Showing 5 results for Sod
Seyyed Abolghassem Sajjadi, Hossein Hossein-Zadeh, Seyyed Ahmad Mohajeri,
Volume 2, Issue 1 (5-2003)
Abstract
Objective: To compare the effect on insulin absorption intra-nasally of Acanthophyllum squarrosum (ASQ) compared with Acanthophyllum saponaria (ASA) and sodium cholate (NAC), which have proven pro-absorptive effects.
Methods: The formulation used in this study contained 2IU insulin (per rat), 1% carboxymethylcellulose (CMC) and a pro-absorptive agent at the same concentration. We assessed the hypoglycaemic effect of each formulation in 5 rats in the fasting state.
Results: There was no significant difference in the pro-absorptive effects of ASQ, ASA, and NAC. Blood glucose levels 2 hours after administration of insulin, given as a percentage of baseline glucose concentration, were as follows for the three formulations used: ASQ: 36.78±11.06%, ASA: 27.46±2.39%, and NAC: 39.94±14.93%. Conclusion: Acanthophyllum squarrosum has a significant pro-absorptive effect, comparable to that to Acanthophyllum saponaria.
Masoomeh Kourosh Arami, Abdolrahman Sarihi, Jila Behzadi, Seyed Mansour Malakouti, Iraj Amiri, Rafat Zare Ekbatani,
Volume 4, Issue 3 (5-2005)
Abstract
Background: The role of nucleus tractus solitarius in cardiovascular system regulation is controversial. On the other hand, study on the problem of hypertension in diabetic animals is the subject of many research programs. The aim of the present study was to determine wheather inactivation of nucleus can affect blood pressure in diabetic rats.
Methods: To this end , stereptosotocin-induced diabetic rats were anesthetized with Urethane and a cannula was inserted above nucleus. Blood pressure and heart rate were monitored using an intraarterial cannula. The cannulas were filled with L-glutamate (78 pmol/60 nL, to functionally identify the NTS see below), L-NAME(1nmol, to inhibit the nitric oxidergic neurons) and sodium nitroprusside (100mmol,as a NO-donor) .
Results: The results indicated that inactivation of nucleus in diabetic rats, had no effect on systolic and mean arterial pressure but enhanced diastolic blood pressure (P<0.05). There was no significant difference in heart rate between control and test groups.
Conclusion: Glucose affect on increasing blood pressure in rats with induced diabetes, in part, is caused by nitric oxidergic neurons resided in neucleus tractus solitarius.
Hamed Rezaei Nasab, Abdolhamid Habibi, Masoud Nikbakht, Mohamad Rashno, Saeid Shakerian,
Volume 18, Issue 4 (4-2019)
Abstract
Background: Oxidative stress plays a key role in the onset and development of diabetes Complications, Including diabetic cardiomyopathy. The purpose of this study was to investigate the role of dichloroacetate (DCA) on SOD and GPX expression following six weeks’ endurance training in cardiac muscle of diabetic male rats.
Methods: In this experimental study, 64 male Wistar rats were selected and randomly divided into eight groups after streptozotocin (STZ) solution diabetic treatment. The endurance training protocol was performed on a treadmill for 6 weeks. In the present study, for Inhibition of PDK4 in the cardiac muscle, intraperitoneal injection of DCA of 50 mg/ kg body weight was used. Gene expressions were measured by Real-Time PCR method. One-way ANOVA and Tukey's test were used to analyze the data.
Results: The results of the study showed that after endurance training, PDK4 gene expression increased and SOD and GPX genes expression in training endurance + diabetic group and endurance training group decreased compared to control group (P <0.05). By Inhibition of PDK4, the of SOD and GPX genes expression increased in DCA + training endurance + diabetic group and DCA + endurance training group compared to control group (P <0.05).
Conclusion: According to the results of this study, DCA injections may reduce the recurrence of free radicals induced by endurance training in diabetic patients by mitochondrial adaptation. Which can reduce the oxidative stress in the heart tissue of diabetic patients and increase cardiac efficiency.
Marayam Arabloei Sani, Parichehreh Yaghmaei, Zahra Hajebrahimi, Nasim Hayati Roodbari,
Volume 22, Issue 3 (9-2022)
Abstract
Diabetes is a serious public health problem in low- and middle-income countries. There is a strong association between hyperglycemia, oxidative stress and the development of diabetes. Therefore, screening and early diagnosis of this disease in people at high risk can be effective in preventing these complications. The main route of insulin signaling is to control lipid and glucose metabolism, and its imbalance leads to type 2 diabetes. P-Cymene is an aromatic monoterpene with a wide range of therapeutic properties including antioxidant activity. The aim of this study was to evaluate the effect of p-Cymene at a dose of 50 mg / kg in preventing the symptoms of diabetes and serum factors.
Materials and Methods: 30 male Wistar rats weighing approximately 250 g were randomly selected and divided into five groups: control, diabetic control (sham), metformin-treated diabetic (met), and non-diabetic treated. P-Cymene and diabetics treated with P-Cymene were divided. One week after streptozotocin injection, treatment with P-Cymene at a dose of 50 mg / kg was performed by sunflower oil solvent for 28 days by gavage. At the end of the experiment, blood samples were taken from the hearts of rats and the parameters of glucose, insulin, and superoxide dismutase (SOD) were measured.
Results: The results showed that diabetes increased water and food intake as well as glucose levels and decreased insulin (P <0.001) and superoxide dismutase activity in rats and administration of P-Cymene extract improved the symptoms of diabetes and oxidative stress in Became diabetic rat.
Malahat Kashfi Moghadam, Farnaz Seifi-Skishahr, Lotfali Bolboli,
Volume 24, Issue 3 (7-2024)
Abstract
Background: The present study aimed to investigate the changes in TRx-sh/TRx-s2 levels, GSH values, and total antioxidant capacity following 8 weeks of intense interval training with and without sodium citrate supplementation in diabetic rats.
Methods: In this semi-experimental and fundamental study, 50 male Wistar rats were randomly divided into 5 groups: healthy control, control control, selective - exercise, consumption-sodium citrate supplementation, and drink-sodium citrate supplementation. The training protocol included 8 weeks of HIIT training with an intensity of 90% of the maximum speed. The supplement and exercise-supplement groups received daily (764 mg/kg) sodium citrate supplement in the form of a solution in water, three hours before the exercise. 72 hours after the last training session, blood sampling was done and the ELISA method analyzed research variables. To compare study groups, one-way analysis of variance and LSD post hoc test were used in SPSS software (P≥ 0.05).
Results: The results showed that the levels of TRx-sh/TRx-s2, GSH, and TAC were significantly different among the five research groups (P= 0.001). Also, the results showed the levels of TRx-sh/TRx-s2, TAC, and GSH in the control-diabetic group (P= 0.001), diabetic-exercise (P= 0.001), and diabetic-supplement group (P= 0.001). and diabetic-supplement-exercise (P= 0.001) had a significant decrease compared to the healthy control group. The levels of TRx-sh/TRx-s2, GSH, and TAC in the diabetic-supplement and diabetic-supplement-exercise groups were significantly increased compared to the diabetic control group (P= 0.001). According to the difference in means, the increase of TRx-sh/TRx-s2, TAC, and GSH was higher in the diabetic-supplemented group.
Conclusion: According to the results of the research, it can be assumed that training and sodium citrate supplementation are effective in improving diabetes and this effect is probably exerted by increasing TRx-sh/TRx-s2, TAC, GSH.
