Mohammad Ali Ghaffari, Taibeh Ghiasvand,
Volume 7, Issue 1 (7-2007)
Abstract
Background: The oxidative modification of low density lipoprotein (LDL) may play an important role in atherogenesis. Mechanism of LDL oxidation and factors that determine its susceptibility to oxidation is unknown. Copper is account as an attributing factor in LDL oxidation atherosclerotic lesions. The binding of copper ions to LDL is usually thought to be a prerequisite for LDL oxidation by copper. The aim of study was to investigate the effect of Naringin and Quercetin on copper bound to LDL and furthermore effect of this binding on the susceptibility of LDL to oxidative modification.
Methods: LDL was isolated from EDTA-plasma by ultracentrifugation using a discontinuous gradient. The oxidizability of LDL was measured by thiobarbitoric acid reactive substances (TBARS) after addition of CuSO4 in absence and/or presence of Naringin and Quercetin. Finally effect of Naringin and Quercetin on formation of LDL-copper complex was studied by gel filtration.
Results: This study showed that Naringin suppresses formation of TBARS and LDL-copper complex, whereas Quercetin enhances formation of TBARS and LDL-copper complex.
Conclusion: Results revealed that Naringin with inhibition of binding of Copper to LDL may decrease the susceptibility of LDL oxidation in counter to this ion and thus may have a role in prevention of atherosclerosis. But Quercetin with stimulation of binding of copper to LDL may increase the susceptibility of LDL oxidation to this ion and thus may have a role in progression atherosclerosis.
Fatemeh Janbozorgi, Farshad Ghazalian, Khosrow Ebrahim, Hosein Abed Natanzi , Mandana Gholami,
Volume 22, Issue 4 (11-2022)
Abstract
Introduction: The purpose of this research was to explain the protective effect of quercetin on cardiac fatigue caused by exercise in skyrunning runners.
Methods: 26 professional sky running athletes voluntarily and purposefully participated in this race. Random people were placed in 2 groups: quercetin (13 people) and placebo (13 people). The race was held in the central Alborz mountains, the total distance traveled was 21 km and 200 meters, the altitude of the starting point was 1650 meters above sea level, the maximum altitude was 3150 meters above sea level. Before and immediately and 1 hour after the end of the race, blood was taken from the subjects. In order to check the changes of the studied variables, the independent T-test was used at the significance level of alpha 0.05.
Results: The amount of cardiac troponin T decreased significantly immediately and 1 hour after the end of the race in the quercetin group compared to the placebo group (P < 0.05). No significant difference was observed between the two groups of quercetin and placebo in the pre-test, immediately after the test and 1 hour after the test (P>0.05).
Conclusion: It seems that the increase of free fatty acids after the competition and long-term sports play an important role in reducing cardiac inotropic during the same period. Skyrunning competitions cause an increase in heart damage indices in professional athletes, despite this, quercetin supplementation reduces the increase in cardiac troponin T and can have a protective effect on the athlete's heart
