal women. Postmenopausal diabetics, however, had higher BMD at the lumbar spine compared with the healthy postmenopausal controls. An age-related decrease in BMD values (lumbar and femur) was observable in all groups and a significant correlation between BMI and BMD was found. Adjusting for age and BMI, the effect of lifestyle on BMD at all sites was investigated. Occupation was associated with BMD in postmenopausal, but not in premenopausal women. Among the investigated dietary items, milk, yogurt and cheese were all associated with increased BMD in at least one region in diabetic patients. Smoking was not associated with BMD.
Conclusion: Type 2 Diabetes does not seem to be complicated by bone loss and osteoporosis. Physical activity and milk consumption in postmenopausal diabetic women can be a protective factor against bone loss.
Faranak Sharifi, Niloufar Ahmadi Moghaddam, Noureddin Mousavi-Nasab,
Volume 5, Issue 2 (9-2005)
Abstract
Background: To determine the importance of type 2 Diabetes mellitus as a risk factor for osteoporosis in postmenopausal women, this study was designed in endocrine clinic of zanjan in 2003.
Methods: As a case-control study, 40 diabetic and 40 healthy menopause women have been recruited. These two groups were matched in terms of their age, length of their menopausal period and body mass index. Serum Calcium, Phosphorus, Alkaline phosphatase and Estradiol were measured in all the cases and bone densities in three sites (Femoral neck, lumbar spine and forearm) were evaluated with DXA. All data were analyzed using T-test, analysis of variance, chi-square and multiple regression tests.
Results: The frequency of osteoporosis and osteopenia in diabetic women were not significantly different from non diabetics. The mean bone density in femoral neck was higher in diabetic group (P= 0.013). In both groups there was a significant relationship between bone density and length of menopause (P<0.01) .The relationship between BMI and Bone density was significant only in femoral neck (P<0.01) in both groups. In diabetic women, the higher HbA1c accompanied with the lower bone density in lumbar spine.
Conclusion: Although the level of HbA1c as a marker of blood glucose control, has a relationship with lumbar spine density in diabetics, Diabetes type 2 is not a risk factor for osteoporosis, So screening, diagnosis and management of osteoporosis in diabetes type 2, Should be done independently and according to other risk factors.
Sommayeh Rashid Shomali, Vahideh Montazeri, Seyed Mohammad Akrami, Ramin Heshmat, Bagher Larijani,
Volume 7, Issue 1 (7-2007)
Abstract
Background: High prevalence of consanguineous marriages has been reported in Iran. Since this pattern of marriage may increase the prevalence of diseases with autosomal recessive pattern of expression, the study was assigned to determine this among patients referred to diabetes and osteoporosis clinics of Dr Shariati hospital, Tehran, Iran.
Methods: The consanguineous marriage was studied among 1789 couples of three successive generations via Questionnaire.
Results: The prevalence of consanguineous marriages in three successive generations was 9%, 17% and 19%, respectively with an increasing pattern of prevalence. Overall the prevalence of first cousins marriage was 10% with 69% among consanguineous marriage group. The higher the level of education, the lower the prevalence of consanguineous marriage.
Conclusion: In view of the increasing prevalence of consanguineous marriage that may be followed by some trouble consequences about disease expression, it seems necessary to provide facilities for genetic counseling before marriage for youth.
Habib Moazami Goodarzi, Bagher Larijani, Abbasali Keshtkar, Patricia Khashayar,
Volume 13, Issue 2 (1-2014)
Abstract
Background: Discordance (the presence of different categories of T scores in two skeletal sites of a
single patient) can affect the physician’s decision to start medication or not. The present study was
therefore conducted to assess the prevalence of T-score discordance between spine and femoral neck
as well as its risk factors in a group of postmenopausal Iranian women.
Methods: The present analytical cross sectional research was conducted based on the results of
IROSTEOPs study on 8146 postmenopausal women referred to the bone mineral density (BMD)
center of Shariati Hospital affiliated to Tehran University of Medical Sciences between 2000 and
2011. Based on their BMD results, the patients were categorized into three groups: Concordance and
Minor and Major discordance. The factors affecting the risk of developing discordance was then
studied through uni/and multivariate logistic regression.
Results: Discordance between spine and femoral neck was reported in 3741 (45.9%) of the
participants. Multivariate logistic regression revealed that older age, higher number of pregnancies and
higher body mass index (BMI) are the main risk factors for T-score discordance at the studied sites.
The use of hormonal replacement therapy (HRT) on the other hand played a protective role.
Conclusion: It could be concluded that performing BMD at two different sites is necessary for the
Iranian population, particularly postmenopausal women.
Marziyeh Hadavi, Bagher Larijani, Mostafa Qorbani, Babak Eshrati,
Volume 14, Issue 5 (7-2015)
Abstract
Background: Osteoporosis is the most prevalent metabolic bone disease which is characterized by low bone mass and increased risk of fracture. The present study was conducted to assess the prevalence of osteoporosis and T-score discordance between femur and lumbar spine as well as their risk factors in a group of healthy postmenopausal women and men older than 50 years old based on Iranian Multicenter Osteoporosis Study data in phase 3 compared to phase 1.
Methods: This research is a cross-sectional study. 295 men and 397 women in IMOS 3 from Arak and Sanandag, and 868 men and 685 women from Tehran, Mashad, Tabriz, Shiraz and Bushehr were recruited based on randomized cluster sampling
Results: osteoporosis and osteopenia prevalence in men were 32% and 50% respectively, which were more in IMOS 3 compared to IMOS 1 (28% and 49.3%) but no statistical significance was noticed p=0.258. In postmenopausal women there were no difference in osteoporosis and osteopenia prevalence between IMOS 3 and IMOS1. There were no difference in discordance prevalence in IMOS 3 compared to IMOS 1. Logistic regression analysis revealed body mass index and physical activity had protective role against osteoporosis and osteopenia.
Conclusion: It seems osteoporosis in men has greater rate compared to women. Lifestyle changes especially physical activity and nutrition can play a significant role in the prevention of osteoporosis. And based on T-score discordance between femur and lumbar spinebperforming BMD at two different sites is necessary for the Iranian population.
Mahnaz Sanjari, Noushin Fahimfar, Fatemeh Hajivalizadeh, Safora Gharibzadeh, Kazem Khalaji, Zohreh Hosseinzadeh, Firozeh Hajipour, Kobra Gorgani, Afshin Ostovar,
Volume 20, Issue 1 (1-2021)
Abstract
Background: Osteoporosis is one of the most important health problems in the country due to fracture. Osteoporosis Research Center with more than 20 years of experience in this field tries to present achievements and activities of the management and treatment of osteoporosis in the country while introducing this center. This review aims to overview the osteoporosis research center activities on osteoporosis.
Methods: In these conventional review national and international databases were investigated on osteoporosis without any restriction on time and language. Also, other activities that are not reflected in the papers were obtained from the professional website and official reports.
Results: According to the strategic plan of the osteoporosis research center, the achievements of this center provided in in three areas of research (population-based studies, clinical studies, basic science studies and health system studies), technology (diagnostic, therapeutic technologies, service delivery models) and education (training students at different levels of education). Supplementary, patient education, general education, and service provider training).
Conclusion: Osteoporosis Research Center is recognized as the only specialized research center in the field of osteoporosis in the country. The center is trying to improve its position as a regional center in the field of osteoporosis by relying on its strategic and operational plan, in addition to maintaining its current position.
