Showing 2 results for Swimming Training
Maryam Taheri, Mehrzad Ebadi Ghahramani, Farah Nameni,
Volume 23, Issue 5 (12-2023)
Abstract
Background: Sirtuin-1 is known as a key metabolic sensor in various tissues, including skeletal muscle and tissue, which can play a pivotal role in regulating glucose and lipid metabolism through diacetylase activity. The aim of the present study was to investigate the role of licorice extract and swimming exercise on SIRT1 signaling pathways in the soleus muscle of diabetes male rats.
Methods: The research is of an experimental and fundamental type, and the working method is an experimental work with a descriptive-solution nature. Fifty mice were bought and divided into 5 groups of 10. The main training program consisted of swimming in the rodent tank of the special swimming water tank for 6 weeks and 5 sessions per week. In order to induce diabetes in the mice, streptozotocin was injected. Seven days after the injection, the blood sugar of the mice was measured, and the mice with blood sugar more than 250 ml/dL were selected as diabetes samples. Licorice root extract was given to two groups of rats. In order to analyze, two-way analysis of variance was used using SPSS26 software.
Results: The results showed that the interaction effect of swimming training and consumption of licorice extract on SIRT1 signaling pathways is statistically significant (P= 0.002).
Conclusion: SIRT1 plays an important role in the control of glucose homeostasis. In fact, under certain conditions, the activity and expression level of SIRT1 gene decreases in different SI tissues due to its important metabolic role. Swimming training along with licorice supplement may be used for prevention and treatment of diabetes by positive regulation of SIRT1 gene expression.
Zohreh Massah, Farzaneh Taghian,
Volume 25, Issue 3 (7-2025)
Abstract
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women and has lifelong health effects. This study aimed to investigate the physiological effects of PCOS on neurogenesis and cognitive symptom improvement through lifestyle changes and the use of complementary and alternative medicine.
Methods: In this experimental study, 30 female C57BL/6 mice with a mean weight of 18±2 kg and an age of 6 to 7 weeks were randomly divided into five groups: control group, polycystic group, polycystic + swimming exercise group, polycystic + soy group, and polycystic + exercise + soy group. Real-time PCR measured gene expression. Genes were selected with the help of bioinformatics software. ELISA evaluated luteinizing hormone(LH ) concentration.
Results: FN1-ARC-NGFR-BDNF genes showed decreased expression in mice with PCOS compared to the control group. On the other hand, the expression of FN1-ARC-NGFR-BDNF genes in mice with PCOS, swimming training, and soy supplement consumption significantly increased compared to the PCOS group. Simultaneous administration of swimming training and soy supplement consumption significantly increased LH concentration (p<0.001) and expression of FN1-ARC-NGFR-BDNF genes (p<0.05).
Conclusion: This study showed that combining swimming training and soy extract consumption can enhance neurogenesis in a PCOS model and improve cognitive symptoms. Our findings confirm that this combination not only enhances the function of the nervous system but also contributes to overall health improvement through hormonal regulation. These results provide a new avenue for complementary therapies in the management of PCOS.
