Showing 4 results for Sex
H Fakhrzadeh, S Ghotbi, R Pour-Ebrahim, M Nouri, R Heshmat, A Shafaee, B Larijani,
Volume 3, Issue 0 (7-2004)
Abstract
Introduction: Elevated plasma total homocysteine is an independent risk factor for cardiovascular disease and a sensitive marker of vitamin B12 and folate insufficiency. Folate and vitamin B12 have a protective effect on cardiovascular disease. This effect may be partly explained by mechanisms independent of homocysteine. This survey is the first population based study to evaluate the plasma total homocysteine, folic acid and vitamin B12 in 1214 healthy Iranian persons.
Methods: This study which was a part of the Cardiovascular Risk Factors Survey in the Population Lab region, has been designed and conducted based on MONICA/WHO project. A total of 1214 people have been recruited and assessed on serum homocysteine, folic acid and vitamin B12 with interview, questionnaires, examination and blood sampling. Blood samples were gathered in Venoject tubes and analyzed according to standard methods.
Results: The variables were assessed in 1214 participants include 428 men (35.3%) and 786 women (64.7%). Prevalence of hyperhomocysteinemia was 96.4% in men and 83.3% in women (p<0.0001). Geometric mean of serum homocysteine was 19.02 ± 1.46 µmol/l in men and 14.05± 1.45 µmol/l in women (p<0.004) and increased with age. Folic acid deficiency was seen in 527 (98.9% )men and 833 women (98.0%). 161 (30.1%)men and 232(27.2%) women had vitamin B12 deficiency.
Conclusion: These results revealed that the prevalence of hyperhomocysteinemia, folic acid and vitamin B12 deficiency was higher than other communities considerably. Preventive interventions as food fortification with folic acid is necessary.
Hosein Fakhrzadeh, Sara Ghotbi, Ramin Heshmat, Rasoul Pour-Ebrahim, Masoumeh Nouri, Alireza Shafaee, Bagher Larijani,
Volume 5, Issue 2 (9-2005)
Abstract
Background: Elevated total plasma Homocysteine, is an independent risk factor for cardiovascular disease. Folate and vitamin B12 have not only a protective effect on cardiovascular disease but also an essential effect on total Homocysteine concentrations (tHcy). This survey has been conducted to evaluate the determinants of tHcy in 1191 healthy Iranian adults.
Methods: This study which was a part of the Cardiovascular Risk Factors Survey in the Population Lab Region, has been designed and conducted based on MONICA/WHO project. A total of 1191 people have been recruited and assessed on serum Homocysteine, Folic acid and vitamin B12, triglycerides, cholesterol, HDL-C, LDL-C, FBS, BMI, BP and smoking, with interview, questionnaires, examination and blood sampling. Blood samples were analyzed according to standard methods.
Results: The variables were assessed in 1191 participants include 416 men (34.9%) and 775 women (65.1%). Prevalence of hyperhomocysteinemia was correlated significantly with male sex and aging. Hcy levels were inversely related to serum Folate and vitamin B12 concentrations. After further adjustments, we detected a positive correlation between tHcy and age, male sex, smoking and BMI, and a negative one with LDL-C and diabetes. Although there was a correlation between tHcy and blood pressure, after age, sex, BMI and smoking adjustment, it just remained significant in women and with systolic blood pressure.
Conclusion: We found that dietary and lifestyle parameters such as Folate intake and smoking habit are the main determinants of distribution of plasma Homocysteine in an apparently healthy population. We assumed that lifestyle changes could have considerable subsequences in public health. Our findings confirm the potential advantages of dietary improvements and increased intake of nutrients along with smoking cessation in order to prevent cardiovascular diseases in high-risk patients.
Babak Hooshmand Moghadam, Mohammad Ali Azarbayjani, Sahabeh Mahdian, Ali Bakhtiyari, Mozhgan Eskandari,
Volume 18, Issue 6 (9-2019)
Abstract
Background: Diabetes and obesity are associated with a decrease in sexual function and sexual activity due to changes in sex hormones. The purpose of this study was to investigate the Independent and interactive effect of Tribulus terrestris supplementation and resistance training on testosterone, FSH, LH and erectile function in obese men with type 2 diabetes.
Methods: In this quasi-experimental study, 40 obese men with type II diabetes (41.97±8.01 years old, BMI 31.97±1.87 kg/m2) were divided into four groups: 1) Resistance training+ placebo 2) Tribulus terrestris 3) Resistance training+Tribulus terrestris 4) Control. Subjects in the first and third groups performed a Resistance training protocol for 8 weeks. Also, the subjects in the second and third groups received Tribulus terrestris 1000 mg daily (two 500 mg capsules) and the first group received the same amount of placebo. Blood samples and questionnaires were collected in two stages before and after the test to assess the biochemical values and erectile function. Statistical analysis of data was performed using t-test, one way ANOVA and Tukey post hoc test at a significance level of 0.05.
Results: Results showed that erectile, testosterone, FSH and LH values increased significantly in the three groups of resistance training, tribulus terrestris and resistance training+tribulus terrestris (P≤0.05). Also, were observed significant difference in all variables between resistance training+tribulus terrestris group whit resistance training and tribulus terrestris groups (P≤0.05).
Conclusion: It seams that eight weeks of independent Tribulus terrestris Consumption and performing Resistance training increases sexual and erectile function. But it seams, combining these two, causes more sexual and erectile dysfunction in obese men with type 2 diabetes.
Parisa Dana, Nasim Hayati Rodbari, Parichehreh Yaghmaei, Zahra Haj Ebrahimi,
Volume 21, Issue 4 (10-2021)
Abstract
Background: Empagliflozin, selective glucose-sodium inhibitor of the latest drugs in the treatment of type 2 diabetes. Diabetes induced hypogonadism disrupts sexual function. There is a direct relationship between reducing blood glucose and reduced libido. In this project, the anti-diabetic drug Empagliflozin in addition to treatment has been studied, in terms of effect on sexual function.
Methods: Type 2 diabetes with injection of 60 mg/kg streptozotocin per body weight was create intraperitoneally. The primary diabetes was treated with two doses of 10 and 25 mg/kg Empagliflozin per body weight. Sexual hormones, biochemical parameters and lipid profile were measured. Evaluation of Sperm parameters and morphological studies were performed on testicular tissue, pancreas and epididymis. Data were analyzed by one-way ANOVA in SPSS software version 22 and P˂0.05 was considered as a significant level.
Results: Empagliflozin significantly increases the quality, survival and natural state of sperm head and tail. Empagliflozin reduces weight in diabetic rats. Empagliflozin Without increasing hyperglycemia by reducing blood glucose affects steroidogenesis, maintains fertility strength in testicles, and increases the level of sex hormones. Empagliflozin significantly increases insulin secretion. Empagliflozin maintains and integrity of pancreatic beta cells. Empagliflozin has no effect on lipid profile.
Conclusion: Empagliflozin in addition positive effects on the treatment of diabetes in the early stage improves sexual function in adult rats.
