Bijan Farzami, Abolfazl Golestani, Iraj Ajami Khyavi,
Volume 3, Issue 2 (6-2004)
Abstract
Background: Insulin dependant Diabetes Mellitus (IDDM) is associated with a reduction in production or secretion of insulin from pancreatic Islets. On the other hand increase in insulin secretion will result in destruction of islets that will lead to Diabetes .Therefore the factors that could regulate secretion will prevent the onset of diabetes . Glucose metabolism that commences with the glucokinase action is closely related to insulin secretion.
The aim of this study is to survey the effect of eat ions Zn2+, V5+ and W5+ on insulin secretion and on the key enzyme, glucokinase, which is known to play an important role in insulin secretion .
Methods: 20 single islets were seprated from pancreatic tissues of each normal and diabetic rats and placed in tubes containing perfusion medium . Method ions with different concentrations/ and controls were provided with each set of experiment . Insulin secretion were determined using IDMA method. Glucokinaes activity in homogenate supernatant of normal and diabetic rats was assayed by spectropho to metric methods.
Results: the level of insulin concernlyation was shown to increase with vandate and tungsten treatment in normal and diabetic rats / and decreased by zinc .The effect of zinc on glucokinase activity was similarly reducing . Tungsten caused an increase in glucokinase activity (p<.001) while vandate showed no effect on the activity of enzyme .
Conclusion: The inhibitory effect of zinc on insulin secretion and the enhancing effect of tungsten correlate closely with their effect on glucokinase activity. There for the effect in insulin secretion could be assumed to be via glucokinase activation or inhibition . The effect of vandate on insulin secretion my be through other mechanisms which is not yet clarified.
Masoumeh Akbari, Emad Ashrafi, Asadollah Rajab,
Volume 18, Issue 4 (4-2019)
Abstract
Background: Type 1 diabetes is a chronic disease that children and adolescents do not have the ability to care for themselves, despite having enough information about their self-care (nutrition, insulin, exercise, etc.). Self-care, such as any behavior, can be influenced by the way of thinking, and the philosophy teaching method can be a suitable educational tool for changing thinking. The purpose of this study was to determine the effectiveness of teaching cognitive errors by philosophy for children on increasing the Well-being and reducing the cognitive errors and the level of glucose in children and adolescents with type 1 diabetes.
Methods: The research method was quasi-experiment with pre-test post-test control group (waiting list) design. The sample included 22 children and adolescents of the Iranian Diabetes Association who responded to the cognitive errors scale of children and adolescents Quinn et al., Well-being Questionnaire (WHO-5) and blood glucose (A1C). To test the hypotheses, MANCOVA was used.
Results: The result of MANCOVA was significant. Subsequently, there were significant differences between cognitive errors (F (17,1) =9/01, P=0/008) and Well-being (F (17,1) =7/4, P=0/01) between two groups, but the level of blood glucose (F= (17,1) =0/01, P=0/8) was not significant.
Conclusion: Learning cognitive errors in the philosophy for children and adolescents leads to the growth of reasoning, the rational thinking of children and adolescents, and helps them to take care of themselves in conditions of failure, stress and anxiety, and improves their emotional well-being. However, it seems that it takes longer to effect on blood glucose.
