Ghorban Mohammadzadeh, Nosratollah Zarghami, Bagher Larijani,
Volume 7, Issue 1 (7-2007)
Abstract
Background: Resistin, an adipocyte secreted factor, has been suggested to link obesity with type 2 diabetes and insulin resistance in rodent models but its relevance to human diabetes remains uncertain. The aim of this study was to investigate the relationship between serum resistin concentrations with insulin resistance and obesity indices in type 2 diabetes and non-diabetic obese subjects.
Methods: As a case- control study 35 obese subjects with type 2 diabetes (age, 44.60 ± 6.39yr BMI, 34.23±3.92 kg/m2) and 35 obese non-diabetics (age, 43.14±9.13yr BMI, 35.54 ± 4.07 kg/m2) are recruited. Fasting lipid profile was measured by enzymatic methods. NycoCard HbA1c Kit was used to measure HbA1c.The Serum resistin, insulin and glucose levels were measured by an enzyme immunoassay using a commercially available kit and glucose oxidase methods respectively. The insulin resistance index was calculated from fasting glucose and insulin by the homeostasis model assessment (HOMA-IR) formula.
Results: The mean of insulin resistance index (HOMA-IR), HbA1c, diastolic blood pressure, triglyceride and fasting glucose in diabetics were significantly higher than non-diabetics subjects (P<0.05). Serum resistin concentrations were not different between diabetics and non-diabetics obese subjects but were significantly higher in women as compared to men (8.15±4.40 vs. 5.97±2.31 in non-diabetic) and (7.46±3.98 vs. 5.51±3.98 in diabetic) in both groups. Serum resistin was not significantly related to variables measured in both groups. In control group only, we observed a significant and negative correlation between diastolic blood pressure and resistin (r = -0.381 P = 0.024).
Conclusion: Serum resistin concentrations were not significantly different between type 2 diabetes and non-diabetic obese subjects and resistin is unlikely to be a major link between obesity and diabetes in humans.
Fatah Moradi,
Volume 14, Issue 4 (5-2015)
Abstract
Background: Resistin levels and insulin resistance increase in obese humans. Also, inactive life is associated with high risk of increased insulin resistance. The purpose of this study was to investigate effect of twelve weeks aerobic training on serum levels of resistin, and adiponectin-resistin (AR), homeostasis model assessment-adiponectin (HOMA-AD), and IRAR indices in sedentary obese men. Methods: In a semi-experimental study, twenty one sedentary obese men were randomly placed into two groups: aerobic training (n=10, 27.8±3.2 yr, 93.5±7.1 kg, 31.7±3.4 %, BMI 32.0±3.5 kg/m2) and control (n=11, 27.1±3.1 yr, 94.7±6.0 kg, 31.2±3.1 %, 32.2±3.3 kg/m2). General characteristics of subjects, serum levels of resistin, and HOMA-AD, AR, and IRAR indices were assessed before and after training. Aerobic training consisted of twelve weeks pedaling on cycle ergometer (3 sessions per week, intensity 60-70% of reserved heart rate, duration of each session 20-40 min). Data analyzed by SPSS16 software. Statistical significance was considered at P<0.05. Results: After the training period, serum levels of resistin (P=0.016), HOMA-AD (P=0.007), AR (P=0.020) and IRAR (P=0.003) were reduced, while none of mentioned parameters in control group did not change significantly (P>0.05). Conclusion: Circulating levels of resistin and HOMA-AD, AR, and IRAR, that are novel indices for insulin resistance, were reduced after twelve weeks aerobic training. Therefore, sedentary obese men can reduce risk of type 2 diabetes and cardiovascular diseases with performing aerobic training.
Shahin Riyahi Malayeri, Azam Azadniya, Mohammad Javad Rasaee,
Volume 18, Issue 1 (1-2019)
Abstract
Background: Adiponectin and resin; Adipocytokine relateted with insulin resistance. The purpose of this study was to the Effect of eight-week high intensity interval training and resveratrol intake on Serum Adiponectin and resistin in type 2 diabetic rats.
Methods: During this experiment 32 diabetic rats with High-Dieting Diet Sprague Dowley race with an average weight of 250 ±10 grams and an average age of 10 weeks, were randomly divided into four groups, including the “control group”, the “supplement group”, the “training group” and the “training and supplement group”. For up to 8 weeks, the “practice” groups participated in 5 training sessions weekly; session was 18 minutes under the influence of High-Intensity Interval training with an intensity of 90 to %100 VO2max. moreover, the supplement groups were given 10 milligram daily doses of resveratrol intake solution per kilogram of body weight Gavage was given for 8 weeks and three times a week. The outcome data was analyzed using one-way analysis of variance and significance level of (P≤0.05).
Results: The results showed that eight weeks of exercise and resveratrol consumption increased on serum adiponectin, but did not have a statistically significant effect (P = 0.62). However, serum resistin decreased and significantly affected the training group (P = 0.001). Also, the mean values of fasting glucose, insulin and insulin resistance index decreased significantly in experimental groups (P = 0.001).
Conclusion: It seems high intensity interval training with resveratrol intake can lead to glucose control in type II diabetes by changing its insulin resistance factors.
Sajjad Ramezani, Marefat Siahkouhian,
Volume 24, Issue 2 (6-2024)
Abstract
Background: This review aims to investigate and analyze recent studies related to the effects of various exercise training on adipokines secreted from adipose tissue in patients with type 2 diabetes.
Methods: Search in Persian and Latin databases PubMed, ScienceDirect, Google Scholar, Magiran, and SID with the keywords aerobic exercise, resistance training, High-intensity interval training, diabetes, Adipokine, Leptin, Adiponectin, and Resistin, resistance training, intense interval training, aerobic exercise, combined exercise, adipokine, leptin, adiponectin and resistin were performed to retrieve articles published in the period from 2010 to 2023.
Results: The results obtained from the study showed that aerobic exercise with moderate intensity (60 to 80%) reduces the leptin levels of diabetic patients, however, the effect of combined exercises (aerobic and resistance) is much greater than other types of exercises. In addition, aerobic exercises with moderate intensity (50 to 70%) lead to an increase in adiponectin levels in diabetic patients, however, high-intensity interval training (HIIT) had a greater effect in increasing adiponectin levels than other exercises. Also, studies showed that all three types of activities, aerobic exercise (50-70% intensity), intense intermittent exercise, and resistance exercise (30-70% 1RM) have the same effects in reducing the resistance levels of diabetic patients.
Conclusion: Aerobic exercises with medium and high intensity and especially combined exercises (aerobic and resistance) while improving adipokines, decreasing leptin and resistin levels, and also increasing adiponectin in diabetic patients.
