Showing 2 results for Red Blood Cell
Hossein Salari, Bijan Farzami, Parvin Pasalar, Bagher Larijani,
Volume 5, Issue 1 (8-2005)
Abstract
Background: The determination of insulin receptors on RBC membrane is a suitable tool for the study of these receptors in diabetes and its related complications. The common methods for the study is the biopsy of fat or muscular tissues, cell culture or a preparation of certain amount of monocytes which is associated with some difficulties. Present study utilizes RBC's for this purpose.
Methods: Certain amount of RBCs were exposed to a known amount of labeled Insulin and varying concentration of unlabelled Insulin. The competitive effect of Insulin replacement was determined by the measurement of residual receptor radioactivity. This study was carried out in three groups of healthy, poor controlled and good controlled diabetics.
Results: There were significant differences between the normal and poor controlled diabetics (P=0.017). In addition differences in receptor binding was obtained between good controlled diabetics and normal which were not significant (P=0.09). All changes were inversely proportional to the HbA1C of specimen. Using Scat chard plots the number of receptors in each group, normal, poor controlled and good controlled were determined to be 1820 (± 72.8), 1026 (±40.4) and 1230 (± 49.2) respectively.
Conclusion: Considering the above results, it could be seen that the evaluation of the number of receptors in RBC could be a suitable tool for studying the state of insulin receptor in both physiological and pathological conditions.
Tara Zargham, Bahram Abedi, Sajad Arshadi,
Volume 25, Issue 2 (7-2025)
Abstract
Background: Considering the negative effects of inactivity and increasing fat mass in inactive people, the aim of this study was to investigate the effect of six weeks of aerobic exercise along with the consumption of fenugreek seeds supplementation on C-reactive protein and some blood parameters in inactive women.
Methods: 40 subjects were randomly assigned to 4 groups: exercise and fenugreek (n=10), exercise and placebo (n=10), fenugreek (n=10), placebo (n=10). Two exercise groups participated in the aerobic exercise program for 6 weeks, 3 sessions per week, and each session lasted from 20 to 30 minutes. Subjects consumed 500 mg of fenugreek seeds or placebo (starch) daily after breakfast. The blood samples of the subjects were collected from the vein of the right hand of the subjects in a sitting position. In order to analyze the data, Shapiro-Wilk test, correlated t-test, and Benferroni's post hoc analysis of covariance test were used for natural data at the significance level of p<0.05.
Result: The results showed that aerobic exercise combined with fenugreek seeds supplementation had a decreasing effect (p=0.001) on the response of C-reactive protein (CRP) in inactive women, and an increasing effect on the amount of platelets in inactive women (p=0.003). It had an increasing effect on the amount of red blood cells in inactive women (p=0.003) and a decreasing effect on the amount of white blood cells (p=0.03).
Conclusion: Aerobic training with fenugreek seeds leads to a decrease in C-reactive protein and a decrease in white blood cells and an increase in platelets and red blood cells. These changes reduce the inflammatory condition and increase the immune system and better oxygen supply to the tissues and optimal metabolism of inactive women.
