Showing 2 results for Training Intensity
Elma Tabari, Hamid Mohebbi, Pouran Karimi, Kamilia Moghaddami, Mousa Khalafi,
Volume 18, Issue 4 (4-2019)
Abstract
Background: The purpose of this study was to compare the effects of a 12 weeks interval training with high and moderate intensity on PGC-1α of skeletal muscle in type 2 diabetic male rats.
Methods: 40 male rats were divided into two groups: High fat diet (HFD) (n=32) and standard diet (C) (n=8) for 10 weeks. After inducing type2 diabetes via STZ, 8 diabetic rats (D) and 8 rats in group C rats sacrificed and the remaining 24 Rats were randomly assigned to three groups of diabetic control (DC), moderate intensity interval training (MIIT) and high intensity interval training (HIIT).The MIIT protocol includes 13 bouts of 4-minute activity with equivalent intensity of 60-65% vo2max and the HIIT protocol includes 10 bouts of 4-minute activity with equivalent intensity of 85-90% vo2max with 2 minute active rest periods that was applied for 12 weeks, 5 sessions per week. Western Blot method was used to measure PGC-1α protein levels.
Results: The results showed that PGC-1α protein levels were significantly lower in the D group compared to the HC group. In contrast, the HIIT protocol resulted in an increase in protein levels of PGC-1α compared to DC2 group. While MICT had no significant effect on protein levels of PGC-1α (P <0.05). Also, there was no significant difference between the two training groups (P<0.05).
Conclusion: It seems that the intensity of interval training plays an important role in the regulation of skeletal muscle PGC-1α and possibly mitochondria biogenesis in type 2 diabetic rats.
Abdollah Fatemi, Amin Farzaneh, Hajar Abaszadeh, Mino Dadban,
Volume 21, Issue 1 (3-2021)
Abstract
Background: The formation of islet amyloid polypeptide (IAPP) have been proposed for d increased b-cell apoptosis in type 2 diabetes. Exercise training plays a protective role against diabetes. Alpha lipoic acid (ALA) is a powerful biological antioxidant. However, the role of exercise training and ALA on IAPP are not well understood. The aim of the present study was to investigate the effect of training with different intensity and Alpha lipoic acid supplement on pancreatic mRNA IAPP in rats with type 2 diabetes.
Methods: In this experimental study, 35 wistar rats were randomly divided into seven groups: control, diabetic (D), diabetic+ alpha lipoic acid (ALA), diabetic high intensity training (HIT), diabetic moderate intensity training (MIT), diabetes HIT+ALA (ALA+HIT), diabetic MIT +ALA (ALA+MIT). The HIT and MIT protocols was performed five days a week for six weeks. HIIT included 10 bouts of four minutes (running at 85–90% of VO2max) and MIT 13 bouts of four minutes (running at 65–70% of VO2max). ALA was administered orally 20 mg/kg once a day by gavage. Real-time PCR method for the relative expression of mRNA of IAPP gene were used.
Results: The level of IPAA increased significantly in diabetic group compared to control (p=0.0039). Also, level of IPAA decreased significantly in ALA (p=0.01) and ALA+HIT diabetic group (p=0.021).
Conclusion: diabetes is associated with increased mRNA IAPP in pancreatic b-cell and HIT plus ALA can be as an effective intervention in decreasing IAPP in pancreatic b-cell. in diabetics.
