Showing 3 results for Tlgs
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Volume 11, Issue 1 (1-2012)
Abstract
Bita Faam, Maryam Zarkesh, Maryam Sadat Daneshpour, Fereidoun Azizi, Mehdi Hedayati,
Volume 13, Issue 2 (1-2014)
Abstract
Background: It is now evident that adipose tissue functions as an endocrine organ by releasing
adipokines, and the levels of a number of inflammatory markers elevated in overweight and obese
individuals. The objective of this study was to examine the association between inflammatory markers
(IMs) including C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Homocystein (Hcy) and obesity
variables in Tehran Lipid and Glucose Study (TLGS) adults.
Methods: In this cross-sectional study, 352 individuals (132 men and 220 women), age ≥19 years,
were randomly recruited from among TLGS population. Individuals were categorized based on the
waist circumference. The serum levels of IMs were determined using the Enzyme Linked
Immunosorbent Assay (ELISA) method.
Results: The mean age of participants was 46.1±16.1years and Abdominal obesity were present in
199(56.5%) individuals. The levels of hs-CRP and IL-6 were higher in abdominally obese group
(1507±3.3 vs. 577.8±4.3 ng/mL p<0.001) (3.6±3.3 vs. 1.9±3.8 pg/mL p< 0.001), and in the same
group, the best predictors (based on the adjusted R2) for hs-CRP, IL-6 and Hcy were waist (WC),
waist to height ratio (WHtR) and wrist, respectively. Hip and WHtR were the best predictors for Hcy
and hs-CRP in normal group there was no variable significantly correlated with IL-6, therefore it was
not possible to consider an independent predictor for IL-6.
Conclusion: According to this study, obesity is associated with IM levels, and in abdominally obese
group, the best predictor for Hcy, hs-CRP and IL-6 were Wrist, waist and WHtR respectively.
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Volume 14, Issue 1 (1-2015)
Abstract
Background: Obesity is one of the most important risk factors for cardiovascular disease and genetic and environmental factors play important role in this risk factor. The aim of present study was to estimate the heritability of anthropometric variables in Tehran Lipid and Glucose Study (TLGS) families.
Methods: In this cross-sectional study, 529 two generation families were selected from among phase III TLGS. At least two members of the families were overweight or obese. Anthropometric variables, resting energy expenditure (REE) and body size index (BS) were determined. The heritability (h2) of variables was estimated using SOLAR software.
Results: In this study, 2460 individuals (493 fathers, 573 mothers, 720 sans, 674 daughters) participated, and the mean age of parents and offspring were 45.7±10.2 and 18.4±9.7 years respectively. In Tehran families, the sex and age adjusted heritability for anthropometric variables varied from 0.21(0.037) (hip) to 0.51(0.035) (BS) as expected, body size as a skeletal trait had the highest heritability. By considering the BS as a confounder, the REE heritability increased from 0.26 to 0.47. Therefore body size may have important role in determining the heritability of this variable.
Conclusion: genetic factors have decisive role in obesity phenotype of Tehran families.
