Mandana Hasanzad, Negar Sarhangi, Shekoufeh Nikfar, Bagher Larijani,
Volume 20, Issue 1 (1-2021)
Abstract
Background: Precision medicine is a new approach in the field of medical sciences that utilizes the genetic characteristics of each patient along with clinical information to guide decisions related to diagnosis and early treatment of diseases. The Personalized Medicine Research Center, as the only center approved by the Ministry of Health, is working on precision medicine context and producing the related knowledge.
Methods: In this systematic review, studies that are conducted at the personalized medicine research center with a precision medicine theme based on specific eligibility criteria and a designed search strategy in three databases PubMed, Scopus, and Web of Science (Wos) from December 2016 to December 2019 were retrieved.
Results: Finally, 18 studies focusing on different approaches of precision medicine in prediction, prevention through “omics” including genomics, transcriptomics, and proteomics were selected for further evaluation.
Finally, 18 studies focusing on precision medicine in non-communicable diseases (diabetes) and cancer (prostate and thyroid) were selected for further studies.
Conclusion: Since one of the important goals of precision medicine is prediction and prevention, the identified genetic changes can be used for early diagnosis in high-risk individuals. Actually, the initiative studies are needed to meet the goal of precision medicine.
Negar Sarhangi, Mandana Hasanzad, Fatemeh Rouhollah, Shekoufeh Nikfar, Farshad Sharifi, Negar Niknam,
Volume 25, Issue 2 (7-2025)
Abstract
Background: Pharmacogenomics (PGx), as a growing field of personalized medicine, aims to optimize the efficacy and safety of medications by studying the association between germline genetic variations and drug responses. The present cross-sectional study aims to evaluate the allele frequency of the NUDT15 genetic variant in the Iranian population to provide insights into personalized treatment decisions in the Iranian population.
Methods: A representative sample set of 1142 unrelated healthy Iranian individuals aged 18 and older genotyped using the Infinium Global Screening Array-24 BeadChip.
Results: We identified a pharmacogenetic variant with minor allele frequency (MAF) ≥1% among the present studied population which may explain the substantial variability in drug response phenotypes among different populations
Conclusion: The results of our study revealed significant genetic variation among Iranian populations that could significantly influence clinical decision-making. This study shows the frequency pattern of the effective variant of NUDT15 in determining the phenotype in Iranian population.
