Iranian Journal of

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Background: CoQ10 is a lipid-soluble and a powerful antioxidant. Decreased level of this antioxidant was reported in many conditions like vascular, diabetes, high blood pressure and coronary artery diseases. With regards to increased oxidative stress in diabetes and its role in the development of high blood pressure, this study aimed to examine the effect of Q10 supplementation on blood pressure level and its relation to nitric oxide metabolites (NOx) level in type 2 diabetic patients. Methods: In this 12-week randomized controlled trial, T2D subjects received either placebo or coenzyme Q10 (100 mg twice a day). Anthropometric measures, blood pressure, biochemical analysis including NOx level, fasting blood glucose, glycosylated hemoglobin (HbA1c) and lipid profile were evaluated at the beginning and after the intervention. Results: The intervention resulted in a significant improvement in systolic blood pressure (115.3±27.61 versus 118.2±12.6 mmHg), diastolic blood pressure (77.1±8.22 versus 80.3±12.11mmHg), NOx (Pvalue=0.014) and HbA1c. Moreover Q10 supplementation resulted a significant decrease in elevated levels of cholesterol. Conclusions: In conclusion, CoQ10 supplementation (200 mg/day) for 12 weeks, significantly decreased systolic and diastolic blood pressure, NOx, HbA1c, total cholesterol and LDL-C in type 2 diabetic patients.

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Background: Several studies have evaluated the effects of coenzyme Q10 on glycemic control, but there are large discrepancies between studies.

Objective: This meta-analysis of randomized controlled trials aimed to summarize the effect of Co-Q10 on diabetes’ biomarkers.

Methods: This systematic review and meta-analysis was conducted on studies published from 1998 until December 2015. We searched Pub med, EMBASE, Science direct, ISI web of science and Google Scholar to find relevant studies. Totally, our search resulted in 16 articles reporting the effects of Co-Q10 on fasting blood glucose, fasting insulin and HbA1c. Mean ± standard deviations (SD) were used for calculating mean differences. 95% confidence interval was considered between intervention and control treatments.

Results: The present meta-analysis revealed that Co-Q10 decreased fasting blood glucose (-0.20mg/dl, 95%: -0.38,-0.02). However, Co-Q10 supplementation could not effectively reduce HbA1c (0.05%; 95%: -0.22, 0.12) and fasting insulin (0.12pmol/l; 95%: -0.21, 0.44).

Conclusion: Co-Q10supplementation didn’t result in reduction in HbA1c and fasting insulin. However, it had a significant lowering effect on fasting blood glucose. It should be noted that significant changes in fasting blood glucose reported in this study was due to the extended sample size and this is not clinically significant in the present study.

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Background: Diabetes leads to numerous side effects in the cardiovascular system and also to improper functioning of the body's antioxidant system. The aim of this study is to investigate the effect of six weeks of high-intensity interval training with coenzyme Q10 supplementation on the values of Nrf2 and NQO1 in heart muscle of elderly diabetic rats.
Methods: In this experimental study, 48 elderly male rats (18 months old) were randomly divided into four groups of intense aerobic exercise with coenzyme Q10 supplementation, intense aerobic exercise group, coenzyme Q10 supplement intake group, and control group. Induction of diabetes was done by injecting a single dose of streptozotocin in the amount of 60 mg/kg intraperitoneally. The program of high intensity interval training was done for six weeks. Coenzyme Q10 supplement group received orally at a dose of 200 mg/kg. Western blot method was used to measure Nrf2 and NQO1 values. The data were analyzed by one-way analysis of variance and Tukey's post hoc test at a significance level of P <0.05.
Results: The results showed taking coenzyme Q10 supplement (P= 0.014), intense intermittent exercise (P= 0.001) and intense intermittent exercise with coenzyme Q10 supplement (P= 0.001) significantly increased Nrf2 values in the hearts of diabetic elderly rats. Also, the use of coenzyme Q10 supplement (P=0.0366), intense intermittent exercise (P= 0.014) and intense intermittent exercise along with coenzyme Q10 supplement use (P= 0.002) significantly increased the amount of NQO1 in the hearts of diabetic aged male rats.
Conclusion: Intermittent intense training along with supplement consumption improves heart function in elderly diabetic patients through increasing endogenous antioxidant enzymes.